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1. Full Text Inhibitory interaction potential of 22 antituberculosis drugs on organic anion and cation transporters of the SLC22A family
by Masud Parvez, M and Kaisar, Nazia and Shin, Ho Jung and Jung, Jin Ah and Shin, Jae-Gook
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2016, Volume 60, Issue 11, pp. 6558 - 6567
Twenty-two currently marketed antituberculosis drugs were comprehensively evaluated for their inhibitory effect on organic anionic transporter (OAT)-and... 
IN-VITRO | PHARMACOKINETICS | ZIDOVUDINE | MEMBRANE | OCT2 | METHOTREXATE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | OAT1 | ATORVASTATIN | PREDICTION | Octamer Transcription Factor-1 - antagonists & inhibitors | Organic Anion Transport Protein 1 - metabolism | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Humans | Levofloxacin - pharmacology | Organic Cation Transporter 2 | Pyrazinamide - pharmacology | Rifabutin - pharmacology | Organic Cation Transport Proteins - antagonists & inhibitors | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | Linezolid - pharmacology | Inhibitory Concentration 50 | Ion Transport - drug effects | 1-Methyl-4-phenylpyridinium - metabolism | Organic Anion Transport Protein 1 - antagonists & inhibitors | Organic Cation Transport Proteins - metabolism | Zidovudine - antagonists & inhibitors | Metformin - pharmacology | Antitubercular Agents - pharmacology | Ciprofloxacin - pharmacology | Zidovudine - pharmacology | Metformin - antagonists & inhibitors | Animals | Aminosalicylic Acid - pharmacology | Kinetics | Rifampin - pharmacology | Octamer Transcription Factor-1 - metabolism
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2. Full Text Mitochondria as a Target for Neurotoxins and Neuroprotective Agents
by BACHURIN, SERGEY O and SHEVTSOVA, ELENA P and KIREEVA, ELENA G and OXENKRUG, GREGORY F and SABLIN, SERGEY O
Annals of the New York Academy of Sciences, ISSN 0077-8923, 05/2003, Volume 993, Issue 1, pp. 334 - 344
: Mitochondrial permeability transition pores represent a multiprotein complex that includes components of both inner and outer membrane. The pores regulate... 
N‐acetylserotonin | tacrine | mitochondria | permeability transition pores | neurodegeneration | apoptosis | dimebon | Mitochondria | Neurodegeneration | Dimebon | N-acetylserotonin | Permeability transition pores | Tacrine | Apoptosis | PERMEABILITY TRANSITION PORE | 1-METHYL-4-PHENYLPYRIDINIUM | MELATONIN | ANTIOXIDANTS | MULTIDISCIPLINARY SCIENCES | NEURODEGENERATIVE DISEASES | BRAIN | Rats, Wistar | Calcium - metabolism | Cyclosporine - pharmacology | Mitochondria, Liver - metabolism | 1-Methyl-4-phenylpyridinium - pharmacology | Amyloid beta-Peptides - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Peptide Fragments - pharmacology | Permeability | Mitochondria, Liver - drug effects | Tacrine - pharmacology | Animals | Neuroprotective Agents - pharmacology | Cholinesterase Inhibitors - pharmacology | Serotonin - metabolism | Serotonin - analogs & derivatives | Indoles - pharmacology | Lipid Peroxidation | Nootropic Agents - pharmacology
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3. Full Text Acylated and unacylated ghrelin confer neuroprotection to mesencephalic neurons
by Wagner, Johanna and Vulinović, Franca and Grünewald, Anne and Unger, Marcus M and Möller, Jens C and Klein, Christine and Michel, Patrick P and Ries, Vincent and Oertel, Wolfgang H and Alvarez-Fischer, Daniel
Neuroscience, ISSN 0306-4522, 12/2017, Volume 365, pp. 137 - 145
The polypeptide ghrelin is an endogenous ligand at the growth hormone secretagogue receptor 1a. To ghrelin multiple functions have been ascribed including... 
Parkinson disease | ghrelin | mitochondrial respiratory chain | 3-NP | ghrelin receptor | MPP | APOPTOSIS | DOPAMINERGIC-NEURONS | CELL-SURVIVAL | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | MOUSE MODEL | UNCOUPLING PROTEIN-2 | HORMONE SECRETAGOGUE RECEPTOR | DEPENDENT MECHANISMS | PROMOTES | PARKINSONS-DISEASE | Propionates - pharmacology | Tyrosine 3-Monooxygenase - metabolism | Mesencephalon - cytology | Rats, Wistar | Embryo, Mammalian | 1-Methyl-4-phenylpyridinium - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Ghrelin - pharmacology | Phosphopyruvate Hydratase - metabolism | Calcium Channel Blockers - pharmacology | Peptides - pharmacology | Dose-Response Relationship, Drug | Animals | Neuroprotective Agents - pharmacology | Acylation - physiology | Nitro Compounds - pharmacology | Nicardipine - pharmacology | Neurons - drug effects | Goats | Neurons | Medical research | Somatotropin | Calcium channels | Parkinson's disease | Analysis | Medicine, Experimental
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4. Full Text Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture
by Shimizu, Keiko and Matsubara, Kazuo and Ohtaki, Ko-ichi and Shiono, Hiroshi
Neuroscience Research, ISSN 0168-0102, 2003, Volume 46, Issue 4, pp. 523 - 532
Paraquat (1,1′-dimethyl-4,4′-bipyridinium, PQ) is a herbicide to possibly induce Parkinson's disease (PD), since a strong correlation has been found between... 
Paraquat | Neurotoxicity | Parkinson's disease | Organotypic midbrain slice | Dopamine neurons | PESTICIDE EXPOSURE | paraquat | NITRIC-OXIDE SYNTHASE | HERBICIDE PARAQUAT | ALPHA-SYNUCLEIN | CEREBROSPINAL-FLUID | NEUROSCIENCES | CELL-DEATH | dopamine neurons | neurotoxicity | PARKINSONS-DISEASE MORTALITY | organotypic midbrain slice | BETA-CARBOLINIUM | MESENCEPHALIC CULTURES | ENVIRONMENTAL RISK-FACTORS | Tyrosine 3-Monooxygenase - metabolism | NADPH Dehydrogenase - metabolism | Rats, Wistar | Mesencephalon - metabolism | Selegiline - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Neuroprotective Agents - pharmacology | Caspases - pharmacology | Mesencephalon - drug effects | Protein Synthesis Inhibitors - pharmacology | Organ Culture Techniques | Animals, Newborn | NG-Nitroarginine Methyl Ester - pharmacology | Dopamine Agonists - pharmacology | Dopamine Uptake Inhibitors - pharmacology | 1-Methyl-4-phenylpyridinium - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Herbicides - toxicity | Piperazines - pharmacology | Cycloheximide - pharmacology | Azepines - pharmacology | Immunohistochemistry - methods | Animals | Cell Count - methods | Analysis of Variance | Dizocilpine Maleate - pharmacology | Paraquat - toxicity | Ergolines - pharmacology
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5. Full Text Involvement of IGF-1 receptor signaling pathway in the neuroprotective effects of Icaritin against MPP+-induced toxicity in MES23.5 cells
by Jiang, Ming-Chun and Chen, Xiao-Han and Chen, Wen-Fang and Zhao, Xia and Zhang, Xue-Jie
European Journal of Pharmacology, ISSN 0014-2999, 09/2016, Volume 786, pp. 53 - 59
Icaritin, a natural derivative of Icariin, is the major bioactive component of Epimedium Genus. The present study tested the hypothesis that the... 
ERK1/2 | Insulin-like growth factor-1 receptor | Akt | MES23.5 cells | 1-Methyl-4-phenylpyridinium ion | Icaritin | APOPTOSIS | ACTIVATION | RAT | I RECEPTOR | HERBA-EPIMEDII | NEUROTOXICITY | ESTROGEN-RECEPTOR | N-SH CELLS | LINE | NEURONS | PHARMACOLOGY & PHARMACY | Cell Line | Gene Expression Regulation, Enzymologic - drug effects | Receptor, IGF Type 1 - metabolism | Apoptosis - drug effects | Neuroprotective Agents - antagonists & inhibitors | Flavonoids - antagonists & inhibitors | Morpholines - pharmacology | Neurons - cytology | Neuroprotective Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | 1-Methyl-4-phenylpyridinium - toxicity | Organic Chemicals - pharmacology | Flavonoids - pharmacology | Phosphorylation - drug effects | Chromones - pharmacology | Neurons - drug effects | Oligopeptides - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
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6. Substrate-dependent ligand inhibition of the human organic cation transporter OCT2
by Belzer, Mathew and Morales, Mark and Jagadish, Bhumasamudram and Mash, Eugene A and Wright, Stephen H
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2013, Volume 346, Issue 2, pp. 300 - 310
Organic cation transporter 2 (OCT2) mediates the initial step in renal secretion of organic cations: uptake from the blood, across the basolateral membrane,... 
IN-VITRO | RAT | STRUCTURAL REQUIREMENTS | AFFINITY | DETERMINANTS | AMINO-ACIDS | MULTIDRUG | PHARMACOLOGY & PHARMACY | MOLECULAR-BASIS | BINDING | DRUG-DRUG INTERACTIONS | Cricetinae | Cricetulus | Organic Cation Transport Proteins - metabolism | 1-Methyl-4-phenylpyridinium - pharmacology | Humans | Metformin - pharmacology | Fluorescent Dyes - metabolism | Metformin - metabolism | Organic Cation Transporter 2 | 4-Chloro-7-nitrobenzofurazan - analogs & derivatives | Animals | Organic Cation Transport Proteins - antagonists & inhibitors | Biological Transport | 4-Chloro-7-nitrobenzofurazan - metabolism | HEK293 Cells | Quaternary Ammonium Compounds - metabolism | Fluorescent Dyes - pharmacology | Ligands | Cations | 1-Methyl-4-phenylpyridinium - metabolism | 4-Chloro-7-nitrobenzofurazan - pharmacology | CHO Cells | Quaternary Ammonium Compounds - pharmacology
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7. Full Text Cistanches Herba: An overview of its chemistry, pharmacology, and pharmacokinetics property
by Fu, Zhifei and Fan, Xiang and Wang, Xiaoying and Gao, Xiumei
Journal of Ethnopharmacology, ISSN 0378-8741, 06/2018, Volume 219, pp. 233 - 247
Cistanches Herba is an parasitic plant. As a commonly used Traditional Chinese Medicine (TCM), its traditional functions include treating kidney deficiency,... 
Acteoside | Cistanches Herba | Pharmacology | Echinacoside | Pharmacokinetics | Phytoconstituents | CHEMISTRY, MEDICINAL | PHENYLETHANOID GLYCOSIDES | ACUTE LUNG INJURY | PLANT SCIENCES | PERFORMANCE LIQUID-CHROMATOGRAPHY | IN-VITRO | 1-METHYL-4-PHENYLPYRIDINIUM ION | CHEMICAL-CONSTITUENTS | PHENYLPROPANOID GLYCOSIDES | INTEGRATIVE & COMPLEMENTARY MEDICINE | NITRIC-OXIDE | NEURONAL CELLS | PHARMACOLOGY & PHARMACY | SCHRENK HOOK-F | Antiviral agents | Polysaccharides | Impotence | Analysis | Phytochemistry | Physiological aspects | Medicine, Chinese | Antibacterial agents
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8. Full Text Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
by Okawara, Mitsugi and Katsuki, Hiroshi and Kurimoto, Emi and Shibata, Haruki and Kume, Toshiaki and Akaike, Akinori
Biochemical Pharmacology, ISSN 0006-2952, 2007, Volume 73, Issue 4, pp. 550 - 560
Increasing lines of evidence show that resveratrol, a polyphenol compound contained in several dietary products, exhibits cytoprotective actions. Notably,... 
Dopamine neuron | Oxidative stress | Neuroinflammation | Parkinson's disease | Mitochondrial dysfunction | DNA damage | dopamine neuron | DNA-DAMAGE | mitochondrial dysfunction | SIRT1 DEACETYLASE | HIPPOCAMPAL-NEURONS | SUBSTANTIA-NIGRA | CELL-DEATH | neuroinflammation | IN-VIVO | PHARMACOLOGY & PHARMACY | PC12 CELLS | NF-KAPPA-B | oxidative stress | PARKINSONS-DISEASE | CALORIE RESTRICTION | Mesencephalon - cytology | Rats, Wistar | Sodium Azide - toxicity | Thrombin - toxicity | Glutathione - metabolism | Mesencephalon - metabolism | Stilbenes - pharmacology | Cytotoxins - toxicity | Sirtuins - pharmacology | Dose-Response Relationship, Drug | Neuroprotective Agents - pharmacology | Methylnitronitrosoguanidine - toxicity | Sirtuin 1 | Mesencephalon - drug effects | Neurons - metabolism | Neurons - drug effects | Dopamine - metabolism | Organ Culture Techniques | Animals, Newborn | DNA Damage - drug effects | Cell Survival - drug effects | Tumor Suppressor Protein p53 - metabolism | Rats | Antioxidants - pharmacology | Animals | Quercetin - pharmacology | 1-Methyl-4-phenylpyridinium - toxicity | Niacinamide - pharmacology | Sirtuins - metabolism | Neurons
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9. Full Text Inhibition of the Mitochondrial Permeability Transition by the Nonimmunosuppressive Cyclosporin Derivative NIM811
by Peter C. Waldmeier and Jean-Jacques Feldtrauer and Ting Qian and John J. Lemasters
Molecular Pharmacology, ISSN 0026-895X, 07/2002, Volume 62, Issue 1, pp. 22 - 29
Cyclosporin A (CsA) shows cytoprotective properties in many cellular and in vivo models that may depend on interference of the interaction of cyclophilin A... 
CYTOCHROME-C | APOPTOSIS | COMPLEX-I | PORE | INJURY | PHARMACOLOGY & PHARMACY | DOPAMINERGIC-NEURONS | DYSFUNCTION | NF-KAPPA-B | DAMAGE | BRAIN | Membrane Potentials - drug effects | Calcium - pharmacology | Uncoupling Agents - pharmacology | Mitochondrial Swelling - drug effects | Cyclosporine - pharmacology | 1-Methyl-4-phenylpyridinium - pharmacology | Rats | Male | Mitochondria - metabolism | Calibration | Mitochondria - drug effects | Rats, Sprague-Dawley | Ion Channels - antagonists & inhibitors | Mitochondrial Membrane Transport Proteins | Tumor Necrosis Factor-alpha - pharmacology | Animals | Drug Interactions | Phenazines - metabolism | Cyclosporine - chemistry | Protective Agents - pharmacology | Rotenone - pharmacology | Mitochondria - physiology | Apoptosis
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10. Full Text Prevention of the degeneration of human dopaminergic neurons in an astrocyte co‐culture system allowing endogenous drug metabolism
by Efremova, Liudmila and Schildknecht, Stefan and Adam, Martina and Pape, Regina and Gutbier, Simon and Hanf, Benjamin and Bürkle, Alexander and Leist, Marcel
British Journal of Pharmacology, ISSN 0007-1188, 08/2015, Volume 172, Issue 16, pp. 4119 - 4132
Background and Purpose Few neuropharmacological model systems use human neurons. Moreover, available test systems rarely reflect functional roles of... 
OXIDATIVE STRESS | ACTIVATION | INHIBITION | CONCISE GUIDE | EMBRYONIC STEM-CELLS | LARGE-SCALE GENERATION | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | DEATH | TOXICITY | PARKINSONS-DISEASE | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Cell Line | Coculture Techniques | Humans | Cells, Cultured | Rats | Neurotoxins - toxicity | MPTP Poisoning - prevention & control | Neuroglia - drug effects | Neurotoxins - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Animals | Isoquinolines - pharmacology | Neuroprotective Agents - pharmacology | MPTP Poisoning - metabolism | Dopaminergic Neurons - metabolism | Dopaminergic Neurons - drug effects | Neuroglia - metabolism | Mice | 1-Methyl-4-phenylpyridinium - metabolism | Neurons | Rodents | Index Medicus | Research Papers
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11. Full Text The organic cation transporter 3 (OCT3) as molecular target of psychotropic drugs: transport characteristics and acute regulation of cloned murine OCT3
by Massmann, Vivian and Edemir, Bayram and Schlatter, Eberhard and Al-Monajjed, Rouvier and Harrach, Saliha and Klassen, Philipp and Holle, Svenja K and Sindic, Aleksandra and Dobrivojevic, Marina and Pavenstädt, Hermann and Ciarimboli, Giuliano
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 3/2014, Volume 466, Issue 3, pp. 517 - 527
The organic cation transporter 3 (OCT3) is a widely expressed transporter for endogenous and exogenous organic cations. Of particular interest is OCT3... 
Biomedicine | Human Physiology | Fluoxetine | Regulation | Organic cation transport | Serotonin clearance | Diazepam | REGIONAL-DISTRIBUTION | PHYSIOLOGY | MOUSE PROXIMAL TUBULES | ADD-ON TRIAL | DEFICIENT MICE | KETAMINE | EXTRACELLULAR SEROTONIN | BIPOLAR DEPRESSION | EXPRESSION | BRAIN | METHYL-D-ASPARTATE | Fluoxetine - pharmacology | Histamine - pharmacology | Organic Cation Transport Proteins - metabolism | Species Specificity | 1-Methyl-4-phenylpyridinium - pharmacology | Humans | Cells, Cultured | Male | Serotonin - pharmacology | Diazepam - pharmacology | Animals | Octamer Transcription Factor-3 - metabolism | Psychotropic Drugs - pharmacology | HEK293 Cells | Kidney Tubules, Proximal - metabolism | Ion Transport - drug effects | Mice | Ketamine - pharmacology | Kidney Tubules, Proximal - drug effects | Quaternary Ammonium Compounds - pharmacology | Drugs | Histamine | Antidepressants | Cloning | Phosphotransferases | Antianxiety agents | Calmodulin
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12. Full Text Creatinine Transport by Basolateral Organic Cation Transporter hOCT2 in the Human Kidney
by Urakami, Yumiko and Kimura, Naoko and Okuda, Masahiro and Inui, Ken-ichi
Pharmaceutical Research, ISSN 0724-8741, 6/2004, Volume 21, Issue 6, pp. 976 - 981
Purpose. Creatinine is excreted into urine by tubular secretion in addition to glomerular filtration. The purpose of this study was to clarify molecular... 
Biochemistry, general | Biomedical Engineering | creatinine | Biomedicine | hOCT2 | glomerular filtration rate | Pharmacy | organic cation transporter | tubular secretion | Medical Law | Pharmacology/Toxicology | CLEARANCE | LOCALIZATION | MEMBRANE | ROCT1 | CHEMISTRY, MULTIDISCIPLINARY | GLOMERULAR-FILTRATION-RATE | FUNCTIONAL EXPRESSION | OCT2 | RENAL EXCRETION | PHARMACOLOGY & PHARMACY | SECRETION | CDNA CLONING | Anions - pharmacology | Trimethoprim - pharmacology | Cations - metabolism | Humans | Organic Cation Transporter 1 - metabolism | Tritium | Anions - chemistry | Organic Cation Transporter 2 | Organic Cation Transporter 1 - genetics | Dose-Response Relationship, Drug | Creatinine - metabolism | Creatinine - pharmacology | Transfection | Cations - pharmacology | Organic Cation Transport Proteins - drug effects | Kidney Tubules - metabolism | Creatinine - antagonists & inhibitors | Membrane Potentials - drug effects | Cell Line | Estrone - pharmacology | Cations - chemistry | Kidney Tubules - drug effects | Organic Cation Transport Proteins - metabolism | 1-Methyl-4-phenylpyridinium - pharmacology | Japan | Membrane Potentials - physiology | Anions - metabolism | Cimetidine - pharmacology | Organic Cation Transporter 1 - drug effects | Organic Cation Transport Proteins - genetics | Carbon Radioisotopes
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13. Full Text Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function
by Wang, Cheng and Ko, Han Seok and Thomas, Bobby and Tsang, Fai and Chew, Katherine C.M and Tay, Shiam-Peng and Ho, Michelle W.L and Lim, Tit-Meng and Soong, Tuck-Wah and Pletnikova, Olga and Troncoso, Juan and Dawson, Valina L and Dawson, Ted M and Lim, Kah-Leong
Human Molecular Genetics, ISSN 0964-6906, 12/2005, Volume 14, Issue 24, pp. 3885 - 3897
Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggests that parkin expression... 
S-NITROSYLATION | LOCALIZATION | OXIDATIVE STRESS | UBIQUITIN-PROTEIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | GENETICS & HEREDITY | ALPHA-SYNUCLEIN | MUTATIONS | LEWY-BODY FORMATION | RAT MODEL | CELL-DEATH | Humans | Stress, Physiological | Male | Reference Values | Nitroso Compounds - pharmacology | Rotenone - pharmacology | Nitric Oxide Donors - pharmacology | Paraquat - pharmacology | Parkinson Disease - pathology | 1-Methyl-4-phenylpyridinium - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Dopamine - pharmacology | Hydrogen Peroxide - pharmacology | Solubility | Ubiquitin-Protein Ligases - metabolism | Parkinson Disease - genetics | Ubiquitin-Protein Ligases - chemistry | Animals | Ubiquitin-Protein Ligases - drug effects | Brain - pathology | Mice | Mutation | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics
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