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BREAST CANCER RESEARCH, ISSN 1465-542X, 07/2015, Volume 17
Transforming growth factor beta (TGF-beta) readily suppresses the development of early-stage breast cancers, an activity that gives way to tumor promotion in... 
ONCOLOGY | PATHWAY | 14-3-3-SIGMA | TUMOR-SUPPRESSOR | PROGRESSION
Journal Article
CANCER CELL, ISSN 1535-6108, 02/2015, Volume 27, Issue 2, pp. 177 - 192
Transforming growth factor beta (TGF-beta) functions as a tumor suppressor in premalignant cells but as a metastasis promoter in cancer cells. The dichotomous... 
YES-ASSOCIATED PROTEIN | CELLS | GROWTH-FACTOR-BETA | ONCOLOGY | IN-VIVO | 14-3-3-SIGMA | DISEASE | HIPPO PATHWAY | REGULATES P53 | BONE METASTASIS | YAP | CELL BIOLOGY
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 05/2019, Volume 25, Issue 9, pp. 2809 - 2820
Purpose: Aberrant overexpression of SFN (stratifin) plays an oncogenic role in lung adenocarcinoma. We have shown previously that SKP1, an adapter component of... 
CYCLIN-E | PROTEIN | PHARMACOKINETICS | TICAGRELOR | ONCOLOGY | ACCURATE DOCKING | 14-3-3-SIGMA | APREPITANT | F-BOX | CANCER | PROGRESSION
Journal Article
Cancer Research, ISSN 0008-5472, 08/2006, Volume 66, Issue 16, pp. 8210 - 8218
Gene expression signatures generated from DNA microarray analyses have shown promise as predictive biomarkers of clinical outcome. In this study, we determined... 
SURVIVAL | INHIBITION | P53 GENE | ONCOLOGY | GROWTH | 14-3-3-SIGMA | SENSITIVITY | PHENOTYPE | PATTERNS | CANCER | RADIATION
Journal Article
NATURE REVIEWS CANCER, ISSN 1474-175X, 03/2005, Volume 5, Issue 3, pp. 231 - 237
The inactivation of programmed cell death, or apoptosis, is central to the development of cancer. This disabling of apoptotic responses might be a major... 
CLONOGENIC SURVIVAL | VIDEO TIME-LAPSE | ONCOLOGY | P53 STATUS | MITOTIC CATASTROPHE | IN-VIVO | 14-3-3-SIGMA | TUMOR RESPONSE | CHEMOTHERAPY | RADIATION-INDUCED APOPTOSIS | CELL-DEATH
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 10/2012, Volume 18, Issue 20, pp. 5617 - 5627
Purpose: Androgen receptor is an essential transcriptional factor that contributes to the development and progression of prostate cancer. In this study, we... 
BREAST-CANCER | JNK PHOSPHORYLATION | ACTIVATION | ONCOLOGY | CHROMATIN IMMUNOPRECIPITATION | 14-3-3-SIGMA | RECEPTOR | IDENTIFICATION | PROTEINS | TUMOR-GROWTH | 14-3-3-PROTEINS
Journal Article
by Burk, Robert D and Chen, Zigui and Saller, Charles and Tarvin, Katherine and Carvalho, Andre L and Scapulatempo-Neto, Cristovam and Silveira, Henrique C and Fregnani, José H and Creighton, Chad J and Anderson, Matthew L and Castro, Patricia and Wang, Sophia S and Yau, Christina and Benz, Christopher and Gordon Robertson, A and Mungall, Karen and Lim, Lynette and Bowlby, Reanne and Sadeghi, Sara and Brooks, Denise and Sipahimalani, Payal and Mar, Richard and Ally, Adrian and Clarke, Amanda and Mungall, Andrew J and Tam, Angela and Lee, Darlene and Chuah, Eric and Schein, Jacqueline E and Tse, Kane and Kasaian, Katayoon and Ma, Yussanne and Marra, Marco A and Mayo, Michael and Balasundaram, Miruna and Thiessen, Nina and Dhalla, Noreen and Carlsen, Rebecca and Moore, Richard A and Holt, Robert A and Jones, Steven J. M and Wong, Tina and Pantazi, Angeliki and Parfenov, Michael and Kucherlapati, Raju and Hadjipanayis, Angela and Seidman, Jonathan and Kucherlapati, Melanie and Ren, Xiaojia and Xu, Andrew W and Yang, Lixing and Park, Peter J and Lee, Semin and Rabeno, Brenda and Huelsenbeck-Dill, Lori and Borowsky, Mark and Cadungog, Mark and Iacocca, Mary and Petrelli, Nicholas and Swanson, Patricia and Ojesina, Akinyemi I and Ojesina, Akinyemi I and Ojesina, Akinyemi I and Le, Xuan and Sandusky, George and Adebamowo, Sally N and Akeredolu, Teniola and Adebamowo, Clement and Reynolds, Sheila M and Shmulevich, Ilya and Shelton, Candace and Crain, Daniel and Mallery, David and Curley, Erin and Gardner, Johanna and Penny, Robert and Morris, Scott and Shelton, Troy and Liu, Jia and Lolla, Laxmi and Chudamani, Sudha and Wu, Ye and Birrer, Michael and McLellan, Michael D and Bailey, Matthew H and Miller, Christopher A and Wyczalkowski, Matthew A and Fulton, Robert S and Fronick, Catrina C and Lu, Charles and Mardis, Elaine R and Appelbaum, Elizabeth L and Schmidt, Heather K and Fulton, Lucinda A and Cordes, Matthew G and Li, Tiandao and Ding, Li and Wilson, Richard K and Rader, Janet S and Behmaram, Behnaz and ... and Canc Genome Atlas Res Network and Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University and Research Institute at Nationwide Children's Hospital and University of Alabama at Birmingham and McDonnell Genome Institute at Washington University and Washington University in St Louis and University of Wisconsin School of Medicine &Public Health and National Hospital, Abuja, Nigeria and Baylor College of Medicine and Barretos Cancer Hospital and Indiana University School of Medicine and Ontario Tumour Bank, The Ottawa Hospital and Massachusetts General Hospital and University of New Mexico Health Sciences Center and National Institute on Deafness &Other Communication Disorders and University of North Carolina at Chapel Hill and Buck Institute for Research on Aging and Cancer Genome Atlas Research Network and Medical College of Wisconsin and University of Abuja Teaching Hospital and University of Oklahoma Health Sciences Center and Institute of Human Virology and St Joseph's Candler Health System and University of Pittsburgh and University of Texas MD Anderson Cancer Center and National Cancer Institute and Montefiore Medical Center and University of Southern California and Institute for Systems Biology and University of Washington and Analytical Biological Services and Harvard Medical School and National Human Genome Research Institute and Memorial Sloan Kettering Cancer Center and Medical University of South Carolina and Ontario Tumour Bank, London Health Sciences Centre and SRA International and University of Kansas Medical Center and University of Lausanne and ILSbio, LLC and University of Bergen and University of California, Irvine and Canada's Michael Smith Genome Sciences Centre and International Genomics Consortium and Oregon Health &Science University and NantOmics and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University and University of São Paulo, Ribeir ão Preto Medical School and HudsonAlpha Institute for Biotechnology and Albert Einstein College of Medicine and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center and National Institute of Environmental Health Sciences and Van Andel Research Institute and Ontario Tumour Bank, Ontario Institute for Cancer Research and University of California Santa Cruz and Beckman Research Institute of City of Hope and Leidos Biomedical and Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7645, pp. 378 - 384
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary... 
TRANSCRIPTION FACTORS | BREAST-CANCER | TO-MESENCHYMAL TRANSITION | ACCURATE | DNA METHYLATION | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | 14-3-3-SIGMA | RESISTANCE | EXPRESSION | SIGNATURE | Receptors, Transforming Growth Factor beta - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Squamous Cell - genetics | Genomics | Humans | APOBEC-1 Deaminase - genetics | Phosphatidylinositol 3-Kinases - metabolism | Molecular Targeted Therapy | Caspase 8 - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Human papillomavirus 16 - isolation & purification | Female | Adenocarcinoma - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | PTEN Phosphohydrolase - genetics | Signal Transduction | Programmed Cell Death 1 Ligand 2 Protein - genetics | Protein-Serine-Threonine Kinases - genetics | Uterine Cervical Neoplasms - drug therapy | RNA, Long Noncoding - genetics | Receptor, ErbB-3 - genetics | Transcription Factors - genetics | Uterine Cervical Neoplasms - genetics | Virus Integration | B7-H1 Antigen - genetics | Receptors, Transforming Growth Factor beta - metabolism | HLA-A Antigens - genetics | Proteomics | Mutation | Keratins - genetics | Human papillomavirus 16 - genetics | Uterine Cervical Neoplasms - classification | Causes of | Care and treatment | Genetic aspects | Gene mutations | Health aspects | Cervical cancer | Human papillomavirus | Gynecology | Molecular biology | Cancer therapies | Tumors | Index Medicus
Journal Article
PLOS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7
14-3-3 proteins are ubiquitously expressed dimeric adaptor proteins that have emerged as key mediators of many cell signaling pathways in multiple cell types.... 
PROTEIN | REDUCTION | 14-3-3-SIGMA | BIOLOGY | SLINGSHOT | ONCOGENIC TRANSFORMATION | INHIBITOR | EXPRESSION | BINDING | 14-3-3-PROTEINS | PROTEOMICS
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 7
The 14-3-3 proteins are a set of highly conserved scaffolding proteins that have been implicated in the regulation of a variety of important cellular processes... 
BREAST-CANCER | LUNG-CANCER | CELLS | ACTIVATION | PHOSPHORYLATION | RAS | 14-3-3-SIGMA | BIOLOGY | TSC2 | TUBEROUS SCLEROSIS | PROTEINS
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 02/2018, Volume 821, pp. 57 - 67
Isoliquiritigenin is a natural chalcone derived from , which has been reported to have anti-tumor activity in recent years. Here, we investigate the anticancer... 
Cell cycle arrest | CDK1 | Isoliquiritigenin | Microarray profiling | Prostate cancer | DNA-DAMAGE | DOWN-REGULATION | RECEPTOR | DOCETAXEL | TRANSITION | THERAPY | GROWTH | 14-3-3-SIGMA | RESISTANCE | PHARMACOLOGY & PHARMACY | LICORICE ROOT | Index Medicus
Journal Article
by Shao, ZY and Cai, YJ and Xu, LJ and Yao, XQ and Shi, JL and Zhang, FF and Luo, YH and Zheng, KH and Liu, J and Deng, FL and Li, R and Zhang, LZ and Wang, H and Li, MY and Ding, YQ and Zhao, L
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2016, Volume 6
LIM and SH3 protein 1 (LASP1) can promote colorectal cancer (CRC) progression and metastasis, but the direct evidence that elucidates the molecular mechanism... 
INACTIVATION | CELLS | LIM | METASTASIS | SH3 DOMAIN PROTEIN-1 | STRUCTURAL BASIS | 14-3-3-SIGMA EXPRESSION | MULTIDISCIPLINARY SCIENCES | PROGNOSTIC MARKER | CARCINOMA | INFLUENCES ZYXIN LOCALIZATION
Journal Article
by Sun, NF and Xue, Y and Dai, T and Li, XD and Zheng, NX
BIOSCIENCE REPORTS, ISSN 0144-8463, 08/2017, Volume 37
Tripartite motif containing 25 (TRIM25) is a member of TRIM proteins and functions as an E3 (ubiquitin ligase). It has been found to act as an oncogene in... 
EPITHELIAL-MESENCHYMAL TRANSITION | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 14-3-3-SIGMA | GROWTH | RIG-I | TRIM25 | TARGETS | PROTEINS | EXPRESSION | PROGRESSION | CELL BIOLOGY
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 01/2008, Volume 105, Issue 1, pp. 162 - 167
The family of 14-3-3 proteins has emerged as critical regulators of diverse cellular responses under both physiological and pathological conditions. Here, we... 
SURVIVAL | RNAi | HYPERMETHYLATION | SIGMA GENE | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | apoptosis | IDENTIFICATION | molecular target | 14-3-3-PROTEINS | BH3-only | BREAST-CANCER | 14-3-3-SIGMA | tumorigenesis | EXPRESSION | CARCINOMA
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2018, Volume 497, Issue 2, pp. 473 - 479
FBW7 is an E3 ubiquitin ligase and frequently mutated in various types of cancer. As a component of SCF ubiquitin ligase complex, FBW7 usually targets the... 
K63-linked ubiquitin | 14-3-3σ | FBW7 | G2/M transition | γ-Catenin | PLAKOGLOBIN | METASTASIS | UBIQUITIN LIGASE | TUMOR SUPPRESSION | FBXW7 | BIOCHEMISTRY & MOLECULAR BIOLOGY | 14-3-3 sigma | BETA-CATENIN | BREAST-CANCER | BIOPHYSICS | GENE | gamma-Catenin | 14-3-3-SIGMA | EXPRESSION | Index Medicus
Journal Article
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 09/2018, Volume 19, Issue 9, pp. 809 - 824
Nasopharyngeal carcinoma (NPC) is a highly prevalent disease in Southeast Asia. The disease is typically diagnosed in the later stages, and chemotherapy... 
nasopharyngeal carcinoma | chemoresistance | ANXA1 | TRIM29 | bioinformatics | iTRAQ | proteomic profiles | CANCER-CELLS | CISPLATIN RESISTANCE | ANNEXIN A1 | DRUG-RESISTANCE | CYCLE COMPUTATIONAL NETWORK | EPITHELIAL-MESENCHYMAL TRANSITION | PROMOTES PROLIFERATION | ONCOLOGY | GASTRIC-CANCER | 14-3-3-SIGMA EXPRESSION | HUMAN HEPATOCELLULAR-CARCINOMA
Journal Article