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Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 08/2018, Volume 86, pp. 122 - 130
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 05/2019, Volume 113, pp. 108752 - 108752
Honey is a food known for its medical properties. In this work, we have studied the impact of different types of honey on insulin signalling pathway. We found... 
Type 2 diabetes | Protein-tyrosine phosphatase 1B | Phenolic compounds | Tuscany honey | Insulin signaling | MEDICINE, RESEARCH & EXPERIMENTAL | RISK-FACTORS | PHENOLIC-COMPOUNDS | NATURAL-PRODUCTS | BLOOD-GLUCOSE | FLAVONOIDS | DIABETES-MELLITUS | TYROSINE-PHOSPHATASE 1B | SUCROSE | RESISTANCE | PHARMACOLOGY & PHARMACY | HEALTH
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 497 - 506
We report here the synthesis and mechanism of inhibition of pyrazolecarboxamide derivatives as a new class of HCV inhibitors. Compounds 6, 7, 8 and 16... 
Pyrazolecarboxamide | Subgenomic replicon 1b genotype | HCV | Cyclooxigenase-2
Journal Article
Neuroscience Letters, ISSN 0304-3940, 2011, Volume 504, Issue 3, pp. 325 - 329
► Medial prefrontal cortex modulates anxiogenic behaviors in rats. ► 5HT receptors of medial prefrontal cortex modulates anxiogenic behaviors in rats. ► 5HT... 
5HT 1A | Anxiety | Rat | 5HT 1B | 5HT
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 144, pp. 692 - 700
PTP1B serving as a key negative regulator of insulin signaling is a novel target for type 2 diabetes and obesity. Modification at ring B of... 
PTP1B | Type 2 diabetes mellitus | N-(2,5-diethoxy-phenyl)-methane sulfonamide | Protein tyrosine phosphatase 1B inhibitors | OBESITY | CHEMISTRY, MEDICINAL | TYROSINE-PHOSPHATASE 1B | ACIDS | RECEPTOR | STRUCTURE-BASED DESIGN
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 09/2015, Volume 25, Issue 18, pp. 3921 - 3923
series of novel indolylpiperidine derivatives were synthesized, and their pharmacological profiles were assessed at rat alpha(1A) and alpha(1B) adrenoceptors... 
CHEMISTRY, MEDICINAL | alpha(1B) | ALPHA(1B)-ADRENERGIC RECEPTOR | CHEMISTRY, ORGANIC | 1,2,3,4-Tetrahydroisoquinoline | 4-(Indol-3-yl)piperidine | Adrenoceptor | KMD-3213
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/2016, Volume 138, Issue 27, pp. 8400 - 8403
Electrochemical oxidation of toluene derivatives in the presence of a sulfilimine gave benzylaminosulfonium ions as stabilized benzyl cation pools, which... 
AMINATION | ALKOXYSULFONIUM IONS | TYROSINE-PHOSPHATASE 1B | CARBON NUCLEOPHILES | AMINES | CARBOCATIONS | BOND FUNCTIONALIZATION | ANODIC OXIDATIONS | GENERATION | FORMYLCHROMONE DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 03/2008, Volume 9, Issue 3, pp. 193 - 205
Nearly unlimited supplies of energy-dense foods and technologies that encourage sedentary behaviour have introduced a new threat to the survival of our... 
SKELETAL-MUSCLE | GLUCOSE-HOMEOSTASIS | SIGNALING PATHWAYS | TYROSINE-PHOSPHATASE 1B | RAT PANCREATIC-ISLETS | UNCOUPLING PROTEIN-2 | SATURATED FATTY-ACIDS | KNOCKOUT MICE | HEPATIC STEATOSIS | NMR ISOTOPOMER ANALYSIS | CELL BIOLOGY
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 12/2017, Volume 23, Issue 23, pp. 7158 - 7164
In recent years, investigators have recognized the rigidity of single agent, safety only, traditional designs, rendering them ineffective for conducting... 
Clinical trials | Phase 1b | Targeted therapy | Lymphoma | Combination
Journal Article
CELLULAR AND MOLECULAR LIFE SCIENCES, ISSN 1420-682X, 02/2010, Volume 67, Issue 3, pp. 405 - 417
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 09/2014, Volume 78, Issue 3, pp. 587 - 598
Aims Rosuvastatin and pitavastatin have been proposed as probe substrates for the organic anion‐transporting polypeptide (OATP) 1B, but clinical data on their... 
regulatory guidance | organic anion‐transporting polypeptide 1B | breast cancer resistance protein | pitavastatin | rosuvastatin | drug–drug interactions | drug-drug interactions | organic anion-transporting polypeptide 1B | RIFAMPICIN | DRUG-DRUG INTERACTION | HEPATIC-CLEARANCE | P-GLYCOPROTEIN | ATORVASTATIN | INHIBITION | PHARMACOKINETICS | HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | METABOLIZING-ENZYMES | Fluorobenzenes - pharmacokinetics | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Area Under Curve | Humans | Middle Aged | Male | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Quinolines - pharmacokinetics | Young Adult | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Drug Interactions | Organic Anion Transporters, Sodium-Independent - metabolism | Adult | Female | Rifampin - administration & dosage | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Organic Anion Transporters - antagonists & inhibitors | Administration, Oral | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Cross-Over Studies | Administration, Intravenous | Pyrimidines - pharmacokinetics | Rifampin - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1b1 | Rosuvastatin | Drug resistance | Investigations | Antilipemic agents | Drug Metabolism
Journal Article