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11/2013
Glioblastoma (GBM), similar to many other cancers, exhibits enhanced aerobic glycolysis with concomitant lactate production, a phenomenon known as the Warburg... 
0992 | Glioblastoma | Metabolism
Dissertation
11/2013
Survival rates for pediatric B-cell acute lymphoblastic leukemia (B-ALL) have improved dramatically, but outcomes for the 15% who relapse and for adults with... 
RANKL | Flt3 | 0992
Dissertation
11/2012
Hematopoiesis describes the formation and development of blood cells. All blood cells originate from a pluripotent hematopoietic stem cell (HSC) which has the... 
leukemia | hematopoiesis | 0992
Dissertation
11/2012
The Hedgehog (Hh) signaling pathway plays a critical role in modulating various developmental processes that requires fine tuning of the Hh signal, such that... 
0369 | Chondrosarcoma | Hedgehog | 0992
Dissertation
11/2012
Myeloproliferative neoplasms (MPNs) are a group of disorders characterized by an excess production of a specific, fully functional blood cell type. Many cases... 
Molecular Biology | 0992 | Cancer
Dissertation
06/2012
In Canada, ovarian cancer kills about 67% of diagnosed patients, largely due to difficulties in early diagnosis. Current treatment consists of debulking... 
0992 | ovarian cancer | chemotherapy
Dissertation
03/2012
Polo-like kinase 4 (Plk4) has been identified as a molecular marker of resistance to therapy in cancer. Our laboratory has recently shown a motility defect in... 
Plk4 | 0992 | motility | cancer
Dissertation
11/2011
The pediatric sarcoma alveolar rhabdomyosarcoma (ARMS) is highly aggressive with a poor prognosis for diagnosed patients. Here, we demonstrate that targeting... 
0379 | 0992 | 0307
Dissertation
06/2014
Breast cancer is a major health issue, affecting annually approximately 1.4 million women worldwide. It is a highly heterogeneous disease with the different... 
0992 | breast cancer | mass spectrometry
Dissertation
03/2014
Large intergenic RNAs (lincRNA) are involved in numerous cellular processes, including many relevant to normal development and cancer progression. In my... 
0379 | 0992 | 0564 | Glioblastoma | lincRNAs
Dissertation
11/2010
BACKGROUND: The incidence of liver metastases from colorectal cancer (CLM) is on the rise. Older cancer patients are frequently subject to under-treatment.... 
0992 | geriatric | surgical oncology
Dissertation
11/2010
Chemotherapy is often administered once every three weeks to allow repopulation of essential normal tissues such as the bone marrow. Repopulation of surviving... 
Repopulation | 0992 | Solid tumours
Dissertation
11/2010
Compared to radical nephrectomy (RN), partial nephrectomy (PN) leads to improved renal function preservation. However, PN may be infrequently utilized,... 
Nephrectomy | 0992 | Kidney Cancer
Dissertation
06/2010
FDA-approved drugs with previously unrecognized anti-cancer activity could be rapidly repurposed for this new indication. We compiled a library of such... 
0992 | Leukemia | Ivermectin
Dissertation
06/2010
Introduction: Objectives were to describe time intervals between presentation to a tertiary care center, diagnosis and treatment in pediatric acute... 
Pediatrics | 0992 | Oncology
Dissertation
06/2013
This thesis employed methods used in health care decision making to evaluate strategies for prevention and treatment of febrile neutropenia (FN) in non-Hodgkin... 
0992 | lymphoma | cost-effectiveness analysis
Dissertation
11/2012
The ability of cancer cells to escape anti-tumor immune responses is acknowledged as one of the hallmarks of cancer. Overexpression of immunoregulatory... 
CLL | 0992 | 0982 | immunotherapy | CD200
Dissertation
11/2013
Low Dose Metronomic (LDM) chemotherapy, combined with VEGF pathway inhibitors, is a highly effective strategy to coordinately inhibit angiogenesis and tumor... 
Angiogenesis | Pediatric cancer | 0992 | Metronomic topotecan | Pazopanib
Dissertation
11/2013
Paediatric ependymomas are the third most common childhood brain cancer and represent a prognostic and therapeutic challenge. Previous evidence suggests that... 
ependymoma | Imetelstat | telomerase | 0992 | telomerase inhibition
Dissertation
06/2010
MicroRNA is a single-stranded RNA molecule of about 22 nucleotides in length and is expressed endogenously. It functions as a gene regulator by pairing... 
0379 | 0992 | microRNA | 0307
Dissertation
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