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The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 08/2017, Volume 102, Issue 8, pp. 2701 - 2710
Context: Patients with 21-hydroxylase deficiency (21OHD) have long-term complications, resulting from poor disease control and/or glucocorticoid overtreatment.... 
ADRENOGENITAL SYNDROME | STIMULATION | FINAL HEIGHT | ADULT MALES | TISSUE | ENDOCRINOLOGY & METABOLISM | PATIENT | PREVALENCE | LONGITUDINAL ANALYSIS | 19-CARBON STEROIDS | HYPERPLASIA | Adrenal Glands - pathology | Hydroxytestosterones - metabolism | 17-alpha-Hydroxypregnenolone - analogs & derivatives | Adrenal Rest Tumor - metabolism | Humans | Middle Aged | Child, Preschool | Male | Hirsutism - metabolism | Testosterone - analogs & derivatives | Age Determination by Skeleton | Androstenedione - metabolism | Pregnenolone - metabolism | Young Adult | Androstenedione - analogs & derivatives | Menstruation Disturbances - metabolism | Testosterone - metabolism | Adult | Female | Child | 17-alpha-Hydroxypregnenolone - metabolism | Cross-Sectional Studies | Adrenal Hyperplasia, Congenital - metabolism | Testicular Neoplasms - metabolism | Organ Size | Cortodoxone - metabolism | Adolescent | Androstenes - metabolism | Aged | Androgens - metabolism | Drugs | Correlation | Glucocorticoids | Disorders | Bone tumors | Hormones | Males | Sulfates | Pregnenolone | Spectrometry | Bioindicators | Children | Pituitary hormones | Menstruation | Complications | Hydroxylase | Hirsutism | Disease control | Patients | Testosterone | Androgens | Pregnenolone sulfate | Pituitary | Biomarkers | Adults | Sulfate | Females | Testes | Oxygenation | Steroid hormones | Tumors | Steroids
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 32, pp. 13168 - 13185
Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17 alpha-hydroxylation of pregnenolone and progesterone and... 
B | HUMAN P450C17 | ACTIVE-SITE | ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER | 17-ALPHA-HYDROXYLASE-17,20-LYASE CYP17 | INHIBITOR | MICROSOMAL CYTOCHROME-P-450 | ORTERONEL TAK-700 | ISOLATED 17,20-LYASE DEFICIENCY | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | NADPH-Ferrihemoprotein Reductase - genetics | Stereoisomerism | Humans | Imidazoles - chemistry | Cytochrome P-450 Enzyme Inhibitors - metabolism | Cytochromes b5 - metabolism | Androstenedione - metabolism | Cytochromes b5 - genetics | Pregnenolone - metabolism | Progesterone - chemistry | Biocatalysis - drug effects | Dehydroepiandrosterone - chemistry | Cytochrome P-450 Enzyme Inhibitors - chemistry | Dehydroepiandrosterone - metabolism | Naphthalenes - metabolism | Binding Sites | 17-alpha-Hydroxypregnenolone - metabolism | Imidazoles - metabolism | Naphthalenes - chemistry | Recombinant Proteins - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Oxidation-Reduction | Models, Molecular | Rats | Recombinant Proteins - chemistry | Imidazoles - pharmacology | Naphthalenes - pharmacology | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Progesterone - metabolism | Androstenedione - chemistry | Ligands | Pregnenolone - chemistry | Protein Conformation | Steroid 17-alpha-Hydroxylase - genetics | 17-alpha-Hydroxypregnenolone - chemistry | Steroid 17-alpha-Hydroxylase - metabolism | Kinetics | Steroid 17-alpha-Hydroxylase - chemistry | pre-steady-state kinetics | steroid metabolism | oxidation-reduction (redox) | steroidogenesis | cytochrome P450 | Enzymology | steady-state kinetics | enzyme kinetics
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 06/2003, Volume 120, Issue 6, pp. 905 - 914
Journal Article
Endocrinology, ISSN 0013-7227, 07/2015, Volume 156, Issue 7, pp. 2646 - 2656
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, p. e0159203
Intrahepatic cholestasis of pregnancy (ICP) is a common liver disorder, mostly occurring in the third trimester. ICP is defined as an elevation of serum bile... 
CORTICOTROPIN-RELEASING HORMONE | FETAL ADRENAL-CELLS | DELTA-3-OXOSTEROID 5-BETA-REDUCTASE | SUBSTRATE-SPECIFICITY | URSODEOXYCHOLIC ACID | X RECEPTOR | POTENTIAL BIOMARKERS | SALT EXPORT PUMP | MULTIDISCIPLINARY SCIENCES | PROGESTERONE METABOLITES | BILE-ACIDS | Pregnancy Complications - pathology | Gas Chromatography-Mass Spectrometry | Area Under Curve | Humans | Alanine Transaminase - blood | Hydrocortisone - chemistry | Radioimmunoassay | Steroids - metabolism | Adult | Female | Pregnancy Complications - metabolism | Bile Acids and Salts - analysis | Hydrocortisone - blood | Steroids - blood | 17-alpha-Hydroxyprogesterone - chemistry | Steroids - chemistry | Liver Function Tests | Cholestasis, Intrahepatic - pathology | 17-alpha-Hydroxyprogesterone - blood | Pregnancy Complications - diagnosis | 17-alpha-Hydroxypregnenolone - blood | Gestational Age | Pregnancy | Cholestasis, Intrahepatic - metabolism | Aspartate Aminotransferases - blood | Cholestasis, Intrahepatic - diagnosis | ROC Curve | 17-alpha-Hydroxypregnenolone - chemistry | Dorsal Raphe Nucleus | Jaundice, Obstructive | Pregnant women | Drug metabolism | Physiological aspects | Development and progression | Genetic aspects | Research | Cholestasis | Liver | Pruritus | Bilirubin | Hydrocortisone | Metabolites | Rodents | Diols | Evaluation | Sensitivity analysis | Bile acids | Liver diseases | Secretion | Fetuses | Data processing | Regression analysis | Metabolism | Patients | Sensitivity | Acids | Steroidogenesis | Sulfate | Steroid hormones | Steroids | Bile
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2015, Volume 112, Issue 52, pp. 15856 - 15861
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Journal Article
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Journal Article
Biology of Reproduction, ISSN 0006-3363, 01/2016, Volume 94, Issue 1, p. 9
Journal Article