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Journal of Clinical Investigation, ISSN 0021-9738, 09/2003, Volume 112, Issue 6, pp. 892 - 901
Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of the nigrostriatal dopaminergic neurons accompanied by a deficit in... 
ELECTRON-TRANSPORT CHAIN | RAT-LIVER | MEDICINE, RESEARCH & EXPERIMENTAL | COMPLEX-I | 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MOUSE MODEL | NITRIC-OXIDE | NEURODEGENERATION | DIETARY RESTRICTION | MPTP | DOPAMINERGIC NEUROTOXICITY | BRAIN
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2013, Volume 288, Issue 6, pp. 4436 - 4451
Journal Article
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 11/2015, Volume 23, Issue 13, pp. 11 - 1016
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 05/2013, Volume 125, Issue 3, pp. 473 - 485
Peroxiredoxin‐5 ( PRDX 5) is an antioxidant enzyme which differs from the other peroxiredoxins with regards to its enzymatic mechanism, its high affinity for... 
neurodegeneration | peroxiredoxin | calcium | MPP | mitochondria | OXIDATIVE STRESS | NEURODEGENERATIVE DISORDERS | 2-AMINOETHOXYDIPHENYL BORATE | INDUCED APOPTOSIS | BAX-CLEAVAGE | CALCIUM HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SH-SY5Y NEUROBLASTOMA-CELLS | DOPAMINERGIC-NEURONS | NEUROSCIENCES | ANTIOXIDANT ENZYME PEROXIREDOXIN-5 | PARKINSONS-DISEASE | RNA, Small Interfering - genetics | Calpain - metabolism | Caspase 9 - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Calcium - metabolism | Humans | Peroxiredoxins - metabolism | Caspase 3 - metabolism | Endoplasmic Reticulum - metabolism | Tyrosine - analogs & derivatives | DNA, Mitochondrial - genetics | Peroxiredoxins - genetics | Transfection | Dopamine Agents - pharmacology | Adenosine Triphosphate - metabolism | Endoplasmic Reticulum - drug effects | Hydro-Lyases - metabolism | Neuroblastoma - pathology | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Boron Compounds - pharmacology | DNA, Mitochondrial - metabolism | Subcellular Fractions - drug effects | Gene Expression Regulation - genetics | Enzyme Inhibitors - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Subcellular Fractions - metabolism | Gene Expression Regulation - drug effects | Tyrosine - metabolism | Animals | Cell Line, Tumor | Mice | RNA, Small Interfering - metabolism | Antioxidants | Enzymes | Inositol | Nimodipine | Cell death | Biochemistry | Mitochondrial DNA | Cells | DNA damage | Index Medicus
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2014, Volume 67, pp. 10 - 18
Endoplasmic reticulum (ER) stress has been implicated in Parkinson disease. We previously reported that thioredoxin 1 (Trx-1) suppressed the ER stress caused... 
MPP+/MPTP | Parkinson disease | ER stress | Free radicals | Thioredoxin-1 | MPTP | MPP | APOPTOSIS | ACTIVATION | UNFOLDED-PROTEIN RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | NEUROTOXICITY | P38 MAP KINASE | IRE1 | ENDOCRINOLOGY & METABOLISM | PC12 CELLS | TRANSCRIPTION FACTOR | Transcription Factor CHOP - genetics | Endoribonucleases - genetics | TNF Receptor-Associated Factor 2 - genetics | MPTP Poisoning - physiopathology | Endoplasmic Reticulum Stress - genetics | PC12 Cells | Heat-Shock Proteins - genetics | MPTP Poisoning - genetics | MAP Kinase Kinase 4 - metabolism | Thioredoxins - genetics | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - analogs & derivatives | Thioredoxins - metabolism | Protein-Serine-Threonine Kinases - metabolism | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Signal Transduction | Caspase 12 - genetics | 1-Methyl-4-phenylpyridinium - pharmacology | Heat-Shock Proteins - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Rats | TNF Receptor-Associated Factor 2 - metabolism | Mice, Transgenic | Caspase 12 - metabolism | Animals | MPTP Poisoning - metabolism | MAP Kinase Kinase 4 - genetics | Mice | MPTP Poisoning - chemically induced | Transcription Factor CHOP - metabolism | Glucose metabolism | Enzymes | Inositol | Parkinson's disease | Genetic engineering | Stress (Physiology) | Glucose | Thioredoxin | Dextrose | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2004, Volume 279, Issue 19, pp. 19936 - 19947
Reactive gliosis is a hallmark of disease-, trauma-, and chemical-induced damage to the central nervous system. The signaling pathways associated with this... 
DNA-BINDING | JAK/STAT PATHWAY | DOPAMINERGIC NEUROTOXICANT | CHRONIC PARKINSONISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL CEREBRAL-ISCHEMIA | STAT3 | LEUKEMIA INHIBITORY FACTOR | SERINE PHOSPHORYLATION | EXPRESSION | BRAIN | Immunohistochemistry | Up-Regulation | Protein-Tyrosine Kinases - metabolism | Membrane Glycoproteins - biosynthesis | Immunoblotting | Male | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Tissue Distribution | Peptides - metabolism | Time Factors | Dopamine Agents - pharmacology | Dimerization | Interleukin-6 - metabolism | Dopamine - metabolism | RNA - metabolism | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Nomifensine - pharmacology | Cytokine Receptor gp130 | Dopamine Uptake Inhibitors - pharmacology | Signal Transduction | Oncostatin M | Reverse Transcriptase Polymerase Chain Reaction | Astrocytes - physiology | Tyrosine - metabolism | Models, Biological | Ligands | Mice | Enzyme Activation | Astrocytes - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphorylation | Antigens, CD - biosynthesis | Chromatography, High Pressure Liquid | MAP Kinase Signaling System | DNA-Binding Proteins - metabolism | Janus Kinase 2 | Proto-Oncogene Proteins | Active Transport, Cell Nucleus | Leukemia Inhibitory Factor | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Gene Expression Regulation | Protein Transport | Animals | Trans-Activators - metabolism | STAT3 Transcription Factor | DNA, Complementary - metabolism | Mitogen-Activated Protein Kinase 3 | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
PLOS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, pp. e0171285 - e0171285
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2010, Volume 185, Issue 2, pp. 1230 - 1237
The present study examined whether the antidepressant paroxetine promotes the survival of nigrostriatal dopaminergic (DA) neurons in the... 
NADPH OXIDASE | IN-VITRO | MICROGLIAL ACTIVATION | MPTP MODEL | 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MOUSE MODEL | NITRIC-OXIDE SYNTHASE | REUPTAKE INHIBITORS | MICE | TNF-ALPHA | IMMUNOLOGY | NEUROTOXICITY | Immunohistochemistry | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Tumor Necrosis Factor-alpha - genetics | NADPH Oxidases - metabolism | Motor Activity - drug effects | Male | Interleukin-1beta - genetics | Substantia Nigra - metabolism | Substantia Nigra - cytology | Brain - metabolism | Inflammation - metabolism | Interleukin-1beta - metabolism | Parkinson Disease, Secondary - prevention & control | Neurons - metabolism | Parkinson Disease, Secondary - chemically induced | Neurons - drug effects | Dopamine - metabolism | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | Antidepressive Agents, Second-Generation - pharmacology | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Brain - drug effects | Substantia Nigra - drug effects | Animals | Nitric Oxide Synthase Type II - genetics | Parkinson Disease, Secondary - physiopathology | Brain - pathology | Inflammation - genetics | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Mice | Oxidative Stress - drug effects | Paroxetine - pharmacology | Nitric Oxide Synthase Type II - metabolism | Peroxidase - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 10/2017, Volume 125, pp. 319 - 332
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 3955 - 3959
Progranulin (PGRN) is a widely expressed secreted protein that is linked to inflammation. In humans, PGRN haploinsufficiency is a major inherited cause of... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | TNF RECEPTORS | INHIBITION | TDP-43 | HOST-DEFENSE | NECROSIS-FACTOR-ALPHA | NEUROPATHOLOGY | FRONTOTEMPORAL LOBAR DEGENERATION | EXPRESSION | PARKINSONS-DISEASE | Inflammation - chemically induced | Inflammation - pathology | Microglia - metabolism | Neurons - pathology | Humans | Cerebral Cortex - pathology | Cerebral Cortex - metabolism | Frontotemporal Dementia - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Inflammation - metabolism | MPTP Poisoning - genetics | Cell Death - genetics | MPTP Poisoning - pathology | Microglia - pathology | Neurons - metabolism | Cell Death - drug effects | Frontotemporal Dementia - pathology | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Frontotemporal Dementia - genetics | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - adverse effects | Neurotoxins - adverse effects | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Neurotoxins - pharmacology | Animals | MPTP Poisoning - metabolism | Lipopolysaccharides - pharmacology | Inflammation - genetics | Mice | Interferon-gamma - pharmacology | Care and treatment | Neurons | Development and progression | Genetic aspects | Research | Gene expression | Dementia | Index Medicus | Abridged Index Medicus | haploinsufficiency | Media (selective) | Neurodegeneration | Central nervous system | gamma -Interferon | Conditional mutant | Inflammation | MPTP | Frontotemporal dementia | Injuries | Lipopolysaccharides | Microglia | Brief Report
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 04/2011, Volume 33, Issue 7, pp. 1264 - 1274
Journal Article
Experimental Neurology, ISSN 0014-4886, 04/2018, Volume 302, pp. 205 - 213
Triggering receptor expressed on myeloid cells-2 (TREM2) was a newly identified receptor expressed on microglia. Several observations support the hypothesis... 
Neuroinflammation | Triggering receptor expressed on myeloid cells-2 | Parkinson's disease | Microglia | ALZHEIMERS-DISEASE | MYELOID CELLS 2 | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | CUTTING EDGE | INFLAMMATION | MOUSE MODEL | MICE | MPTP | UP-REGULATION | Tyrosine 3-Monooxygenase - metabolism | Membrane Glycoproteins - metabolism | Parkinsonian Disorders - complications | Male | NF-kappa B - metabolism | Glial Fibrillary Acidic Protein - metabolism | Inflammation - metabolism | Cyclooxygenase 2 - genetics | Dopaminergic Neurons - metabolism | Adenoviridae - genetics | Dopaminergic Neurons - drug effects | Cytokines - genetics | Disease Models, Animal | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | 3,4-Dihydroxyphenylacetic Acid - metabolism | Cytokines - metabolism | Mice, Inbred C57BL | Gene Expression Regulation - physiology | Toll-Like Receptor 4 - genetics | Inflammation - etiology | Toll-Like Receptor 4 - metabolism | Gene Expression Regulation - drug effects | Animals | NF-kappa B - genetics | Parkinsonian Disorders - pathology | Signal Transduction - drug effects | Cyclooxygenase 2 - metabolism | Mice | Receptors, Immunologic - metabolism | Tyrosine | Medical colleges | Neurons | Analysis | Models | Disease susceptibility | Mass spectrometry | Alzheimer's disease | High performance liquid chromatography | Index Medicus
Journal Article