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14-3-3-proteins (643) 643
biochemistry & molecular biology (306) 306
phosphorylation (292) 292
14-3-3 proteins (284) 284
humans (237) 237
animals (224) 224
proteins (201) 201
index medicus (189) 189
14-3-3 proteins - metabolism (180) 180
binding (159) 159
protein binding (151) 151
cell biology (149) 149
molecular sequence data (144) 144
expression (141) 141
amino acid sequence (140) 140
activation (139) 139
identification (120) 120
14-3-3 (107) 107
14-3-3 protein (105) 105
14-3-3 proteins - genetics (104) 104
tyrosine 3-monooxygenase (90) 90
apoptosis (87) 87
signal transduction (80) 80
tyrosine 3-monooxygenase - metabolism (80) 80
plant sciences (76) 76
proteins - metabolism (76) 76
mice (74) 74
binding sites (69) 69
in-vivo (64) 64
biophysics (60) 60
cells (60) 60
association (58) 58
oncology (57) 57
female (55) 55
rats (55) 55
family (54) 54
kinase (54) 54
protein isoforms - metabolism (54) 54
physiological aspects (53) 53
research (52) 52
neurosciences (49) 49
male (46) 46
localization (45) 45
mutation (45) 45
analysis (44) 44
protein (44) 44
protein structure, tertiary (44) 44
saccharomyces-cerevisiae (43) 43
14-3-3 proteins - chemistry (42) 42
protein-kinase (42) 42
sequence homology, amino acid (42) 42
cell line (41) 41
genetics & heredity (41) 41
protein isoforms (41) 41
yeast (41) 41
arabidopsis (40) 40
base sequence (40) 40
gene expression (40) 40
life sciences (40) 40
nitrate reductase (40) 40
genes (39) 39
protein-serine-threonine kinases - metabolism (39) 39
brain (38) 38
sequence alignment (38) 38
tyrosine 3-monooxygenase - genetics (38) 38
blotting, western (37) 37
proteins - genetics (37) 37
crystal-structure (35) 35
signal-transduction (35) 35
specificity (35) 35
multidisciplinary sciences (34) 34
gene (33) 33
gene-expression (33) 33
genetic aspects (33) 33
growth (33) 33
cancer (32) 32
cos cells (32) 32
in-vitro (32) 32
recombinant proteins - metabolism (32) 32
transfection (32) 32
biochemical research methods (31) 31
complex (31) 31
fusicoccin (31) 31
inhibition (31) 31
isoforms (31) 31
isoform (30) 30
plant proteins - metabolism (30) 30
proton-translocating atpases - metabolism (30) 30
t-cells (30) 30
cells, cultured (29) 29
gene expression regulation (29) 29
immunohistochemistry (29) 29
membrane h+-atpase (29) 29
molecular-cloning (29) 29
recombinant fusion proteins - metabolism (29) 29
two-hybrid system techniques (29) 29
middle aged (28) 28
phylogeny (28) 28
plants (28) 28
biology (27) 27
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CANCER RESEARCH, ISSN 0008-5472, 08/2007, Volume 67, Issue 16, pp. 7901 - 7906
A functional genomic approach integrating microarray and proteomic analyses done in our laboratory has identified 14-3-3 zeta as a putative oncogene whose... 
ONCOLOGY | 14-3-3-PROTEINS
Journal Article
Drug Discovery Today, ISSN 1359-6446, 02/2016, Volume 21, Issue 2, pp. 278 - 287
•A thorough review of 14-3-3 protein function.•Discussion of 14-3-3 proteins in health, disease, and animal models.•Review of 14-3-3 protein-targeted... 
INTRACELLULAR PEPTIDES | CELLS | ACTIVATION | KINASE | PHARMACOLOGY & PHARMACY | INDUCTION | IDENTIFICATION | 14-3-3-EPSILON | ADAPTER PROTEIN | ASSOCIATION | 14-3-3-PROTEINS | 14-3-3 Proteins - metabolism | Neoplasms - metabolism | Animals | Hypogonadism - metabolism | Humans | Nervous System Diseases - metabolism | Drug Discovery | Proteins | Cellular signal transduction | Drug discovery
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 10/2012, Volume 18, Issue 20, pp. 5617 - 5627
Purpose: Androgen receptor is an essential transcriptional factor that contributes to the development and progression of prostate cancer. In this study, we... 
BREAST-CANCER | JNK PHOSPHORYLATION | ACTIVATION | ONCOLOGY | CHROMATIN IMMUNOPRECIPITATION | 14-3-3-SIGMA | RECEPTOR | IDENTIFICATION | PROTEINS | TUMOR-GROWTH | 14-3-3-PROTEINS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 46, pp. E9811 - E9820
The 14-3-3 proteins, a family of highly conserved scaffolding proteins ubiquitously expressed in all eukaryotic cells, interact with and regulate the function... 
Allostery | 14-3-3 Protein | Enzyme | Trehalase | Crystal structure | enzyme | SIGNAL | COMPLEX | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | 14-3-3-PROTEINS | 14-3-3 protein | INHIBITION | METABOLISM | STRUCTURAL BASIS | GLUCOSE | trehalase | crystal structure | BINDING | allostery | Biological Sciences | PNAS Plus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 08/2018, Volume 832, pp. 67 - 74
Lipopolysaccharide (LPS) is one of the many reasons that can cause myocardial injury. Our previous works have demonstrated that 14-3-3γ could protect... 
Lipopolysaccharide | Cardioprotection | 14-3-3γ | Mitochondrial function | Tetramethylpyrazine | APOPTOSIS | LIGUSTRAZINE | NEONATAL-RAT CARDIOMYOCYTES | 14-3-3-PROTEINS | PROTECTS | 14-3-3 gamma | (ROS)-INDUCED ROS RELEASE | ANTIOXIDANT | PHARMACOLOGY & PHARMACY | EXPRESSION | CELL | DYSFUNCTION ROLE
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 07/2018, Volume 27, Issue 13, pp. 2244 - 2261
Abstract Neurodegenerative dementias collectively known as Tauopathies involve aberrant phosphorylation and aggregation of the neuronal protein Tau. The... 
GLYCOGEN-SYNTHASE KINASE-3-BETA | GENE-MUTATIONS | MEDIATES PHOSPHORYLATION | OXIDATIVE STRESS | INDUCED NEURODEGENERATION | LEARNING-DEFICITS | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | PROTEIN-PROTEIN INTERACTIONS | DROSOPHILA | 14-3-3-PROTEINS | Index Medicus
Journal Article
Journal of Experimental Botany, ISSN 0022-0957, 04/2018, Volume 69, Issue 8, pp. 1903 - 1912
HbGF14a interacts with a RING zinc finger protein to regulate expression of the rubber transferase gene, a key gene participating in natural rubber... 
RING zinc finger protein | Hevea brasiliensis | natural rubber | rubber transferase | 14-3-3 protein | Expression | PLANT | POLYISOPRENE | CIS | PRENYLTRANSFERASE | 14-3-3-PROTEINS | FAMILY | PLANT SCIENCES | NATURAL-RUBBER | BIOSYNTHESIS | ISOPENTENYL DIPHOSPHATE ISOMERASE | LATEX
Journal Article
Molecular BioSystems, ISSN 1742-206X, 01/2012, Volume 8, Issue 1, pp. 178 - 184
Disordered regions are segments of a protein that do not fold completely and thus remain flexible. These regions have key physiological roles, particularly in... 
INTRINSIC DISORDER | ACTIVATION | RECOGNITION | STABILIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | INHIBITOR | BINDING | STRUCTURAL RATIONALE | 14-3-3-PROTEINS | FLEXIBLE NETS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2012, Volume 109, Issue 3, pp. 929 - 934
Journal Article
Fish and Shellfish Immunology, ISSN 1050-4648, 12/2019, Volume 95, pp. 297 - 304
The sea cucumber is one of the most economically significant echinoderms. The immunity against exogenous stimulation of sea cucumber is of great academic and... 
Sea cucumber | MicroRNAs | Innate immunity regulation | APOPTOSIS | MECHANISMS | PROLIFERATION | IMMUNOLOGY | 14-3-3-PROTEINS | MOLECULES | FISHERIES | MARINE & FRESHWATER BIOLOGY | ROS | CELOMOCYTES | VETERINARY SCIENCES | NF-KAPPA-B | APOSTICHOPUS-JAPONICUS | EXPRESSION
Journal Article
Comparative Biochemistry and Physiology, Part A, ISSN 1095-6433, 09/2019, Volume 235, pp. 1 - 11
The tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation (14-3-3) proteins are a group of highly conserved homologous and heterologous proteins... 
In vitro experiment | Expression patterns | Gill | Lateolabrax maculatus | 14-3-3 genes | LOCALIZATION | PHYSIOLOGY | RAINBOW-TROUT | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRUCTURAL-ANALYSIS | ALPHA | CANCER | 14-3-3-PROTEINS | SALT | EVOLUTION | ZOOLOGY | DUAL ROLE | PROTEINS | Proteins | Tyrosine | Anopheles | Genes | Genomics | Physiological aspects | Genomes | Phylogeny | Salinity
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2010, Volume 430, Issue 3, pp. 393 - 404
LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of Parkinson's disease patients, but still little is understood about how it is... 
Pathogenic mutation | 14-3-3 protein | Phosphorylation | Cytoplasmic localization | Parkinson's disease | Leucine-rich repeat protein kinase 2 (LRRK2) | KINASE-ACTIVITY | leucine-rich repeat protein kinase 2 (LRRK2) | cytoplasmic localization | pathogenic mutation | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPHOSPHORYLATION | PROTEINS | phosphorylation | 14-3-3-PROTEINS | Immunoprecipitation | Humans | Swiss 3T3 Cells | Molecular Sequence Data | Cytoplasm - metabolism | Green Fluorescent Proteins - genetics | Brain - metabolism | Kidney - metabolism | Protein-Serine-Threonine Kinases - metabolism | 14-3-3 Proteins - genetics | Amino Acid Sequence | Cell Line | Green Fluorescent Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Serine - genetics | Binding Sites - genetics | Parkinson Disease - genetics | Serine - metabolism | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Mice, Knockout | 14-3-3 Proteins - metabolism | Sequence Homology, Amino Acid | Animals | Spleen - metabolism | Protein Binding | Mice | Mutation | Microscopy, Fluorescence | DIG, digoxigenin | GFP, green fluorescent protein | COR, C-terminal of ROC | FBS, fetal bovine serum | SILAC, stable isotope labelling of amino acids | TBST, Tris-buffered saline with Tween 20 | DTT, dithiothreitol | HEK-293, human embryonic kidney | Hsp90, heat-shock protein 90 | PD, Parkinson's disease | DMEM, Dulbecco's modified Eagle's medium | IPI, International Protein Index | MARK3, microtubule affinity-regulating kinase 3 | CDC, cell division cycle | LRRK2, leucine-rich repeat protein kinase 2 | ROC, Ras of complex GTPase domain | KLH, keyhole-limpet haemocyanin
Journal Article
Frontiers in Plant Science, ISSN 1664-462X, 12/2011, Volume 2
14-3-3 Dimers are well known to interact with diverse target proteins throughout eukaryotes. Most notably, association of 14-3-3s commonly requires... 
14-3-3 | Interactome | PLANT | PHOSPHORYLATION | COMPLEXES | CHANNELS | interactome | FLORAL INDUCTION | 14-3-3-PROTEINS | PLANT SCIENCES
Journal Article
The Plant Cell, ISSN 1040-4651, 1/2010, Volume 22, Issue 1, pp. 260 - 272
Programmed cell death (PCD) is triggered when Pto, a Ser-Thr protein kinase, recognizes either the AvrPto or AvrPtoB effector from Pseudomonas syringae pv... 
14-3-3 proteins | Proteins | Yeasts | Disease resistance | Pathogens | Leaves | Phosphorylation | Plant immunity | Gene expression regulation | Plant cells | DEFENSE RESPONSES | RECOGNITION | PRF | BIOCHEMISTRY & MOLECULAR BIOLOGY | PTO KINASE | PSEUDOMONAS-SYRINGAE | BACTERIAL | CASCADES | 14-3-3-PROTEINS | PLANT SCIENCES | CELL BIOLOGY | INTERACTS | DISEASE RESISTANCE GENES
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2015, Volume 137, Issue 50, pp. 15624 - 15627
Synthetic agents that disrupt intracellular protein–protein interactions (PPIs) are highly desirable for elucidating signaling networks and developing new... 
DESIGN | SMALL MOLECULES | FUSICOCCIN | PROTEIN-PROTEIN INTERACTIONS | STAPLED PEPTIDES | TARGETS | IDENTIFICATION | BINDING | CHEMISTRY, MULTIDISCIPLINARY | CYCLIC-PEPTIDES | 14-3-3-PROTEINS | Peptides - chemistry | Humans | HEK293 Cells | Protein Binding | 14-3-3 Proteins - chemistry | Molecular Docking Simulation | Diterpenes - chemistry | Diterpenes | Peptide aptamers | Chemical properties
Journal Article