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CLINICAL CANCER RESEARCH, ISSN 1078-0432, 03/2018, Volume 24, Issue 6, pp. 1426 - 1435
Journal Article
Endocrinology, ISSN 0013-7227, 02/2007, Volume 148, Issue 2, pp. 512 - 529
Among its pleiotropic actions, ghrelin modulates insulin secretion and glucose metabolism. Herein we investigated the role of ghrelin in pancreatic β-cell... 
CYCLIC-AMP | CYTOKINE-INDUCED APOPTOSIS | NITRIC-OXIDE SYNTHASE | PROTEIN-KINASE | DES-OCTANOYL GHRELIN | ENDOCRINOLOGY & METABOLISM | RAT ISLETS | RELEASE | HORMONE SECRETAGOGUE RECEPTOR | EXPRESSION | STIMULATES INSULIN-SECRETION | GTP-Binding Protein alpha Subunits, Gs - metabolism | Peptide Hormones - pharmacology | Receptors, G-Protein-Coupled - metabolism | Apoptosis - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Cyclic AMP - physiology | Insulin-Secreting Cells - metabolism | Ghrelin | Islets of Langerhans - cytology | Cyclic AMP-Dependent Protein Kinase Type II | Peptide Hormones - chemistry | Insulin-Secreting Cells - cytology | Culture Media, Serum-Free - pharmacology | Extracellular Signal-Regulated MAP Kinases - physiology | Proto-Oncogene Proteins c-akt - metabolism | Binding Sites | Insulin Secretion | Acylation | Receptors, Ghrelin | Insulin-Secreting Cells - physiology | Cell Line | Nitric Oxide - biosynthesis | Cricetinae | Islets of Langerhans - physiology | Nitric Oxide - antagonists & inhibitors | Drug Synergism | Tumor Necrosis Factor-alpha - pharmacology | Cyclic AMP-Dependent Protein Kinases - physiology | Insulin - metabolism | Animals | Signal Transduction - physiology | Cell Proliferation - drug effects | In Vitro Techniques | Interferon-gamma - pharmacology | Index Medicus | Abridged Index Medicus | cytology | Cell Proliferation | MEDICIN OCH HÄLSOVETENSKAP | Serum-Free | GTP-Binding Protein alpha Subunits | Peptide Hormones | Receptors | Culture Media | Interferon Type II | pharmacology | biosynthesis | Insulin-Secreting Cells | Cyclic AMP-Dependent Protein Kinases | MEDICAL AND HEALTH SCIENCES | G-Protein-Coupled | chemistry | 1-Phosphatidylinositol 3-Kinase | Signal Transduction | Cyclic AMP | physiology | drug effects | Extracellular Signal-Regulated MAP Kinases | Nitric Oxide | Insulin | Tumor Necrosis Factor-alpha | antagonists & inhibitors | Proto-Oncogene Proteins c-akt | secretion | metabolism | Islets of Langerhans | Apoptosis
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 06/2017, Volume 23, Issue 11, pp. 2795 - 2805
Purpose: Determine the roles of the PI3K isoforms p110 alpha and p110 beta in PTEN-deficient, estrogen receptor a (ER)-positive breast cancer, and the... 
RAPAMYCIN | PIK3CA MUTATIONS | ONCOLOGY | PHOSPHORYLATION | PI3K PATHWAY | ANTIESTROGEN RESISTANCE | GROWTH | SENSITIVITY | SUPPRESSION | EXPRESSION | CARCINOMA | PTEN Phosphohydrolase - genetics | Class I Phosphatidylinositol 3-Kinases - genetics | Apoptosis - drug effects | Humans | Thiazoles - administration & dosage | Breast Neoplasms - drug therapy | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Animals | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Retinoblastoma Protein - genetics | Cell Line, Tumor | Female | Cell Proliferation - drug effects | Mice | Gene Expression Regulation, Neoplastic - drug effects | Class Ia Phosphatidylinositol 3-Kinase - genetics | Phosphorylation | Estrogens | Estrogen | Estrogen receptors | Cytotoxicity | AKT protein | Activation | Fulvestrant | Xenografts | Cytostatic agents | Bioindicators | Inhibition | Growth factors | Regression | Breast cancer | Tumor cell lines | 1-Phosphatidylinositol 3-kinase | Signaling | Inhibitors | Experimental design | Isoforms | Cell lines | Biomarkers | Breast | Cytotoxic agents | PTEN protein | Cancer | Apoptosis | Index Medicus | PTEN | p110-beta | breast cancer | anti-estrogen | PI3K
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, pp. e0170551 - e0170551
Cudraflavone C (Cud C) is a naturally-occurring flavonol with reported anti-proliferative activities. However, the mechanisms by which Cud C induced... 
LUNG-CANCER | PI3K/AKT PATHWAY | HUMAN BREAST | CUDRANIA-TRICUSPIDATA | MULTIDISCIPLINARY SCIENCES | CYCLIN B1 | CONNECTIVITY MAP | GENE-EXPRESSION | ISOPRENYLATED FLAVONES | ROOT BARK | CLINICAL-SIGNIFICANCE | Caco-2 Cells | Apoptosis - drug effects | HCT116 Cells | Humans | Gene Expression Profiling | HT29 Cells | Signal Transduction - drug effects | Colorectal Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - drug effects | Cell Line, Tumor | Real-Time Polymerase Chain Reaction | Flavones - pharmacology | Proto-Oncogene Proteins c-akt - drug effects | Phosphoinositides | Colorectal cancer | Genetic aspects | Research | Gene expression | Health aspects | Apoptosis | Cell proliferation | Phosphorylation | Toxicity | Epithelial cells | Colorectal carcinoma | Clinical trials | Cytotoxicity | AKT protein | Oncology | Insulin-like growth factors | Metastasis | Kinases | Phosphatase | Cancer therapies | Depolarization | Signal transduction | Mitochondria | Cell activation | Cell growth | Inhibition | Huwe1 protein | Medical research | EGR-1 protein | Caspase | Protein biosynthesis | Pharmacology | Breast cancer | FDA approval | Chemical compounds | 1-Phosphatidylinositol 3-kinase | Studies | Signaling | DNA microarrays | Inhibitors | Protein synthesis | Pharmacy | Stem cells | Lipid kinase | Tumor suppressor genes | Mutation | Cancer | Index Medicus
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 08/2017, Volume 118, Issue 8, pp. 2271 - 2284
SHIP decreases in the kidneys of diabetic mice concomitant with increased phospho‐Akt, TGF‐β1, and extracellular matrix deposit. Again, high glucose decreases... 
DIABETIC MICE | EXTRACELLULAR MATRIX | SRC HOMOLOGY 2 DOMAIN‐CONTAINING INOSITOL 5’‐PHOSPHATASE | PHOSPHATIDYLINOSITOL 3‐KINASE/PROTEIN KINASE B | TRANSFORMING GROWTH FACTOR‐β1 | RENAL TUBULAR CELLS | TRANSFORMING GROWTH FACTOR-β1 | SRC HOMOLOGY 2 DOMAIN-CONTAINING INOSITOL 5’-PHOSPHATASE | PHOSPHATIDYLINOSITOL 3-KINASE/PROTEIN KINASE B | FIBROSIS | ACTIVATION | PROTEIN KINASE B | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSFORMING GROWTH FACTOR-1 | SRC HOMOLOGY 2 DOMAIN-CONTAINING INOSITOL 5'-PHOSPHATASE | DIABETIC-NEPHROPATHY | CELL BIOLOGY | TO-MESENCHYMAL TRANSITION | DISEASE | SHIP-1 | STRESS | EXPRESSION | PROGRESSION | TGF-BETA-1 | Epithelial Cells - metabolism | Cadherins - metabolism | Epithelial Cells - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | Extracellular Matrix - metabolism | Inositol Polyphosphate 5-Phosphatases - genetics | Dioxoles - pharmacology | Benzamides - pharmacology | Cadherins - genetics | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - metabolism | Cell Line | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - genetics | Extracellular Matrix - drug effects | Inositol Polyphosphate 5-Phosphatases - metabolism | Morpholines - pharmacology | Glucose - pharmacology | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Kidney Tubules - cytology | Phosphatidylinositol 3-Kinase - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins c-akt - drug effects | Inositol | Phosphatases | Collagen | Bone morphogenetic proteins | Phospholipids | Kidney diseases | Glucose | Muscle proteins | Transforming growth factors | Dextrose | Surgical implants | Epithelial cells | Electrochemical machining | Smooth muscle | Homology | AKT protein | Activation | Biochemistry | Kinases | Phosphatase | E-cadherin | Signal transduction | Biomedical materials | Actin | Ships | Extracellular matrix | Attenuation | Inhibition | Deposition | Diabetes mellitus | Src protein | 1-Phosphatidylinositol 3-kinase | Inhibitors | Protein kinase | Fibrosis | Glomerulus | Mice | Diabetes | In vitro methods and tests | Clear cell-type renal cell carcinoma | Kidney transplantation | inositol 5'-phosphatase | Index Medicus
Journal Article
Journal Article
The Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, 09/2018, Volume 6, Issue 5, pp. 1763 - 1765
The striking advances in sequencing technology have led to an era in which a wide variety of specific genetic mutations in clinically similar syndromes can be... 
NODULAR REGENERATIVE HYPERPLASIA | ALLERGY | DISEASE | COMMON VARIABLE IMMUNODEFICIENCY | COHORT | IMMUNOLOGY | HEPATIC ABNORMALITIES | Hypertension | Enzymes | Liver diseases | Immune response | Transplants & implants | Laboratories | Liver | Kinases | Patients | 1-Phosphatidylinositol 3-kinase | Next-generation sequencing | Biopsy | Stem cells | Lipid kinase | Mutation | Age
Journal Article
Journal Article