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science & technology (8) 8
life sciences & biomedicine (6) 6
animals (5) 5
apoptosis (3) 3
enzyme inhibitors - pharmacology (3) 3
female (3) 3
mice, inbred c57bl (3) 3
research article (3) 3
apoptosis - drug effects (2) 2
biochemistry (2) 2
biological and medical sciences (2) 2
biology (2) 2
calcium-calmodulin-dependent protein kinase type 1 - metabolism (2) 2
calmodulin (2) 2
cell biology (2) 2
cell death (2) 2
cell survival - drug effects (2) 2
cells, cultured (2) 2
cytokines (2) 2
humans (2) 2
kinases (2) 2
kinetics (2) 2
medical sciences (2) 2
medicine (2) 2
mice (2) 2
molecular biology (2) 2
molecular cell biology (2) 2
multidisciplinary sciences (2) 2
pharmacology & pharmacy (2) 2
pharmacology. drug treatments (2) 2
protein kinase c - antagonists & inhibitors (2) 2
proteins (2) 2
rodents (2) 2
science (2) 2
science & technology - other topics (2) 2
signal transduction (2) 2
signaling (2) 2
tritium (2) 2
1--2- methylpiperazine (1) 1
5'-nucleotidase - metabolism (1) 1
[ca2]i, free intracellular ca2+ concentration (1) 1
aa, arachidonic acid (1) 1
abdomen (1) 1
acyltransferases - physiology (1) 1
adenosine - pharmacology (1) 1
adenosine triphosphatases - metabolism (1) 1
adenosine triphosphate (1) 1
adenosine triphosphate - pharmacology (1) 1
adenosine triphosphate - secretion (1) 1
adipocytes (1) 1
alanine - metabolism (1) 1
amino acid sequence (1) 1
amino acids (1) 1
analysis (1) 1
anatomy & physiology (1) 1
anatomy and physiology (1) 1
animal models (1) 1
anthocyanins (1) 1
anthocyanins - pharmacology (1) 1
antigens (1) 1
apyrase - metabolism (1) 1
arachidonic acid - metabolism (1) 1
arachidonic and docosahexaenoic acids (1) 1
atp (1) 1
atp-binding cassette, sub-family b, member 1 - metabolism (1) 1
autophagy (1) 1
autophagy - drug effects (1) 1
axon outgrowth (1) 1
axons - metabolism (1) 1
b cells (1) 1
bacterial genetics (1) 1
bapta, [1,2-bisethane-n,n,n′,n′-tetraacteic acid, sodium] (1) 1
bcl-2-associated x protein (1) 1
bel, bromoenollactone-6- (1) 1
binding sites (1) 1
biochemistry & molecular biology (1) 1
biology and life sciences (1) 1
biomacromolecule-ligand interactions (1) 1
biomedical research (1) 1
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biotechnology & applied microbiology (1) 1
body regions (1) 1
bsa, bovine serum albumin (1) 1
bzatp, 3′-o--benzoyl-atp (1) 1
ca2+ signaling (1) 1
ca2+-independent pla2 (1) 1
ca2+/calmodulin-dependent protein kinase ii (1) 1
calcimycin - pharmacology (1) 1
calcium (1) 1
calcium - physiology (1) 1
calcium signaling cascade (1) 1
calcium-binding protein (1) 1
calcium-calmodulin-dependent protein kinase kinase - metabolism (1) 1
calcium-calmodulin-dependent protein kinase type 1 (1) 1
calcium-calmodulin-dependent protein kinase type 1 - antagonists & inhibitors (1) 1
calcium-calmodulin-dependent protein kinase type 2 - antagonists & inhibitors (1) 1
calcium-calmodulin-dependent protein kinase type 2 - metabolism (1) 1
calcium-calmodulin-dependent protein kinases - antagonists & inhibitors (1) 1
calcium-mediated signal transduction (1) 1
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1. Full Text Unique Inhibitory Action of the Synthetic Compound 2-[ N-(2-Aminoethyl)- N-(5-isoquinolinesulfonyl)]amino- N-(4-chlorocinnamyl)- N-methylbenzylamine (CKA-1306) against Calcium/Calmodulin-dependent Protein Kinase I
by Sakaguchi, Hiromi and Yokokura, Hisayuki and Terada, Osamu and Naito, Yasuhito and Nimura, Yuji and Hidaka, Hiroyoshi
Biochemical pharmacology, ISSN 0006-2952, 1998, Volume 56, Issue 3, pp. 329 - 334
pharmacogenesis | calmodulin | kinetic analysis | protein kinase | Kinetic analysis | Protein kinase | Pharmacogenesis | Calmodulin | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions | Animals | Isoquinolines - pharmacology | Cattle | Sulfonamides | Enzyme Inhibitors - pharmacology | Kinetics | Calcium-Calmodulin-Dependent Protein Kinase Type 1 | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Cinnamates - pharmacology | Index Medicus
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2. Full Text Induction of apoptosis in two human leukemia cell lines as well as differentiation in human promyelocytic cells by cyanidin-3- O-β-glucopyranoside
by Fimognari, Carmela and Berti, Fausto and Nüsse, Michael and Cantelli-Forti, Giorgio and Hrelia, Patrizia
Biochemical pharmacology, ISSN 0006-2952, 2004, Volume 67, Issue 11, pp. 2047 - 2056
Human T-lymphoblastoid cells | Anthocyanins | Cytodifferentiation | Chemoprevention | Promyelocytic leukemia cells | Apoptosis | Cy-g | NBT | PI3-K | H-7 | 1-(5-isoquinolinesulfonyl)-2- methylpiperazine | nitroblue tetrazolium | inhibitory concentration causing cell toxicity by 50% following one cell-cycle exposure | cyanidin-3-O-β-glucopyranoside | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Anthocyanins - pharmacology | Leukemia, Promyelocytic, Acute - pathology | Gene Expression - drug effects | Jurkat Cells | Humans | Enzyme Inhibitors - pharmacology | Tumor Suppressor Protein p53 - metabolism | Protein Kinase C - antagonists & inhibitors | bcl-2-Associated X Protein | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-myc - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Drug Interactions | Cell Differentiation - drug effects | HL-60 Cells | Index Medicus
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3. Full Text The P2X7 receptor from Xenopus laevis: formation of a large pore in Xenopus oocytes
by Paukert, Martin and Hidayat, Susanti and Gründer, Stefan
FEBS letters, ISSN 0014-5793, 02/2002, Volume 513, Issue 2-3, pp. 253 - 258
Two-electrode voltage-clamp | P2 purinoceptor | Ion channel | Ion selectivity | NMDG, N-methyl-D-glucamine | HMA, N,N-hexamethylene amiloride | cDNA, complementary DNA | cRNA, complementary RNA | KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine | BzATP, 3′-O-(4-benzoyl)-benzoyl-ATP
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4. Full Text Protein kinase C inhibitors stimulate arachidonic and docosahexaenoic acids release from uterine stromal cells through a Ca2+‐independent pathway
by Birbes, Hélène and Pageaux, Jean-François and Fayard, Jean-Michel and Lagarde, Michel and Laugier, Christian
FEBS letters, ISSN 0014-5793, 08/1998, Volume 432, Issue 3, pp. 219 - 224
PC, phosphatidylcholine | DPPC, 1,2-dipalmitoyl phosphatidylcholine | Arachidonic and docosahexaenoic acids | BSA, bovine serum albumin | Ca2+-independent PLA2 | PKC, protein kinase C | PLA2, phospholipase A2 | BAPTA, [1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacteic acid, sodium] | cPLA2, cytosolic PLA2 | PE, phosphatidylethanolamine | DHA, docosahexaenoic acid | DTT, dithiothreitol | iPLA2, Ca2+-independent PLA2 | H-89, {N-[2-((p-bromo-cinnamyl)amino)ethyl]-5-isoquinoline sulfonamide, HCl} | AA, arachidonic acid | EDTA, (ethylenediaminetetraacetic acid, sodium) | PKC inhibitor | H-7, [1-(5-isoquinolinesulfonyl)-2-methyl piperazine, HCl] | Uterine stromal cell | BEL, bromoenollactone ((E)-6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one) | EGTA, [ethylenebis (oxyethylenenitrilo)] tetraacetic acid | PMA, phorbol myristate acetate | MAPK, mitogen-activated protein kinase | PKA, protein kinase A | independent PLA | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Acyltransferases - physiology | Arachidonic Acid - metabolism | Stromal Cells - metabolism | Enzyme Inhibitors - pharmacology | Rats | Tritium | Protein Kinase C - antagonists & inhibitors | Phospholipases A - metabolism | Phospholipases A2 | Calcimycin - pharmacology | Animals | Calcium - physiology | Signal Transduction - drug effects | Stromal Cells - drug effects | Uterus - cytology | Female | Signal Transduction - physiology | Phospholipases A - drug effects | Phospholipids - metabolism | Stromal Cells - cytology | Docosahexaenoic Acids - metabolism | Index Medicus
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5. Full Text GTP/ggS-Induced phosphorylation of myosin light chain kinase in smooth muscle
by Tang, Da-Chun and Kubota, Yasutaka and Kamm, Kristine E and Stull, James T
FEBS letters, ISSN 0014-5793, 1993, Volume 331, Issue 3, pp. 272 - 275
Smooth muscle contraction | Protein phosphatase | GTPγS | Myosin light chain kinase | Myosin light chain | [Ca2]i, free intracellular Ca2+ concentration | G-protein, guanine nucleotide-binding protein | EDTA, ethylenediamine-tetraacetic acid | k cam, concentration of Ca2+/calmodulin required for half-maximal activation | PIPES, piperazine-N,N-bis[2-ethane-sulfonic acid] | EGTA, ethyleneglycol-bis (β-aminoethylether)N,N,N',N',-tetraacetic acid | MOPS, 3-[N-morpholino]propane-sulfonic acid | PSS, physiological salt solution | PMSF, phenylmethylsulfonyl fluoride | PAGE, polyacrylamide gel electrophoresis | KN-62, 1-[N-O-Bis(5-isoquinolinesulfonyl)-N+-methyl-l-tyrosyl]-4-phenylpiperazine
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6. Full Text Improving a natural CaMKII inhibitor by random and rational design
by Coultrap, Steven J and Bayer, K. Ulrich
PloS one, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, pp. e25245 - e25245
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Amino Acid Sequence | Peptides - chemistry | Mutagenesis - genetics | Molecular Sequence Data | Serine - genetics | Alanine - metabolism | Mutation - genetics | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors | Peptides - pharmacology | Protein Kinase Inhibitors - chemistry | Substrate Specificity - drug effects | Solutions | Drug Design | Calcium-Calmodulin-Dependent Protein Kinase Type 1 - metabolism | Protein Kinase Inhibitors - pharmacology | Phosphorylation - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 1 - antagonists & inhibitors | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Amino acids | Cellular signal transduction | Peptides | Protein kinases | Calmodulin | Residues | Enzymes | Phosphorylation | Calcium | Visual evoked potentials | Genomes | Selectivity | Kinases | Proteins | Signal transduction | Signaling | Inhibitors | Mutagenesis | Rodents | Calcium-binding protein | Evolution | Regulation | Mutation | Inhibition | Binding sites | Ca2+/calmodulin-dependent protein kinase II | Index Medicus | Transduction
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7. Full Text Transcriptomic analysis of peritoneal cells in a mouse model of sepsis: Confirmatory and novel results in early and late sepsis
by Bhatty, Minny and Fan, Ruping and Muir, William M and Pruett, Stephen B and Nanduri, Bindu
BMC genomics, ISSN 1471-2164, 09/2012, Volume 13, Issue 1, pp. 509 - 509
Microarray | Peritoneal leukocytes | Intra-abdominal sepsis | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | RNA-Binding Proteins - genetics | Early Growth Response Transcription Factors - biosynthesis | Oligonucleotide Array Sequence Analysis | Escherichia coli | Transcriptome | Gene Expression Profiling | Intraabdominal Infections - genetics | RNA-Binding Proteins - biosynthesis | Early Growth Response Transcription Factors - genetics | Trans-Activators - genetics | Female | Transcription, Genetic | Trans-Activators - biosynthesis | Disease Models, Animal | Kruppel-Like Transcription Factors - biosynthesis | Gene Expression | Intraabdominal Infections - microbiology | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Hepatocyte Nuclear Factor 1-alpha | Escherichia coli Infections - microbiology | Peritoneum - microbiology | Repressor Proteins - genetics | Transcription Factors - biosynthesis | Genetic Markers | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, Inbred C3H | Sepsis - genetics | T Cell Transcription Factor 1 - genetics | T Cell Transcription Factor 1 - biosynthesis | Animals | Repressor Proteins - biosynthesis | Mice | DNA-Binding Proteins - biosynthesis | Kruppel-Like Transcription Factors - genetics | Sepsis - microbiology | Infection | DNA microarrays | Cell death | Analysis | Genes | Sepsis | Genetic aspects | Genetic transcription | Gene expression | Bacterial genetics | Health sciences | Statistical analysis | Cytokines | E coli | Mortality | Rodents | Anatomy & physiology | Kinases | Chemokines | Abdomen | Index Medicus
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8. Full Text Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIα pathway during neuronal polarization
by Horigane, Shin-Ichiro and Ageta-Ishihara, Natsumi and Kamijo, Satoshi and Fujii, Hajime and Okamura, Michiko and Kinoshita, Makoto and Takemoto-Kimura, Sayaka and Bito, Haruhiko
Molecular brain, ISSN 1756-6606, 01/2016, Volume 9, Issue 1, pp. 8 - 8
Axon outgrowth | CaMKK | signaling | CaMKIα | Wnt5a | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Cell Polarity | Dendrites - metabolism | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Axons - metabolism | Wnt-5a Protein | Wnt Proteins - metabolism | Cerebral Cortex - cytology | Mice, Inbred ICR | Morphogenesis | Animals | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Female | Calcium-Calmodulin-Dependent Protein Kinase Type 1 - metabolism | Cell Differentiation | Cell Movement | Index Medicus | Research | Ca2+ signaling
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9. Full Text ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages
by Ayna, Gizem and Krysko, Dmitri V and Kaczmarek, Agnieszka and Petrovski, Goran and Vandenabeele, Peter and Fésüs, László
PloS one, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, pp. e40069 - e40069
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Inflammation - pathology | Inflammasomes - metabolism | Apoptosis - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein | Adenosine Triphosphate - secretion | Macrophages, Peritoneal - pathology | Caspase 1 - metabolism | Autophagy - drug effects | Necrosis | Thioglycolates | Indoles - pharmacology | Macrophages, Peritoneal - drug effects | Neutrophil Infiltration - drug effects | Interleukin-1beta - secretion | Cell Line | Phagocytosis - drug effects | Peritoneal Cavity - pathology | Mice, Inbred C57BL | Injections, Intraperitoneal | Macrophages, Peritoneal - enzymology | Interleukin-3 - deficiency | Imidazoles - pharmacology | Macrophages, Peritoneal - secretion | Interleukin-6 - secretion | Animals | Carrier Proteins - metabolism | Lipopolysaccharides - pharmacology | Mice | Inflammation | B cells | Macrophages | Apoptosis | Biomedical research | Science | Biochemistry | Adipocytes | Autophagy | Caspase-1 | Recruitment | Cell activation | Immunology | Interleukin 3 | Growth factors | Adenosine triphosphate | Immune system | Efflux | Antigens | Cytokines | Neutrophils | Caspase | Leukocytes (neutrophilic) | Permeability | Damage patterns | Lymphocytes B | Receptor mechanisms | Molecular biology | Endoplasmic reticulum | ATP | Potassium | Phagocytosis | Cancer | Index Medicus
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10. Full Text Effect of Extracellular ATP on the Human Leukaemic Cell Line K562 and its Multidrug Counterpart
by Bernardo, Alcira A and Pinto-Silva, Flavio Eduardo and Persechini, Pedro M and Coutinho-Silva, Robson and Meyer-Fernandes, José Roberto and de Souza, André Luiz Fonseca and Rumjanek, Vivian M
Molecular and cellular biochemistry, ISSN 0300-8177, 9/2006, Volume 289, Issue 1, pp. 111 - 124
multidrug resistance | apoptosis | leukaemias | ecto-ATPase | ecto-5′nucleotidase | extracellular ATP | Ecto-ATPase | Ecto-5′nucleotidase | Extracellular ATP | Leukaemias | Multidrug resistance | Apoptosis | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Survival - drug effects | Apoptosis - drug effects | Drug Resistance, Multiple - drug effects | Humans | Uridine Triphosphate - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Apyrase - metabolism | Adenosine Triphosphatases - metabolism | Purinergic P2 Receptor Antagonists | Tritium | Purinergic P2 Receptor Agonists | Adenosine - pharmacology | Adenosine Triphosphate - pharmacology | Receptors, Purinergic P2X7 | Thymidine - biosynthesis | Phenotype | Cell Membrane Permeability - drug effects | Protein Binding - drug effects | K562 Cells | Kinetics | Tumor Cells, Cultured | 5'-Nucleotidase - metabolism | Cell Cycle - drug effects | Proteins | Cell cycle | Index Medicus
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