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Journal of Biological Chemistry, ISSN 0021-9258, 05/2017, Volume 292, Issue 18, pp. 7542 - 7553
The aim of the study was to characterize the role of Rac1 GTPase for the mineralocorticoid receptor (MR)-mediated pro-fibrotic remodeling. Transgenic mice with... 
SURVIVAL | connective tissue growth factor (CTGF) | aldosterone | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | INJURY | MECHANISMS | mineralocorticoid receptor | Rac (Rac GTPase) | ATRIAL-FIBRILLATION | 11 hydroxysteroid dehydrogenase type 2 | fibrosis | Rac1 | CARDIAC FIBROSIS | HYPERTENSION | ASSOCIATION | MINERALOCORTICOID RECEPTOR ACTIVATION | Endomyocardial Fibrosis - enzymology | Fibroblasts - enzymology | Fibronectins - biosynthesis | Tetradecanoylphorbol Acetate - pharmacology | Humans | Methionine - pharmacology | Connective Tissue Growth Factor - biosynthesis | Myocytes, Cardiac - enzymology | Methionine - analogs & derivatives | Mice, Mutant Strains | Neuropeptides - biosynthesis | Endomyocardial Fibrosis - pathology | Neuropeptides - genetics | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics | Cell Line | Sulfoxides - pharmacology | Signal Transduction | Rats | Aldosterone - pharmacology | Myocardium - pathology | Fibroblasts - pathology | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Myocytes, Cardiac - pathology | Myocardium - enzymology | Animals | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - biosynthesis | Connective Tissue Growth Factor - genetics | Fibronectins - genetics | Mice | rac1 GTP-Binding Protein - biosynthesis | rac1 GTP-Binding Protein - genetics | Index Medicus | 11β hydroxysteroid dehydrogenase type 2
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 08/2010, Volume 399, Issue 2, pp. 215 - 220
Journal Article
British Journal of Cancer, ISSN 0007-0920, 09/2017, Volume 117, Issue 7, pp. 984 - 993
Background: Recent studies have shown that production of cortisol not only takes place in several non-adrenal peripheral tissues such as epithelial cells but,... 
cortisol | 11β-HSDs | cancer | lymphocytes | keratinocytes | cell adhesion | CELLS | LOCALIZATION | 11 beta-HSDs | TUMORS | FIBROBLASTS | INHIBITION | ONCOLOGY | SENESCENCE | EXPRESSION | PROGRESSION | ANTIGEN | Humans | Skin Neoplasms - chemistry | Adrenocorticotropic Hormone - pharmacology | Hydrocortisone - metabolism | Melanoma - enzymology | Culture Media, Conditioned - pharmacology | Receptors, Glucocorticoid - metabolism | Glycyrrhetinic Acid - pharmacology | Skin Neoplasms - enzymology | MCF-7 Cells | Hydrocortisone - immunology | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - antagonists & inhibitors | Melanoma - chemistry | Carcinoma, Squamous Cell - enzymology | Paracrine Communication | Glycyrrhetinic Acid - analogs & derivatives | Down-Regulation | Gene Silencing | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - analysis | Carcinoma, Squamous Cell - chemistry | Receptors, Glucocorticoid - immunology | Cell Adhesion | HT29 Cells | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism | Cortisone - pharmacology | Keratinocytes - drug effects | Keratinocytes - metabolism | CD8-Positive T-Lymphocytes - drug effects | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism | Epithelial Cells - enzymology | Cell Proliferation - drug effects | Hydrocortisone - pharmacology | CD8-Positive T-Lymphocytes - immunology | Index Medicus | Molecular Diagnostics
Journal Article
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2011, Volume 125, Issue 1, pp. 129 - 142
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 2014, Volume 48, pp. 1 - 10
Journal Article
Journal of Hypertension, ISSN 0263-6352, 02/2011, Volume 29, Issue 2, pp. 282 - 289
OBJECTIVEPrenatal glucocorticoid excess programs hypertension in adulthood. The underlying mechanisms are unknown. Here, we tested whether hypertension in this... 
fetal programming | glucocorticoids | hypertension | 11β-hydroxysteroid dehydrogenase type 2 | salt sensitivity | APPARENT MINERALOCORTICOID EXCESS | MOLECULAR MECHANISMS | ADULT DISEASE | RECEPTOR | BLOOD-PRESSURE | LICORICE | GROWTH | PERIPHERAL VASCULAR DISEASE | 11 beta-hydroxysteroid dehydrogenase type 2 | FETAL | CORTISOL-CORTISONE SHUTTLE | EXPOSURE | Gene Expression Regulation, Enzymologic - drug effects | Receptors, Mineralocorticoid - genetics | Prenatal Exposure Delayed Effects - enzymology | Rats, Wistar | Kidney - enzymology | Sodium Chloride, Dietary - administration & dosage | Stress, Physiological | Dexamethasone - toxicity | RNA, Messenger - metabolism | Hypertension - etiology | Aldosterone - metabolism | Female | Glucocorticoids - toxicity | Blood Pressure - drug effects | Hypertension - genetics | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics | Kidney - physiopathology | Animals, Newborn | Dexamethasone - administration & dosage | Kidney - drug effects | Mineralocorticoids - metabolism | RNA, Messenger - genetics | Gene Expression Regulation, Developmental - drug effects | Rats | Renin - blood | Electrolytes - blood | Hypertension - physiopathology | Pregnancy | Prenatal Exposure Delayed Effects - genetics | Animals | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism | Receptors, Glucocorticoid - genetics | Hydrocortisone - pharmacology | Index Medicus
Journal Article
MOLECULAR ASPECTS OF MEDICINE, ISSN 0098-2997, 04/2007, Volume 28, Issue 2, pp. 220 - 226
Journal Article
HUMAN REPRODUCTION, ISSN 0268-1161, 04/1998, Volume 13, Issue 4, pp. 799 - 804
The type 2 isoform of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD2), which inactivates cortisol (F) to cortisone (E), has been suggested to play a role... 
CORTICOTROPIN-RELEASING HORMONE | cortisone | APPARENT MINERALOCORTICOID EXCESS | LOCALIZATION | HUMAN-PLACENTA | HUMAN KIDNEY | OBSTETRICS & GYNECOLOGY | cortisol | REPRODUCTIVE BIOLOGY | 11 beta-hydroxysteroid dehydrogenase | MESSENGER-RIBONUCLEIC-ACID | TISSUE DISTRIBUTION | placenta | BABOON PLACENTA | FETAL MEMBRANES | fetal growth | HYPERTENSION
Journal Article
GENERAL AND COMPARATIVE ENDOCRINOLOGY, ISSN 0016-6480, 05/2010, Volume 166, Issue 3, pp. 600 - 605
The enzyme 11 beta HSD2 inactivates glucocorticoids by synthesizing metabolites that bind poorly to mineralocorticoid and glucocorticoid receptors. Oscine... 
Brain | CORTICOSTERONE | Glucocorticoids | MESSENGER-RNA EXPRESSION | TAENIOPYGIA-GUTTATA | Zebra finch | Sex differences | MINERALOCORTICOID RECEPTOR | GLUCOCORTICOID-RECEPTOR | DOMESTIC-FOWL | METABOLISM | CLONING | Mineralocorticoid receptors | ENDOCRINOLOGY & METABOLISM | 11 beta-hydroxysteroid dehydrogenase type 2 | RAT-BRAIN | STRESS
Journal Article