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1. Full Text Vitamin D3: a helpful immuno‐modulator
by Di Rosa, Michelino and Malaguarnera, Michele and Nicoletti, Ferdinando and Malaguarnera, Lucia
Immunology, ISSN 0019-2805, 10/2011, Volume 134, Issue 2, pp. 123 - 139
Summary The active metabolite of vitamin D, 1α, 25‐dihydroxyvitamin D3 [1,25(OH)2D3], is involved in calcium and phosphate metabolism and exerts a large number... 
immune cells | immunoregulation | innate immunity | adaptive immunity | vitamin D3 | Vitamin D3 | Innate immunity | Adaptive immunity | Immune cells | Immunoregulation | MYCOBACTERIUM-TUBERCULOSIS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DENDRITIC CELLS | NORMAL HUMAN MACROPHAGES | IMMUNOLOGY | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | CATHELICIDIN ANTIMICROBIAL PEPTIDE | REGULATORY T-CELLS | 1,25-DIHYDROXYVITAMIN D-3 | D-RECEPTOR | HUMAN-MONOCYTES | Immunity, Cellular - immunology | Animals | Virus Diseases - drug therapy | Virus Diseases - immunology | Bacterial Infections - drug therapy | Bacterial Infections - immunology | Immunomodulation | Humans | Calcitriol - metabolism | Mice | Calcitriol - therapeutic use | Phosphates | Vitamin D | Metabolites | Immunotherapy | Calcifediol | Disease susceptibility | Alfacalcidol | Medical research | Rodents | Immune system | Review
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2. Full Text Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts
by Van Etten, Evelyne and Mathieu, Chantal
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 10/2005, Volume 97, Issue 1-2, pp. 93 - 101
1,25-Dihydroxyvitamin D (1,25(OH) D ), the biologically active metabolite of Vitamin D , not only regulates bone and calcium metabolism but also exerts other... 
Thelper cells | Immunomodulatory effects | Transplantation | Autoimmune diseases | Antigen-presenting cells | 1,25-Dihydroxyvitamin D | Calcitriol - analogs & derivatives | Animals | Calcitriol - deficiency | Receptors, Calcitriol - immunology | Immune System - metabolism | Humans | Immune System - immunology | Calcitriol - immunology
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3. Full Text Ligation of TLR9 induced on human IL-10-secreting Tregs by 1α,25-dihydroxyvitamin D3 abrogates regulatory function
by Urry, Zoë and Xystrakis, Emmanuel and Richards, David F and McDonald, Joanne and Sattar, Zahid and Cousins, David J and Corrigan, Christopher J and Hickman, Emma and Brown, Zarin and Hawrylowicz, Catherine M
Journal of Clinical Investigation, ISSN 0021-9738, 02/2009, Volume 119, Issue 2, pp. 387 - 398
Signaling through the TLR family of molecular pattern recognition receptors has been implicated in the induction of innate and adaptive immune responses. A... 
RAGWEED ALLERGY | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | DENDRITIC CELLS | IMMUNOSTIMULATORY DNA | TOLL-LIKE RECEPTORS | CD4(+) T-CELLS | VITAMIN-D-RECEPTOR | 1,25-DIHYDROXYVITAMIN D-3 | PULMONARY-FUNCTION | EXPRESSION
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4. Full Text Protective effect of 1α,25-dihydroxyvitamin D3 on effector CD4+ T cell induced injury in human renal proximal tubular epithelial cells
by Chung, Byung Ha and Kim, Bo-Mi and Doh, Kyoung Chan and Cho, Mi-La and Kim, Kyoung Woon and Yang, Chul Woo
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0172536
Background The aim of this study was to investigate the protective effect of 1 alpha, 25-dihydroxyvitamin D3 [1,25(OH)(2)D3] on effector CD4(+) T cells or on... 
MAMMALIAN TARGET | RHEUMATOID-ARTHRITIS | IMMUNE-SYSTEM | PHOSPHATIDYLINOSITOL 3-KINASE | TUBULOINTERSTITIAL INJURY | MULTIDISCIPLINARY SCIENCES | CHEMOKINE PRODUCTION | 25-HYDROXYVITAMIN D | 1,25-DIHYDROXYVITAMIN D-3 | TRANSPLANT RECIPIENTS | VITAMIN-D DEFICIENCY | Kidney Tubules, Proximal - cytology | Leukocytes, Mononuclear - metabolism | Epithelial Cells - metabolism | Leukocytes, Mononuclear - drug effects | Epithelial Cells - drug effects | Humans | Middle Aged | Vitamin D - pharmacology | Male | Hepatitis A Virus Cellular Receptor 1 - genetics | Interleukin-17 - pharmacology | CD4-Positive T-Lymphocytes - physiology | Transforming Growth Factor beta - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Adult | Female | Vitamin D - analogs & derivatives | Cell Proliferation - drug effects | Fibronectins - genetics | Epithelial Cells - cytology | Cytokines - pharmacology | Kidney Tubules, Proximal - drug effects | TOR protein | Cell proliferation | Phosphorylation | Nephrology | Transplants & implants | Disease | Syngeneic grafts | Epithelial cells | Helper cells | Calcitriol | Effector cells | Lymphocytes T | Kinases | Interleukin 6 | Consortia | Cell growth | Dihydroxyvitamin D3 | Vitamin D | Lymphocytes | Interleukin 8 | Enzyme-linked immunosorbent assay | 25-Hydroxyvitamin D | Urine | Creatinine | Cytokines | Blood & organ donations | Incubation | Internal medicine | Secretion | Research & development--R&D | Stat3 protein | Extracellular signal-regulated kinase | Inflammation | Interleukin 17 | CD4 antigen | Medicine | Studies | Hospitals | Tumor necrosis factor | Fibrosis | Informed consent | Kidney transplantation | Research & development | R&D
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5. Full Text Comparative therapeutic effects of orally administered 1,25-dihydroxyvitamin D3 and 1alpha-hydroxyvitamin D3 on type-1 diabetes in non-obese diabetic mice fed a normal-calcaemic diet
by Driver, J. P and Foreman, O and Mathieu, C and van Etten, E and Serreze, D. V
Clinical & Experimental Immunology, ISSN 0009-9104, 01/2008, Volume 151, Issue 1, pp. 76 - 85
Summary Frequent injections of the hormonal form of vitamin D3, 1,25 dihydroxyvitamin D3 (1,25D3) reportedly inhibits autoimmune type 1 diabetes (T1D) in... 
type 1 diabetes | calcium | 1,25-dihydroxyvitamin D3 analogues | NOD mouse | dietary supplementation | 1,25‐dihydroxyvitamin D3 analogues | analogues | Calcium | Dietary supplementation | 1,25-dihydroxyvitamin D | Type 1 diabetes | Translational Studies
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6. Full Text Estimated GFR and Circulating 24,25-Dihydroxyvitamin D3  Concentration: A Participant-Level Analysis of 5 Cohort Studies and Clinical Trials
by de Boer, Ian H., MD, MS and Sachs, Michael C., PhD and Chonchol, Michel, MD and Himmelfarb, Jonathan, MD and Hoofnagle, Andrew N., MD, PhD and Ix, Joachim H., MD, MAS and Kremsdorf, Robin A., MD, MS and Lin, Yvonne S., PhD and Mehrotra, Rajnish, MD and Robinson-Cohen, Cassianne, PhD and Siscovick, David S., MD, MPH and Steffes, Michael W., MD, PhD and Thummel, Kenneth E., PhD and Tracy, Russell P., PhD and Wang, Zhican, PhD and Kestenbaum, Bryan, MD, MS
American Journal of Kidney Diseases, ISSN 0272-6386, 2014, Volume 64, Issue 2, pp. 187 - 197
Background Decreased glomerular filtration rate (GFR) leads to reduced production of 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3 (25[OH]D3 ). Effects of... 
Nephrology | low estimated glomerular filtration rate | 1,25-dihydroxyvitamin D3 | Decreased renal function | 25-hydroxyvitamin D3 | vitamin D catabolism | active vitamin D | chronic kidney disease (CKD) | biomarker | Index Words | Diabetes Mellitus - blood | Kidney Failure, Chronic - physiopathology | Kidney Failure, Chronic - diagnosis | Cross-Sectional Studies | Randomized Controlled Trials as Topic - methods | Humans | Middle Aged | Male | Biomarkers - blood | Glomerular Filtration Rate - physiology | Young Adult | Kidney Failure, Chronic - blood | Observational Studies as Topic - methods | Diabetes Mellitus - physiopathology | Aged, 80 and over | Adult | Female | Aged | Diabetes Mellitus - diagnosis | 24,25-Dihydroxyvitamin D 3 - blood | Cohort Studies | decreased renal function
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7. Full Text Effects of 1α,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells
by Wang, Wei-Lin W and Chatterjee, Namita and Chittur, Sridar V and Welsh, JoEllen and Tenniswood, Martin P
Molecular Cancer, ISSN 1476-4598, 05/2011, Volume 10, Issue 1, pp. 58 - 58
Background: There is evidence from epidemiological and in vitro studies that the biological effects of testosterone (T) on cell cycle and survival are... 
BREAST-CANCER | ANDROGEN RECEPTOR | TARGET GENES | ONCOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER CELLS | GENE-EXPRESSION | VITAMIN-D-RECEPTOR | 1,25-DIHYDROXYVITAMIN D-3 | HORMONAL TREATMENT | MICRORNA EXPRESSION | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | Reproducibility of Results | Humans | Molecular Sequence Annotation | RNA, Messenger - genetics | Vitamin D - pharmacology | Male | MicroRNAs - metabolism | Gene Expression Profiling | Prostatic Neoplasms - physiopathology | RNA, Messenger - metabolism | Testosterone - pharmacology | Vitamins - pharmacology | Prostatic Neoplasms - genetics | Androgens - pharmacology | Cell Death | Cell Line, Tumor | Vitamin D - analogs & derivatives | MicroRNAs - genetics | Gene Expression Regulation, Neoplastic - drug effects | Cell Cycle - drug effects | Homeostasis - genetics | Cell proliferation | Transcription | Calcitriol | Intracellular signalling | Lipids | Regulatory sequences | Hormones | Second messengers | Dihydroxyvitamin D3 | Vitamin D | Feedback | Cell cycle | miRNA | Age | Calcium homeostasis | Cell survival | Statistical analysis | Tumor cells | Data processing | Gene expression | Nuclear receptors | Promoters | Testosterone | Androgens | DNA microarrays | Cell death | Prostate cancer | Cell migration | Steroid hormones | Tumors
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8. Full Text Vitamin D3 inhibits the proliferation of T helper cells, downregulate CD4+ T cell cytokines and upregulate inhibitory markers
by Sheikh, Vida and Kasapoglu, Pinar and Zamani, Alireza and Basiri, Zahra and Tahamoli-Roudsari, Ahmad and Alahgholi-Hajibehzad, Mahdi
Human Immunology, ISSN 0198-8859, 06/2018, Volume 79, Issue 6, pp. 439 - 445
1 α, 25-dihydroxyvitamin D3 (VitD3) has been suggested to have strong modulatory properties in the immune system. Researchers in the present study primarily... 
Vitamin D3 | CTLA4 | PD1 | T cell | Cytokine | MYCOBACTERIUM-TUBERCULOSIS | D DEFICIENCY | IMMUNOLOGY | Cytolcine | IMMUNE-SYSTEM | AUTOIMMUNITY | INFLAMMATION | 1,25-DIHYDROXYVITAMIN D-3 | INFECTION | D-RECEPTOR | MYASTHENIA-GRAVIS | CALCITRIOL
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9. Full Text 20-Hydroxyvitamin D3, a Product of Vitamin D3 Hydroxylation by Cytochrome P450scc, Stimulates Keratinocyte Differentiation
by Zbytek, Blazej and Janjetovic, Zorica and Tuckey, Robert C and Zmijewski, Michal A and Sweatman, Trevor W and Jones, Emily and Nguyen, Minh N and Slominski, Andrzej T
Journal of Investigative Dermatology, ISSN 0022-202X, 09/2008, Volume 128, Issue 9, pp. 2271 - 2280
It has been shown that mammalian cytochrome P450scc can metabolize vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,22(OH)2D3. To define the biological... 
SYSTEM | ACTIVATION | D METABOLITES | PATHWAY | HUMAN-SKIN | CALCIUM | 1,25-DIHYDROXYVITAMIN-D3 | GENE-EXPRESSION | ERGOSTEROL | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | DERMATOLOGY | Cell Line | Steroid Hydroxylases - metabolism | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Hydroxylation | Skin - metabolism | Humans | Cells, Cultured | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism | Calcifediol - analogs & derivatives | Vitamin D3 24-Hydroxylase | Keratin-14 - metabolism | Keratinocytes - cytology | Receptors, Calcitriol - metabolism | Calcifediol - pharmacology | Protein Precursors - metabolism | Adrenal Glands - metabolism | Cell Differentiation - drug effects | Cholecalciferol - metabolism | Cholestanetriol 26-Monooxygenase - metabolism | Keratinocytes - metabolism | Calcifediol - metabolism | Calcitriol - metabolism | Cell Proliferation - drug effects | Cell Differentiation - physiology | Original
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10. Full Text Vitamin D3 induces the expression of membrane progesterone receptors (mPRs) on naive CD4+ T lymphocyte cells in women of reproductive age
by Rafiee, Mitra and Naseri, Mohsen and Akbari-Fakhrabadi, Maryam and Motamedi, Narges and Ghahiri, Ataollah and Mehrabian, Ferdous and Rezaei, Abbas
International Immunopharmacology, ISSN 1567-5769, 07/2019, Volume 72, pp. 55 - 61
Vitamin D3 and progesterone (P4) both belong to steroid hormones. These hormones have effects on the function of each other in different ways. The... 
Vitamin D3 | membrane progesterone receptors | Progesterone | TOLERANCE | D DEFICIENCY | IMMUNOLOGY | HUMAN BREAST-CANCER | PREGNANCY | HORMONE | REGULATORY CELLS | PHARMACOLOGY & PHARMACY | 1,25-DIHYDROXYVITAMIN D-3 | SUPPRESSES | Cell culture | Immunomodulation | Channel gating | Fetuses | Fluorescence | Lymphocytes T | CD3 antigen | Hormones | CD28 antigen | Immunological tolerance | CD4 antigen | Progesterone receptors | Pregnancy | Receptors | Lymphocytes | Correlation analysis | Peripheral blood | Monoclonal antibodies | Gating | Steroid hormones | Steroids
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11. Full Text Cholecalciferol (Vitamin D3) Improves Myelination and Recovery after Nerve Injury
by Chabas, Jean-Francois and Stephan, Delphine and Marqueste, Tanguy and Garcia, Stephane and Lavaut, Marie-Noelle and Nguyen, Catherine and Legre, Regis and Khrestchatisky, Michel and Decherchi, Patrick and Feron, Francois
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e65034
Previously, we demonstrated i) that ergocalciferol (vitamin D-2) increases axon diameter and potentiates nerve regeneration in a rat model of transected... 
PROTEIN | MESSENGER-RNA | RAT | MULTIDISCIPLINARY SCIENCES | D DEFICIENCY | TIBIALIS-ANTERIOR MUSCLE | 1,25-DIHYDROXYVITAMIN D-3 | GROWTH-FACTOR | AFFERENT ACTIVITIES | D-RECEPTOR | BRAIN | Peroneal Nerve - physiology | Peripheral Nerve Injuries - rehabilitation | Motor Activity - drug effects | Myelin Sheath - drug effects | Male | Axons - physiology | Gene Expression Profiling | Muscle Fibers, Skeletal - drug effects | Gene Regulatory Networks | Neurogenesis - genetics | Cholecalciferol - administration & dosage | Time Factors | Peripheral Nerve Injuries - metabolism | Muscle, Skeletal - drug effects | Neurogenesis - drug effects | Muscle Fibers, Skeletal - physiology | Muscle, Skeletal - anatomy & histology | Axons - drug effects | Organ Size | Rats | Gene Expression Regulation - drug effects | Animals | Peroneal Nerve - drug effects | Signal Transduction - drug effects | Nerve Regeneration - drug effects | Peripheral Nerve Injuries - genetics | Cholecalciferol - pharmacology | Vitamin D | Calcifediol | Alfacalcidol | Vitamin D2 | Brain | Peroneal nerve | Vitamin D3 | Spinal cord | Genes | Clinical trials | Recovery of function | Insulin-like growth factors | Kinases | Recovery | Proteins | Paraplegia | Dorsal root ganglia | Rodents | Transcription activation | Supplementation | Medical research | Myelin | Schwann cells | Gene expression | Trauma | Ganglia | Regeneration | Axons | Myelination | Breathing | Life Sciences | Pharmacology | Neurons and Cognition | Pharmaceutical sciences | Neurobiology
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12. Full Text 1,25‐dihydroxyvitamin D3 and its nuclear receptor repress human α1(I) collagen expression and type I collagen formation
by Potter, James J and Liu, Xiaopu and Koteish, Ayman and Mezey, Esteban
Liver International, ISSN 1478-3223, 05/2013, Volume 33, Issue 5, pp. 677 - 686
Background Vitamin D deficiency is common in chronic liver disease particularly in those with severe liver fibrosis. Aims To determine the effect of... 
1,25‐dihydroxyvitamin D3 | stellate cells | vitamin D receptor | Sp1 | α1(I) collagen | transforming growth factor β1 | Stellate cells | 1,25-dihydroxyvitamin D3 | Transforming growth factor β1 | Vitamin D receptor | (I) collagen | Oligonucleotides - genetics | Apoptosis - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | Caspase 3 - metabolism | Hepatic Stellate Cells - metabolism | Promoter Regions, Genetic - genetics | Collagen Type I - genetics | Chromatin Immunoprecipitation | Luciferases | Plasmids - genetics | Calcitriol - metabolism | Electrophoretic Mobility Shift Assay | Cell Line | Enzyme-Linked Immunosorbent Assay | Collagen Type I - antagonists & inhibitors | Drosophila | Receptors, Calcitriol - metabolism | Blotting, Western | Gene Expression Regulation - drug effects | Collagen Type I - biosynthesis | Animals | Analysis of Variance | Calcitriol - pharmacology | Collagen Type I - drug effects
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