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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2016, Volume 60, Issue 11, pp. 6558 - 6567
Journal Article
Nature, ISSN 0028-0836, 01/1991, Volume 349, Issue 6308, pp. 414 - 418
Journal Article
Cell death & disease, ISSN 2041-4889, 06/2017, Volume 8, Issue 6, pp. e2858 - e2858
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. Although its pathogenesis remains unclear, mitochondrial dysfunction plays a... 
PERMEABILITY TRANSITION PORE | OXIDATIVE STRESS | GLYCOGEN-SYNTHASE KINASE-3 | MOUSE MODEL | MITOCHONDRIAL DYSFUNCTION | AMINOPROPYL CARBAZOLES | NEUROPROTECTIVE EFFICACY | PROMOTES | PARKINSONS-DISEASE | P53 | CELL BIOLOGY | Antiparkinson Agents - pharmacology | Reactive Oxygen Species - metabolism | Oxidative Stress | Substantia Nigra - pathology | Dopaminergic Neurons - pathology | Neuroglia - pathology | Glycogen Synthase Kinase 3 beta - genetics | Substantia Nigra - metabolism | Membrane Potential, Mitochondrial - drug effects | Reactive Oxygen Species - agonists | Tumor Suppressor Protein p53 - genetics | Neuroglia - drug effects | Neuroprotective Agents - pharmacology | Dopaminergic Neurons - metabolism | Dopaminergic Neurons - drug effects | bcl-2-Associated X Protein - genetics | Cytochromes c - antagonists & inhibitors | Cytochromes c - secretion | Signal Transduction | 1-Methyl-4-phenylpyridinium - antagonists & inhibitors | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Rats | Glycogen Synthase Kinase 3 beta - antagonists & inhibitors | Mitochondria - metabolism | Mitochondria - drug effects | bcl-2-Associated X Protein - antagonists & inhibitors | Glycogen Synthase Kinase 3 beta - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Substantia Nigra - drug effects | Animals | 1-Methyl-4-phenylpyridinium - toxicity | Cell Line, Tumor | Neuroglia - metabolism | Mice | Carbazoles - pharmacology | Chimera | Index Medicus | Original
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 08/1999, Volume 73, Issue 2, pp. 750 - 757
: Altered glutamatergic neurotransmission appears to be central to the pathophysiology of Parkinson's disease ; consequently, considerable effort has been made... 
Dopaminergic neuroprotection | 2,3‐Dihydroxy‐6‐nitro‐7‐sulfamoylbenzo (f)quinoxaline | 6‐Cyano‐7‐nitroquinoxaline‐2,3‐dione | Rat striatum | Dizocilpine | Kynurenic acid | MPP | 6-Cyano-7-nitroquinoxaline-2,3-dione | 2,3-Dihydroxy-6-nitro- 7-sulfamoylbenzo(f)quinoxaline | RAT | PROTECTION | 1-METHYL-4-PHENYLPYRIDINIUM ION MPP | BASAL GANGLIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | 6-cyano-7-nitroquinoxaline-2,3-dione | DOPAMINERGIC-NEURONS | dizocilpine | NEUROSCIENCES | rat striatum | D-ASPARTATE ANTAGONISTS | dopaminergic neuroprotection | MK-801 FAILS | 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline | GENE-EXPRESSION | kynurenic acid | PARKINSONS-DISEASE | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Rats, Wistar | Receptors, Kainic Acid - antagonists & inhibitors | Corpus Striatum - chemistry | Quinoxalines - pharmacology | Neuroprotective Agents - pharmacology | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Female | Kynurenic Acid - pharmacology | Corpus Striatum - enzymology | Dopamine - analysis | Dopamine - metabolism | Homovanillic Acid - analysis | Microinjections | Rats | Excitatory Amino Acid Antagonists - pharmacology | Tyrosine 3-Monooxygenase - analysis | 3,4-Dihydroxyphenylacetic Acid - analysis | Animals | Dopamine - analogs & derivatives | 1-Methyl-4-phenylpyridinium - toxicity | Corpus Striatum - drug effects | Dopamine Agents - toxicity | Dizocilpine Maleate - pharmacology | Receptors, AMPA - antagonists & inhibitors
Journal Article
Journal Article
Brain Research, ISSN 0006-8993, 2011, Volume 1382, pp. 9 - 18
Abstract Oxidative stress plays an important role in Parkinson's disease and other neurodegenerative disorders. Salidroside, a phenylpropanoid glycoside... 
Neurology | Salidroside | Parkinson's disease | MPP | Nitric oxide | PC12 cells | Apoptosis | GREEN TEA POLYPHENOLS | NEURODEGENERATION | NEUROSCIENCES | NERVE GROWTH-FACTOR | SYNTHASE | PHENYLPROPANOID GLYCOSIDES | NITRIC-OXIDE | INDUCED NEUROTOXICITY | LEWY BODIES | BRAIN | PARKINSONS-DISEASE | Neuroprotective Agents - therapeutic use | Neurons - pathology | Apoptosis - drug effects | Oxidative Stress - physiology | Nitric Oxide Synthase Type II - physiology | Membrane Potential, Mitochondrial - drug effects | PC12 Cells | Nerve Degeneration - metabolism | Parkinsonian Disorders - metabolism | Neuroprotective Agents - pharmacology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Parkinsonian Disorders - drug therapy | Nitric Oxide Synthase Type I - antagonists & inhibitors | Membrane Potential, Mitochondrial - physiology | Glucosides - therapeutic use | Neurons - metabolism | Neurons - drug effects | Phenols - pharmacology | Glucosides - pharmacology | Nitric Oxide - antagonists & inhibitors | 1-Methyl-4-phenylpyridinium - pharmacology | Rats | Nitric Oxide - physiology | Nerve Degeneration - pathology | Neurotoxins - pharmacology | Reactive Oxygen Species - antagonists & inhibitors | Animals | Parkinsonian Disorders - pathology | Signal Transduction - drug effects | Phenols - therapeutic use | Signal Transduction - physiology | Apoptosis - physiology | Nitric Oxide Synthase Type I - physiology | Oxidative Stress - drug effects | Nerve Degeneration - drug therapy
Journal Article
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 393 - 403
Cimetidine, an H 2 receptor antagonist, has been used to investigate the tubular secretion of organic cations in human kidney. We report a systematic... 
RENAL TUBULAR SECRETION | METFORMIN | CLEARANCE | PROCAINAMIDE | MEMBRANE | IN-VIVO | HUMANS | ELIMINATION | PHARMACOLOGY & PHARMACY | FUNCTIONAL-CHARACTERIZATION | RANITIDINE | Tetraethylammonium - pharmacokinetics | Cimetidine - pharmacokinetics | Humans | Cephalexin - metabolism | Male | Organic Cation Transporter 1 - metabolism | Metformin - metabolism | Organic Cation Transporter 2 | Organic Cation Transporter 1 - genetics | Dose-Response Relationship, Drug | Kidney - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Transfection | Liver - drug effects | Metformin - urine | Organic Cation Transport Proteins - drug effects | Tetraethylammonium - urine | 3-Iodobenzylguanidine - metabolism | HEK293 Cells | Biological Transport - drug effects | 1-Methyl-4-phenylpyridinium - metabolism | Metformin - administration & dosage | Cimetidine - administration & dosage | Metformin - blood | Binding, Competitive - physiology | Kidney - drug effects | Metformin - pharmacokinetics | Organic Cation Transport Proteins - metabolism | Tetraethylammonium - administration & dosage | Cephalexin - administration & dosage | Liver - metabolism | Cephalexin - urine | Mice, Inbred Strains | Tetraethylammonium - blood | Animals | Pyridines - metabolism | Tetraethylammonium - metabolism | Drug Interactions - physiology | Organic Cation Transporter 1 - antagonists & inhibitors | Cimetidine - pharmacology | Cimetidine - metabolism | Mice | Organic Cation Transporter 1 - drug effects | Kinetics | Organic Cation Transport Proteins - genetics | Cephalexin - blood | Cephalexin - pharmacokinetics
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 42, pp. 17010 - 17015
Journal Article
Toxicology Mechanisms and Methods, ISSN 1537-6516, 10/2015, Volume 25, Issue 8, pp. 637 - 644
Epidemiological evidence has shown associations between prevalence of Parkinson's disease (PD) and exposure to environmental pollutants, but the mechanisms of... 
neurotoxicity | Parkinson's disease | MPP | Heavy metal | TYROSINE-HYDROXYLASE ACTIVITY | OXIDATIVE STRESS | RAT STRIATUM | D-ASPARTATE RECEPTORS | NEUROBLASTOMA-CELLS | ALPHA-SYNUCLEIN AGGREGATION | MONOAMINE-OXIDASE ACTIVITY | GENE-EXPRESSION | TOXICOLOGY | PC12 CELLS | PARKINSONS-DISEASE | Dopamine Plasma Membrane Transport Proteins - metabolism | Tyrosine 3-Monooxygenase - metabolism | 3,4-Dihydroxyphenylacetic Acid - antagonists & inhibitors | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Monoamine Oxidase - chemistry | Dopamine - secretion | Dopaminergic Neurons - metabolism | Dopaminergic Neurons - drug effects | alpha-Synuclein - genetics | Environmental Pollutants - toxicity | Dopaminergic Neurons - secretion | Cell Line | Cell Survival - drug effects | Homovanillic Acid - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | 3,4-Dihydroxyphenylacetic Acid - metabolism | Tyrosine 3-Monooxygenase - antagonists & inhibitors | Dopamine Plasma Membrane Transport Proteins - genetics | Nerve Tissue Proteins - genetics | Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Tyrosine 3-Monooxygenase - genetics | Animals | Homovanillic Acid - metabolism | 1-Methyl-4-phenylpyridinium - toxicity | Methylmercury Compounds - toxicity | Mice | alpha-Synuclein - agonists | Kinetics | alpha-Synuclein - metabolism | Monoamine Oxidase - metabolism | Index Medicus
Journal Article