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1h-pyrazolo[3,4-d]pyrimidine (7) 7
chemistry, organic (6) 6
index medicus (6) 6
resveratrol (5) 5
derivatives (4) 4
pyrimidines (4) 4
chemistry (3) 3
humans (3) 3
organic chemistry (3) 3
potent (3) 3
pyrimidines - chemistry (3) 3
1,10-phenanthroline (2) 2
1h-pyrazolo[3,4-d]pyrimidines (2) 2
animals (2) 2
anticancer (2) 2
biochemistry & molecular biology (2) 2
braf (2) 2
cell proliferation - drug effects (2) 2
chemistry, medicinal (2) 2
chemistry, multidisciplinary (2) 2
crystal structure (2) 2
c–h arylation (2) 2
discovery (2) 2
docking (2) 2
dual inhibitor (2) 2
egfr (2) 2
egfr-tkis (2) 2
inhibitors (2) 2
inhibitory concentration 50 (2) 2
kinase inhibitors (2) 2
metastatic melanoma (2) 2
molecular structure (2) 2
nitrogenous bicycles (2) 2
nsclc (2) 2
palladium (2) 2
particle mesh ewald (2) 2
pharmacological and biochemical properties (2) 2
protein kinase inhibitors - chemical synthesis (2) 2
protein kinase inhibitors - chemistry (2) 2
protein kinase inhibitors - pharmacology (2) 2
pyrazoles - chemistry (2) 2
pyrimidines - chemical synthesis (2) 2
pyrimidines - pharmacology (2) 2
regioselectivity (2) 2
structure-activity relationship (2) 2
synthesis (2) 2
tyrosine kinase (2) 2
vegfr-2 (2) 2
π–π interactions (2) 2
1 h-pyrazolo[4,3- e]pyrimidine (1) 1
1,8-2h-pyrazolo[3,4-d][1,2,4]triazolo[1,5-a]pyrimidin-4-one (1) 1
1h-pyrazolo (1) 1
1h-pyrazolo [3,4-d]pyrimidine (1) 1
1h-pyrazolo[3,4-d]pyrimidin-4-amine (1) 1
1h-pyrazolo[3,4-d]pyrimidin-4-amino derivatives (1) 1
1h-pyrazolo[3,4-d]pyrimidin-4-one (1) 1
1h-pyrazolo[3,4-d]pyrimidine derivatives (1) 1
1h-pyrazolo[4,3-e]pyrimidine (1) 1
1h‐pyrazolo[3,4‐d]pyrimidine (1) 1
2,2,4-trimethyl-1,2-dihydroquinoline (1) 1
2-aminophenyl alkyl ketone (1) 1
2’-acylbenzanilide (1) 1
3h-1,2,3-triazolo-[4,5-d]pyrimidine (1) 1
4-amino-1--1h-pyrazolo [3, 4-d] pyrimidines (1) 1
4-d]pyrimidine derivatives (1) 1
4-n-acyl derivatives (1) 1
4-n-alkyl or phenyl derivatives (1) 1
4-substituted quinazoline (1) 1
5-acetyl-6-methyl-2,4-di pyrimidine (1) 1
5-acetyl-6-methyl-2,4-dipyrimidine (1) 1
5-aminopyrazole-4-carbonitrile (1) 1
6--1 h -pyrazolo[3,4- d ]pyrimidines (1) 1
6--1h-pyrazolo[3,4-d]pyrimidines (1) 1
6-hydrazino-1 h -pyrazolo[3,4- d ]pyrimidine (1) 1
6-hydrazino-1h-pyrazolo[3,4-d]pyrimidine (1) 1
7h-pyrrolo[2,3-d]pyrimidin-4-amine (1) 1
8--1,2-dihydroquinoline (1) 1
a549 cells (1) 1
accurate docking (1) 1
acrylamide - chemistry (1) 1
activation (1) 1
adenosine receptor antagonists (1) 1
agents (1) 1
aldehydes (1) 1
amber (1) 1
amide acetals (1) 1
amides (1) 1
anti-hyperglycemic evaluation (1) 1
anti-tumor activity (1) 1
antifungal (1) 1
antifungal agents - chemical synthesis (1) 1
antifungal agents - pharmacology (1) 1
antiprotozoal agents - chemical synthesis (1) 1
antiprotozoal agents - pharmacokinetics (1) 1
antiprotozoal agents - pharmacology (1) 1
antiprotozoal agents - toxicity (1) 1
aristeromycin analogue (1) 1
aromatic compounds (1) 1
aryl halides (1) 1
arylation (1) 1
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Comptes Rendus Chimie, ISSN 1631-0748, 09/2017, Volume 20, Issue 9-10, pp. 927 - 933
Nitrogenous bicycles are an apparently endless field of organic and biological research. In this study, we disclose an efficient pathway to the synthesis of... 
1,10-Phenanthroline | Palladium | Regioselectivity | 1H-Pyrazolo[3,4-d]pyrimidines | C–H arylation | Nitrogenous bicycles | ACTIVATION | C-H arylation | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | CROSS-COUPLING REACTIONS | HETEROARENES | POTENT | ARYL HALIDES | HETEROAROMATICS | AGENTS | INHIBITORS | DERIVATIVES | Care and treatment | Pyrimidines | Gout | Bicycles | Resveratrol
Journal Article
Comptes rendus - Chimie, ISSN 1631-0748, 09/2017, Volume 20, Issue 9-10, pp. 927 - 933
Nitrogenous bicycles are an apparently endless field of organic and biological research. In this study, we disclose an efficient pathway to the synthesis of... 
1,10-Phenanthroline | Palladium | Regioselectivity | 1H-Pyrazolo[3,4-d]pyrimidines | C–H arylation | Nitrogenous bicycles | Pyrimidines | Resveratrol
Journal Article
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, ISSN 2056-9890, 12/2014, Volume 70, Issue Pt 12, pp. O1281 - O1281
In the title compound, C7H8N4S, the non-H atoms of the pyrazolo[3,4-d]pyrimidine ring system and the methylsulfanyl group lie on a crystallographic mirror... 
crystal structure | 1H-pyrazolo[3,4-d]pyrimidine | CRYSTALLOGRAPHY | pi-pi interactions | pharmacological and biochemical properties
Journal Article
Molecules, ISSN 1420-3049, 04/2017, Volume 22, Issue 4, p. 542
RAF (Ras activating factor) kinases are important and attractive targets for cancer therapy. With the aim of discovering RAF inhibitors that bind to DFG-out... 
4-d]pyrimidine derivatives | Biological activities | 1H-pyrazolo | Pan-RAF inhibitor | Molecular dynamics simulation | Molecular docking | DFG-out | DABRAFENIB | 1H-pyrazolo[3,4-d]pyrimidine derivatives | molecular dynamics simulation | CHEMISTRY, ORGANIC | BRAF V600E MUTATION | PARTICLE MESH EWALD | KINASE INHIBITORS | MULTIKINASE INHIBITOR | RAF/MEK/ERK PATHWAY | METASTATIC MELANOMA | biological activities | pan-RAF inhibitor | molecular docking | AMBER | DYNAMICS | HUMAN CANCER | A549 Cells | Protein Kinase Inhibitors - chemical synthesis | Pyrimidines - chemical synthesis | Humans | Models, Molecular | Structure-Activity Relationship | Pyrimidines - pharmacology | Pyrimidines - chemistry | HT29 Cells | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Drug Design | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Drug Screening Assays, Antitumor | Proto-Oncogene Proteins B-raf - chemistry | Biotechnology | Phosphorylation | Sarcoma | Computer simulation | Molecular dynamics | MAP kinase | Raf protein | Homology | Selectivity | Tumor cell lines | Drug development | Kinases | Free energy | Proteins | Molecular modelling | Inhibitors | Protein kinase | Chemical synthesis | Scaffolds | Cancer
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2018, Volume 155, pp. 210 - 228
Aiming to explore novel BRAFV600E and VEGFR-2 dual inhibitors, a series of 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed, synthesized and biologically... 
Tyrosine kinase | 1H-pyrazolo[3,4-d]pyrimidine | BRAFV600E | Dual inhibitor | VEGFR-2 | BRAF
Journal Article
by Wang, YY and Wan, SH and Li, ZH and Fu, Y and Wang, GF and Zhang, JJ and Wu, X
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 07/2018, Volume 155, pp. 210 - 228
Aiming to explore novel BRAF(V600E) and VEGFR-2 dual inhibitors, a series of 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed, synthesized and... 
CHEMISTRY, MEDICINAL | Dual inhibitor | 1H-pyrazolo[3,4-d]pyrimidine | PARTICLE MESH EWALD | KINASE INHIBITORS | BRAF | FREE-ENERGIES | BRAF(V600E) | Tyrosine kinase | METASTATIC MELANOMA | SIGNALING PATHWAY | ACCURATE DOCKING | VEGFR-2 | FORCE-FIELD | BINDING | RATIONAL DESIGN
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 10/2018, Volume 80, pp. 375 - 395
[Display omitted] •Thirty compounds of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesized.•In vitro anti EGFRWT and EGFRT790M... 
NSCLC | EGFRT790M | EGFR-TKIs | Docking | Anticancer | EGFRWT | 1H-Pyrazolo[3,4-d]pyrimidine | EGFR
Journal Article
Acta Crystallographica Section E: Structure Reports Online, ISSN 1600-5368, 12/2014, Volume 70, Issue 12, pp. o1281 - o1281
In the title compound, C7H8N4S, the non-H atoms of the pyrazolo[3,4-d]pyrimidine ring system and the methylsulfanyl group lie on a crystallographic mirror... 
crystal structure | 1H-pyrazolo[3,4-d]pyrimidine | π-π interactions | pharmacological and biochemical properties | π–π interactions
Journal Article
Heterocycles, ISSN 0385-5414, 01/2010, Volume 81, Issue 1, pp. 73 - 77
By developing an improved procedure for arylboronates, twenty 1H-pyrazolo[3,4-d]pyrimidine analogs were efficiently synthesized as a source of a potent kinase... 
Suzuki-Miyaura Cross-Coupling Reaction | Arylboronate | Protein Kinase Inhibitor | 1H-Pyrazolo[3,4-d]pyrimidine | DESIGN | POTENT | CHEMISTRY, ORGANIC | SELECTIVE KINASE INHIBITORS
Journal Article
Helvetica Chimica Acta, ISSN 0018-019X, 05/2008, Volume 91, Issue 5, pp. 958 - 963
In support of a research program aimed at discovering purine‐related anticancer drug candidates, a method for the 14C‐labeling of pyrazolopyrimidines utilizing... 
Cyclocondensation | Aristeromycin analogue | 1H‐Pyrazolo[3,4‐d]pyrimidine | Isotope labeling | Pyrazolopyrimidines
Journal Article
ACS Infectious Diseases, 04/2018, Volume 4, Issue 4, pp. 516 - 522
Journal Article
YAKUGAKU ZASSHI, ISSN 0031-6903, 1977, Volume 97, Issue 12, pp. 1328 - 1333
4-Amino-1-(o-, m-, or p-nitrophenyl)-1H-pyrazolo [3, 4-d] pyrimidine (Io, Im, or Ip), and 41 kinds of their derivatives were synthesized and the compounds were... 
4-amino-1-(o-, m- or p-nitrophenyl)-1H-pyrazolo [3, 4-d] pyrimidines | Ehrlich carcinoma | anti-tumor activity | syntheses | 4-N-alkyl or phenyl derivatives | 4-N-acyl derivatives
Journal Article
Tetrahedron, ISSN 0040-4020, 2008, Volume 64, Issue 45, pp. 10339 - 10343
A series of pyrazolo[4,3- e][1,2,4]triazolo[4,3- c]pyrimidines were prepared via oxidative cyclization of aldehyde N-(1,3-diphenylpyrazolo[3,4-... 
Hydrazones | Heterocycles | 1 H-Pyrazolo[4,3- e]pyrimidine | Nitrilimines | Dimroth rearrangement | 1H-Pyrazolo[4,3-e]pyrimidine | CHEMISTRY, ORGANIC | FACILE | DERIVATIVES | HYDRAZIDOYL HALIDES | Deterrence (Strategy) | Flexible response (Strategy) | Pyrimidines
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 1984, Volume 32, Issue 9, pp. 3690 - 3694
Under the Reissert reaction conditions, quinazoline (1a) afforded 2'-formylbenzanilide (2a), o-aminobenzaldehyde (3a), and N-formylbenzamide (4). Similarly,... 
ring fission | N-formylbenzamide | 2-aminophenyl alkyl ketone | 1H-pyrazolo[3,4-d]pyrimidine | 4-substituted quinazoline | 2’-acylbenzanilide | 3H-1,2,3-triazolo-[4,5-d]pyrimidine
Journal Article
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