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azoles (15) 15
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Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 44, pp. 31602 - 31615
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2014, Volume 4, Issue 1, pp. 1 - 11
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 05/2014, Volume 99, Issue 5, pp. 1623 - 1630
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2014, Volume 57, Issue 23, pp. 10162 - 10175
Journal Article
Parasitology, ISSN 0031-1820, 12/2018, Volume 145, Issue 14, pp. 1820 - 1836
Journal Article
FEBS Letters, ISSN 0014-5793, 11/2014, Volume 588, Issue 21, pp. 3878 - 3885
CYP51 (sterol 14α-demethylase) is an efficient target for clinical and agricultural antifungals and an emerging target for treatment of Chagas disease, the... 
Structure-based drug design | Sterol 14α-demethylase | Drug resistance | CYP51 sequence variation | Trypanosoma cruzi | (R)-N-(1-(3,4′-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide | VFV | cytochrome P450 gene or protein | T. cruzi | green fluorescent protein | drug concentration that gives half-maximal response in cellular growth reduction | (R)-N-(1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide | GFP | VNI | (R)-N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide | SRS | EC50 | CYP | VNT | substrate recognition site | Sterol 14a-demethylase | TARGET | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHAGAS-DISEASE | SUBSTRATE PREFERENCES | CELL BIOLOGY | Sterol 14 alpha-demethylase | IN-VITRO | STRUCTURAL-BASIS | BIOPHYSICS | DRUGS | STEROL 14-ALPHA-DEMETHYLASE CYP51 | BENZNIDAZOLE | Amino Acid Sequence | Biocatalysis | Humans | Chagas Disease - enzymology | Cytochrome P-450 Enzyme System - metabolism | Models, Molecular | Molecular Sequence Data | Trypanosoma cruzi - enzymology | Cytochrome P-450 Enzyme System - chemistry | Animals | 14-alpha Demethylase Inhibitors - pharmacology | Chagas Disease - drug therapy | Conserved Sequence | Cytochrome P-450 Enzyme System - genetics | Trypanosoma cruzi - drug effects | Protein Conformation | 14-alpha Demethylase Inhibitors - therapeutic use | Amino Acid Substitution | structure-based drug design | drug resistance | CYP51 sequence variations
Journal Article
Journal of Chemotherapy, ISSN 1120-009X, 12/2012, Volume 24, Issue 6, pp. 311 - 327
Invasive fungal diseases are associated with significant morbidity and mortality in immunocompromized patients. Voriconazole is the first line treatment of... 
Therapeutic drug monitoring | Aspergillus | Dosing | Side effects | Candida | Interactions | Invasive fungal infections | INFECTIOUS DISEASES | RISK-FACTORS | EMPIRICAL ANTIFUNGAL THERAPY | NEUTROPENIC PATIENTS | INVASIVE FUNGAL-INFECTIONS | EPIDEMIOLOGIC CUTOFF VALUES | VERSUS-HOST-DISEASE | LIPOSOMAL AMPHOTERICIN-B | CELL TRANSPLANT RECIPIENTS | BROTH MICRODILUTION METHOD | ONCOLOGY | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | Triazoles - administration & dosage | Triazoles - adverse effects | 14-alpha Demethylase Inhibitors - pharmacokinetics | Antifungal Agents - adverse effects | Humans | Mycoses - microbiology | Antifungal Agents - therapeutic use | Dose-Response Relationship, Drug | Antifungal Agents - pharmacokinetics | Candidiasis, Invasive - drug therapy | Voriconazole | Triazoles - pharmacokinetics | 14-alpha Demethylase Inhibitors - therapeutic use | Drug Resistance, Fungal | Aspergillosis - drug therapy | Triazoles - therapeutic use | 14-alpha Demethylase Inhibitors - adverse effects | Fungi - drug effects | Pyrimidines - administration & dosage | Evidence-Based Medicine | 14-alpha Demethylase Inhibitors - administration & dosage | Animals | Pyrimidines - therapeutic use | Aspergillosis - microbiology | Mycoses - drug therapy | Pyrimidines - adverse effects | Pyrimidines - pharmacokinetics | Candidiasis, Invasive - microbiology | Drug Monitoring | Antifungal Agents - administration & dosage
Journal Article