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Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2007, Volume 50, Issue 13, pp. 3070 - 3076
We have previously shown that the endozepine octadecaneuropeptide (ODN) stimulates the biosynthesis of neurosteroids from frog hypothalamic explants. In the... 
STEROID-BIOSYNTHESIS | IMMUNOCYTOCHEMICAL LOCALIZATION | CHEMISTRY, MEDICINAL | MITOCHONDRIAL BENZODIAZEPINE RECEPTORS | TRIAKONTATETRANEUROPEPTIDE TTN | BIOLOGICAL-ACTIVITY | DIAZEPAM-BINDING INHIBITOR | CENTRAL-NERVOUS-SYSTEM | RAT-BRAIN | PROCESSING PRODUCTS | FROG HYPOTHALAMUS | Dehydroepiandrosterone - biosynthesis | Male | Peptide Fragments - pharmacology | Peptides, Cyclic - pharmacology | Diazepam Binding Inhibitor - chemical synthesis | Structure-Activity Relationship | Peptides, Cyclic - chemistry | Diazepam Binding Inhibitor - pharmacology | 17-alpha-Hydroxyprogesterone - metabolism | Neuropeptides - pharmacology | Rana esculenta | 3-Hydroxysteroid Dehydrogenases - metabolism | Progesterone - biosynthesis | Hypothalamus - drug effects | Steroids - biosynthesis | 17-alpha-Hydroxypregnenolone - metabolism | Amino Acid Sequence | Diazepam Binding Inhibitor - chemistry | Peptide Fragments - chemical synthesis | Peptide Fragments - chemistry | Animals | Hypothalamus - metabolism | Peptides, Cyclic - chemical synthesis | Steroid 17-alpha-Hydroxylase - metabolism | Enzyme Activation | In Vitro Techniques | Neuropeptides - chemical synthesis | Neuropeptides - chemistry | Peptide Fragments | Neurons and Cognition | Neurobiology | Neuropeptides | Hypothalamus | Cellular Biology | 17-alpha-Hydroxyprogesterone | Chemical Sciences | Life Sciences | 3-Hydroxysteroid Dehydrogenases | Pharmaceutical sciences | Cell Behavior | Pharmacology | Diazepam Binding Inhibitor | Peptides, Cyclic | Medicinal Chemistry | Dehydroepiandrosterone | 17-alpha-Hydroxypregnenolone | Progesterone | Steroid 17-alpha-Hydroxylase | Steroids
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 08/2017, Volume 102, Issue 8, pp. 2701 - 2710
Context: Patients with 21-hydroxylase deficiency (21OHD) have long-term complications, resulting from poor disease control and/or glucocorticoid overtreatment.... 
ADRENOGENITAL SYNDROME | STIMULATION | FINAL HEIGHT | ADULT MALES | TISSUE | ENDOCRINOLOGY & METABOLISM | PATIENT | PREVALENCE | LONGITUDINAL ANALYSIS | 19-CARBON STEROIDS | HYPERPLASIA | Adrenal Glands - pathology | Hydroxytestosterones - metabolism | 17-alpha-Hydroxypregnenolone - analogs & derivatives | Adrenal Rest Tumor - metabolism | Humans | Middle Aged | Child, Preschool | Male | Hirsutism - metabolism | Testosterone - analogs & derivatives | Age Determination by Skeleton | Androstenedione - metabolism | Pregnenolone - metabolism | Young Adult | Androstenedione - analogs & derivatives | Menstruation Disturbances - metabolism | Testosterone - metabolism | Adult | Female | Child | 17-alpha-Hydroxypregnenolone - metabolism | Cross-Sectional Studies | Adrenal Hyperplasia, Congenital - metabolism | Testicular Neoplasms - metabolism | Organ Size | Cortodoxone - metabolism | Adolescent | Androstenes - metabolism | Aged | Androgens - metabolism | Drugs | Correlation | Glucocorticoids | Disorders | Bone tumors | Hormones | Males | Sulfates | Pregnenolone | Spectrometry | Bioindicators | Children | Pituitary hormones | Menstruation | Complications | Hydroxylase | Hirsutism | Disease control | Patients | Testosterone | Androgens | Pregnenolone sulfate | Pituitary | Biomarkers | Adults | Sulfate | Females | Testes | Oxygenation | Steroid hormones | Tumors | Steroids
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2017, Volume 102, Issue 6, pp. 1797 - 1806
Context: The classic androgen synthesis pathway proceeds via dehydroepiandrosterone, androstenedione, and testosterone to 5 alpha-dihydrotestosterone. However,... 
BACKDOOR PATHWAY | 21-HYDROXYLASE DEFICIENCY | OXIDOREDUCTASE | ENDOCRINOLOGY & METABOLISM | ADULTS | INSUFFICIENCY | TAMMAR WALLABY | TESTES | 19-CARBON STEROIDS | DIHYDROTESTOSTERONE | HYDROCORTISONE | Glucocorticoids - administration & dosage | Glucocorticoids - therapeutic use | Gas Chromatography-Mass Spectrometry | Adrenal Hyperplasia, Congenital - drug therapy | 17-alpha-Hydroxypregnenolone - urine | Humans | Middle Aged | Hydrocortisone - therapeutic use | Male | Young Adult | Hydrocortisone - administration & dosage | Cortodoxone - analogs & derivatives | Androsterone - urine | Adult | Female | Prednisolone - therapeutic use | Pregnanetriol - urine | Cortodoxone - urine | Androgens - secretion | Adrenal Hyperplasia, Congenital - metabolism | Circadian Rhythm | Androsterone - analogs & derivatives | Dexamethasone - therapeutic use | Adolescent | Adrenal Hyperplasia, Congenital - urine | Pregnanetriol - analogs & derivatives | Delayed-Action Preparations | Therapy | Excretion | Dexamethasone | Glucocorticoids | Adrenal glands | Hyperplasia | Mass spectroscopy | Hydrocortisone | Patients | Diurnal | Impact analysis | Testosterone | Gas chromatography | Androgens | Dihydrotestosterone | Dehydroepiandrosterone | Synthesis | Metabolites | Adults | Androstenedione | Mass spectrometry | Prednisolone | Steroid hormones | Steroids
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 12, pp. 4864 - 4869
The circadian clock is phase-delayed or -advanced by light when given at early or late subjective night, respectively. Despite the importance of the... 
Locomotion | Shock heating | Transcription factors | Sterols | Genes | Pineal gland | Liver | Chickens | Gene expression regulation | Cholesterols | ENTRAINMENT | TEMPERATURE | METABOLISM | MELATONIN | OSCILLATORS | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GENE-EXPRESSION | PINEAL CLOCK | TIME | STRESS | 17-alpha-Hydroxypregnenolone - analogs & derivatives | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Male | Behavior, Animal - radiation effects | DNA-Binding Proteins - metabolism | Base Sequence | Light | 17-alpha-Hydroxypregnenolone - pharmacology | Behavior, Animal - drug effects | Signal Transduction - radiation effects | Circadian Rhythm - radiation effects | Sterol Regulatory Element Binding Protein 1 - metabolism | Locomotion - drug effects | Genome-Wide Association Study | Heat-Shock Proteins - metabolism | Gene Expression Regulation - physiology | Behavior, Animal - physiology | Circadian Rhythm - physiology | Regulatory Factor X Transcription Factors | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Locomotion - radiation effects | Animals | Signal Transduction - drug effects | Gene Expression Regulation - radiation effects | Signal Transduction - physiology | Cholesterol - biosynthesis | Locomotion - physiology | Circadian Rhythm - drug effects | Circadian rhythms | Physiological aspects | Genetic aspects | Research | Gene expression | Photobiology | Biological Sciences
Journal Article
General and Comparative Endocrinology, ISSN 0016-6480, 2011, Volume 176, Issue 3, pp. 440 - 447
Journal Article