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16,16-dimethyl prostaglandin-e2 (102) 102
animals (87) 87
rats (61) 61
male (58) 58
gastroenterology & hepatology (43) 43
gastric mucosa - drug effects (30) 30
rats, inbred strains (26) 26
cytoprotection (25) 25
injury (23) 23
humans (22) 22
pharmacology & pharmacy (22) 22
protection (22) 22
16,16-dimethylprostaglandin e2 - pharmacology (19) 19
gastric mucosa - pathology (18) 18
prostaglandins (18) 18
rat (18) 18
rats, sprague-dawley (17) 17
stomach (17) 17
16,16-dimethyl prostaglandin e2 (16) 16
damage (14) 14
female (14) 14
16,16-dimethyl prostaglandin e (13) 13
mice (13) 13
liver - drug effects (12) 12
secretion (12) 12
biochemistry & molecular biology (11) 11
dose-response relationship, drug (11) 11
ethanol (11) 11
gastroenterology and hepatology (11) 11
mucosa (11) 11
prostaglandin e (11) 11
prostaglandins e, synthetic - pharmacology (11) 11
time factors (11) 11
blood-flow (10) 10
gastric mucosa - metabolism (10) 10
indomethacin (10) 10
misoprostol (10) 10
alprostadil - pharmacology (9) 9
indomethacin - pharmacology (9) 9
physiology (9) 9
disease models, animal (8) 8
gastric mucosa (8) 8
acid (7) 7
alprostadil - analogs & derivatives (7) 7
aspirin (7) 7
dmpge (7) 7
dogs (7) 7
gastric mucosa - blood supply (7) 7
histamine (7) 7
in vitro techniques (7) 7
liver - pathology (7) 7
prostacyclin (7) 7
prostaglandins - pharmacology (7) 7
tumor-necrosis-factor (7) 7
16,16-dimethyl pge2 (6) 6
apoptosis (6) 6
cells (6) 6
duodenal-ulcer (6) 6
ethanol - antagonists & inhibitors (6) 6
gastric acid - secretion (6) 6
hepatocytes (6) 6
hydrogen-ion concentration (6) 6
index medicus (6) 6
inhibition (6) 6
microscopy, electron, scanning (6) 6
misoprostol - pharmacology (6) 6
mucosal blood-flow (6) 6
necrosis (6) 6
nitric-oxide (6) 6
nonsteroidal antiinflammatory drugs (6) 6
oncology (6) 6
prostaglandins - physiology (6) 6
rat-liver (6) 6
rats, wistar (6) 6
acid-secretion (5) 5
anti-inflammatory agents, non-steroidal - adverse effects (5) 5
cell biology (5) 5
cells, cultured (5) 5
d-galactosamine (5) 5
dinoprostone - pharmacology (5) 5
ethanol - adverse effects (5) 5
ethanol - toxicity (5) 5
expression (5) 5
gastric mucosa - physiology (5) 5
gastric mucosa - ultrastructure (5) 5
hematopoietic stem-cells (5) 5
induced damage (5) 5
intestinal mucosa - metabolism (5) 5
invitro (5) 5
mammalian-cells (5) 5
pathology (5) 5
pge (5) 5
prevention (5) 5
radiation-protective agents - pharmacology (5) 5
radioprotection (5) 5
rat stomach (5) 5
regional blood flow - drug effects (5) 5
sucralfate (5) 5
surface hydrophobicity (5) 5
thickness (5) 5
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STEM CELLS, ISSN 1066-5099, 02/2013, Volume 31, Issue 2, pp. 372 - 383
Hematopoietic stem and progenitor cells (HSPCs), which continuously maintain all mature blood cells, are regulated within the marrow microenvironment. We... 
Bone marrow | Irradiation | Prostaglandin E2 | Hematopoietic stem cells | Apoptosis | PROGENITOR CELLS | OSTEOBLASTIC MC3T3-E1 CELLS | WHOLE-BODY IRRADIATION | DUODENAL-ULCER | 16,16-DIMETHYL PROSTAGLANDIN-E2 | MACROPHAGES | BONE-MARROW | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CYCLOOXYGENASE-2 EXPRESSION | HEMATOLOGY | EXPOSURE | MEGAKARYOCYTE MATURATION | Whole-Body Irradiation | Gene Expression - drug effects | Apoptosis - drug effects | Apoptosis - radiation effects | Radiation Injuries, Experimental - immunology | Hematopoietic Stem Cells - pathology | Male | Actins - immunology | Actins - genetics | Cellular Microenvironment - radiation effects | Cyclooxygenase 2 - genetics | Radiation Injuries, Experimental - drug therapy | Radiation-Protective Agents - pharmacology | Bone Marrow Cells - drug effects | Macrophages - radiation effects | Cyclooxygenase 2 - immunology | Hematopoietic Stem Cells - radiation effects | Cell Differentiation - radiation effects | Hematopoietic Stem Cells - drug effects | Cell Survival - drug effects | Dinoprostone - pharmacology | Macrophages - pathology | Bone Marrow Cells - pathology | Mice, Transgenic | Bone Marrow Cells - radiation effects | Radiation Injuries, Experimental - pathology | Cell Survival - radiation effects | Gene Expression - radiation effects | Animals | Cell Differentiation - drug effects | Dinoprostone - analogs & derivatives | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Cellular Microenvironment - drug effects | Cell Proliferation - radiation effects | Medical colleges | Nuclear radiation | Analysis | Prostaglandins E | Information management | Macrophages
Journal Article
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 07/2009, Volume 41, Issue 1, pp. 50 - 58
Journal Article
Digestive Diseases and Sciences, ISSN 0163-2116, 4/2002, Volume 47, Issue 4, pp. 894 - 904
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 04/2003, Volume 278, Issue 15, pp. 12752 - 12758
Prostaglandin E-2 (PGE(2)) has a strong protective effect on the gastric mucosa in vivo; however, the molecular mechanism of a direct cytoprotective effect of... 
EP RECEPTORS | SELECTIVE INHIBITOR | RAT | SUBTYPES | 16,16-DIMETHYL PROSTAGLANDIN-E2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTEGRAL-PART | ACID-INDUCED APOPTOSIS | CYTOCHROME-C RELEASE | CASPASE ACTIVATION | BICARBONATE SECRETION
Journal Article
BLOOD CELLS MOLECULES AND DISEASES, ISSN 1079-9796, 03/2013, Volume 50, Issue 3, pp. 147 - 153
While high dose total body irradiation (TBI) is used therapeutically, the proliferation of nuclear weapons, increasing use of nuclear power, and worldwide... 
STEM-CELLS | HS-ARS | GAMMA-IRRADIATED MICE | RADIOLOGICAL TERRORISM | NSAID | 16,16-DIMETHYL PROSTAGLANDIN-E2 | Radiation | Prostaglandin E-2 | PROLIFERATION | GRANULOCYTE | INVIVO MODULATION | Hematopoietic stem cell | MYELOPOIESIS | HEMATOLOGY | MACROPHAGE PROGENITOR CELLS | COLONY-FORMING CELLS
Journal Article
Biochemical Journal, ISSN 0264-6021, 2010, Volume 425, Issue 2, pp. 361 - 371
mPGES-1 (microsomal prostaglandin E synthase-1) is a stimulus-inducible enzyme that functions downstream of COX (cyclooxygenase)-2 in the PGE(2) (prostaglandin... 
Microsomal prostaglandin E synthase-1 | Tumorigenesis | Metastasis | Prostaglandin E | Knockout mouse | CYCLOOXYGENASE-2 | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATRIX METALLOPROTEINASE-2 | INTESTINAL TUMORIGENESIS | E-2 BIOSYNTHESIS | prostaglandin E-2 | COLON-CANCER | GENETIC DELETION | metastasis | HYPERPLASTIC GASTRIC TUMORS | RECEPTOR SUBTYPE EP1 | tumorigenesis | knockout mouse | microsomal prostaglandin E synthase-1 | TRANSGENIC MICE | Cell Proliferation | Dinoprostone - biosynthesis | Neoplasm Invasiveness | Intramolecular Oxidoreductases - physiology | Neoplasms - enzymology | Microsomes - enzymology | Intramolecular Oxidoreductases - deficiency | Mice, Knockout | Neoplasm Metastasis | Animals | Metabolic Networks and Pathways | Prostaglandin-E Synthases | Mice | Neoplasms - pathology | Index Medicus | WT, wild-type | dmPGE2, 16,16-dimethyl prostaglandin E2 | ECM, extracellular matrix | mPGES, microsomal prostaglandin E synthase | HEK, human embryonic kidney | KD, knockdown | TBS, Tris-buffered saline | cPGES, cytosolic prostaglandin E synthase | DMEM, Dulbecco's modified Eagle's medium | prostaglandin E2 | RT, reverse transcriptase | NSAID, non-steroidal anti-inflammatory drug | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | PG, prostaglandin | COX, cyclo-oxygenase | TBS-Tween, TBS containing 0.05% Tween 20 | VEGF, vascular endothelial growth factor | LLC, Lewis lung carcinoma | siRNA, small interfering RNA | PGES, PGE synthase | KO, knockout | EP, prostaglandin E receptor | MMP, matrix metalloproteinase | FCS, fetal calf serum
Journal Article
by Das, UN
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, ISSN 0952-3278, 01/2012, Volume 86, Issue 1-2, pp. 3 - 11
Journal Article
LEUKEMIA, ISSN 0887-6924, 06/2008, Volume 22, Issue 6, pp. 1125 - 1130
In acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA) triggers cell differentiation, while arsenic trioxide (As2O3) generates partial... 
prostaglandin | 16,16-DIMETHYL PROSTAGLANDIN-E2 | cyclooxygenase | MYELOID DIFFERENTIATION | TRANS-RETINOIC ACID | arsenic | TRANSRETINOIC ACID | CHEMOTHERAPY | CROSS-TALK | GENE | ONCOLOGY | SP1 | LINE | HEMATOLOGY | APL | UP-REGULATION | retinoids
Journal Article
Journal of Veterinary Medical Science, ISSN 0916-7250, 2012, Volume 74, Issue 9, pp. 1103 - 1108
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 03/2003, Volume 16, Issue 3, pp. 312 - 319
Prostaglandins (PGs) act locally to maintain cellular homeostasis and stimulate stress response signaling pathways. These cellular effects are diverse and are... 
thromboxane | prostaglandins | 11-Deoxy,16,16-dimethyl-prostaglandin E2 | hydroquinone
Journal Article
FREE RADICAL RESEARCH, ISSN 1071-5762, 03/2002, Volume 36, Issue 3, pp. 345 - 355
D-galactosamine (D-GalN) toxicity is a useful experimental model of liver failure in human. It has been previously observed that PGE(1) treatment reduced... 
liver injury | ACTIVATION | LIVER-CELL NECROSIS | 16,16-DIMETHYL PROSTAGLANDIN-E2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | apoptosis | FACTOR-KAPPA-B | HEPATIC-INJURY | PGE | D-galactosamine | TUMOR-NECROSIS-FACTOR | necrosis | GLUTATHIONE | TNF-ALPHA | CYTOTOXICITY | oxidative stress
Journal Article
Gastroenterology, ISSN 0016-5085, 01/1985, Volume 88, Issue 1, pp. 308 - 314
The canine gastric mucosa has a uniquely hydrophobic or nonwettable surface that is rapidly disrupted by damaging agents such as aspirin. In this study we... 
dmPGE | 16,16-dimethyl prostaglandin E | Surface Tension | Animals | Gastric Mucosa - physiology | Chemical Phenomena | Dogs | Gastric Mucosa - drug effects | 16,16-Dimethylprostaglandin E2 - pharmacology | Aspirin - pharmacology | In Vitro Techniques | Chemistry, Physical | Prostaglandins E, Synthetic - pharmacology
Journal Article
Journal Article
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