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1h-indazoles (49) 49
chemistry, organic (46) 46
derivatives (27) 27
1h-indazole (20) 20
chemistry, multidisciplinary (20) 20
cyclization (19) 19
efficient synthesis (19) 19
indazoles (19) 19
index medicus (18) 18
1,3-dipolar cycloaddition (14) 14
1-aryl-1h-indazoles (13) 13
indazoles - chemistry (13) 13
synthesis (13) 13
catalysis (11) 11
chemistry (10) 10
chemistry, medicinal (10) 10
inhibitors (10) 10
3-substituted indazoles (9) 9
heterocycles (9) 9
indazoles - chemical synthesis (9) 9
functionalization (8) 8
indazole (8) 8
molecular structure (8) 8
n bond formation (8) 8
arynes (7) 7
palladium (7) 7
substituted 1h-indazoles (7) 7
amination (6) 6
chemistry, applied (6) 6
humans (6) 6
one-pot (6) 6
organic chemistry (6) 6
alkynes (5) 5
antineoplastic agents - pharmacology (5) 5
bond formation (5) 5
chemical reactions (5) 5
chemical synthesis (5) 5
chemistry, inorganic & nuclear (5) 5
cyclisation (5) 5
cycloaddition (5) 5
design (5) 5
diazo-compounds (5) 5
hydrazones (5) 5
pharmacology & pharmacy (5) 5
access (4) 4
acid (4) 4
activation (4) 4
amidation (4) 4
antitumor activity (4) 4
cancer (4) 4
coupling reactions (4) 4
death (4) 4
indazoles - pharmacology (4) 4
inhibition (4) 4
intramolecular amination reaction (4) 4
one-pot synthesis (4) 4
reagents (4) 4
strategy (4) 4
structure-activity relationship (4) 4
substrates (4) 4
synthetic methods (4) 4
tetrahedrons (4) 4
tosylhydrazones (4) 4
2h-indazoles (3) 3
acids (3) 3
agents (3) 3
amination reaction (3) 3
antineoplastic agents - chemistry (3) 3
antitumor (3) 3
apoptosis - drug effects (3) 3
arenes (3) 3
aryl halides (3) 3
arylation (3) 3
azo compounds - chemistry (3) 3
azobenzenes (3) 3
binding sites (3) 3
biochemistry & molecular biology (3) 3
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c-n (3) 3
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esters (3) 3
functional groups (3) 3
h bond functionalization (3) 3
heterocyclic-compounds (3) 3
hmbc (3) 3
indazole derivatives (3) 3
indoleamine 2,3-dioxygenase 1 (3) 3
iodine (3) 3
noesy spectra (3) 3
nucleophilic substitution (3) 3
pharmacy (3) 3
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Organic Letters, ISSN 1523-7060, 01/2019, Volume 21, Issue 2, pp. 365 - 368
A rhodium(III)-catalyzed intermolecular C-H amination of ketoxime and iodobenzene diacetate-enabled N-N bond formation in the synthesis of indazoles has been... 
AZIDES | AZOBENZENES | AMIDATION | CHEMISTRY, ORGANIC | 1H-INDAZOLES | CYCLIZATION | ACCESS
Journal Article
Organic Letters, ISSN 1523-7060, 06/2017, Volume 19, Issue 11, pp. 2777 - 2780
A Rh­(III)-catalyzed tandem C–H alkylation/intramolecular decarboxylative cyclization of azoxy compounds with diazoesters for the synthesis of... 
PALLADIUM | AZOXYBENZENES | ONE-POT | AZOBENZENES | INDAZOLES | CHEMISTRY, ORGANIC | 1H-INDAZOLES | H BOND FUNCTIONALIZATION | CARBENE MIGRATORY INSERTION | ORTHO-ACYLATION | DERIVATIVES
Journal Article
by Wang, Q and Wang, F and Yang, XF and Zhou, XK and Li, XW
ORGANIC LETTERS, ISSN 1523-7060, 12/2016, Volume 18, Issue 23, pp. 6144 - 6147
Quinazoline N-oxides have been prepared from simple ketoximes and 1,4,2-dioxazol-5-ones via Rh(III)-catalyzed C-H activation amidation of the ketoximes and... 
FUNCTIONALIZATION | ACTIVATION | AMINATION | NATURAL-PRODUCTS | CATALYZED ANNULATION | DRUG DISCOVERY | ARENES | CHEMISTRY, ORGANIC | BOND FORMATION | 1H-INDAZOLES | ALKYNES
Journal Article
The Journal of organic chemistry, ISSN 0022-3263, 08/2019, Volume 84, Issue 20, pp. 13203 - 13210
Cobalt-catalyzed C-H allylation reactions of NH-free benzimidates using vinylcyclopropanes or allyl carbonate are reported. The reactive and relatively... 
FUNCTIONALIZATION | ACTIVATION | ISOQUINOLINES | COUPLING/CYCLIZATION | AMIDATION | CHEMISTRY, ORGANIC | OLEFINS | 1H-INDAZOLES | ACCESS | CYCLIZATION | QUINAZOLINES
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2019, Volume 27, Issue 6, pp. 1087 - 1098
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important... 
Antitumor activity | Dual inhibitor | 1H-Indazoles | Cancer immunotherapy | Tryptophan 2,3-dioxygenase (TDO) | Indoleamine 2,3-dioxygenase 1 (IDO1)
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 07/2016, Volume 18, Issue 13, pp. 3218 - 3221
3-(Hetero)arylindazoles are important motifs in several biologically active compounds. Mild and flexible palladium-mediated Negishi reaction conditions are... 
ACIDS | ARYLATION | EFFICIENT SYNTHESIS | PROTOCOL | C-3 | CHEMISTRY, ORGANIC | 1H-INDAZOLES | ARYL | INHIBITORS
Journal Article
Organic Letters, ISSN 1523-7060, 01/2019, Volume 21, Issue 1, pp. 124 - 128
A novel and efficient strategy for the direct synthesis of benzo[f]indazoles via copper-catalyzed cascade reaction of sulfonyl hydrazides with 1,3-enynes under... 
FUNCTIONALIZATION | CYCLIZATION CASCADES | 1-ARYL-1H-INDAZOLES | ONE-POT SYNTHESIS | 1,3-DIPOLAR CYCLOADDITION | INDAZOLES | CHEMISTRY, ORGANIC | 1H-INDAZOLES | ALKYNES | DERIVATIVES | 1,N-ENYNES
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 08/2019, Volume 21, Issue 15, pp. 6058 - 6062
The Davis-Beirut reaction provides access to 2H-indazoles from aromatic nitro compounds. However, N-aryl targets have been traditionally challenging to access... 
DENSITY FUNCTIONALS | MILD | 2-NITROBENZYL COMPOUNDS | THERMOCHEMISTRY | CHEMISTRY | INDAZOLES | CHEMISTRY, ORGANIC | HETEROCYCLIZATION | REACTION-MECHANISMS | 1H-INDAZOLES | CYCLIZATION
Journal Article
by Zhang, Y and Duan, DY and Zhong, Y and Guo, XA and Guo, JW and Gou, J and Gao, ZW and Yu, BX
ORGANIC LETTERS, ISSN 1523-7060, 07/2019, Volume 21, Issue 13, pp. 4960 - 4965
An Fe(III)-catalyzed intramolecular N-N coupling of aliphatic azidoamines that forms diverse five-and six-membered semisaturated diazoheterocycles using air as... 
CYCLOADDITION | NITROGEN-NITROGEN BOND | LIGANDS | NATURAL-PRODUCTS | RADICAL CYCLIZATIONS | CHEMISTRY | CHEMISTRY, ORGANIC | HETEROCYCLIZATION | 1H-INDAZOLES | GENERATION | PYRAZOLINES
Journal Article
Organic Letters, ISSN 1523-7060, 12/2017, Volume 19, Issue 24, pp. 6678 - 6681
1H-Isoindoles and 2H-isoindoles are synthesized via a ruthenium-catalyzed oxidant-free cyclization of benzimidates with alkenes at room temperature with the... 
DIRECTING GROUP | ACTIVATION | DIRECT ARYLATION | RUTHENIUM-CATALYZED CYCLIZATION | CHEMISTRY, ORGANIC | N BOND FORMATION | 1H-INDAZOLES | C-H FUNCTIONALIZATION | ALKYNES | HYDROARYLATION | ORTHO-ALKENYLATION
Journal Article
Organic Letters, ISSN 1523-7060, 01/2016, Volume 18, Issue 2, pp. 232 - 235
The rhodium­(III)-catalyzed direct C–H functionalization of azobenzenes with ethyl glyoxalate and aryl glyoxals is described. This protocol provides the facile... 
FUNCTIONALIZATION | AMIDATION | INDAZOLES | CHEMISTRY, ORGANIC | OLEFINS | N BOND FORMATION | ARYL | 1H-INDAZOLES | CLEAVAGE | ALKENYLATION | Azo Compounds - chemistry | Glyoxal - chemistry | Indazoles - chemistry | Cyclization | Indazoles - chemical synthesis | Ketones - chemistry | Molecular Structure | Catalysis | Glyoxal - analogs & derivatives | Rhodium - chemistry | Aldehydes - chemistry
Journal Article
Organic Letters, ISSN 1523-7060, 07/2011, Volume 13, Issue 13, pp. 3340 - 3343
Readily available, stable, and inexpensive N-tosylhydrazones react with arynes under mild reaction conditions to afford 3-substituted indazoles in moderate to... 
GENERATED IN-SITU | 1,3-DIPOLAR CYCLOADDITION | CHEMISTRY, ORGANIC | BAMFORD-STEVENS REACTION | DIAZO-COMPOUNDS | 1H-INDAZOLES | DERIVATIVES | SELECTIVITY | SALTS | Molecular Structure | Indazoles - chemical synthesis | Stereoisomerism | Hydrazones - chemistry
Journal Article
by Han, S and Shin, Y and Sharma, S and Mishra, NK and Park, J and Kim, M and Jang, J and Kim, IS
ORGANIC LETTERS, ISSN 1523-7060, 05/2014, Volume 16, Issue 9, pp. 2494 - 2497
A rhodium(III)-catalyzed oxidative olefination of 1,2-disubstituted arylhydrazines with alkenes via sp(2) C-H bond activation followed by an intramolecular... 
PALLADIUM | BIOLOGICAL-ACTIVITY | CATALYZED DECARBOXYLATIVE ACYLATION | EFFICIENT SYNTHESIS | C-C | CHEMISTRY, ORGANIC | OXOCARBOXYLIC ACIDS | 1H-INDAZOLES | H BOND FUNCTIONALIZATION | PROTEASE INHIBITORS | CYCLIZATION
Journal Article
Organic Letters, ISSN 1523-7060, 10/2018, Volume 20, Issue 20, pp. 6573 - 6577
A controllable Rh­(III)-catalyzed C–H arylation and dealcoholization of benzimidates with arylboronic esters was developed, delivering various... 
FUNCTIONALIZATION | CROSS-COUPLING REACTIONS | ONE-POT | ARENES | CHEMISTRY, ORGANIC | BOND ACTIVATION | DIAZO-COMPOUNDS | 1H-INDAZOLES | CYCLIZATION | CATALYZED DIRECT ARYLATION | CASCADE REACTION
Journal Article
by Yang, LL and Chen, Y and He, JL and Njoya, EM and Chen, JJ and Liu, SY and Xie, CQ and Huang, WZ and Wang, F and Wang, ZY and Li, YZ and Qian, S
BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 03/2019, Volume 27, Issue 6, pp. 1087 - 1098
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important... 
CHEMISTRY, MEDICINAL | Dual inhibitor | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | Antitumor activity | 1H-Indazoles | Cancer immunotherapy | Tryptophan 2,3-dioxygenase (TDO) | Indoleamine 2,3-dioxygenase 1 (IDO1)
Journal Article
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 06/2017, Volume 15, Issue 23, pp. 5062 - 5069
The nickel-catalyzed cyclization of in situ generated ortho-chlorobenzophenone hydrazone derivatives, to afford 3-(hetero) aryl-1H-indazoles, is documented for... 
1-ARYL-1H-INDAZOLES | 3-SUBSTITUTED INDAZOLES | METAL-FREE CONDITIONS | 1,3-DIPOLAR CYCLOADDITION | EFFICIENT SYNTHESIS | TOSYLHYDRAZONES | CHEMISTRY, ORGANIC | BOND FORMATION | INTRAMOLECULAR AMINATION REACTION | 1H-INDAZOLES | CYCLIZATION
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 06/2017, Volume 15, Issue 23, pp. 5062 - 5069
The nickel-catalyzed cyclization of in situ generated ortho-chlorobenzophenone hydrazone derivatives, to afford 3-(hetero)aryl-1H-indazoles, is documented for... 
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 01/2008, Volume 73, Issue 1, pp. 219 - 226
The [3+2] cycloaddition of a variety of diazo compounds with o-(trimethylsilyl)aryl triflates in the presence of CsF or TBAF at room temperature provides a... 
CONVENIENT ROUTE | INSERTION | ACID | HETEROCYCLES | 1,3-DIPOLAR CYCLOADDITION | EFFICIENT SYNTHESIS | DECOMPOSITION | CHEMISTRY, ORGANIC | 1H-INDAZOLES | DERIVATIVES | SPIRO | Azo Compounds - chemistry | Indazoles - chemistry | Cyclization | Indazoles - chemical synthesis | Stereoisomerism | Alkynes - chemistry | Molecular Structure
Journal Article
by Wei, W and Wang, Z and Yang, XK and Yu, WQ and Chang, JB
ADVANCED SYNTHESIS & CATALYSIS, ISSN 1615-4150, 10/2017, Volume 359, Issue 19, pp. 3378 - 3387
A divergent intramolecular C-H amination of hydrazones has been developed employing molecular iodine (I-2) as the sole oxidant. The required hydrazone... 
C-H amination | 1H-indazoles | DESIGN | 1H-pyrazoles | ONE-POT SYNTHESIS | PYRAZOLE DERIVATIVES | INDAZOLES | CHEMISTRY, ORGANIC | NITRILE IMINES | KINASE INHIBITOR | IDENTIFICATION | CYCLOADDITION | BIOLOGICAL EVALUATION | iodine | N BOND FORMATION | CHEMISTRY, APPLIED | hydrazones
Journal Article
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