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1. Full Text Inhibitory interaction potential of 22 antituberculosis drugs on organic anion and cation transporters of the SLC22A family
by Masud Parvez, M and Kaisar, Nazia and Shin, Ho Jung and Jung, Jin Ah and Shin, Jae-Gook
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 11/2016, Volume 60, Issue 11, pp. 6558 - 6567
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Octamer Transcription Factor-1 - antagonists & inhibitors | Organic Anion Transport Protein 1 - metabolism | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Humans | Levofloxacin - pharmacology | Organic Cation Transporter 2 | Pyrazinamide - pharmacology | Rifabutin - pharmacology | Organic Cation Transport Proteins - antagonists & inhibitors | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | Linezolid - pharmacology | Inhibitory Concentration 50 | Ion Transport - drug effects | 1-Methyl-4-phenylpyridinium - metabolism | Organic Anion Transport Protein 1 - antagonists & inhibitors | Organic Cation Transport Proteins - metabolism | Zidovudine - antagonists & inhibitors | Metformin - pharmacology | Antitubercular Agents - pharmacology | Ciprofloxacin - pharmacology | Zidovudine - pharmacology | Metformin - antagonists & inhibitors | Animals | Aminosalicylic Acid - pharmacology | Kinetics | Rifampin - pharmacology | Octamer Transcription Factor-1 - metabolism | Index Medicus
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2. Full Text Acylated and unacylated ghrelin confer neuroprotection to mesencephalic neurons
by Wagner, Johanna and Vulinović, Franca and Grünewald, Anne and Unger, Marcus M and Möller, Jens C and Klein, Christine and Michel, Patrick P and Ries, Vincent and Oertel, Wolfgang H and Alvarez-Fischer, Daniel
Neuroscience, ISSN 0306-4522, 12/2017, Volume 365, pp. 137 - 145
Parkinson disease | ghrelin | mitochondrial respiratory chain | 3-NP | ghrelin receptor | MPP | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Propionates - pharmacology | Tyrosine 3-Monooxygenase - metabolism | Mesencephalon - cytology | Rats, Wistar | Embryo, Mammalian | 1-Methyl-4-phenylpyridinium - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Ghrelin - pharmacology | Phosphopyruvate Hydratase - metabolism | Calcium Channel Blockers - pharmacology | Peptides - pharmacology | Dose-Response Relationship, Drug | Animals | Neuroprotective Agents - pharmacology | Acylation - physiology | Nitro Compounds - pharmacology | Nicardipine - pharmacology | Neurons - drug effects | Goats | Neurons | Medical research | Somatotropin | Calcium channels | Parkinson's disease | Analysis | Medicine, Experimental | Index Medicus
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3. Substrate-dependent ligand inhibition of the human organic cation transporter OCT2
by Belzer, Mathew and Morales, Mark and Jagadish, Bhumasamudram and Mash, Eugene A and Wright, Stephen H
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 2013, Volume 346, Issue 2, pp. 300 - 310
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cricetinae | Cricetulus | Organic Cation Transport Proteins - metabolism | 1-Methyl-4-phenylpyridinium - pharmacology | Humans | Metformin - pharmacology | Fluorescent Dyes - metabolism | Metformin - metabolism | Organic Cation Transporter 2 | 4-Chloro-7-nitrobenzofurazan - analogs & derivatives | Animals | Organic Cation Transport Proteins - antagonists & inhibitors | Biological Transport | 4-Chloro-7-nitrobenzofurazan - metabolism | HEK293 Cells | Quaternary Ammonium Compounds - metabolism | Fluorescent Dyes - pharmacology | Ligands | Cations | 1-Methyl-4-phenylpyridinium - metabolism | 4-Chloro-7-nitrobenzofurazan - pharmacology | CHO Cells | Quaternary Ammonium Compounds - pharmacology
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4. Full Text Involvement of IGF-1 receptor signaling pathway in the neuroprotective effects of Icaritin against MPP+-induced toxicity in MES23.5 cells
by Jiang, Ming-Chun and Chen, Xiao-Han and Zhao, Xia and Zhang, Xue-Jie and Chen, Wen-Fang
European journal of pharmacology, ISSN 0014-2999, 09/2016, Volume 786, pp. 53 - 59
ERK1/2 | Insulin-like growth factor-1 receptor | Akt | MES23.5 cells | 1-Methyl-4-phenylpyridinium ion | Icaritin | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cell Line | Gene Expression Regulation, Enzymologic - drug effects | Receptor, IGF Type 1 - metabolism | Apoptosis - drug effects | Neuroprotective Agents - antagonists & inhibitors | Flavonoids - antagonists & inhibitors | Morpholines - pharmacology | Neurons - cytology | Neuroprotective Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | 1-Methyl-4-phenylpyridinium - toxicity | Organic Chemicals - pharmacology | Flavonoids - pharmacology | Phosphorylation - drug effects | Chromones - pharmacology | Neurons - drug effects | Oligopeptides - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
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5. Full Text Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
by Okawara, Mitsugi and Katsuki, Hiroshi and Kurimoto, Emi and Shibata, Haruki and Kume, Toshiaki and Akaike, Akinori
Biochemical pharmacology, ISSN 0006-2952, 2007, Volume 73, Issue 4, pp. 550 - 560
Dopamine neuron | Oxidative stress | Neuroinflammation | Parkinson's disease | Mitochondrial dysfunction | DNA damage | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Neurology | Pharmacology. Drug treatments | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Biological and medical sciences | Nervous system as a whole | Medical sciences | Nervous system (semeiology, syndromes) | Mesencephalon - cytology | Rats, Wistar | Sodium Azide - toxicity | Thrombin - toxicity | Glutathione - metabolism | Mesencephalon - metabolism | Stilbenes - pharmacology | Cytotoxins - toxicity | Sirtuins - pharmacology | Dose-Response Relationship, Drug | Neuroprotective Agents - pharmacology | Methylnitronitrosoguanidine - toxicity | Sirtuin 1 | Mesencephalon - drug effects | Neurons - metabolism | Neurons - drug effects | Dopamine - metabolism | Organ Culture Techniques | Animals, Newborn | DNA Damage - drug effects | Cell Survival - drug effects | Tumor Suppressor Protein p53 - metabolism | Rats | Antioxidants - pharmacology | Animals | Quercetin - pharmacology | 1-Methyl-4-phenylpyridinium - toxicity | Niacinamide - pharmacology | Sirtuins - metabolism | Neurons | Index Medicus
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6. Full Text Prevention of the degeneration of human dopaminergic neurons in an astrocyte co‐culture system allowing endogenous drug metabolism
by Efremova, Liudmila and Schildknecht, Stefan and Adam, Martina and Pape, Regina and Gutbier, Simon and Hanf, Benjamin and Bürkle, Alexander and Leist, Marcel
British journal of pharmacology, ISSN 0007-1188, 08/2015, Volume 172, Issue 16, pp. 4119 - 4132
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Cell Line | Coculture Techniques | Humans | Cells, Cultured | Rats | Neurotoxins - toxicity | MPTP Poisoning - prevention & control | Neuroglia - drug effects | Neurotoxins - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Animals | Isoquinolines - pharmacology | Neuroprotective Agents - pharmacology | MPTP Poisoning - metabolism | Dopaminergic Neurons - metabolism | Dopaminergic Neurons - drug effects | Neuroglia - metabolism | Mice | 1-Methyl-4-phenylpyridinium - metabolism | Neurons | Rodents | Index Medicus | Research Papers
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7. Full Text Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture
by Shimizu, Keiko and Matsubara, Kazuo and Ohtaki, Ko-ichi and Shiono, Hiroshi
Neuroscience research, ISSN 0168-0102, 2003, Volume 46, Issue 4, pp. 523 - 532
Paraquat | Neurotoxicity | Parkinson's disease | Organotypic midbrain slice | Dopamine neurons | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Tyrosine 3-Monooxygenase - metabolism | NADPH Dehydrogenase - metabolism | Rats, Wistar | Mesencephalon - metabolism | Selegiline - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Neuroprotective Agents - pharmacology | Caspases - pharmacology | Mesencephalon - drug effects | Protein Synthesis Inhibitors - pharmacology | Organ Culture Techniques | Animals, Newborn | NG-Nitroarginine Methyl Ester - pharmacology | Dopamine Agonists - pharmacology | Dopamine Uptake Inhibitors - pharmacology | 1-Methyl-4-phenylpyridinium - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Herbicides - toxicity | Piperazines - pharmacology | Cycloheximide - pharmacology | Azepines - pharmacology | Immunohistochemistry - methods | Animals | Cell Count - methods | Analysis of Variance | Dizocilpine Maleate - pharmacology | Paraquat - toxicity | Ergolines - pharmacology | Index Medicus
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8. Full Text Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons
by Pacelli, Consiglia and Giguère, Nicolas and Bourque, Marie-Josée and Lévesque, Martin and Slack, Ruth S and Trudeau, Louis-Éric
Current biology, ISSN 0960-9822, 09/2015, Volume 25, Issue 18, pp. 2349 - 2360
Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | 1-Methyl-4-phenylpyridinium - pharmacology | Mice, Inbred C57BL | Hydrogen Peroxide - pharmacology | Oxidative Phosphorylation | Mice, Transgenic | Axons - physiology | Mitochondria - metabolism | Ventral Tegmental Area - physiology | Neurotoxins - pharmacology | Animals | Energy Metabolism | Neuronal Plasticity | Rotenone - pharmacology | Dopaminergic Neurons - physiology | Pars Compacta - physiology | Mice | Parkinson Disease - metabolism | Neurosciences | Calcium channels | Dopamine | Neurons | Phenols | Mitochondrial DNA | Isradipine | Index Medicus
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9. Full Text Lipophilic Cationic Cyanines Are Potent Complex I Inhibitors and Specific in Vitro Dopaminergic Toxins with Mechanistic Similarities to Both Rotenone and MPP
by Kadigamuwa, Chamila C and Mapa, Mapa S. T and Wimalasena, Kandatege
Chemical research in toxicology, ISSN 0893-228X, 09/2016, Volume 29, Issue 9, pp. 1468 - 1479
Physical Sciences | Toxicology | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Cell Survival - drug effects | Mitochondria - enzymology | Carbocyanines - chemistry | Reactive Oxygen Species | 1-Methyl-4-phenylpyridinium - pharmacology | Humans | Dopamine - pharmacology | Enzyme Inhibitors - pharmacology | Substrate Specificity | Carbocyanines - pharmacology | Membrane Potential, Mitochondrial - drug effects | Hep G2 Cells | Lipids - chemistry | Cations - pharmacology | Dopamine Agents - pharmacology | Rotenone - pharmacology | Molecular Structure | Mitochondria - chemistry | Apoptosis | Index Medicus | complex I inhibition | reactive oxygen species | neurotoxins | MPP | cyanine dyes | mitochondrial stress | Parkinson’s disease
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10. Full Text Inhibition of hepatic uptake transporters by flavonoids
by Mandery, Kathrin and Balk, Bettina and Bujok, Krystyna and Schmidt, Ingrid and Fromm, Martin F and Glaeser, Hartmut
European journal of pharmaceutical sciences, ISSN 0928-0987, 05/2012, Volume 46, Issue 1-2, pp. 79 - 85
Atorvastatin | Flavonoids | Inhibition | SLC transporter | Food–drug interaction | Herbal drugs | Food-drug interaction | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Pyrroles - pharmacokinetics | Heptanoic Acids - pharmacokinetics | Humans | Rutin - pharmacology | Organic Cation Transporter 1 - metabolism | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Kaempferols - blood | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | Inhibitory Concentration 50 | Biological Transport - drug effects | Flavonoids - pharmacology | Rutin - blood | Solute Carrier Organic Anion Transporter Family Member 1B3 | Organic Anion Transporters - antagonists & inhibitors | Flavanones - blood | Metformin - pharmacokinetics | 1-Methyl-4-phenylpyridinium - pharmacokinetics | Flavanones - pharmacology | Food-Drug Interactions | Atorvastatin Calcium | Quercetin - blood | Quercetin - pharmacology | Sulfobromophthalein - pharmacokinetics | Flavonoids - blood | Organic Cation Transporter 1 - antagonists & inhibitors | Kaempferols - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1b1 | Apigenin - pharmacology | Tritium - pharmacokinetics | Flavones | Bioflavonoids | Isoflavones | Index Medicus
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