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Synthesis (Stuttgart), ISSN 0039-7881, 2016, Volume 48, Issue 8, pp. 1122 - 1130
We describe the hitherto unknown use of N-Boc-protected hydrazine in the Ugi tetrazole reaction to access a library of highly substituted... 
tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 3 methylbutyl]hydrazine 1 carboxylic acid | tert butyl 2 [2 methyl 1 (1 phenethyl 1h tetrazol 5 yl)propyl]hydrazine 1 carboxylic acid | unclassified drug | proton transport | Ugi reaction | Ugi tetrazole reaction | tert butyl 2[1 (1 tert butyl 1h tetrazol 5 yl) 3 phenylpropyl]hydrazine 1 carboxylic acid | hydrazine | drug isolation | electrospray mass spectrometry | isocyanides | benzyl 4 [2 (tert butoxycarbonyl)hydrazino] 4[1 [2 (1h indol 3 yl)ethyl] 1h tetrazol 5 yl]piperidine 1 carboxylic acid | deprotection reaction | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 3 phenylpropyl]hydrazine 1 carboxylic acid | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 2 phenylethyl]hydrazine 1 carboxylic acid | tert butyl 2 [2 [1 (1 methoxy 4 methyl 1 oxopentan 2 yl) 1h tetrazol 5 yl]propan 2 yl]hydrazine 1 carboxylic acid | mass spectrometry | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 2 methylpropyl]hydrazine 1 carboxylic acid | tert butyl 2 [cyclohexyl(1 cyclohexyl 1h tetrazol 5 yl)methyl]hydrazine 1 carboxylic acid | proton nuclear magnetic resonance | hydrazine derivative | drug screening | chemical reaction | supercritical fluid chromatography | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl)(cyclohexyl)methyl]hydrazine 1 carboxylic acid | tert butyl 2 [1 (1 phenethyl 1h tetrazol 5 yl)cyclohexyl]hydrazine 1 carboxylic acid | article | carbon nuclear magnetic resonance | To be checked by Faculty | tert butyl 2 [3 methyl 1 (1 phenethyl 1h tetrazol 5 yl)butyl]hydrazine 1 carboxylic acid | one pot synthesis | tetrazoles | tert butyl 2 [1 chloro 2 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]propan 2 yl]hydrazine 1 carboxylic acid | tert butyl 2 [2 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]butan 2 yl]hydrazine 1 carboxylic acid | tert butyl 2 [1 [1 benzyl 4 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]piperidin 4 yl]]hydrazine 1 carboxylic acid | tert butyl 2 [cyclohexyl (1 phenethyl 1h tetrazol 5 yl)methyl]hydrazine 1 carboxylic acid | multicomponent reaction | tert butyl 2 [2 chloro 1 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]ethyl]hydrazine 1 carboxylic acid | paper | 3-COMPONENT REACTION | CHEMISTRY, ORGANIC | ALPHA-AMINO-ACIDS | MULTICOMPONENT REACTIONS | DIASTEREOSELECTIVE SYNTHESIS | CHEMISTRY | DIVERSITY | LEWIS-ACIDS | 4-COMPONENT CONDENSATION | EFFICIENT
Journal Article
Canadian medical education journal, ISSN 1923-1202, 04/2020, Volume 11, Issue 2, pp. e31 - e153
Journal Article
Acta materialia, ISSN 1359-6454, 05/2018, Volume 149, pp. 97 - 107
The ω phase transformation in numerous group IV transition metals plays a key role to change the phase stability and modify mechanical properties, although its... 
{1 1 2}<1 1 1>β | Deformation twinning | ITB-ω phase | {1 1 0}<1 1 0>α | Stress-induced martensitic transformation | Interfacial phase | {1 1 2}<1 1 1> | {1 1 0}<1 1 0> | Mechanics | Engineering Sciences | Mechanics of materials
Journal Article
Letters in drug design & discovery, ISSN 1570-1808, 2016, Volume 13, Issue 1, pp. 64 - 76
A series of 6,7-disubstituted-3-{2-[4-(substituted) piperazin-1-yl]-2-oxoethyl}quinazoline-2,4(1H, 3H)-dione derivatives (7-34) were synthesized and their... 
Cytotoxicity | Sulforhodamine B method | Quinazoline | Anticancer | Quinazoline-2,4(1H,3H)-dione | Piperazine | SUBSTITUTED QUINAZOLINEDIONES | DESIGN | CHEMISTRY, MEDICINAL | AMPA | PROTEIN | piperazine | sulforhodamine B method | ANTICONVULSANT | anticancer | QUINAZOLINE-2,4-DIONE | IN-VITRO | DNA GYRASE | INHIBITORS | TOPOISOMERASE-IV | cytotoxicity | quinazoline-2,4(1H,3H)-dione
Journal Article
Bioorganic & medicinal chemistry, ISSN 0968-0896, 06/2015, Volume 23, Issue 11, pp. 2699 - 2715
[Display omitted] Scaffold diversity is key in the ongoing exercise of discovery of novel bioactive compounds using high throughput screening (HTS). Based on... 
Synthesis | Tetrazol | Parallel | Isocyanide | Ugi | Pictet–Spengler | unclassified drug | n [[(4 chlorophenyl)[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]methyl] 2 3,4 dimethoxyphenyl]ethanamine | 8 ethyl 2,3 dimethoxy 8 methyl 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | n [2 (1h indol 3 yl)ethyl] 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]propan 1 amine | tetracyclic tetrazole scaffold | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)cyclohexanamine | n [[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl](4 fluorophenyl)methyl] 2 (3,4 dimethoxy phenyl)ethanamine | 8 (4 chlorophenyl) 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 isopropyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 phenylethanamine | high throughput screening | mass spectrometry | Pictet-Spengler | multicomponent reaction chemistry | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)propan 1 amine | thin layer chromatography | 1 benzyl 4 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxy phenethyl)piperidin 4 amine | proton nuclear magnetic resonance | n [2 (1h indol 3 yl)ethyl] 1 benzyl 4 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]piperidin 4 amine | 2,3 dimethoxy 8 phenyl 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 7',12',12b',13' tetrahydro 6'h spiro[cyclohexane 1,4' tetrazolo[1'',5'' 4',5']pyrazino[1',2' 1,2]pyrido[3,4 b]indole] | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 phenylpropan 1 amine | 2,3 dimethoxy 8 phenethyl 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | chemical reaction | supercritical fluid chromatography | tetrazole derivative | n [2 (1h indol 3 yl)ethyl] 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]cyclohexanamine | article | carbon nuclear magnetic resonance | n [[1,1' biphenyl] 4 yl[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]methyl] 2 (3,4 dimethoxyphenyl)ethanamine | controlled study | 8 (4 fluorophenyl) 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 benzyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 ethyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 methylpropan 1 amine | 8 [[1,1' biphenyl] 4 yl] 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 benzyl 2',3'dimethoxy 5',6',13',13a' tetrahydrospiro[piperidine 4,8' tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline] | 4 ethyl 4,6,7,12,12b,13 hexahydro tetrazolo[1'',5'' 4',5']pyrazino[1',2' 1,2]pyrido[3,4 b]indole | 2',3'dimethoxy 5',6',13',13a' tetrahydrospiro[cyclohexane 1,8' tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline] | unindexed drug | pharmacophore | n [[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl](phenyl)methyl] 2 (3,4 dimethoxy phenyl)ethanamine | 2 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)butan 2 amine | CHEMISTRY, MEDICINAL | ONE-POT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PRAZIQUANTEL | LIBRARIES | MULTICOMPONENT REACTIONS | CHEMISTRY | DIVERSITY | EFFICIENT | DERIVATIVES | Models, Molecular | Molecular Structure | Tetrazoles - chemical synthesis | Polycyclic Compounds - chemical synthesis | Drug Discovery | Pictet-spengler
Journal Article
Journal Article
Journal of Vascular and Interventional Radiology, ISSN 1051-0443, 2012, Volume 23, Issue 11, pp. 1516 - 1521
Abstract Purpose To clarify the configuration change of N -butyl cyanoacrylate (NBCA) polymerization with increasing proportion of ethanol, the properties of a... 
Radiology | NBCA, lipiodol, and ethanol mixture | NLE110 | NLE112 | NLE211 | NLE111 | NLE213 | NLE312 | NLE411 | NLE113 | NLE212 | NLE311 | NLE | NLE413 | NLE313 | NLE412 | NLE at a ratio of 4:1:1 | NLE at a ratio of 4:1:3 | NLE at a ratio of 4:1:2 | NBCA, lipiodol, and ethanol mixture at a ratio of 1:1:1 | NLE at a ratio of 2:1:1 | N-butyl cyanoacrylate | NLE at a ratio of 1:1:3 | NLE at a ratio of 1:1:2 | NLE at a ratio of 2:1:2 | NLE at a ratio of 2:1:3 | NBCA | NBCA mixed with lipiodol at a ratio of 1:1 | NLE at a ratio of 3:1:3 | NLE at a ratio of 3:1:2 | NLE at a ratio of 3:1:1 | SWINE MODEL | ARTERIOVENOUS-MALFORMATIONS | TRANSCATHETER ARTERIAL EMBOLIZATION | POLYMERIZATION TIME | ANEURYSMS | 2-CYANOACRYLATE | PERIPHERAL VASCULAR DISEASE | EXPERIENCE | GUGLIELMI DETACHABLE COILS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Viscosity | Rheology | Adhesiveness | Ethanol - administration & dosage | Polymerization | Materials Testing | Ethiodized Oil - chemistry | Enbucrilate - chemistry | Feasibility Studies | Ethiodized Oil - administration & dosage | Particle Size | Radiography | Aneurysm - therapy | Carotid Artery Diseases - therapy | Animals | Carotid Artery Diseases - diagnostic imaging | Ethanol - chemistry | Female | Aneurysm - diagnostic imaging | Embolization, Therapeutic - methods | Enbucrilate - administration & dosage | Disease Models, Animal
Journal Article
Autophagy, ISSN 1554-8635, 2015, Volume 11, Issue 2, pp. 200 - 213
Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single... 
TSC, tuberous sclerosis complex | exercise | ATG, autophagy-related | BECN1, Beclin 1, autophagy related | MTMR14/hJumpy, myotubularin related protein 14 | protein breakdown | ULK1, unc-51 like autophagy activating kinase 1 | HSF1, heat shock transcription factor 1 | heat shock response | PBMC, peripheral blood mononuclear cell | FOXO, forkhead box O | EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1 | MTOR, mechanistic target of rapamycin | autophagy | HSP70 | SQSTM1/p62, sequestosome 1 | HSPA8/HSC70, heat shock 70kDa protein 8 | protein synthesis | SOD, superoxide dismutase | TPR, translocated promoter region, nuclear basket protein | PPARGC1A/PGC-1α, peroxisome proliferator-activated receptor, gamma, coactivator 1 α | LC3, MAP1LC3, microtubule-associated protein 1 light chain 3 | NR1D1/Rev-Erb-α, nuclear receptor subfamily 1, group D, member 1 | AMPK, adenosine monophosphate-activated protein kinase | AKT, v-akt murine thymoma viral oncogene homolog 1 | RHEB, Ras homolog enriched in brain | IL, interleukin | HSP, heat shock protein | humans | ER, endoplasmic reticulum | Protein breakdown | Exercise | Protein synthesis | Humans | Heat shock response | Autophagy | MAMMALIAN TARGET | CHAPERONE-MEDIATED AUTOPHAGY | MOLECULAR CHAPERONES | ESSENTIAL AMINO-ACID | EXERCISE-INDUCED INCREASE | HUMAN SKELETAL-MUSCLE | CELL BIOLOGY | MUSCLE PROTEIN-SYNTHESIS | RESISTANCE EXERCISE | ECCENTRIC EXERCISE | NF-KAPPA-B | Animals | Lysosomes - metabolism | Heat-Shock Proteins - metabolism | Metabolic Networks and Pathways - physiology | Signal Transduction - physiology | Autophagy - physiology | Heat-Shock Response - physiology
Journal Article
Biochemical journal, ISSN 1470-8728, 2011, Volume 434, Issue 3, pp. 365 - 381
Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient amounts of iron to satisfy metabolic needs or to accomplish... 
Ferroportin | Iron-sulfur cluster (ISC) | Transferrin receptor (TfR) | Iron-regulatory protein 2 (IRP2) | Ferritin | Iron-regulatory protein 1 (IRP1) | ferritin | iron-sulfur cluster (ISC) | transferrin receptor (TfR) | OXIDATIVE STRESS | MAMMALIAN IRON | MITOCHONDRIAL IRON | iron-regulatory protein 2 (IRP2) | HEME-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | iron-regulatory protein 1 (IRP1) | ferroportin | AMYLOID PRECURSOR PROTEIN | RESPONSIVE ELEMENT | TRANSFERRIN-BOUND IRON | RNA-BINDING | H-FERRITIN | HEPCIDIN EXPRESSION | Neoplasms - metabolism | Oxidation-Reduction | Response Elements | Humans | RNA, Messenger - genetics | RNA, Messenger - physiology | Mitochondria - metabolism | Iron - metabolism | Iron-Regulatory Proteins - genetics | Animals | Ferritins - metabolism | Biological Transport | Iron-Regulatory Proteins - physiology | Transferrin - metabolism | DHBA, dihydroxybenzoic acid | IRP, iron-regulatory protein | UTR, untranslated region | SLC, solute carrier | iron–sulfur cluster (ISC) | MRCKα, myotonic dystrophy kinase-related Cdc42 (cell division cycle 42)-binding kinase α | LIP, labile iron pool | Lcn2, lipocalin 2 | FLVCR, feline leukaemia virus, subgroup C, receptor | CIA, cytosolic ISC assembly | Cfd1, cytosolic Fe–S cluster-deficient protein 1 | BMP, bone morphogenetic protein | PCBP1, poly(rC)-binding protein 1 | Abcb, ATP-binding cassette, subfamily B | STAT3, signal transducer and activator of transcription 3 | SDH, succinate dehydrogenase | TfR, Tf receptor | c-aconitase, cytosolic aconitase | HIF, hypoxia-inducible factor | HO-1, haem oxygenase 1 | IRIDA, iron-refractory iron deficiency anaemia | ISC, iron–sulfur cluster | m-aconitase, mitochondrial aconitase | DMT1, divalent metal transporter 1 | Review | EBPα, CCAAT | IRE, iron-responsive element | IOP1, iron-only hydrogenase-like protein 1 | Nbp35, nucleotide-binding protein 35 | Skp1, S-phase kinase-associated protein 1 | Nfs, nitrogen fixation homologue | FBXL5, F-box and leucine-rich repeat protein 5 | ROS, reactive oxygen species | Tf, transferrin | enhancer-binding protein α | H, heavy | Isu, iron–sulfur cluster scaffold homologue | Rbx1, Ring-box 1 | β-APP, β-amyloid precursor protein | Dcytb, duodenal cytochrome b | Nar1, nuclear architecture-related protein 1 | ALAS, ALA synthase | NTBI, non-transferrin-bound iron | ALA, 5-aminolevulinic acid | Hpx, haemopexin | Cul1, Cullin 1 | Grx, glutaredoxin | ER, endoplasmic reticulum | L, light
Journal Article