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1. Full Text The neuroprotection of cannabidiol against MPP+-induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease
by Santos, Neife Aparecida Guinaim and Martins, Nádia Maria and Sisti, Flávia Malvestio and Fernandes, Laís Silva and Ferreira, Rafaela Scalco and Queiroz, Regina Helena Costa and Santos, Antônio Cardozo
Toxicology in vitro, ISSN 0887-2333, 12/2015, Volume 30, Issue 1, pp. 231 - 240
trkA receptors | Synapsin I | Synaptophysin | Neuroprotection | Cannabidiol (CBD) | GAP-43 | TrkA receptors | Life Sciences & Biomedicine | Toxicology | Science & Technology | Up-Regulation | Receptor, trkA - physiology | Neurites - physiology | Humans | Axons - metabolism | Rats | Cannabidiol - pharmacology | PC12 Cells | Parkinson Disease - prevention & control | Animals | Neuroprotective Agents - pharmacology | Synapses - metabolism | Nerve Growth Factor - physiology | 1-Methyl-4-phenylpyridinium - toxicity | Nerve Tissue Proteins - biosynthesis | Neurites - drug effects | Neuroblastoma - pathology | Index Medicus
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2. Full Text Involvement of IGF-1 receptor signaling pathway in the neuroprotective effects of Icaritin against MPP+-induced toxicity in MES23.5 cells
by Jiang, Ming-Chun and Chen, Xiao-Han and Zhao, Xia and Zhang, Xue-Jie and Chen, Wen-Fang
European journal of pharmacology, ISSN 0014-2999, 09/2016, Volume 786, pp. 53 - 59
ERK1/2 | Insulin-like growth factor-1 receptor | Akt | MES23.5 cells | 1-Methyl-4-phenylpyridinium ion | Icaritin | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cell Line | Gene Expression Regulation, Enzymologic - drug effects | Receptor, IGF Type 1 - metabolism | Apoptosis - drug effects | Neuroprotective Agents - antagonists & inhibitors | Flavonoids - antagonists & inhibitors | Morpholines - pharmacology | Neurons - cytology | Neuroprotective Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | 1-Methyl-4-phenylpyridinium - toxicity | Organic Chemicals - pharmacology | Flavonoids - pharmacology | Phosphorylation - drug effects | Chromones - pharmacology | Neurons - drug effects | Oligopeptides - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
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3. Full Text The effect of α‐synuclein knockdown on MPP+ toxicity in models of human neurons
by Fountaine, Timothy M and Venda, Lara Lourenco and Warrick, Nicholas and Christian, Helen C and Brundin, Patrik and Channon, Keith M and Wade‐Martins, Richard
The European journal of neuroscience, ISSN 0953-816X, 12/2008, Volume 28, Issue 12, pp. 2459 - 2473
dopamine transporter | RNA interference | nitric oxide synthase | vesicular monoamine transporter 2 | α‐synuclein | MPP | Dopamine transporter | Nitric oxide synthase | Vesicular monoamine transporter 2 | α-synuclein | Cell Line | Dopamine Plasma Membrane Transport Proteins - metabolism | RNA, Small Interfering - genetics | Vesicular Monoamine Transport Proteins - metabolism | Humans | Neurons - cytology | Herbicides - toxicity | Gene Knockdown Techniques | Animals | 1-Methyl-4-phenylpyridinium - toxicity | Cytoplasmic Vesicles - metabolism | Neurons - physiology | Superoxides - metabolism | Mice | Nitric Oxide Synthase - metabolism | alpha-Synuclein - genetics | 1-Methyl-4-phenylpyridinium - metabolism | Enzyme Activation | Neurons - drug effects | Herbicides - metabolism | alpha-Synuclein - metabolism | Dopamine - metabolism | RNA, Small Interfering - metabolism | Index Medicus
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4. Full Text Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP+-induced apoptosis but not rotenone or 6-hydroxydopamine toxicity
by Garcia-Garcia, Aracely and Anandhan, Annandurai and Burns, Michaela and Chen, Han and Zhou, You and Franco, Rodrigo
Toxicological sciences, ISSN 1096-6080, 11/2013, Volume 136, Issue 1, pp. 166 - 182
6-hydroxydopamine | Parkinson's disease | Neurodegeneration | Cathepsins | Paraquat | MPP | Autophagy | Atg5 | Apoptosis | Rotenone | Life Sciences & Biomedicine | Toxicology | Science & Technology | Enzyme Activators - pharmacology | Neurons - pathology | Caspase Inhibitors - pharmacology | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Caspase 3 - metabolism | Dose-Response Relationship, Drug | Transfection | Rotenone - toxicity | Neurons - metabolism | Neurons - drug effects | Phosphatidylinositol 3-Kinase - metabolism | Cathepsins - antagonists & inhibitors | Oxidopamine - toxicity | Autophagy-Related Protein 5 | Signal Transduction - drug effects | Cathepsins - metabolism | 1-Methyl-4-phenylpyridinium - toxicity | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Paraquat - toxicity | Index Medicus | autophagy | paraquat | cathepsins | rotenone | neurodegeneration | apoptosis | Parkinson’s disease
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5. Full Text Protection of dopaminergic cells from MPP+ -mediated toxicity by histone deacetylase inhibition
by Kidd, Sarah K and Schneider, Jay S
Brain research, ISSN 0006-8993, 2010, Volume 1354, pp. 172 - 178
Neurology | Sodium butyrate | SAHA | Dopamine | HDACI (histone deacetylase inhibitor) | MPP | Valproate | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Pharmacology. Drug treatments | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Biological and medical sciences | Anticonvulsants. Antiepileptics. Antiparkinson agents | Medical sciences | Neuropharmacology | Immunohistochemistry | Cell Line | Apoptosis - drug effects | 1-Methyl-4-phenylpyridinium - pharmacology | Humans | Cells, Cultured | Rats | Valproic Acid - pharmacology | Nerve Degeneration - metabolism | Animals | Analysis of Variance | Histone Deacetylase Inhibitors - pharmacology | Butyric Acid - pharmacology | Neurons - metabolism | Acetylation | Histones - metabolism | Neurons - drug effects | Hydroxamic Acids - pharmacology | Dopamine - metabolism | Index Medicus | HDACI (Histone deacetylase Inhibitor) | Sodium Butyrate
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6. Full Text DLP1‐dependent mitochondrial fragmentation mediates 1‐methyl‐4‐phenylpyridinium toxicity in neurons: implications for Parkinson’s disease
by Wang, Xinglong and Su, Bo and Liu, Wanhong and He, Xiaohua and Gao, Yuan and Castellani, Rudy J and Perry, George and Smith, Mark A and Zhu, Xiongwei
Aging cell, ISSN 1474-9718, 10/2011, Volume 10, Issue 5, pp. 807 - 823
DLP1/Drp1 | mitochondrial fragmentation | neurotoxicity | MPP | Parkinson’s disease | mitochondrial dynamics | Neurotoxicity | Parkinson's disease | Mitochondrial dynamics | Mitochondrial fragmentation | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Cell Biology | Neurons - pathology | Tyrosine 3-Monooxygenase - metabolism | Dynamins - metabolism | Reactive Oxygen Species | Microtubule-Associated Proteins - metabolism | Humans | Fluorescent Dyes - metabolism | Autophagy | Transfection | RNA Interference | Mitochondrial Proteins - metabolism | Adenosine Triphosphate - metabolism | Membrane Potential, Mitochondrial | Neurons - metabolism | Neurons - drug effects | Cell Line | Parkinson Disease - pathology | Cell Survival | Gene Silencing | Genetic Vectors - metabolism | Rats | Excitatory Amino Acid Antagonists - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Blotting, Western | Genetic Vectors - genetics | Animals | GTP Phosphohydrolases - metabolism | Image Processing, Computer-Assisted | 1-Methyl-4-phenylpyridinium - toxicity | Fluorescent Antibody Technique | Adenosine Diphosphate - metabolism | Index Medicus | Parkinson disease | DLP1 | Drp1
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7. Full Text Nurr1 and PPARγ protect PC12 cells against MPP+ toxicity: involvement of selective genes, anti-inflammatory, ROS generation, and antimitochondrial impairment
by Jodeiri Farshbaf, Mohammad and Forouzanfar, Mahboobeh and Ghaedi, Kamran and Kiani-Esfahani, Abbas and Peymani, Maryam and Shoaraye Nejati, Alireza and Izadi, Tayebeh and Karbalaie, Khadijeh and Noorbakhshnia, Maryam and Rahgozar, Soheila and Baharvand, Hossein and Nasr-Esfahani, Mohammad Hossein
Molecular and cellular biochemistry, ISSN 0300-8177, 9/2016, Volume 420, Issue 1, pp. 29 - 42
Life Sciences | Biochemistry, general | PC12 | Nurr1 | Medical Biochemistry | Oncology | Cardiology | MPP | Parkinson’s disease | PPARγ | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Animals | Reactive Oxygen Species - metabolism | 1-Methyl-4-phenylpyridinium - toxicity | PPAR gamma - agonists | Rats | Mitochondria - metabolism | Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism | Nuclear Receptor Subfamily 4, Group A, Member 2 - agonists | Membrane Potential, Mitochondrial - drug effects | PPAR gamma - metabolism | PC12 Cells | Index Medicus
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8. Full Text Probenecid potentiates MPTP/MPP+ toxicity by interference with cellular energy metabolism
by Alvarez‐Fischer, Daniel and Noelker, Carmen and Grünewald, Anne and Vulinović, Franca and Guerreiro, Serge and Fuchs, Julia and Lu, Lixia and Lombès, Anne and Hirsch, Etienne C and Oertel, Wolfgang H and Michel, Patrick P and Hartmann, Andreas
Journal of neurochemistry, ISSN 0022-3042, 12/2013, Volume 127, Issue 6, pp. 782 - 792
probenecid | Parkinson's disease | MPTP | MPP | ATP | mitochondria | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Parkinson Disease - pathology | Electron Transport Complex I - antagonists & inhibitors | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - metabolism | Dopaminergic Neurons - pathology | Neurotoxins - toxicity | Corpus Striatum - metabolism | Uricosuric Agents - toxicity | Drug Synergism | Animals | Energy Metabolism | Probenecid - toxicity | Dopaminergic Neurons - metabolism | Rotenone - toxicity | Corpus Striatum - drug effects | Dopaminergic Neurons - drug effects | Dopamine Agents - toxicity | Mice | Parkinson Disease - metabolism | 1-Methyl-4-phenylpyridinium - metabolism | Corpus Striatum - pathology | Disease Models, Animal | Parkinson Disease - etiology | Physiological aspects | Mitochondrial DNA | Metabolites | Analysis | Probenecid | Cellular biology | Metabolism | Toxicity | Index Medicus | Life Sciences
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