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06/2010
Many neural control systems are at least roughly optimized, but how is optimal control learned in the brain? There are algorithms for this purpose, but in... 
0719
Dissertation
11/2013
Glucagon-like peptide-2 (GLP-2) is an intestinal hormone that promotes gut growth through an insulin-like growth factor (IGF)-1 and intestinal epithelial... 
0719 | GLP-2
Dissertation
06/2014
Neuronal vulnerability to ischemia is dependent on the balance between pro-survival and pro-death cellular signaling. In the latter, it is increasingly... 
TRPM2 NMDA | 0719 | ischemia
Dissertation
11/2008
Type 2 diabetes is hallmarked by insufficient beta-cell insulin secretion and inappropriate alpha-cell glucagon secretion concomitant to peripheral insulin... 
0719 | Physiology
Dissertation
11/2008
Retrospective epidemiological studies of British cohorts have found an inverse relationship between birth size and rates of mortality from cardiovascular... 
physiology | 0719
Dissertation
11/2013
The hippocampus is a brain region that is critically involved in memory formation. Stratum oriens-lacunosum/moleculare (O-LM) interneurons have been shown to... 
neuroscience | 0719 | computational
Dissertation
11/2013
SIRT1 has emerged as a critical regulator of glucose homeostasis and metabolism in the past decade. Glucose homeostasis is tightly regulated by insulin... 
0719 | Diabetes | SIRT1
Dissertation
11/2012
Previous studies have shown that NACHT, leucine rich repeat and PYD domain containing 5 (Nlrp5) deficient embryos fail to develop beyond the two-cell stage.... 
Embryo | Nlrp5 | 0719
Dissertation
11/2012
Cholecystokinin (CCK) is a gut peptide involved in the regulation of energy homeostasis by duodenal lipids via a neuronal network. However, it is unknown... 
gut | 0719 | CCK
Dissertation
06/2012
Pancreatic alpha- and beta-cells play vital roles in maintaining glucose homeostasis. While much work has investigated beta-cell biology, alpha-cell research... 
Electrophysiology | 0719 | Diabetes
Dissertation
03/2012
Whether vascular endothelial growth factor A (VEGF) plays an augmented role during pregnancy is unknown. In this thesis expression of VEGF in the placenta,... 
VEGF | placenta | 0719
Dissertation
03/2012
Multidrug resistance phosphoglycoprotein (P-gp) is expressed in the placenta and fetal blood-brain barrier (BBB) and plays a critical role in reducing fetal... 
Reproduction | Development | 0719 | 0758
Dissertation
03/2012
Excitatory synaptic transmission and plasticity mediated by glutamate receptors are important for many brain functions, including learning and memory. Various... 
Synaptic plasticity | 0719 | GluR2
Dissertation
11/2011
The CAPS1 protein was initially discovered as a cytosolic soluble 145kDa protein which was necessary to restore calcium dependent norephinephrine secretion in... 
Secretion | 0719 | CAPS1
Dissertation
11/2011
DISC1 is an established susceptibility gene for schizophrenia. To gain insight on the neural mechanisms responsible for hippocampal deficits in schizophrenia,... 
Schizophrenia | 0719 | Place Cells
Dissertation
11/2011
Neuronal regeneration in the mammalian central nervous system (CNS) is severely compromised due to the presence of extrinsic inhibitory signals and a reduced... 
Invertebrate | Regeneration | 0719
Dissertation
11/2011
The incretin hormone glucagon-like peptide-1 enhances glucose-dependent insulin secretion and is therefore a most attractive therapeutic approach for the... 
GLP-1 | metformin | 0719
Dissertation
11/2011
Sirtuins are a family of nicotinamide adenine dinucleotide - dependent enzymes, which have gained recent interest due to their ability to directly or... 
mitochondria | 0719 | SIRT3
Dissertation
03/2014
Our laboratory has demonstrated previously that the proglucagon gene (gcg), which encodes the incretin hormone GLP-1, is among the downstream targets of the... 
Pak1 | GLP-1 | 0719 | Gcg | Diabetes
Dissertation
11/2010
Sciatic and saphenous neurectomy produces in mice a neuropathic pain-like behaviour (‘autotomy’). A/J mice express higher autotomy levels than C57BL6/J mice. A... 
Gene | Neuropathic Pain | 0719
Dissertation
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