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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 06/2014, Volume 111, Issue 24, pp. E2482 - E2491
The adverse metabolic effects of prescribed and endogenous glucocorticoid (GC) excess, Cushing syndrome, create a significant health burden. We found that... 
METABOLIC SYNDROME | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | MULTIDISCIPLINARY SCIENCES | CORTISONE | HSD11b1 | cortisol | CUSHINGS-SYNDROME | OBESITY | hypercortisolemia | DISEASE | steroids | MICE | RECEPTOR AGONIST | endocrinology | ADIPOSE-TISSUE | AGE
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 08/2009, Volume 94, Issue 8, pp. 2692 - 2701
Context: The metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increase the risk for type 2 diabetes mellitus and vascular disease. The... 
11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | LOW-BIRTH-WEIGHT | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | BODY-FAT DISTRIBUTION | SUBCLINICAL CUSHINGS-SYNDROME | CORONARY-HEART-DISEASE | PITUITARY-ADRENAL AXIS | SERUM URIC-ACID | CARDIOVASCULAR RISK-FACTORS | ADIPOSE-TISSUE
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 05/2019, Volume 160, Issue 7, pp. 1659 - 1673
Excess of glucocorticoids (GC) is a leading cause of bone fragility, and novel therapeutic targets are sorely needed. We report that genetic deletion or... 
INDUCED OSTEOPOROSIS | OSTEOCYTES | BISPHOSPHONATES | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | OSTEOCLAST APOPTOSIS | OSTEOBLASTS | ENDOCRINOLOGY & METABOLISM | TERIPARATIDE | MECHANISMS | OSTEONECROSIS | ALENDRONATE
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 08/2005, Volume 202, Issue 4, pp. 517 - 527
The enzyme 11 beta-hydroxysteroid dehydrogenase (HSD) type 1 converts inactive cortisone into active cortisol in cells, thereby raising the effective... 
SELECTIVE-INHIBITION | MEDICINE, RESEARCH & EXPERIMENTAL | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | HEPATIC INSULIN SENSITIVITY | CENTRAL OBESITY | THERAPEUTIC TARGET | CUSHINGS-DISEASE | MUSCLE CELLS | IMMUNOLOGY | EXPRESSION | ADIPOSE-TISSUE | CORTISOL METABOLISM
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 08/2019, Volume 62, Issue 15, pp. 6925 - 6940
The natural product colletoic acid (CA) is a selective inhibitor of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which primarily converts... 
11-BETA-HSD1 | ADIPOCYTE HYPERTROPHY | CHEMISTRY, MEDICINAL | GLUCOCORTICOID-RECEPTOR | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | PHARMACOKINETICS | NATURAL-PRODUCTS | CRYSTAL-STRUCTURES | INHIBITORS | DIFFERENTIATION | CELL | Index Medicus
Journal Article
Journal Article
AJP - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 03/2007, Volume 292, Issue 3, pp. R1101 - R1109
Section of Endocrinology and Metabolism, Departments of 1 Internal Medicine and 2 Physiology, University of Manitoba, Winnipeg, Manitoba, Canada Submitted 13... 
Animals, Newborn | Pregnancy | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism | Prenatal Exposure Delayed Effects | Animals | Liver - enzymology | Ethanol - toxicity | Rats | Female | Adipose Tissue - enzymology | Rats, Sprague-Dawley | Carbohydrate Dehydrogenases - metabolism | Index Medicus
Journal Article
Biology of reproduction, ISSN 0006-3363, 06/2019, Volume 100, Issue 6, pp. 1605 - 1616
Dexamethasone (Dex), a corticosteroid hormone, is used during the perinatal period to help fetal lung and other organ development. Conversely, Dex-induced cell... 
preterm birth | CYTOKINES | GLUCOCORTICOIDS | lung maturity | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | RU486 | ANTENATAL BETAMETHASONE | INDUCTION | HUMAN FETAL MEMBRANES | PREGNANCY | REPRODUCTIVE BIOLOGY | inflammation | steroids | aging | PROGESTERONE-RECEPTOR | EXPRESSION | CORTISOL
Journal Article
European Journal of Endocrinology, ISSN 0804-4643, 12/2016, Volume 175, Issue 6, pp. R265 - R282
In recent years, the condition of subclinical hypercortisolism (SH) has become a topic of growing interest. This is due to the fact that SH prevalence is not... 
GROWTH-HORMONE GH | CUSHINGS-SYNDROME | MINERAL DENSITY | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | VERTEBRAL FRACTURES | EUGONADAL MALE-PATIENTS | ADRENAL INCIDENTALOMA | ENDOCRINOLOGY & METABOLISM | GLUCOCORTICOID-RECEPTOR GENE | REPLACEMENT THERAPY | OSTEOPOROTIC FRACTURES
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 02/2019, Volume 33, Issue 2, pp. 2770 - 2781
Journal Article
by Wang, WS and Chen, ZJ and Myatt, L and Sun, K
ENDOCRINE REVIEWS, ISSN 0163-769X, 06/2018, Volume 39, Issue 3, pp. 241 - 260
Journal Article
American Journal of Veterinary Research, ISSN 0002-9645, 02/2018, Volume 79, Issue 2, pp. 199 - 210
OBJECTIVE To identify signs of tissue-specific cortisol activity in samples of suspensory ligament (SL) and neck skin tissue from horses with and without... 
POPULATION | DIAGNOSIS | CELLS | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | DYSREGULATION | ACHILLES-TENDON | SENSITIVITY | RESISTANCE | VETERINARY SCIENCES | EXPRESSION | BODY
Journal Article
EUROPEAN JOURNAL OF ENDOCRINOLOGY, ISSN 0804-4643, 08/2016, Volume 175, Issue 2, pp. R81 - R87
Glucocorticoids are widely prescribed for their anti-inflammatory properties, but have 'Cushingoid' side effects including visceral obesity, muscle myopathy,... 
SELECTIVE-INHIBITION | 11-BETA-HSD1 INHIBITION | LOCALIZATION | METABOLIC SYNDROME | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | GLUCOCORTICOID-RECEPTOR AGONIST | HYPERGLYCEMIC MICE | DISEASE | ENDOCRINOLOGY & METABOLISM | EXPRESSION | ADIPOSE-TISSUE
Journal Article
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, ISSN 0362-1642, 2007, Volume 47, pp. 293 - 322
Journal Article
DRUGS, ISSN 0012-6667, 09/2013, Volume 73, Issue 13, pp. 1385 - 1393
Inhibition of the enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) has been proposed as a novel therapeutic target for the treatment of type 2... 
SELECTIVE-INHIBITION | SPLANCHNIC CORTISOL PRODUCTION | METABOLIC SYNDROME | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | HEPATIC INSULIN SENSITIVITY | HYPERGLYCEMIC MICE | HUMAN OBESITY | GLUCOCORTICOID ACTION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | IMPROVES COGNITIVE FUNCTION | ADIPOSE-TISSUE
Journal Article
Journal Article
ENDOCRINOLOGY, ISSN 0013-7227, 06/2017, Volume 158, Issue 6, pp. 1964 - 1976
Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with... 
NONSHIVERING THERMOGENESIS | LIPID-METABOLISM | ADIPOCYTES | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | INDUCED APOPTOSIS | UNCOUPLING PROTEIN | MITOCHONDRIAL-FUNCTION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | VISCERAL OBESITY | INSULIN SENSITIVITY
Journal Article
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