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Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 23, pp. 10724 - 10738
Intracellular elevation of E2 levels in bone by inhibition of 17 beta hydroxysteroid dehydrogenase type 2 (17 beta-HSD2) without affecting systemic E2 levels... 
DESIGN | CHEMISTRY, MEDICINAL | II 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | LEAD OPTIMIZATION | BIOLOGICAL EVALUATION | IDENTIFICATION | TYPE-2 | DERIVATIVES | DISCOVERY | SOLUBILITY
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2019, Volume 25, Issue 4, pp. 1291 - 1301
Purpose: Steroidogenic enzymes are essential for prostate cancer development. Enzymes inactivating potent androgens were not investigated thoroughly, which... 
ANDROGEN-DEPRIVATION THERAPY | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | TARGET | ONCOLOGY | STATISTICS | HSD3B1 | GENE-EXPRESSION | AKR1C3 | MECHANISMS | DRUG-RESISTANCE | ABIRATERONE
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 06/2019, Volume 84, Issue 11, pp. 7051 - 7065
Irradiation of a series of 3-acylestrones under a nitrogen atmosphere in cyclohexane, acetonitrile (MeCN), and methanol (MeOH) was investigated under... 
EXCITED-STATE | STEROIDS | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | PHOTODEGRADATION | CHEMISTRY, ORGANIC | PHOTOCHEMICAL-REACTIONS | PROTON-TRANSFER | N-ACETYL | AROMATIC ESTERS | CYCLIZATION | ESTROGENIC ACTIVITY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2019, Volume 62, Issue 7, pp. 3590 - 3616
Aldo-keto reductase 1C3 (AKR1C3) catalyzes the synthesis of 9 alpha,11 beta-prostaglandin (PG) F-2 alpha and PGF(2 alpha) prostanoids that sustain the growth... 
TARGET | CHEMISTRY, MEDICINAL | RETINOIC ACID | OLDER PATIENTS | ANALOGS | PROSTATE-CANCER | RESISTANCE | RECEPTOR | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | F SYNTHASE | CARBOHYDRATE BINDERS
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2018, Volume 61, Issue 20, pp. 9229 - 9245
Cytochrome P450 (CYP) 1B1 is involved in the bioactivation of procarcinogens and drug resistance. To obtain selective CYP1B1 inhibitors over CYP1A1, we... 
BREAST-CANCER | 17-ALPHA-HYDROXYLASE/17,20-LYASE CYP17 | CHEMISTRY, MEDICINAL | METABOLISM | PROSTATE-CANCER | ESTRADIOL | RESISTANCE | TYPE-1 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | CHEMICAL-SYNTHESIS | ESTRONE | EXPRESSION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2018, Volume 62, Issue 9, pp. 4252 - 4264
Alzheimers disease (AD) is the most common dementia. No cure exists, and current treatment only manages early symptoms. Mitochondrial dysfunction is a hallmark... 
METHYLENE-BLUE | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 10 | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | FLUOROGENIC PROBE | 3-HYDROXYACYL-COA DEHYDROGENASE | GENE-EXPRESSION | A-BETA ACCUMULATION | PRECURSOR PROTEIN | BLOOD-BRAIN-BARRIER | UP-REGULATION
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2018, Volume 17, Issue 9, pp. 1833 - 1845
Aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17 beta-hydroxysteroid dehydrogenase, is responsible for intratumoral androgen biosynthesis,... 
ANDROGEN RECEPTOR | ACTIVATION | METABOLISM | ONCOLOGY | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | TESTOSTERONE | RESISTANCE | PHASE-II | F SYNTHASE | CANCER | ADRENAL ANDROGENS | Index Medicus
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 01/2018, Volume 8
Mammary epithelial cells (MECs) affect milk production capacity during lactation and are critical for the maintenance of tissue homeostasis. Our previous... 
BREAST-CANCER | ORGANIZATION | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | PATHWAY | MULTIDISCIPLINARY SCIENCES | ACETYL-COENZYME | MIRNAS | MAMMARY EPITHELIAL-CELL | EXPRESSION | 12 HSD17B12 | ADIPOSE
Journal Article
Journal Article
Endocrine Reviews, ISSN 0163-769X, 04/2019, Volume 40, Issue 4, pp. 1048 - 1079
Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including... 
ESTROGEN-RECEPTOR-BETA | PROSTAGLANDIN-E SYNTHASE | STEROIDOGENIC-FACTOR-I | CHRONIC PELVIC PAIN | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 EXPRESSION | ENDOCRINOLOGY & METABOLISM | CANCER-ASSOCIATED MUTATIONS | UP-REGULATES CYCLOOXYGENASE-2 | PROGESTERONE-RECEPTOR | STROMAL CELLS | GENOME-WIDE ASSOCIATION
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 01/2018, Volume 59, Issue 1, pp. 26 - 28
The Suzuki-Miyaura reactions of 16- -(triflyloxymethylidene)-3-methoxy-α-estrone allow for a convenient synthesis of various 16-... 
Suzuki-reaction | Palladium | Cross-coupling | Steroids | STEREOISOMERS | CHEMISTRY, ORGANIC | ESTROGENIC ACTIVITY | IMPACT | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | IN-VIVO | ESTRADIOL | AGENTS | STRUCTURAL MODIFICATIONS | INHIBITORS | DERIVATIVES
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 07/2017, Volume 58, Issue 29, pp. 2801 - 2803
16- -Arylidene-3-methoxy-estrones were synthesized using a palladium catalysed Mizoroki-Heck reaction. This methodology tolerates various functional groups and... 
Palladium | Cross-coupling | Heck-reaction | Steroids | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-1 | CELLS | STEREOISOMERS | ARYLATION | CHEMISTRY, ORGANIC | ESTRONE | BUTYROLACTONES | LACTONES | BIOLOGICAL-ACTIVITY | INHIBITORS | DERIVATIVES | Substitution reactions
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 03/2009, Volume 94, Issue 3, pp. 876 - 883
Context: substantial evidence suggests that the expression of steroid metabolizing enzymes in endometriosis is altered, turning the ectopic endometrium into a... 
17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | MOLECULAR-BIOLOGY | REDOX STATE | OVARIAN ENDOMETRIOSIS | UTERINE ENDOMETRIUM | RAT LIVER | ENDOCRINOLOGY & METABOLISM | DEHYDROGENASE-ACTIVITY | NICOTINAMIDE-ADENINE DINUCLEOTIDE | STEROID SULFATASE | AROMATASE EXPRESSION
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 04/2015, Volume 43, Issue 10, pp. 5112 - 5119
SDR5C1 is an amino and fatty acid dehydrogenase/reductase, moonlighting as a component of human mitochondrial RNase P, which is the enzyme removing... 
17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 10 | L-3-HYDROXYACYL-COA DEHYDROGENASE | ENZYME | ACID | GENE | PEPTIDE-BINDING PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOLEUCINE METABOLISM | COENZYME-A DEHYDROGENASE | 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE-DEFICIENCY | DROSOPHILA | Index Medicus
Journal Article