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Journal Article
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2016, Volume 117, Issue 4, pp. 917 - 926
ABSTRACT Parkinson's disease (PD) is a common chronic neurodegenerative disorder associated with aging that primarily caused by the death of dopaminergic... 
INSULIN | GLYCOGEN SYNTHASE KINASE‐3 (GSK‐3) | TYROSINE HYDROXYLASE (TH) | Bcl‐2 | PROTEIN KINASE B (Akt) | SH‐SY5Y | Bcl-2 | SH-SY5Y | GLYCOGEN SYNTHASE KINASE-3 (GSK-3) | NERVOUS-SYSTEM | OXIDATIVE STRESS | TYROSINE-HYDROXYLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT/BCL-2 SIGNALING PATHWAYS | DEATH | DOPAMINERGIC-NEURONS | CELL BIOLOGY | INHIBITION | GENE-EXPRESSION | NITRIC-OXIDE | BRAIN | Tyrosine 3-Monooxygenase - metabolism | Reactive Oxygen Species - metabolism | Calcium - metabolism | Dopaminergic Neurons - pathology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Cytotoxins - toxicity | Proto-Oncogene Proteins c-akt - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Neuroprotective Agents - pharmacology | Dopaminergic Neurons - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Dopaminergic Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cytotoxins - antagonists & inhibitors | bcl-2-Associated X Protein - genetics | Tretinoin - pharmacology | Insulin - pharmacology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | 1-Methyl-4-phenylpyridinium - antagonists & inhibitors | Gene Expression Regulation | bcl-2-Associated X Protein - metabolism | Glycogen Synthase Kinase 3 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Tyrosine 3-Monooxygenase - genetics | Glycogen Synthase Kinase 3 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Nitric Oxide Synthase Type II - genetics | Cell Differentiation - drug effects | 1-Methyl-4-phenylpyridinium - toxicity | Cell Line, Tumor | Nitric Oxide - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Nitric Oxide Synthase Type II - metabolism | Insulin | Analysis | Nitric oxide | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 393 - 403
Cimetidine, an H 2 receptor antagonist, has been used to investigate the tubular secretion of organic cations in human kidney. We report a systematic... 
RENAL TUBULAR SECRETION | METFORMIN | CLEARANCE | PROCAINAMIDE | MEMBRANE | IN-VIVO | HUMANS | ELIMINATION | PHARMACOLOGY & PHARMACY | FUNCTIONAL-CHARACTERIZATION | RANITIDINE | Tetraethylammonium - pharmacokinetics | Cimetidine - pharmacokinetics | Humans | Cephalexin - metabolism | Male | Organic Cation Transporter 1 - metabolism | Metformin - metabolism | Organic Cation Transporter 2 | Organic Cation Transporter 1 - genetics | Dose-Response Relationship, Drug | Kidney - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Transfection | Liver - drug effects | Metformin - urine | Organic Cation Transport Proteins - drug effects | Tetraethylammonium - urine | 3-Iodobenzylguanidine - metabolism | HEK293 Cells | Biological Transport - drug effects | 1-Methyl-4-phenylpyridinium - metabolism | Metformin - administration & dosage | Cimetidine - administration & dosage | Metformin - blood | Binding, Competitive - physiology | Kidney - drug effects | Metformin - pharmacokinetics | Organic Cation Transport Proteins - metabolism | Tetraethylammonium - administration & dosage | Cephalexin - administration & dosage | Liver - metabolism | Cephalexin - urine | Mice, Inbred Strains | Tetraethylammonium - blood | Animals | Pyridines - metabolism | Tetraethylammonium - metabolism | Drug Interactions - physiology | Organic Cation Transporter 1 - antagonists & inhibitors | Cimetidine - pharmacology | Cimetidine - metabolism | Mice | Organic Cation Transporter 1 - drug effects | Kinetics | Organic Cation Transport Proteins - genetics | Cephalexin - blood | Cephalexin - pharmacokinetics
Journal Article
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 11/2015, Volume 23, Issue 13, pp. 11 - 1016
Journal Article
Cell Death and Disease, ISSN 2041-4889, 02/2017, Volume 8, Issue 2, p. e2574
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2014, Volume 67, pp. 10 - 18
Endoplasmic reticulum (ER) stress has been implicated in Parkinson disease. We previously reported that thioredoxin 1 (Trx-1) suppressed the ER stress caused... 
MPP+/MPTP | Parkinson disease | ER stress | Free radicals | Thioredoxin-1 | MPTP | MPP | APOPTOSIS | ACTIVATION | UNFOLDED-PROTEIN RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | NEUROTOXICITY | P38 MAP KINASE | IRE1 | ENDOCRINOLOGY & METABOLISM | PC12 CELLS | TRANSCRIPTION FACTOR | Transcription Factor CHOP - genetics | Endoribonucleases - genetics | TNF Receptor-Associated Factor 2 - genetics | MPTP Poisoning - physiopathology | Endoplasmic Reticulum Stress - genetics | PC12 Cells | Heat-Shock Proteins - genetics | MPTP Poisoning - genetics | MAP Kinase Kinase 4 - metabolism | Thioredoxins - genetics | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - analogs & derivatives | Thioredoxins - metabolism | Protein-Serine-Threonine Kinases - metabolism | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Signal Transduction | Caspase 12 - genetics | 1-Methyl-4-phenylpyridinium - pharmacology | Heat-Shock Proteins - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Rats | TNF Receptor-Associated Factor 2 - metabolism | Mice, Transgenic | Caspase 12 - metabolism | Animals | MPTP Poisoning - metabolism | MAP Kinase Kinase 4 - genetics | Mice | MPTP Poisoning - chemically induced | Transcription Factor CHOP - metabolism | Glucose metabolism | Enzymes | Inositol | Parkinson's disease | Genetic engineering | Stress (Physiology) | Glucose | Thioredoxin | Dextrose
Journal Article
Journal Article
Aging Cell, ISSN 1474-9718, 10/2011, Volume 10, Issue 5, pp. 807 - 823
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 2011, Volume 43, Issue 4, pp. 297 - 307
While the utility of cryopreserved human hepatocyte suspensions (CHHS) for drug metabolism assays has been established, less is known about the effects of... 
Drug transport | Cryopreserved human hepatocytes | Drug interaction | OATP | Hepatic drug uptake | NTCP | COLLAGEN-SANDWICH CONFIGURATION | CHOLYL-GLYCYLAMIDO-FLUORESCEIN | METABOLIC-CLEARANCE | HEPATIC-UPTAKE | HEPATOBILIARY DISPOSITION | PROTEASE INHIBITORS | ORGANIC CATION TRANSPORTERS | CULTURED RAT HEPATOCYTES | PHARMACOLOGY & PHARMACY | HUMAN LIVER | ANION TRANSPORTER | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Corticosterone - pharmacology | Digoxin - metabolism | Taurocholic Acid - metabolism | Humans | Middle Aged | Male | Organic Cation Transporter 1 - metabolism | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Biological Transport | Cryopreservation | Organic Anion Transporters, Sodium-Independent - metabolism | Prazosin - pharmacology | Adult | Membrane Transport Proteins - metabolism | 1-Methyl-4-phenylpyridinium - metabolism | Solute Carrier Organic Anion Transporter Family Member 1B3 | Estradiol - metabolism | Organic Cation Transport Proteins - metabolism | RNA, Messenger - genetics | Symporters - metabolism | Estrone - analogs & derivatives | Estrone - metabolism | Adolescent | Organic Cation Transporter 1 - antagonists & inhibitors | Rifampin - pharmacology | Organic Anion Transporters, Sodium-Dependent - metabolism | Messenger RNA | Gastrointestinal agents | Peptides | Digoxin | Corticosterone | Analysis | Drug interactions | Sulfates | Rifampin | Estradiol
Journal Article
Cell Death and Disease, ISSN 2041-4889, 2014, Volume 5, Issue 5, pp. e1222 - e1222
Assessment of the network of toxicity pathways by Omics technologies and bioinformatic data processing paves the road toward a new toxicology for the... 
ATF-4 | Metabolomics | Reactive oxygen species | Respiratory chain | Transcriptomics | Systems toxicology | OXIDATIVE STRESS | 1-METHYL-4-PHENYLPYRIDINIUM | systems toxicology | DOPAMINERGIC-NEURONS | NEUROBLASTOMA-CELLS | CELL-DEATH | CELL BIOLOGY | INHIBITION | metabolomics | GLUTATHIONE | reactive oxygen species | IN-VIVO | transcriptomics | GENERATION | respiratory chain | PARKINSONS-DISEASE | Adaptation, Physiological | Transcription, Genetic - drug effects | Neurotoxicity Syndromes - genetics | Oligonucleotide Array Sequence Analysis | Dopaminergic Neurons - pathology | Glutathione - metabolism | Humans | Transfection | Neurotoxicity Syndromes - pathology | RNA Interference | Time Factors | Adenosine Triphosphate - metabolism | Dopaminergic Neurons - metabolism | Mass Spectrometry | Dopaminergic Neurons - drug effects | Cell Line | Computational Biology | Gene Expression Regulation | Neural Stem Cells - drug effects | Oxidative Stress - genetics | Activating Transcription Factor 4 - genetics | Gene Expression Profiling - methods | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Metabolomics - methods | Neural Stem Cells - pathology | Neurotoxicity Syndromes - etiology | Activating Transcription Factor 4 - metabolism | 1-Methyl-4-phenylpyridinium - toxicity | Glucose - metabolism | Neurotoxicity Syndromes - metabolism | High-Throughput Nucleotide Sequencing | Phosphocreatine - metabolism | Oxidative Stress - drug effects | Neural Stem Cells - metabolism | Energy Metabolism - drug effects | Original
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 1906 - 1920
CHDH (choline dehydrogenase) is an enzyme catalyzing the dehydrogenation of choline to betaine aldehyde in mitochondria. Apart from this well-known activity,... 
IM, inner membrane | MTS, mitochondrial targeting sequence | choline dehydrogenase | PARK2/parkin | FB2, FAD/NAD (P)-binding domain 2 | CHX, cycloheximide | PK, proteinase K | MPP+, 1-methyl-4-phenylpyridinium | ANT, adenine nucleotide translocator | FB1, FAD/NAD (P)-binding domain 1 | PB1, Phox and Bem 1 domain | 1 | PD, Parkinson disease | mitophagy | SQSTM1/p62 | CCCP, carbonyl cyanide m-chlorophenylhydrazone | RD, FAD-linked reductase domain | Baf, bafilomycin A | IMS, inter-membrane space | LC3 | Mat, matrix | OM, outer membrane | Mitophagy | Choline dehydrogenase | PROTEIN | PARKIN-MEDIATED MITOPHAGY | DAMAGED MITOCHONDRIA | P62/SQSTM1 | DEPOLARIZED MITOCHONDRIA | QUALITY-CONTROL | SELECTIVE AUTOPHAGY | CELL BIOLOGY | BREAST-CANCER | PINK1 | MITOCHONDRIAL DYSFUNCTION | Dopamine - chemistry | Green Fluorescent Proteins - metabolism | DNA, Mitochondrial - metabolism | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Choline Dehydrogenase - metabolism | Ubiquitin-Protein Ligases - metabolism | Mitochondria - metabolism | Mitochondrial Degradation | Animals | Flow Cytometry | Endopeptidase K - metabolism | Gene Deletion | Mass Spectrometry | HEK293 Cells | Cell Line, Tumor | Chromatography, Liquid | Protein Binding | Cytosol - metabolism | Neurons - metabolism | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - metabolism
Journal Article
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