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1. Full Text Analytical measurement and clinical relevance of vitamin D-3 C3-epimer
by Bailey, D and Veljkovic, K and Yazdanpanah, M and Adeli, K
CLINICAL BIOCHEMISTRY, ISSN 0009-9120, 02/2013, Volume 46, Issue 3, pp. 190 - 196
With an ever-increasing clinical interest in vitamin D insufficiency, numerous automated immunoassays, protein binding assays, and in-house LC-MS/MS methods... 
C-3 EPIMERIZATION | POTENT SUPPRESSOR | C3-epimer | TANDEM MASS-SPECTROMETRY | HUMAN SERUM | HUMAN KERATINOCYTES | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | LC-MS | Vitamin D | 1-ALPHA,25-DIHYDROXY-3-EPI-VITAMIN D-3 | 25-HYDROXYVITAMIN D-3 | PARATHYROID-HORMONE SECRETION | MEDICAL LABORATORY TECHNOLOGY | NATURAL METABOLITE | Pediatric
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2. Full Text Effects of 1,25(OH)(2)D-3 and 25(OH)D-3 on C2C12 Myoblast Proliferation, Differentiation, and Myotube Hypertrophy
by van der Meijden, K and Bravenboer, N and Dirks, NF and Heijboer, AC and den Heijer, M and de Wit, GMJ and Offringa, C and Lips, P and Jaspers, RT
JOURNAL OF CELLULAR PHYSIOLOGY, ISSN 0021-9541, 11/2016, Volume 231, Issue 11, pp. 2517 - 2528
An adequate vitamin D status is essential to optimize muscle strength. However, whether vitamin D directly reduces muscle fiber atrophy or stimulates muscle... 
25-HYDROXYVITAMIN D 25OHD | PHYSIOLOGY | SKELETAL-MUSCLE CELLS | 24R,25-DIHYDROXYVITAMIN D-3 | HUMAN-BONE-CELLS | PHYSICAL PERFORMANCE | GENE-EXPRESSION | 1,25-DIHYDROXYVITAMIN D-3 | VITAMIN-D STATUS | CALCIUM-CONCENTRATION | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | CELL BIOLOGY
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3. Full Text Availability of 25-Hydroxyvitamin D-3 to APCs Controls the Balance between Regulatory and Inflammatory T Cell Responses
by Jeffery, LE and Wood, AM and Qureshi, OS and Hou, TZ and Gardner, D and Briggs, Z and Kaur, S and Raza, K and Sansom, DM
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 12/2012, Volume 189, Issue 11, pp. 5155 - 5164
1,25-Dihydroxyvitamin D-3 [1,25(OH)(2)D-3], the active form of vitamin D, exerts potent effects on several tissues including cells of the immune system, where... 
RHEUMATOID-ARTHRITIS | D-BINDING-PROTEIN | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | GC-GLOBULIN | VITAMIN-D METABOLITES | 1,25-DIHYDROXYVITAMIN D-3 | IMMUNOLOGY | D ENDOCRINE SYSTEM | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | BOWEL-DISEASE
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4. Full Text Enzymatic Desymmetrization of 19-nor-Vitamin D-3 A-Ring Synthon Precursor: Synthesis, Structure Elucidation, and Biological Activity of 1 alpha,25-Dihydroxy-3-epi-19-nor-vitamin D-3 and 1 beta,25-Dihydroxy-19-nor-vitamin D-3
by Gonzalez-Garcia, T and Verstuyf, A and Verlinden, L and Fernandez, S and Ferrero, M
ADVANCED SYNTHESIS & CATALYSIS, ISSN 1615-4150, 07/2018, Volume 360, Issue 14, pp. 2762 - 2772
In a search for novel vitamin D derivatives of potential therapeutic value, structurally simple but synthetically challenging A-ring epimers of the... 
19-nor analogues | A-Ring modified analogues | VITAMIN-D | ALKOXYCARBONYLATION | Enzymatic desymmetrization | ANALOGS | ACYLATION | Calcitriol | CARBAMATE DERIVATIVES | CHEMISTRY, ORGANIC | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | Vitamin D | CHEMOENZYMATIC SYNTHESIS | ENZYMES | DIASTEREOMERS | CHEMISTRY, APPLIED
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5. Full Text C-3 epimerization of vitamin D-3 metabolites and further metabolism of C-3 epimers - 25-hydroxyvitamin D-3 is metabolized to 3-epi-25-hydroxyvitamin D-3 and subsequently metabolized through C-1 alpha or C-24 hydroxylation
by Kamao, M and Tatematsu, S and Hatakeyama, S and Sakaki, T and Sawada, N and Inouye, K and Ozono, K and Kubodera, N and Reddy, GS and Okano, T
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 04/2004, Volume 279, Issue 16, pp. 15897 - 15907
Recently, it was revealed that 1alpha, 25-dihydroxyvitamin D-3 (1alpha,25(OH)(2)D-3) and24R,25-dihydroxyvitamin D-3 (24,25 (OH)(2)D-3) were metabolized to... 
CALCITROIC ACID | OSTEOSARCOMA CELLS UMR-106 | LEUKEMIA HL-60 CELLS | OXIDATION PATHWAY | 1-ALPHA,25-DIHYDROXY-3-EPI-VITAMIN D-3 | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGICAL-ACTIVITY | ESCHERICHIA-COLI | NATURAL METABOLITE | 1-ALPHA,25-DIHYDROXYVITAMIN D-3
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6. Full Text 1 alpha,25(OH)(2)-3-Epi-Vitamin D-3, a Natural Physiological Metabolite of Vitamin D-3: Its Synthesis, Biological Activity and Crystal Structure with Its Receptor
by Molnar, F and Sigueiro, R and Sato, Y and Araujo, C and Schuster, I and Antony, P and Peluso, J and Muller, C and Mourino, A and Moras, D and Rochel, N
PLOS ONE, ISSN 1932-6203, 03/2011, Volume 6, Issue 3
Background: The 1 alpha,25-dihydroxy-3-epi-vitamin-D-3 (1 alpha,25(OH)(2)-3-epi-D-3), a natural metabolite of the seco-steroid vitamin D-3, exerts its... 
ORGANIC-CHEMISTRY | D-NUCLEAR-RECEPTOR | GENE PROMOTER | 1-ALPHA,25-DIHYDROXY-3-EPI-VITAMIN D-3 | C-24 OXIDATION PATHWAY | BIOLOGY | A-RING DIASTEREOMERS | C-3 EPIMERIZATION PATHWAY | CALCIUM-TRANSPORT | PHOSPHINE OXIDE | 1-ALPHA,25-DIHYDROXYVITAMIN D-3
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7. Full Text Immunoregulation by 1,25-dihydroxyvitamin D 3: Basic concepts
by Etten, Evelyne van and Mathieu, Chantal
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2005, Volume 97, Issue 1, pp. 93 - 101
1,25-Dihydroxyvitamin D (1,25(OH) D ), the biologically active metabolite of Vitamin D , not only regulates bone and calcium metabolism but also exerts other... 
Thelper cells | Immunomodulatory effects | Transplantation | 1,25-Dihydroxyvitamin D 3 | Autoimmune diseases | Antigen-presenting cells | autoimmune diseases | D ANALOG | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | antigen-presenting cells | NOD MICE | COLONY-STIMULATING FACTOR | DENDRITIC CELLS | 1,25-dihydroxyvitamin D-3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | D DEFICIENCY | VITAMIN-D-RECEPTOR | CD4(+) T-CELLS | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | immunomodulatory effects | NONOBESE DIABETIC MICE | transplantation | ENDOCRINOLOGY & METABOLISM | thelper cells
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8. Metabolism of vitamin D-3 by cytochromes P450
by Sakaki, T and Kagawa, N and Yamamoto, K and Inouye, K
FRONTIERS IN BIOSCIENCE, ISSN 1093-9946, 01/2005, Volume 10, pp. 119 - 134
The vitamin D-3 25-hydroxylase (CYP27A1), 25-hydroxyvitamin D-3 1alpha-hydroxylase (CYP27B1) and 1alpha, 25-dihydroxyvitamin D-3 24-hydroxylase (CYP24A1) are... 
D-DEFICIENCY RICKETS | vitamin D | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | RAT-KIDNEY MITOCHONDRIA | cytochrome P450 | CEREBROTENDINOUS XANTHOMATOSIS | ENZYMATIC-PROPERTIES | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | CELL BIOLOGY | CYP27A1 | CYP27B1 | CYP24A1 | SPECIES-BASED DIFFERENCE | review | 25-HYDROXYVITAMIN D-3 1-ALPHA-HYDROXYLASE | A-RING DIASTEREOMERS | BIOLOGICAL EVALUATION | coexpression
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9. Full Text 1,25-dihydroxyvitamin D-3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells
by Penna, G and Amuchastegui, S and Giarratana, N and Daniel, KC and Vulcano, M and Sozzani, S and Adorini, L
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 01/2007, Volume 178, Issue 1, pp. 145 - 153
1,25-Dihydroxyvitamin D-3 (1,25(OH)(2)A(3)) is an immunomodulatory agent inducing dendritic cells (DCs) to become tolerogenic. To further understand its... 
PANCREATIC-ISLETS | IN-VIVO | CHEMOKINE PRODUCTION | REGULATORY T-CELLS | TRANSCRIPTIONAL REPRESSION | VITAMIN-D-RECEPTOR | IMMUNOLOGY | NF-KAPPA-B | DIFFERENTIAL REGULATION | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | DIHYDROXYVITAMIN D-3
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10. Full Text Human prostate cells synthesize 1,25-dihydroxyvitamin D-3 from 25-hydroxyvitamin D-3(1)
by Schwartz, GG and Whitlatch, LW and Chen, TC and Lokeshwar, BL and Holick, MF
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, ISSN 1055-9965, 05/1998, Volume 7, Issue 5, pp. 391 - 395
Epidemiological and laboratory data support a role for vitamin D in the growth and differentiation of human prostatic cells. These findings prompted us to ask... 
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 1-ALPHA,25-DIHYDROXYVITAMIN-D3 | RAT | ONCOLOGY | VITAMIN-D ANALOGS | GROWTH | LINE | PROXIMAL TUBULES | HUMAN EPIDERMAL-KERATINOCYTES | PRIMARY CULTURES | CANCER | EXPRESSION
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11. Full Text Potencies of vitamin D analogs, 1-hydroxyvitamin D-3, 1-hydroxyvitamin D-2 and 25-hydroxyvitamin D-3, in lowering cholesterol in hypercholesterolemic mice in vivo
by Quach, HP and Dzekic, T and Bukuroshi, P and Pang, KS
BIOPHARMACEUTICS & DRUG DISPOSITION, ISSN 0142-2782, 04/2018, Volume 39, Issue 4, pp. 196 - 204
Vitamin D-3 and the synthetic vitamin D analogs, 1 alpha-hydroxyvitamin D-3 [1 alpha(OH)D-3], 1 alpha-hydroxyvitamin D-2 [1 alpha(OH)D-2] and 25-hydroxyvitamin... 
1 alpha-hydroxyvitamin D-3 | 1 alpha-hydroxyvitamin D-2 | RAT | NUCLEAR RECEPTORS | 1-ALPHA-HYDROXYVITAMIN D-2 | BILE-ACID SYNTHESIS | D 25-HYDROXYLASE | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | CALCIUM-ABSORPTION | cholesterol | FARNESOID-X-RECEPTOR | PHARMACOLOGY & PHARMACY | 1,25-DIHYDROXYVITAMIN D-3 | 25-hydroxyvitamin D-3 | EXPRESSION | 1 alpha,25-dihydroxyvitamin D-3
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12. Full Text New C15-Substituted Active Vitamin D-3
by Shindo, K and Kumagai, G and Takano, M and Sawada, D and Saito, N and Saito, H and Kakuda, S and Takagi, K and Ochiai, E and Horie, K and Takimoto-Kamimura, M and Ishizuka, S and Takenouchi, K and Kittaka, A
ORGANIC LETTERS, ISSN 1523-7060, 06/2011, Volume 13, Issue 11, pp. 2852 - 2855
C15-Substituted 1 alpha,25-dihydroxyvitamin D-3 analogs were synthesized for the first time to investigate the effects of the modified CD-ring on biological... 
SIDE-CHAINS | ANALOGS | 1-ALPHA,25-DIHYDROXYVITAMIN-D-3 | A-RING | CHEMISTRY, ORGANIC | HL-60 CELLS | D-RECEPTOR | D-3 | DIFFERENTIATION | LIGAND | DERIVATIVES
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13. Full Text 1 alpha, 25-dihydroxyvitamin D-3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis
by Bao, BY and Yao, J and Lee, YF
CARCINOGENESIS, ISSN 0143-3334, 09/2006, Volume 27, Issue 9, pp. 1883 - 1893
Angiogenesis is an essential step in initial tumor development and metastasis. Consequently, compounds that inhibit angiogenesis would be useful in treating... 
IMMEDIATE-EARLY GENE | IN-VITRO | DNA-BINDING | INHIBITION | ONCOLOGY | PROLIFERATION | NF-KAPPA-B | TUMOR-GROWTH | EXPRESSION | CYR61 | 1-ALPHA,25-DIHYDROXYVITAMIN D-3
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14. Full Text Metabolic Stability of 3-Epi-1 alpha, 25-Dihydroxyvitamin D-3 Over 1 alpha 25-Dihydroxyvitamin D-3: Metabolism and Molecular Docking Studies Using Rat CYP24A1
by Rhieu, SY and Annalora, AJ and Wang, GC and Flarakos, CC and Gathungu, RM and Vouros, P and Sigueiro, R and Mourino, A and Schuster, I and Palmore, GTR and Reddy, GS
JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN 0730-2312, 10/2013, Volume 114, Issue 10, pp. 2293 - 2305
3-epi-1,25-dihydroxyvitamin D-3 (3-epi-1,25(OH)(2)D-3), a natural metabolite of 1,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3), exhibits potent vitamin D receptor... 
3-EPI-CALCITROIC ACID | 3-EPI-VITAMIN D-3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | VITAMIN-D-RECEPTOR | MOLECULAR DOCKING | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | CELL BIOLOGY | CALCITROIC ACID | 3-EPI-1 | CYP24A1 | 1-ALPHA,25-DIHYDROXY-3-EPI-VITAMIN D-3 | PARATHYROID-HORMONE SECRETION | C-24 OXIDATION PATHWAY | BIOLOGICAL-ACTIVITY | 25-DIHYDROXYVITAMIN D-3 | A-RING DIASTEREOMERS | C-3 EPIMERIZATION PATHWAY | NATURAL METABOLITE
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15. Full Text The C-3 epimer of 25-hydroxyvitamin D 3 is present in adult serum
by Lensmeyer, G and Poquette, M and Wiebe, D and Binkley, Neil
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 01/2012, Volume 97, Issue 1, pp. 163 - 168
Context: Epimers have identical molecular structure but differ in stereochemical configuration. It is widely believed that the C-3 epimer of 25-hydroxyvitamin... 
VITAMIN-D | ACCURATE | EPIMERIZATION | 1-ALPHA,25-DIHYDROXY-3-EPI-VITAMIN D-3 | PERFORMANCE | POTENT SUPPRESSOR | ENDOCRINOLOGY & METABOLISM | TANDEM MASS-SPECTROMETRY | NATURAL METABOLITE | 1-ALPHA,25-DIHYDROXYVITAMIN D-3
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16. Full Text Primary Vitamin D Target Genes Allow a Categorization of Possible Benefits of Vitamin D-3 Supplementation
by Carlberg, C and Seuter, S and de Mello, VDF and Schwab, U and Voutilainen, S and Pulkki, K and Nurmi, T and Virtanen, J and Tuomainen, TP and Uusitupa, M
PLOS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7
Vitamin D deficiency has been associated with an increased risk of developing a number of diseases. Here we investigated samples from 71 pre-diabetic... 
RESPONSE ELEMENT | HORMONE | 25-HYDROXYVITAMIN-D | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | D DEFICIENCY | D-RECEPTOR BINDING | CORONARY-HEART-DISEASE | EXPRESSION | CANCER | 1-ALPHA,25-DIHYDROXYVITAMIN D-3
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17. Full Text 1,25-Dihydroxyvitamin D-3 Is an Autonomous Regulator of the Transcriptional Changes Leading to a Tolerogenic Dendritic Cell Phenotype
by Szeles, L and Keresztes, G and Torocsik, D and Balajthy, Z and Krenacs, L and Poliska, S and Steinmeyer, A and Zuegel, U and Pruenster, M and Rot, A and Nagy, L
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 02/2009, Volume 182, Issue 4, pp. 2074 - 2083
Activation of vitamin D receptor (VDR) by 1,25-dihydroxyvitamin D-3 (1,25-vitD) reprograms dendritic cells (DC) to become tolerogenic. Previous studies... 
IN-VITRO | GENE | VITAMIN-D-RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | MYELOID CELLS | MATURATION | T-CELLS | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | DIHYDROXYVITAMIN D-3 | NUCLEAR RECEPTOR
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18. Full Text Antineoplastic effects of 1,25(OH)(2)D-3 and its analogs in breast, prostate and colorectal cancer
by Leyssens, C and Verlinden, L and Verstuyf, A
ENDOCRINE-RELATED CANCER, ISSN 1351-0088, 04/2013, Volume 20, Issue 2, pp. R31 - R47
The active form of vitamin D-3, 1,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3), is mostly known for its importance in the maintenance of calcium and phosphate... 
colorectal cancer | PROSTAGLANDIN METABOLIZING ENZYMES | SERUM 25-HYDROXYVITAMIN D | NORMAL COLON MUCOSA | vitamin D | D SUPPLEMENTATION | breast cancer | VITAMIN-D-RECEPTOR | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | NCI-H929 MYELOMA CELLS | analog | prostate cancer | ONCOLOGY | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | 1,25-DIHYDROXYVITAMIN D-3 | HIGH-DOSE CALCITRIOL
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19. Full Text Evidence for Vitamin D Receptor Expression and Direct Effects of 1 alpha,25(OH)(2)D-3 in Human Skeletal Muscle Precursor Cells
by Olsson, K and Saini, A and Stromberg, A and Alam, S and Lilja, M and Rullman, E and Gustafsson, T
ENDOCRINOLOGY, ISSN 0013-7227, 01/2016, Volume 157, Issue 1, pp. 98 - 111
Presence of the vitamin D receptor and direct effects of vitamin D on the proliferation and differentiation of muscle precursor cells have been demonstrated in... 
STEM-CELLS | MYOGENIC DIFFERENTIATION | GENE | VDR | GROWTH-FACTORS | ENDOCRINOLOGY & METABOLISM | SELF-RENEWAL | IDENTIFICATION | 1,25-DIHYDROXYVITAMIN-D3 RECEPTORS | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | MYOBLAST PROLIFERATION
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20. Full Text Influence of 25-hydroxyvitamin D-3 and 1,25-dihydroxyvitamin D-3 on expression of P-glycoprotein and cytochrome P450 3A in sheep
by Wilkens, MR and Mate, LM and Schnepel, N and Klinger, S and Muscher-Banse, AS and Ballent, M and Virkel, G and Lifschitz, AL
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ISSN 0960-0760, 11/2016, Volume 164, pp. 271 - 276
In order to improve calcium and phosphorus balance, beef cattle and dairy cows can be supplemented with vitamin D. However, different vitamin D metabolites... 
Pharmacological interaction | CELLS | QUANTITIES | ABCB1 | RAT | TRANSPORTERS | Cholecalciferol | CALCIUM HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-D-RECEPTOR | X-RECEPTOR | Ruminant | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | MDR1 | IN-VIVO | ENDOCRINOLOGY & METABOLISM | DRUG-METABOLISM | Injections, Intravenous | Receptors, Steroid - metabolism | Retinoid X Receptor alpha - metabolism | Sheep, Domestic | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Jejunum - metabolism | Jejunum - drug effects | Kidney - metabolism | Cytochrome P-450 CYP3A - genetics | Liver - drug effects | Female | Kidney - drug effects | Administration, Oral | Liver - metabolism | Organ Specificity | Calcifediol - pharmacology | Gene Expression Regulation - drug effects | Animals | Rumen - metabolism | Receptors, Steroid - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP3A - metabolism | Calcitriol - pharmacology | Retinoid X Receptor alpha - genetics | Rumen - drug effects
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