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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 4/2007, Volume 24, Issue 4, pp. 688 - 694
To establish a method for isolating highly purified brain capillary endothelial cells (BCECs) from rat brain by using magnetic cell sorting, and clarify the... 
Biomedical Engineering | Biochemistry, general | PECAM-1 | Biomedicine | magnetic cell sorting | Pharmacy | brain capillary endothelial cells | purification | multidrug resistance-associated protein | Medical Law | Pharmacology/Toxicology | Magnetic cell sorting | Brain capillary endothelial cells | Purification | Multidrug resistance-associated protein | MOUSE-BRAIN | LOCALIZATION | DEHYDROEPIANDROSTERONE-SULFATE | BARRIER | PLASMA-MEMBRANE | MRP4 | CHEMISTRY, MULTIDISCIPLINARY | EFFLUX TRANSPORT | 6-MERCAPTOPURINE | PHARMACOLOGY & PHARMACY | BLOOD-BRAIN | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Rats, Wistar | Receptor, TIE-2 - analysis | ATP Binding Cassette Transporter, Sub-Family B - analysis | RNA, Messenger - analysis | Male | Membrane Proteins - analysis | Immunomagnetic Separation - methods | Brain - blood supply | Flow Cytometry | ATP-Binding Cassette Transporters - genetics | Polymerase Chain Reaction | Astrocytes - chemistry | Multidrug Resistance-Associated Proteins - genetics | Endothelial Cells - chemistry | Gene Expression | Multidrug Resistance-Associated Proteins - analysis | Neurons - chemistry | Membrane Proteins - genetics | Capillaries - chemistry | Platelet Endothelial Cell Adhesion Molecule-1 - analysis | Rats | Claudin-5 | ATP-Binding Cassette Transporters - analysis | Receptor, TIE-2 - genetics | Endothelial Cells - immunology | Animals | Capillaries - cytology | Capillaries - immunology | ATP Binding Cassette Transporter, Sub-Family B - genetics | Proteins | Brain | Messenger RNA | Methods | Research & development | R&D | Rodents | Research methodology | Magnetism | Pharmaceutical industry
Journal Article
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