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17-hydroxysteroid dehydrogenases - genetics (672) 672
rats (394) 394
endocrinology & metabolism (392) 392
17-hydroxysteroid dehydrogenases - antagonists & inhibitors (274) 274
3-hydroxysteroid dehydrogenases - metabolism (263) 263
biochemistry & molecular biology (262) 262
mice (261) 261
adult (240) 240
testosterone (223) 223
estradiol - metabolism (214) 214
kinetics (208) 208
expression (202) 202
pregnancy (191) 191
testosterone - metabolism (190) 190
molecular sequence data (189) 189
middle aged (187) 187
testosterone - blood (180) 180
abridged index medicus (179) 179
testis - enzymology (167) 167
testis - drug effects (164) 164
enzymes (160) 160
enzyme inhibitors - pharmacology (157) 157
aromatase - metabolism (155) 155
17-hydroxysteroid dehydrogenases - chemistry (151) 151
amino acid sequence (150) 150
estrogen (149) 149
testis - metabolism (145) 145
17-hydroxysteroid dehydrogenases - deficiency (141) 141
rna, messenger - metabolism (141) 141
placenta - enzymology (140) 140
cells, cultured (137) 137
substrate specificity (129) 129
immunohistochemistry (128) 128
androstenedione - metabolism (124) 124
estrone - metabolism (124) 124
estradiol (122) 122
base sequence (119) 119
estrogens - metabolism (118) 118
aged (116) 116
17-hydroxysteroid dehydrogenases - analysis (111) 111
rats, wistar (111) 111
gene expression (110) 110
toxicology (110) 110
testosterone - biosynthesis (108) 108
breast neoplasms - enzymology (107) 107
rna, messenger - genetics (104) 104
cell line (101) 101
cell line, tumor (101) 101
steroidogenesis (101) 101
structure-activity relationship (98) 98
cell biology (95) 95
reverse transcriptase polymerase chain reaction (94) 94
androgens - metabolism (92) 92
isoenzymes - metabolism (92) 92
17-hydroxysteroid dehydrogenases - biosynthesis (90) 90
adolescent (90) 90
aromatase (90) 90
oxidation-reduction (90) 90
peroxisomal multifunctional protein-2 (90) 90
metabolism (88) 88
aromatase - genetics (87) 87
17β-hydroxysteroid dehydrogenase (86) 86
3-oxo-5-alpha-steroid 4-dehydrogenase - metabolism (86) 86
dose-response relationship, drug (86) 86
models, molecular (86) 86
physiological aspects (86) 86
enzyme inhibitors - chemistry (85) 85
estradiol - pharmacology (85) 85
oncology (85) 85
gene-expression (84) 84
isoenzymes - genetics (84) 84
steroid 17-alpha-hydroxylase - metabolism (83) 83
liver - enzymology (81) 81
testis (81) 81
cells (77) 77
ovary - enzymology (77) 77
androgens (76) 76
rats, sprague-dawley (76) 76
tumor cells, cultured (76) 76
analysis (74) 74
cloning, molecular (74) 74
17 beta-hydroxysteroid dehydrogenase (73) 73
binding sites (72) 72
cancer (72) 72
in vitro techniques (72) 72
progesterone (72) 72
rna, messenger - analysis (72) 72
steroids (72) 72
17-hydroxysteroid dehydrogenases (70) 70
estradiol dehydrogenases - metabolism (70) 70
reproductive biology (70) 70
3-hydroxysteroid dehydrogenases - genetics (69) 69
child (69) 69
gene expression regulation, enzymologic (69) 69
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Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2011, Volume 125, Issue 1, pp. 148 - 161
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2006, Volume 248, Issue 1, pp. 126 - 135
Endometrial cancer is the most common malignancy of the female genital tract. Its incidence correlates with prolonged estrogen stimulation unopposed by... 
Short-chain dehydrogenase reductase | 17β-Hydroxysteroid dehydrogenase | 20α-Hydroxysteroid dehydrogenase | Aldo-keto reductase | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | HYDROXYSTEROID DEHYDROGENASES | ER-BETA | short-chain dehydrogenase reductase | RECEPTOR-B | CELL BIOLOGY | INACTIVATION | CARCINOGENESIS | KETO REDUCTASE SUPERFAMILY | ENDOCRINOLOGY & METABOLISM | 20 alpha-hydroxysteroid dehydrogenase | aldo-keto reductase | 17 beta-hydroxysteroid dehydrogenase | EXPRESSION | CARCINOMA | HORMONES | Humans | Endometrial Neoplasms - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Estrogens - analysis | Endometrial Neoplasms - genetics | Isoenzymes - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Progesterone - biosynthesis | Tumor Cells, Cultured | Estradiol - biosynthesis | Endometrium - metabolism | Progesterone - analysis | 20-Hydroxysteroid Dehydrogenases - genetics | Estrogens - biosynthesis | Endometrial Neoplasms - chemistry | Oxidoreductases - metabolism | Isoenzymes - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Endometrium - chemistry | Animals | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Enzymes | Care and treatment | Endometrial cancer | Phenols | Hormones | Progesterone | Estradiol | Cancer | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2016, Volume 472, Issue 1, pp. 231 - 236
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 02/2009, Volume 296, Issue 2, pp. 244 - 255
The objective was to examine pathways of androgen metabolism in abdominal adipose tissue in women. Abdominal subcutaneous (SC) and omental (OM) adipose tissue... 
Omental visceral fat | Adipocyte differentiation | Short-chain dehydrogenases | Aldo-keto reductases | Estrogen | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | AROMATASE-ACTIVITY | estrogen | PHYSIOLOGY | short-chain dehydrogenases | adipocyte differentiation | omental visceral fat | HUMAN PREADIPOCYTES | 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE | ESTROGEN-RECEPTOR-BETA | OBESITY | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | aldo-keto reductases | DIFFERENTIATION | STROMAL CELLS | Adipose Tissue - physiology | Humans | Middle Aged | Gene Expression Regulation, Enzymologic - physiology | Hydroxyprostaglandin Dehydrogenases - metabolism | Adipogenesis - physiology | Adipose Tissue - metabolism | Subcutaneous Fat - metabolism | Omentum - enzymology | 3-Hydroxysteroid Dehydrogenases - metabolism | Adult | Female | Hydroxysteroid Dehydrogenases - metabolism | Metabolic Networks and Pathways - physiology | Body Fat Distribution | Adipogenesis - genetics | Cells, Cultured | Hydroxysteroid Dehydrogenases - genetics | Omentum - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Abdominal Fat - metabolism | Metabolic Networks and Pathways - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | Models, Biological | 17-Hydroxysteroid Dehydrogenases - genetics | Abdominal Fat - enzymology | Adipose Tissue - enzymology | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | 17-Hydroxysteroid Dehydrogenases - metabolism | Subcutaneous Fat - enzymology | Women | Tissue | Enzymes | Androgens | Body fat | Metabolism | Ribonucleic acid--RNA | Index Medicus
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 09/2017, Volume 172, pp. 36 - 45
This study addresses first the role of human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) in breast cancer (BC) cells. The enzyme has a high... 
Enzyme substrate inhibition | Reductive 17β-hydroxysteroid dehydrogenases | Breast cancer | Estradiol regulation of 17β-hydroxysteroid dehydrogenase type 7 | Enzymology | Reductive | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN ESTROGENIC 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | 17 beta-hydroxysteroid dehydrogenases | PROLIFERATION | ESTRONE REDUCTION | Estradiol regulation of 17 beta-hydroxysteroid dehydrogenase type 7 | 3-DIMENSIONAL STRUCTURE | ENZYME | STEROID DEHYDROGENASE | ESTRADIOL | ENDOCRINOLOGY & METABOLISM | TYPE-1 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | HUMAN-BREAST-CARCINOMA | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Substrate Specificity | 17-Hydroxysteroid Dehydrogenases - isolation & purification | MCF-7 Cells | Dihydrotestosterone - pharmacology | Female | Placenta - chemistry | Epithelial Cells - cytology | Binding Sites | Estradiol - pharmacology | Dihydrotestosterone - metabolism | Estradiol - metabolism | Gene Expression | Protein Structure, Secondary | 17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Models, Molecular | Pregnancy | Feedback, Physiological | 17-Hydroxysteroid Dehydrogenases - genetics | Cell Line, Tumor | Protein Binding | Kinetics | 17-Hydroxysteroid Dehydrogenases - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2007, Volume 402, Issue 3, pp. 419 - 427
To this day, a significant proportion of the human genome remains devoid of functional characterization. In this study, we present evidence that the previously... 
Steroid metabolism | DHRS10 | 17β-hydroxysteroid dehydrogenase | Pre-receptor control | Crystal structure | Short-chain dehydrogenase/reductase | BRAIN-INJURY | 17-BETA-HYDROXYSTEROID DEHYDROGENASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | short-chain dehydrogenase/reductase | WEIGHT-LOSS | SHORT-CHAIN DEHYDROGENASES/REDUCTASES | HUMAN ADIPOSE-TISSUE | steroid metabolism | crystal structure | pre-receptor control | ESTROGEN | REDUCTASE | MOLECULAR-CLONING | TYPE-1 | 17 beta-hydroxysteroid dehydrogenase | EXPRESSION | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Gene Expression | Oxidation-Reduction | Protein Structure, Secondary | Humans | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Organ Specificity | Cytosol - enzymology | Sequence Alignment | 17-Hydroxysteroid Dehydrogenases - isolation & purification | 17-Hydroxysteroid Dehydrogenases - genetics | Ligands | Structural Homology, Protein | Kinetics | 17-Hydroxysteroid Dehydrogenases - chemistry | 17-Hydroxysteroid Dehydrogenases - metabolism | Binding Sites | NAD - metabolism | Index Medicus | GFP, green fluorescent protein | RMSD, root mean square deviation | HEK-293T cells, HEK-293 cells (human embryonic kidney cells) expressing the large T-antigen of SV40 (simian virus 40) | NCS, non-crystallographic symmetry | TCEP, tris-(2-carboxyethyl)phosphine | reductase | HSD, hydroxysteroid dehydrogenase | SDR, short-chain dehydrogenase | ER, oestrogen receptor | MDR, medium-chain dehydrogenase | DHEA, dehydroepiandrosterone | short-chain dehydrogenase
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 393, pp. 16 - 21
Abstract Drug reprofiling is emerging as an effective paradigm for discovery of cancer treatments. Herein, an antipsychotic drug is immobilised using the Magic... 
Hematology, Oncology and Palliative Medicine | Adenocarcinoma | Chemical genomics | Drug reprofiling | 17-β-Hydroxysteroid dehydrogenase 10 | Drosophila melanogaster | THERAPEUTICS | CELLS | 17-beta-Hydroxysteroid dehydrogenase 10 | ALZHEIMERS-DISEASE | GLIDE | IDENTIFICATION | CANCER | DROSOPHILA | DISCOVERY | ONCOLOGY | ACCURATE DOCKING | INHIBITOR | Humans | 3-Hydroxyacyl CoA Dehydrogenases - metabolism | Male | Structure-Activity Relationship | 3-Hydroxyacyl CoA Dehydrogenases - genetics | Molecular Targeted Therapy | Drosophila melanogaster - genetics | Dose-Response Relationship, Drug | Prostatic Neoplasms - genetics | Time Factors | Enzyme Inhibitors - chemistry | Drug Compounding | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | 3-Hydroxyacyl CoA Dehydrogenases - chemistry | Genomics - methods | Prostatic Neoplasms - drug therapy | Bacteriophage T7 - genetics | 3-Hydroxyacyl CoA Dehydrogenases - antagonists & inhibitors | Gene Library | 17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Adenocarcinoma - enzymology | Enzyme Inhibitors - pharmacology | Risperidone - pharmacology | Risperidone - chemistry | Antineoplastic Agents - chemistry | Adenocarcinoma - drug therapy | Drosophila melanogaster - drug effects | Xenograft Model Antitumor Assays | Animals | Antipsychotic Agents - chemistry | Tumor Burden - drug effects | Mice, Nude | 17-Hydroxysteroid Dehydrogenases - genetics | Drug Repositioning - methods | Cell Line, Tumor | Drosophila melanogaster - enzymology | Linoleic Acids, Conjugated - chemistry | Prostatic Neoplasms - enzymology | Protein Conformation | Cell Proliferation - drug effects | Molecular Docking Simulation | Antipsychotic Agents - pharmacology | 17-Hydroxysteroid Dehydrogenases - chemistry | 17-Hydroxysteroid Dehydrogenases - metabolism | Enzymes | Antipsychotic drugs | Analysis | Genomics | Genetic research | Genetic aspects | Drug therapy | Prostate cancer | Cancer | Drugs | Medical colleges | Fruit-flies | Drug discovery | Polypeptides | Multiple myeloma | Oncology | Breast cancer | Genomes | Experiments | Fatty acids | Cancer therapies | Psychotropic drugs | Organic chemicals | Enzyme kinetics | Drug dosages | Index Medicus
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 210 - 217
► In endometrial cancer progesterone biosynthesis genes are down-regulated. ► Expression of most progesterone metabolism genes is not altered in cancerous... 
Steroidogenic acute regulatory protein | 5α-Reductase | Pre-receptor metabolism | Side-chain cleavage enzyme | 3-Keto/20-keto-reductase | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEROID 5-ALPHA-REDUCTASE | RECEPTOR-A | 5 alpha-Reductase | ER-ALPHA | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | KETO REDUCTASE SUPERFAMILY | ESTROGEN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | YOUNG-WOMEN | TYPE-2 | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Progesterone Reductase - metabolism | Humans | Middle Aged | Endometrial Neoplasms - metabolism | Multienzyme Complexes - metabolism | Receptors, Progesterone - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Receptors, Progesterone - metabolism | Cholesterol Side-Chain Cleavage Enzyme - genetics | Endometrial Neoplasms - genetics | Phosphoproteins | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Adult | Female | Progesterone - biosynthesis | Membrane Proteins - metabolism | Steroid Isomerases - genetics | Endometrium - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Membrane Proteins - genetics | Steroid Isomerases - metabolism | RNA, Messenger - genetics | Multienzyme Complexes - genetics | Progesterone Reductase - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Down-Regulation - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Estradiol Dehydrogenases - metabolism | Progesterone - metabolism | Aged | Progesterone - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Endometrial cancer | RNA | Genes | Cytochrome P-450 | Physiological aspects | Genetic aspects | Progesterone | Cancer | Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 09/2015, Volume 29, Issue 9, pp. 3806 - 3816
Hydroxysteroid (17 beta)-dehydrogenase type 1 (HSD17B1) catalyzes the conversion of low active 17-ketosteroids, androstenedione (A-dione) and estrone (E1) to... 
Ovary | HSD17B enzymes | Fertility | Estrogen | estrogen | SEX REVERSAL | GRANULOSA-CELLS | CHORIONIC-GONADOTROPIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | fertility | ER-ALPHA | CELL BIOLOGY | BREAST-CANCER | ovary | MESSENGER-RNA | IN-VIVO | BIOLOGY | ESTROGEN-RECEPTORS ALPHA | FOLLICLE-STIMULATING-HORMONE | RAT 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-1 | Cholesterol Side-Chain Cleavage Enzyme - biosynthesis | Male | Infertility, Female - genetics | Cholesterol Side-Chain Cleavage Enzyme - genetics | Female | Progesterone - biosynthesis | Infertility, Female - enzymology | Estrous Cycle | Ovary - metabolism | Ovary - pathology | Phosphoproteins - biosynthesis | Sexual Maturation - genetics | Luteinization | Phosphoproteins - genetics | Mice, Knockout | Pregnancy | 17-Hydroxysteroid Dehydrogenases - biosynthesis | Animals | 17-Hydroxysteroid Dehydrogenases - deficiency | 17-Hydroxysteroid Dehydrogenases - genetics | Steroid 17-alpha-Hydroxylase - genetics | Mice | Progesterone - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Steroid 17-alpha-Hydroxylase - biosynthesis | Index Medicus | UTANEN M | P2639 | P386 | Biology | Biochemistry & Molecular Biology | LEAN MP | Endokrinologi och diabetes | V65 | 1993 | 1992 | Physiology | V133 | ENDOCRINOLOGY | Endocrinology and Diabetes | INTERNATIONAL JOURNAL OF CANCER | Fysiologi | 1990 | P757 | P1796 | Cell Biology | URNETDULGUEROV N | V50 | 1987 | V126 | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2008, Volume 93, Issue 6, pp. 2366 - 2374
Context: Experimental and clinical studies in a variety of nonprimate species demonstrate that progesterone withdrawal leads to changes in gene expression that... 
17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | UTERINE CERVIX | ENDOCRINOLOGY & METABOLISM | PRETERM BIRTH | 5-ALPHA-REDUCTASE TYPE-1 | DEHYDROGENASE-ACTIVITY | HUMAN-ENDOMETRIUM | GUINEA-PIG | RECEPTOR-A | EXPRESSION | INTERLEUKIN-8 PRODUCTION | Cervical Ripening - metabolism | Cervix Uteri - metabolism | Humans | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Myometrium - metabolism | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Hydroxysteroid Dehydrogenases - metabolism | Estrogens - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Oxidoreductases - metabolism | Oxidoreductases - genetics | Cervix Uteri - enzymology | Parturition - genetics | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Gestational Age | Hydroxyprostaglandin Dehydrogenases - genetics | Gene Expression Regulation, Enzymologic | Pregnancy | Animals | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | Models, Biological | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Cervix Uteri - physiology | Progesterone - metabolism | Mice | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Parturition - metabolism | Index Medicus | Abridged Index Medicus | Original
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/1993, Volume 268, Issue 17, pp. 12964 - 12969
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 09/2017, Volume 18, Issue 9, p. 2007
Journal Article
Neurochemistry International, ISSN 0197-0186, 02/2018, Volume 113, pp. 46 - 55
Journal Article
ChemBioChem, ISSN 1439-4227, 06/2016, Volume 17, Issue 11, pp. 1029 - 1037
A major hallmark of Alzheimer's disease (AD) is the formation of toxic aggregates of the β‐amyloid peptide (Aβ). Given that Aβ peptides are known to localise... 
dehydrogenases | amyloid beta-peptides | neurochemistry | Alzheimer's disease | fluorescent probes | IN-VITRO | CHEMISTRY, MEDICINAL | THIOFLAVIN T-FLUORESCENCE | BINDING ALCOHOL-DEHYDROGENASE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | A-BETA | MITO