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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2016, Volume 472, Issue 1, pp. 231 - 236
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 18, pp. 30552 - 30562
Journal Article
Neurochemistry International, ISSN 0197-0186, 02/2018, Volume 113, pp. 46 - 55
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 393, pp. 16 - 21
Abstract Drug reprofiling is emerging as an effective paradigm for discovery of cancer treatments. Herein, an antipsychotic drug is immobilised using the Magic... 
Hematology, Oncology and Palliative Medicine | Adenocarcinoma | Chemical genomics | Drug reprofiling | 17-β-Hydroxysteroid dehydrogenase 10 | Drosophila melanogaster | THERAPEUTICS | CELLS | 17-beta-Hydroxysteroid dehydrogenase 10 | ALZHEIMERS-DISEASE | GLIDE | IDENTIFICATION | CANCER | DROSOPHILA | DISCOVERY | ONCOLOGY | ACCURATE DOCKING | INHIBITOR | Humans | 3-Hydroxyacyl CoA Dehydrogenases - metabolism | Male | Structure-Activity Relationship | 3-Hydroxyacyl CoA Dehydrogenases - genetics | Molecular Targeted Therapy | Drosophila melanogaster - genetics | Dose-Response Relationship, Drug | Prostatic Neoplasms - genetics | Time Factors | Enzyme Inhibitors - chemistry | Drug Compounding | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | 3-Hydroxyacyl CoA Dehydrogenases - chemistry | Genomics - methods | Prostatic Neoplasms - drug therapy | Bacteriophage T7 - genetics | 3-Hydroxyacyl CoA Dehydrogenases - antagonists & inhibitors | Gene Library | 17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Adenocarcinoma - enzymology | Enzyme Inhibitors - pharmacology | Risperidone - pharmacology | Risperidone - chemistry | Antineoplastic Agents - chemistry | Adenocarcinoma - drug therapy | Drosophila melanogaster - drug effects | Xenograft Model Antitumor Assays | Animals | Antipsychotic Agents - chemistry | Tumor Burden - drug effects | Mice, Nude | 17-Hydroxysteroid Dehydrogenases - genetics | Drug Repositioning - methods | Cell Line, Tumor | Drosophila melanogaster - enzymology | Linoleic Acids, Conjugated - chemistry | Prostatic Neoplasms - enzymology | Protein Conformation | Cell Proliferation - drug effects | Molecular Docking Simulation | Antipsychotic Agents - pharmacology | 17-Hydroxysteroid Dehydrogenases - chemistry | 17-Hydroxysteroid Dehydrogenases - metabolism | Enzymes | Antipsychotic drugs | Analysis | Genomics | Genetic research | Genetic aspects | Drug therapy | Prostate cancer | Cancer | Drugs | Medical colleges | Fruit-flies | Drug discovery | Polypeptides | Multiple myeloma | Oncology | Breast cancer | Genomes | Experiments | Fatty acids | Cancer therapies | Psychotropic drugs | Organic chemicals | Enzyme kinetics | Drug dosages
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2011, Volume 125, Issue 1, pp. 148 - 161
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 09/2017, Volume 172, pp. 36 - 45
This study addresses first the role of human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) in breast cancer (BC) cells. The enzyme has a high... 
Enzyme substrate inhibition | Reductive 17β-hydroxysteroid dehydrogenases | Breast cancer | Estradiol regulation of 17β-hydroxysteroid dehydrogenase type 7 | Enzymology | Reductive | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN ESTROGENIC 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | 17 beta-hydroxysteroid dehydrogenases | PROLIFERATION | ESTRONE REDUCTION | Estradiol regulation of 17 beta-hydroxysteroid dehydrogenase type 7 | 3-DIMENSIONAL STRUCTURE | ENZYME | STEROID DEHYDROGENASE | ESTRADIOL | ENDOCRINOLOGY & METABOLISM | TYPE-1 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | HUMAN-BREAST-CARCINOMA | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Substrate Specificity | 17-Hydroxysteroid Dehydrogenases - isolation & purification | MCF-7 Cells | Dihydrotestosterone - pharmacology | Female | Placenta - chemistry | Epithelial Cells - cytology | Binding Sites | Estradiol - pharmacology | Dihydrotestosterone - metabolism | Estradiol - metabolism | Gene Expression | Protein Structure, Secondary | 17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Models, Molecular | Pregnancy | Feedback, Physiological | 17-Hydroxysteroid Dehydrogenases - genetics | Cell Line, Tumor | Protein Binding | Kinetics | 17-Hydroxysteroid Dehydrogenases - metabolism | RNA, Small Interfering - metabolism
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 07/2017, Volume 171, pp. 80 - 93
Phytoestrogens are plant-derived compounds that functionally and structurally mimic mammalian estrogens. Phytoestrogens have broad inhibitory activities toward... 
Hydroxysteroid dehydrogenases | Phytoestrogens | Flavonoids | Structure–activity relationships | Structural biology | Enzyme inhibition kinetics | COENZYME | CONSTANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTALLOGRAPHY | Structure-activity relationships | COCHLIOBOLUS-LUNATUS | GENISTEIN | SUBSTRATE-SPECIFICITY | ENDOCRINOLOGY & METABOLISM | TYPE-1 | INSIGHTS | Fungal Proteins - chemistry | Molecular Conformation | Phytoestrogens - chemistry | Crystallography, X-Ray | Holoenzymes - chemistry | Fungal Proteins - antagonists & inhibitors | Structure-Activity Relationship | Holoenzymes - metabolism | Genistein - metabolism | Databases, Protein | Enzyme Inhibitors - chemistry | Kaempferols - metabolism | Binding Sites | Recombinant Proteins - metabolism | Biocatalysis | Enzyme Inhibitors - metabolism | Hydroxylation | Kaempferols - chemistry | 17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Models, Molecular | Recombinant Proteins - chemistry | Genistein - chemistry | Ascomycota - enzymology | Fungal Proteins - genetics | 17-Hydroxysteroid Dehydrogenases - genetics | Flavonoids - metabolism | Phytoestrogens - metabolism | Protein Conformation | Holoenzymes - genetics | 17-Hydroxysteroid Dehydrogenases - chemistry | 17-Hydroxysteroid Dehydrogenases - metabolism | Dietary Supplements | Flavonoids - chemistry | Fungal Proteins - metabolism
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2016, Volume 117, Issue 4, pp. 904 - 916
Journal Article