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1,4-trifluoromethylation (13) 13
chemistry, organic (10) 10
derivatives (7) 7
chemistry, multidisciplinary (6) 6
ketones (6) 6
trifluoromethylation (6) 6
trimethylsilane (6) 6
chemistry (4) 4
michael addition (4) 4
nucleophilic trifluoromethylation (4) 4
2-polyfluoroalkylchromones (3) 3
carbonyl-compounds (3) 3
chemistry, inorganic & nuclear (3) 3
chemistry/food science, general (3) 3
conjugate addition (3) 3
fluorine (3) 3
organic chemistry (3) 3
regioselective 1,4-trifluoromethylation (3) 3
1st example (2) 2
alcohols (2) 2
aldehydes (2) 2
aldimines (2) 2
alkylation (2) 2
allylic alcohols (2) 2
anions (2) 2
asymmetric trifluoromethylation (2) 2
chemical sciences (2) 2
facile synthesis (2) 2
inorganic chemistry (2) 2
michael reaction (2) 2
oxidase-a inhibitor (2) 2
radical reactions (2) 2
reagents (2) 2
reduction (2) 2
sulfones (2) 2
1,4-addition (1) 1
2,2- bis-2h-chromenes (1) 1
2,2-bis-2 h -chromenes (1) 1
2,2-bis-2h-chromenes (1) 1
3-substituted 5-alkylisoxazoles (1) 1
4h-chromene-4-spiro-5 '-isoxazolines (1) 1
4h-chromene-4-spiro-5′-isoxazolines (1) 1
8-aza- and 1-thiochromones (1) 1
[ chim ] chemical sciences (1) 1
[ chim.anal ] chemical sciences/analytical chemistry (1) 1
[ chim.cata ] chemical sciences/catalysis (1) 1
[ chim.chem ] chemical sciences/cheminformatics (1) 1
[ chim.orga ] chemical sciences/organic chemistry (1) 1
[ chim.theo ] chemical sciences/theoretical and/or physical chemistry (1) 1
[ chim.ther ] chemical sciences/medicinal chemistry (1) 1
addition-reaction (1) 1
alkenes (1) 1
alpha (1) 1
alpha,beta-enones (1) 1
alpha,beta-unsaturated carbonyl-compounds (1) 1
alpha,beta-unsaturated oximes (1) 1
alpha-trifluoromethyl (1) 1
analogs (1) 1
analytical chemistry (1) 1
anti-juvenile hormones (1) 1
antiallergic substances (1) 1
antianaphylactic agents (1) 1
antihypertensive activity (1) 1
arylidene meldrum's acids (1) 1
arylidene meldrums acids (1) 1
arylidenemalononitriles (1) 1
asymmetric-synthesis (1) 1
ate enolate (1) 1
azines (1) 1
beckmann rearrangement (1) 1
befloxatone (1) 1
bisphosphonates (1) 1
bonding (1) 1
bromination (1) 1
building-block (1) 1
butenolides (1) 1
cannabinoids (1) 1
carbonates (1) 1
carbonyl compounds (1) 1
carbonyl compounds, α,β-unsaturated (1) 1
carbonyl compounds, α,β‐unsaturated (1) 1
catalysis (1) 1
center (1) 1
chemical libraries (1) 1
cheminformatics (1) 1
chroman-4-ols (1) 1
chroman-4-ones (1) 1
chromanone (1) 1
chromanones (1) 1
chromones (1) 1
chromones; activated alkenes; nucleophilic 1,4-trifluoromethylation; trimethylsilane (1) 1
conjugates (1) 1
construction (1) 1
construction of r (1) 1
construction of r-f-containing c center (1) 1
construction of rf-containing c center (1) 1
containing c(sp (1) 1
convenient synthesis (1) 1
copper-powder (1) 1
cycloadditions (1) 1
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Organic Letters, ISSN 1523-7060, 08/2011, Volume 13, Issue 15, pp. 3972 - 3975
The organocatalyzed regioselective allylic trifluoromethylation of Morita–Baylis–Hillman adducts using Ruppert–Prakash reagent was achieved in high to... 
NUCLEOPHILIC TRIFLUOROMETHYLATION | SUBSTITUTION | 1,4-TRIFLUOROMETHYLATION | BUTENOLIDES | ALKYLATION | ASYMMETRIC TRIFLUOROMETHYLATION | CONSTRUCTION | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS
Journal Article
by Fan, P and Zhang, C and Lan, Y and Lin, ZY and Zhang, LC and Wang, C
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 10/2019, Volume 55, Issue 84, pp. 12691 - 12694
Hydrofunctionalization of trifluoromethyl alkenes is highly challenging, because the nucleophilic addition is oftentimes followed by beta-F elimination in this... 
ELECTROPHILIC ALKENES | ADDITION-REACTION | NUCLEOPHILIC 5-ENDO-TRIG CYCLIZATION | ALKYLATION | FUNCTIONALIZED GEM-DIFLUOROALKENES | MAGNETIC-RESONANCE | REGIOSELECTIVE 1,4-TRIFLUOROMETHYLATION | FLUORINE | DECATUNGSTATE ANION | CHEMISTRY, MULTIDISCIPLINARY | RADICAL REACTIONS
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 07/2015, Volume 2015, Issue 19, pp. 4093 - 4097
Regioselective trifluoromethylation at a remote position represents an important challenge in the development of biologically active molecules and functional... 
Propargylic alcohols | Radical reactions | Trifluoromethylation | Ketones | Photocatalysis | NUCLEOPHILIC TRIFLUOROMETHYLATION | CHEMISTRY, ORGANIC | ALPHA | SUBSTITUTED KETONES | ALKENES | FACILE SYNTHESIS | ALLYLIC ALCOHOLS | SILYL ENOL ETHERS | ATE ENOLATE | RADICAL TRIFLUOROMETHYLATION | REGIOSELECTIVE 1,4-TRIFLUOROMETHYLATION
Journal Article
Synlett, ISSN 0936-5214, 10/2014, Volume 25, Issue 17, pp. 2451 - 2454
Abstract New chroman-4-ones with gem -difluoroalkyl side chains in position 2 are easily accessible in five steps from salicylaldehyde-type derivatives. The... 
letter | oxa-Michael additions | heterocycles | chromanones | fluorine | FLAVANONE | ASYMMETRIC-SYNTHESIS | gem-difluoroalkyls | CHEMISTRY, ORGANIC | FLAVONOIDS | CHROMANONE | CHEMICAL LIBRARIES | 1,4-TRIFLUOROMETHYLATION | DERIVATIVES | Chemical Sciences
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 06/2009, Volume 50, Issue 25, pp. 2998 - 3000
A method for the trifluoromethylation of arylidene Meldrum's acids using Me SiCF followed by transformation of the initial products to CF -substituted esters... 
Trifluoromethylation | Arylidene Meldrum's acids | Michael reaction | ELECTROPHILICITY PARAMETERS | ALDIMINES | CHEMISTRY, ORGANIC | ALPHA-TRIFLUOROMETHYL | MICHAEL ADDITION | ALCOHOLS | (TRIFLUOROMETHYL)TRIMETHYLSILANE | FACILE SYNTHESIS | 1,4-TRIFLUOROMETHYLATION | TRIMETHYL(TRIFLUOROMETHYL)SILANE | 1ST EXAMPLE
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 11/2013, Volume 54, Issue 45, pp. 6129 - 6132
A mild procedure for the conjugate addition of the trifluoromethyl anion to activated Michael acceptors such as arylidenemalononitriles (15 examples) and... 
Befloxatone | Conjugate addition | Phenyl trifluoromethyl sulfone | Trifluoromethylation | OXIDASE-A INHIBITOR | IMINES | ASYMMETRIC TRIFLUOROMETHYLATION | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | ALDEHYDES | KETONES | 1,4-TRIFLUOROMETHYLATION | MEDIATED REDUCTIVE TRIFLUOROMETHYLATION | Conjugates | Anions | Phenyls | Inhibitors | Oxidase | Tetrahedrons | Magnesium | Sulfones
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2008, Volume 49, Issue 28, pp. 4352 - 4354
Michael addition of the CF -carbanion to arylidenemalononitriles is described. A method for the nucleophilic trifluoromethylation of arylidenemalononitriles... 
Trifluoromethylation | Michael reaction | Arylidenemalononitriles | PENTAFLUOROPHENYLATION | ALDIMINES | CHEMISTRY, ORGANIC | PERFLUOROALKYLATION | arylidenemalononitriles | ALCOHOLS | (TRIFLUOROMETHYL)TRIMETHYLSILANE | SILICON MANNICH REACTION | 1,4-TRIFLUOROMETHYLATION | ORGANIC-COMPOUNDS | trifluoromethylation | 1ST EXAMPLE | DERIVATIVES
Journal Article
Helvetica Chimica Acta, ISSN 0018-019X, 10/2012, Volume 95, Issue 10, pp. 2043 - 2051
A detailed investigation of the reactions of PhSO2CF2H and PhSO2CH2F with (E)‐chalcone (=(E)‐1,3‐diphenylprop‐2‐en‐1‐one) at low temperatures revealed that... 
Carbonyl compounds, α,β‐unsaturated | Nucleophilic fluoroalkylation | Fluorine compounds | Fluoroalkylation | Carbonyl compounds, α,β-unsaturated | ANIONS | Carbonyl compounds | REAGENTS | ss-unsaturated | ALDEHYDES | REGIOSELECTIVITY | CHEMISTRY, MULTIDISCIPLINARY | MICHAEL ADDITION | 1,4-TRIFLUOROMETHYLATION | ENONES | DERIVATIVES | CONJUGATE ADDITION | TRIFLUOROMETHYLATION
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 2011, Volume 132, Issue 5, pp. 363 - 366
Tetraethyl fluoromethylenebisphosphonate in the presence of cesium carbonate in DMF undergoes efficient 1,4-addition to Michael acceptors having terminal... 
Fluorine | Phosphonates | 1,4-Addition | NUCLEOPHILIC TRIFLUOROMETHYLATION | CHEMISTRY, ORGANIC | MECHANISMS | MICHAEL ADDITION | MOLECULES | CHEMISTRY, INORGANIC & NUCLEAR | (TRIFLUOROMETHYL)TRIMETHYLSILANE | BISPHOSPHONATES | ALPHA,BETA-ENONES | 1,4-TRIFLUOROMETHYLATION | RISEDRONATE | DERIVATIVES | Ketones | Esters | Terminals | Carbonates | Bonding | Fluorometers | Sulfones
Journal Article
Heteroatom Chemistry, ISSN 1042-7163, 2005, Volume 16, Issue 6, pp. 492 - 496
The reaction of activated trihalome‐ thylsubstituted alkenes with salicylaldehydes in the presence of triethylamine gives 3‐substituted 2‐trifluo‐... 
CONVENIENT SYNTHESIS | KETONES | 1,4-TRIFLUOROMETHYLATION | REDUCTION | CYCLOADDITIONS | ANTIHYPERTENSIVE ACTIVITY | ANTI-JUVENILE HORMONES | BUILDING-BLOCK | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | POTASSIUM CHANNEL ACTIVATORS
Journal Article
Russian Chemical Bulletin, ISSN 1066-5285, 12/2009, Volume 58, Issue 12, pp. 2465 - 2473
Journal Article
Russian Chemical Bulletin, ISSN 1066-5285, 8/2004, Volume 53, Issue 8, pp. 1776 - 1777
Journal Article
Chimica Techno Acta, ISSN 2409-5613, 2017, Volume 4, Issue 1, pp. 29 - 44
This review summarizes data on the reactions of chromones and activated alkenes with trimethyl(trifluoromethyl)silane (Ruppert’s reagent), which occures as a... 
триметил(трифторметил)силан | хромоны | активированные алкены | нуклеофильное 1,4-трифторметилирование
Journal Article
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