Neuro-Oncology, ISSN 1522-8517, 2017, Volume 19, Issue 6, pp. 786 - 795
Background. Co-deletion of 1p and 19q marks a diffuse glioma subtype associated with relatively favorable overall survival; however, heterogeneous clinical...
Prognostic factor | Glioma | 1p/19q co-deletion | elastic net Cox regression model | SURVIVAL | 1P/19Q | prognostic factor | MICROARRAY | GENOMIC ANALYSIS | PROCARBAZINE | CLINICAL NEUROLOGY | MOLECULAR CLASSIFICATION | ONCOLOGY | RNA-SEQ | VINCRISTINE | GENE-EXPRESSION | glioma | PROGRESSION | Prognosis | Follow-Up Studies | Humans | Middle Aged | Brain Neoplasms - pathology | Transcriptome | Male | Glioma - genetics | Young Adult | Chromosomes, Human, Pair 1 | Glioma - pathology | Glioma - therapy | Aged, 80 and over | Adult | Female | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Survival Rate | Chromosomes, Human, Pair 19 | Adolescent | Brain Neoplasms - therapy | Chromosome Aberrations | Aged | Biomarkers, Tumor - genetics | Mutation | 19q co-deletion | Basic and Translational Investigations
Prognostic factor | Glioma | 1p/19q co-deletion | elastic net Cox regression model | SURVIVAL | 1P/19Q | prognostic factor | MICROARRAY | GENOMIC ANALYSIS | PROCARBAZINE | CLINICAL NEUROLOGY | MOLECULAR CLASSIFICATION | ONCOLOGY | RNA-SEQ | VINCRISTINE | GENE-EXPRESSION | glioma | PROGRESSION | Prognosis | Follow-Up Studies | Humans | Middle Aged | Brain Neoplasms - pathology | Transcriptome | Male | Glioma - genetics | Young Adult | Chromosomes, Human, Pair 1 | Glioma - pathology | Glioma - therapy | Aged, 80 and over | Adult | Female | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Survival Rate | Chromosomes, Human, Pair 19 | Adolescent | Brain Neoplasms - therapy | Chromosome Aberrations | Aged | Biomarkers, Tumor - genetics | Mutation | 19q co-deletion | Basic and Translational Investigations
Journal Article
Modern pathology, ISSN 0893-3952, 2013, Volume 26, Issue 7, pp. 922 - 929
The histopathological diagnosis of diffuse gliomas often lacks the precision that is needed for tailored treatment of individual patients. Assessment of the...
glioma | complete 1p/19q co-deletion | MGMT | molecular markers | IDH1 | SURVIVAL | DEPENDENT PROBE AMPLIFICATION | NUMBER CHANGES | PROGNOSIS | NEWLY-DIAGNOSED GLIOBLASTOMA | MARKERS | CLASSIFICATION | PATHOLOGY | GRADE GLIOMAS | GENETIC ALTERATIONS | Prognosis | Glioma - classification | Humans | Middle Aged | DNA Repair Enzymes - genetics | Male | Glioma - genetics | Chromosomes, Human, Pair 19 - genetics | DNA Methylation | Gene Deletion | Tumor Suppressor Proteins - genetics | Adult | Female | Brain Neoplasms - mortality | Chromosomes, Human, Pair 1 - genetics | Chromosome Deletion | Promoter Regions, Genetic | Glioma - mortality | Kaplan-Meier Estimate | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | DNA Modification Methylases - genetics | Brain Neoplasms - classification | Biomarkers, Tumor - genetics | Mutation | Pathology, Molecular | Age
glioma | complete 1p/19q co-deletion | MGMT | molecular markers | IDH1 | SURVIVAL | DEPENDENT PROBE AMPLIFICATION | NUMBER CHANGES | PROGNOSIS | NEWLY-DIAGNOSED GLIOBLASTOMA | MARKERS | CLASSIFICATION | PATHOLOGY | GRADE GLIOMAS | GENETIC ALTERATIONS | Prognosis | Glioma - classification | Humans | Middle Aged | DNA Repair Enzymes - genetics | Male | Glioma - genetics | Chromosomes, Human, Pair 19 - genetics | DNA Methylation | Gene Deletion | Tumor Suppressor Proteins - genetics | Adult | Female | Brain Neoplasms - mortality | Chromosomes, Human, Pair 1 - genetics | Chromosome Deletion | Promoter Regions, Genetic | Glioma - mortality | Kaplan-Meier Estimate | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | DNA Modification Methylases - genetics | Brain Neoplasms - classification | Biomarkers, Tumor - genetics | Mutation | Pathology, Molecular | Age
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 09/2016, Volume 129, Issue 3, pp. 505 - 514
The prognosis of patients with WHO grade III gliomas is highly dependent on their genomic status such as the isocitrate dehydrogenase (IDH) 1/2 mutation...
WHO grade III | 1p/19q | Glioma | Magnetic resonance imaging | IDH | Surgery | SURVIVAL | ANAPLASTIC OLIGODENDROGLIOMAS | GLIOBLASTOMA-MULTIFORME | EUROPEAN ORGANIZATION | CONTRAST ENHANCEMENT | CLINICAL NEUROLOGY | RADIATION-THERAPY | BRAIN-TUMORS | TRIAL | AMPLIFICATION | ONCOLOGY | 2-HYDROXYGLUTARATE | Brain Neoplasms - diagnostic imaging | Humans | Middle Aged | DNA Repair Enzymes - genetics | Male | Brain Neoplasms - surgery | Glioma - genetics | Young Adult | Chromosomes, Human, Pair 19 - genetics | Tumor Suppressor Proteins - genetics | Adult | Female | Retrospective Studies | Brain Neoplasms - mortality | Chromosomes, Human, Pair 1 - genetics | Glioma - surgery | Chromosome Deletion | Glioma - mortality | Tomography Scanners, X-Ray Computed | Kaplan-Meier Estimate | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Mutation - genetics | Magnetic Resonance Imaging | DNA Modification Methylases - genetics | Glioma - diagnostic imaging | Aged | Genetic research | Medical colleges | Care and treatment | Genetic aspects | Gliomas
WHO grade III | 1p/19q | Glioma | Magnetic resonance imaging | IDH | Surgery | SURVIVAL | ANAPLASTIC OLIGODENDROGLIOMAS | GLIOBLASTOMA-MULTIFORME | EUROPEAN ORGANIZATION | CONTRAST ENHANCEMENT | CLINICAL NEUROLOGY | RADIATION-THERAPY | BRAIN-TUMORS | TRIAL | AMPLIFICATION | ONCOLOGY | 2-HYDROXYGLUTARATE | Brain Neoplasms - diagnostic imaging | Humans | Middle Aged | DNA Repair Enzymes - genetics | Male | Brain Neoplasms - surgery | Glioma - genetics | Young Adult | Chromosomes, Human, Pair 19 - genetics | Tumor Suppressor Proteins - genetics | Adult | Female | Retrospective Studies | Brain Neoplasms - mortality | Chromosomes, Human, Pair 1 - genetics | Glioma - surgery | Chromosome Deletion | Glioma - mortality | Tomography Scanners, X-Ray Computed | Kaplan-Meier Estimate | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Mutation - genetics | Magnetic Resonance Imaging | DNA Modification Methylases - genetics | Glioma - diagnostic imaging | Aged | Genetic research | Medical colleges | Care and treatment | Genetic aspects | Gliomas
Journal Article
ANNALS OF NUCLEAR MEDICINE, ISSN 0914-7187, 04/2019, Volume 33, Issue 4, pp. 295 - 302
Objective The role of amino acid positron emission tomography (PET) in glioma grading and outcome prognostication has not yet been well established. This is...
Amino acid PET | Glioma | 1p/19q co-deletion | WHO 2016 | AMINO-ACID PET | IDH mutation | CLASSIFICATION | DOPA | PROGNOSTIC VALUE | TUMORS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PREDICTION
Amino acid PET | Glioma | 1p/19q co-deletion | WHO 2016 | AMINO-ACID PET | IDH mutation | CLASSIFICATION | DOPA | PROGNOSTIC VALUE | TUMORS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PREDICTION
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 11/2018, Volume 140, Issue 2, pp. 297 - 306
To perform radiomics analysis for non-invasively predicting chromosome 1p/19q co-deletion in World Health Organization grade II and III (lower-grade)...
Neurology | Lower-grade glioma | Medicine & Public Health | Magnetic resonance imaging | Prediction | Oncology | 1p/19q Co-deletion | Radiomics | SURVIVAL | MANAGEMENT | GLIOBLASTOMA-MULTIFORME | CLASSIFICATION | 19Q | OLIGODENDROGLIAL TUMORS | CLINICAL NEUROLOGY | TEMOZOLOMIDE | IMPACT | ONCOLOGY | 19q Co-deletion | RADIOTHERAPY | Chromosome Deletion | Area Under Curve | Brain Neoplasms - diagnostic imaging | Humans | Image Interpretation, Computer-Assisted - methods | Middle Aged | Brain Neoplasms - pathology | Brain Neoplasms - genetics | In Situ Hybridization, Fluorescence | Male | Glioma - genetics | Young Adult | Magnetic Resonance Imaging | Chromosomes, Human, Pair 19 | Chromosomes, Human, Pair 1 | Glioma - diagnostic imaging | Neoplasm Grading | Glioma - pathology | Adolescent | Adult | Female | ROC Curve | Aged | Retrospective Studies | Medical research | Algorithms | Gliomas | Genetic research | Medicine, Experimental | Genetic aspects | Glioma | Clonal deletion | Chromosome deletion | Gene deletion | Genotypes | Chromosome 1
Neurology | Lower-grade glioma | Medicine & Public Health | Magnetic resonance imaging | Prediction | Oncology | 1p/19q Co-deletion | Radiomics | SURVIVAL | MANAGEMENT | GLIOBLASTOMA-MULTIFORME | CLASSIFICATION | 19Q | OLIGODENDROGLIAL TUMORS | CLINICAL NEUROLOGY | TEMOZOLOMIDE | IMPACT | ONCOLOGY | 19q Co-deletion | RADIOTHERAPY | Chromosome Deletion | Area Under Curve | Brain Neoplasms - diagnostic imaging | Humans | Image Interpretation, Computer-Assisted - methods | Middle Aged | Brain Neoplasms - pathology | Brain Neoplasms - genetics | In Situ Hybridization, Fluorescence | Male | Glioma - genetics | Young Adult | Magnetic Resonance Imaging | Chromosomes, Human, Pair 19 | Chromosomes, Human, Pair 1 | Glioma - diagnostic imaging | Neoplasm Grading | Glioma - pathology | Adolescent | Adult | Female | ROC Curve | Aged | Retrospective Studies | Medical research | Algorithms | Gliomas | Genetic research | Medicine, Experimental | Genetic aspects | Glioma | Clonal deletion | Chromosome deletion | Gene deletion | Genotypes | Chromosome 1
Journal Article
Annals of Nuclear Medicine, ISSN 0914-7187, 04/2019, Volume 33, Issue 4, pp. 295 - 302
The role of amino acid positron emission tomography (PET) in glioma grading and outcome prognostication has not yet been well established. This is particularly...
IDH mutation | Amino acid PET | Glioma | DOPA | 1p/19q co-deletion | WHO 2016 | Chromosome Deletion | Brain Neoplasms - diagnostic imaging | Humans | Middle Aged | Dihydroxyphenylalanine - analogs & derivatives | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Male | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Positron Emission Tomography Computed Tomography | Chromosomes, Human, Pair 19 - genetics | Dihydroxyphenylalanine - metabolism | Glioma - diagnostic imaging | Biological Transport | Survival Analysis | Female | Chromosomes, Human, Pair 1 - genetics
IDH mutation | Amino acid PET | Glioma | DOPA | 1p/19q co-deletion | WHO 2016 | Chromosome Deletion | Brain Neoplasms - diagnostic imaging | Humans | Middle Aged | Dihydroxyphenylalanine - analogs & derivatives | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Male | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Positron Emission Tomography Computed Tomography | Chromosomes, Human, Pair 19 - genetics | Dihydroxyphenylalanine - metabolism | Glioma - diagnostic imaging | Biological Transport | Survival Analysis | Female | Chromosomes, Human, Pair 1 - genetics
Journal Article
Anticancer research, ISSN 0250-7005, 01/2016, Volume 36, Issue 1, pp. 471 - 476
Background: Anaplastic oligodendrogliomas (AO) are rare tumors. Two phase III clinical trials (RTOG 9402 and EORTC 26951) proved favorable effects of...
prognostic biomarker | predictive biomarker | 1p/19q co-deletion | anaplastic oligodendroglioma | GLIOMAS | GLIOBLASTOMA-MULTIFORME | LOMUSTINE | TUMORS | CHEMOTHERAPY | PHASE-III TRIAL | ADJUVANT PROCARBAZINE | ONCOLOGY | CODON 132 MUTATION | TREATMENT PARADIGM | BRAIN | Biomarkers - metabolism | Chromosome Deletion | Prognosis | Chromosomes, Human, Pair 1 - metabolism | Humans | Male | Brain Neoplasms - drug therapy | Chromosomes, Human, Pair 19 - genetics | Czech Republic | Female | Chromosomes, Human, Pair 1 - genetics | Chromosomes, Human, Pair 19 - metabolism | Oligodendroglioma - drug therapy
prognostic biomarker | predictive biomarker | 1p/19q co-deletion | anaplastic oligodendroglioma | GLIOMAS | GLIOBLASTOMA-MULTIFORME | LOMUSTINE | TUMORS | CHEMOTHERAPY | PHASE-III TRIAL | ADJUVANT PROCARBAZINE | ONCOLOGY | CODON 132 MUTATION | TREATMENT PARADIGM | BRAIN | Biomarkers - metabolism | Chromosome Deletion | Prognosis | Chromosomes, Human, Pair 1 - metabolism | Humans | Male | Brain Neoplasms - drug therapy | Chromosomes, Human, Pair 19 - genetics | Czech Republic | Female | Chromosomes, Human, Pair 1 - genetics | Chromosomes, Human, Pair 19 - metabolism | Oligodendroglioma - drug therapy
Journal Article
Annals of Nuclear Medicine, ISSN 0914-7187, 4/2019, Volume 33, Issue 4, pp. 295 - 302
The role of amino acid positron emission tomography (PET) in glioma grading and outcome prognostication has not yet been well established. This is particularly...
Medicine & Public Health | Amino acid PET | Glioma | 1p/19q co-deletion | WHO 2016 | IDH mutation | Nuclear Medicine | Imaging / Radiology | DOPA | Neuroimaging | Brain | Fingerprints | Brain tumors | Amino acids | Population studies | Gene deletion | Subgroups | Regression models | Clonal deletion | Computed tomography | Neostriatum | Tomography | Deletion | Dihydroxyphenylalanine | Evaluation | Parameters | Phenylalanine | Positron emission | Fluorine isotopes | Regression analysis | Radiation therapy | Patients | Survival | Correlation analysis | Medical prognosis | Mutation | Dopa | Positron emission tomography | Tumors
Medicine & Public Health | Amino acid PET | Glioma | 1p/19q co-deletion | WHO 2016 | IDH mutation | Nuclear Medicine | Imaging / Radiology | DOPA | Neuroimaging | Brain | Fingerprints | Brain tumors | Amino acids | Population studies | Gene deletion | Subgroups | Regression models | Clonal deletion | Computed tomography | Neostriatum | Tomography | Deletion | Dihydroxyphenylalanine | Evaluation | Parameters | Phenylalanine | Positron emission | Fluorine isotopes | Regression analysis | Radiation therapy | Patients | Survival | Correlation analysis | Medical prognosis | Mutation | Dopa | Positron emission tomography | Tumors
Journal Article
World Journal of Surgical Oncology, ISSN 1477-7819, 06/2018, Volume 16, Issue 1, pp. 110 - 6
Background: The response to temozolomide (TMZ) treatment in small-cell lung cancer (SCLC) correlated with O(6)-methylguanine-DNA methyltransferase (MGMT)...
Pulmonary carcinoid | MGMT methylation | Large-cell neuroendocrine carcinoma | 1p/19q co-deletion | SURGERY | MANAGEMENT | RARE | CLASSIFICATION | COMBINATION | TUMORS | CHEMOTHERAPY | TEMOZOLOMIDE | LUNG-CANCER | ONCOLOGY | DNA METHYLTRANSFERASE | EXPERIENCE | Carcinoid Tumor - surgery | Prognosis | Humans | Middle Aged | DNA Repair Enzymes - genetics | Male | Promoter Regions, Genetic - genetics | Chromosomes, Human, Pair 19 - genetics | China | Tumor Suppressor Proteins - genetics | Adult | Female | Carcinoma, Large Cell - genetics | Retrospective Studies | Chromosomes, Human, Pair 1 - genetics | Chromosome Deletion | Lung Neoplasms - genetics | Carcinoma, Neuroendocrine - genetics | Carcinoma, Neuroendocrine - surgery | DNA Methylation - genetics | Disease-Free Survival | DNA Modification Methylases - genetics | Carcinoid Tumor - genetics | Carcinoma, Large Cell - surgery | Lung Neoplasms - surgery | Aged | Cancer patients | Methylation | Health aspects | Analysis | Brain cancer | Lung cancer | Fluorescence | Vertebra | Metastasis | Gene deletion | Cancer therapies | Metastases | O6-methylguanine-DNA methyltransferase | Clonal deletion | Surgery | Fluorescence in situ hybridization | DNA methylation | Deletion | Age | Deoxyribonucleic acid--DNA | Small cell lung carcinoma | Methylguanine | Radiation therapy | Patients | Oligodendroglioma | Chemotherapy | Hospitals | Medical prognosis | Biomarkers | DNA methyltransferase | Fatalities | Mutation | Temozolomide | Tumors
Pulmonary carcinoid | MGMT methylation | Large-cell neuroendocrine carcinoma | 1p/19q co-deletion | SURGERY | MANAGEMENT | RARE | CLASSIFICATION | COMBINATION | TUMORS | CHEMOTHERAPY | TEMOZOLOMIDE | LUNG-CANCER | ONCOLOGY | DNA METHYLTRANSFERASE | EXPERIENCE | Carcinoid Tumor - surgery | Prognosis | Humans | Middle Aged | DNA Repair Enzymes - genetics | Male | Promoter Regions, Genetic - genetics | Chromosomes, Human, Pair 19 - genetics | China | Tumor Suppressor Proteins - genetics | Adult | Female | Carcinoma, Large Cell - genetics | Retrospective Studies | Chromosomes, Human, Pair 1 - genetics | Chromosome Deletion | Lung Neoplasms - genetics | Carcinoma, Neuroendocrine - genetics | Carcinoma, Neuroendocrine - surgery | DNA Methylation - genetics | Disease-Free Survival | DNA Modification Methylases - genetics | Carcinoid Tumor - genetics | Carcinoma, Large Cell - surgery | Lung Neoplasms - surgery | Aged | Cancer patients | Methylation | Health aspects | Analysis | Brain cancer | Lung cancer | Fluorescence | Vertebra | Metastasis | Gene deletion | Cancer therapies | Metastases | O6-methylguanine-DNA methyltransferase | Clonal deletion | Surgery | Fluorescence in situ hybridization | DNA methylation | Deletion | Age | Deoxyribonucleic acid--DNA | Small cell lung carcinoma | Methylguanine | Radiation therapy | Patients | Oligodendroglioma | Chemotherapy | Hospitals | Medical prognosis | Biomarkers | DNA methyltransferase | Fatalities | Mutation | Temozolomide | Tumors
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 2/2018, Volume 136, Issue 3, pp. 523 - 531
In this study we aimed to identify the anatomic features of 1p/19q co-deletion and investigate the predictive values of tumor location and radiological...
Neurology | Oligodendroglial | Medicine & Public Health | 1p/19q | Survival outcome | Radiology | Oncology | Anaplastic | GLIOMAS | LOCATION | GENETIC SIGNATURE | CLINICAL NEUROLOGY | TEMOZOLOMIDE | GRADE II | GLIOBLASTOMA | SPECTROSCOPY | ONCOLOGY | GROWTH | ENHANCEMENT | EPIDEMIOLOGY | Chromosome Deletion | Oligodendroglioma - mortality | Brain - diagnostic imaging | Prognosis | Follow-Up Studies | Oligodendroglioma - genetics | Brain Neoplasms - diagnosis | Humans | Middle Aged | Oligodendroglioma - diagnosis | Brain Neoplasms - genetics | In Situ Hybridization, Fluorescence | Male | Young Adult | Magnetic Resonance Imaging | Chromosomes, Human, Pair 19 | Chromosomes, Human, Pair 1 | Adolescent | Adult | Female | Aged | Retrospective Studies | Brain Neoplasms - mortality | Gliomas | Patient outcomes | Analysis | Brain tumors | Edema | Frontal lobe | Brain cancer | Brain mapping | Data processing | Genomes | Survival | Survival analysis | Glioma | Clonal deletion | Gene mapping | Tumors
Neurology | Oligodendroglial | Medicine & Public Health | 1p/19q | Survival outcome | Radiology | Oncology | Anaplastic | GLIOMAS | LOCATION | GENETIC SIGNATURE | CLINICAL NEUROLOGY | TEMOZOLOMIDE | GRADE II | GLIOBLASTOMA | SPECTROSCOPY | ONCOLOGY | GROWTH | ENHANCEMENT | EPIDEMIOLOGY | Chromosome Deletion | Oligodendroglioma - mortality | Brain - diagnostic imaging | Prognosis | Follow-Up Studies | Oligodendroglioma - genetics | Brain Neoplasms - diagnosis | Humans | Middle Aged | Oligodendroglioma - diagnosis | Brain Neoplasms - genetics | In Situ Hybridization, Fluorescence | Male | Young Adult | Magnetic Resonance Imaging | Chromosomes, Human, Pair 19 | Chromosomes, Human, Pair 1 | Adolescent | Adult | Female | Aged | Retrospective Studies | Brain Neoplasms - mortality | Gliomas | Patient outcomes | Analysis | Brain tumors | Edema | Frontal lobe | Brain cancer | Brain mapping | Data processing | Genomes | Survival | Survival analysis | Glioma | Clonal deletion | Gene mapping | Tumors
Journal Article
ACTA NEUROPATHOLOGICA COMMUNICATIONS, ISSN 2051-5960, 06/2018, Volume 6, Issue 1, pp. 49 - 15
Oligodendrogliomas are primary human brain tumors with a characteristic 1p/19q co-deletion of important prognostic relevance, but little is known about the...
Network biology | Network inference | GLIOMA | Network propagation | Computational systems biology | CELL-PROLIFERATION | NEUROSCIENCES | Cancer genomics | BREAST-CANCER | INVASION | 1p/19q co-deletion | ZINC-FINGER PROTEIN | TUMOR-SUPPRESSOR | CENTRAL-NERVOUS-SYSTEM | HYPERMETHYLATOR PHENOTYPE | MUTATIONS | Bioinformatics | GLIOBLASTOMA CELLS | Oligodendrogliomas | Chromosome Deletion | Oligodendroglioma - genetics | Humans | Computational Biology | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Male | Gene Dosage | Signal Transduction - genetics | Mutation - genetics | Neoplasm Proteins - metabolism | Vesicular Glutamate Transport Protein 1 - genetics | Chromosomes, Human, Pair 19 - genetics | Metabolic Networks and Pathways - genetics | Succinate Dehydrogenase - genetics | Female | Chromosomes, Human, Pair 1 - genetics | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Epigenetic inheritance | Gene mutations | Gliomas | Analysis | Genes | Brain tumors | Genetic research | Kallikrein | Development and progression | Genetic aspects | Gene expression | Cancer | Proteins | Propagation | Brain cancer | Genomes | Mutation | Metabolism | Tumors
Network biology | Network inference | GLIOMA | Network propagation | Computational systems biology | CELL-PROLIFERATION | NEUROSCIENCES | Cancer genomics | BREAST-CANCER | INVASION | 1p/19q co-deletion | ZINC-FINGER PROTEIN | TUMOR-SUPPRESSOR | CENTRAL-NERVOUS-SYSTEM | HYPERMETHYLATOR PHENOTYPE | MUTATIONS | Bioinformatics | GLIOBLASTOMA CELLS | Oligodendrogliomas | Chromosome Deletion | Oligodendroglioma - genetics | Humans | Computational Biology | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Male | Gene Dosage | Signal Transduction - genetics | Mutation - genetics | Neoplasm Proteins - metabolism | Vesicular Glutamate Transport Protein 1 - genetics | Chromosomes, Human, Pair 19 - genetics | Metabolic Networks and Pathways - genetics | Succinate Dehydrogenase - genetics | Female | Chromosomes, Human, Pair 1 - genetics | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Epigenetic inheritance | Gene mutations | Gliomas | Analysis | Genes | Brain tumors | Genetic research | Kallikrein | Development and progression | Genetic aspects | Gene expression | Cancer | Proteins | Propagation | Brain cancer | Genomes | Mutation | Metabolism | Tumors
Journal Article
Cancer Management and Research, ISSN 1179-1322, 2019, Volume 11, pp. 4971 - 4984
The chr1p/19q co-deletion is a favorable prognostic factor in patients with lower grade glioma. The aim of this study was to reveal key genes for prognosis and...
Prognostic signature | Lower grade glioma | 1p/19q co-deletion | Rbsurv | rbsurv | prognostic signature
Prognostic signature | Lower grade glioma | 1p/19q co-deletion | Rbsurv | rbsurv | prognostic signature
Journal Article
Brain Tumor Pathology, ISSN 1433-7398, 7/2012, Volume 29, Issue 3, pp. 148 - 153
Recent developments in molecular analysis have revealed genetic alterations in human gliomas. Loss of heterozygosity (LOH) is a critical molecular marker for...
Pathology | Medicine & Public Health | Diagnostic Radiology | 1p/19q co-deletion | IDH1/2 | Glioblastoma | Oncology | Neurosurgery | OLIG2 | Surgical Oncology | Neuroradiology | Oligodendroglioma | Olig2 | GLIOMAS | SURVIVAL | co-deletion | ANAPLASTIC OLIGODENDROGLIOMAS | 1p/19q | PROGNOSIS | IDH1 | 19Q | PATHOLOGY | CLINICAL NEUROLOGY | BRAIN-TUMORS | PHASE-III TRIAL | ONCOLOGY | GRADE | Receptor, Epidermal Growth Factor - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Humans | Transcriptome | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Oligodendrocyte Transcription Factor 2 | Loss of Heterozygosity | Nerve Tissue Proteins - genetics | Chromosomes, Human, Pair 19 - genetics | Glioblastoma - genetics | Gene Deletion | Chromosomes, Human, Pair 1 - genetics | Real-Time Polymerase Chain Reaction | oligodendroglioma | Epidermal growth factor receptors | Brain tumors | Olig2 protein | Gene deletion | Gene expression | Reviews | Glioma | chromosome 10 | Classification | Loss of heterozygosity | Point mutation | Isocitrate dehydrogenase
Pathology | Medicine & Public Health | Diagnostic Radiology | 1p/19q co-deletion | IDH1/2 | Glioblastoma | Oncology | Neurosurgery | OLIG2 | Surgical Oncology | Neuroradiology | Oligodendroglioma | Olig2 | GLIOMAS | SURVIVAL | co-deletion | ANAPLASTIC OLIGODENDROGLIOMAS | 1p/19q | PROGNOSIS | IDH1 | 19Q | PATHOLOGY | CLINICAL NEUROLOGY | BRAIN-TUMORS | PHASE-III TRIAL | ONCOLOGY | GRADE | Receptor, Epidermal Growth Factor - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Humans | Transcriptome | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Oligodendrocyte Transcription Factor 2 | Loss of Heterozygosity | Nerve Tissue Proteins - genetics | Chromosomes, Human, Pair 19 - genetics | Glioblastoma - genetics | Gene Deletion | Chromosomes, Human, Pair 1 - genetics | Real-Time Polymerase Chain Reaction | oligodendroglioma | Epidermal growth factor receptors | Brain tumors | Olig2 protein | Gene deletion | Gene expression | Reviews | Glioma | chromosome 10 | Classification | Loss of heterozygosity | Point mutation | Isocitrate dehydrogenase
Journal Article
Interdisciplinary Neurosurgery, ISSN 2214-7519, 2016, Volume 5, Issue C, pp. 58 - 63
Abstract Background The impact of chromosomal 1p/19q co-deletion on the prognosis of oligodendrogliomas has been measured in many studies previously. However...
Medical Education | Neurosurgery | Overall survival | Chromosomal 1p/19q co-deletion | Hazard ratio | Standardized mean difference | Progression free survival | Oligodendroglioma
Medical Education | Neurosurgery | Overall survival | Chromosomal 1p/19q co-deletion | Hazard ratio | Standardized mean difference | Progression free survival | Oligodendroglioma
Journal Article
Neuro-Oncology, ISSN 1522-8517, 01/2018, Volume 20, Issue 2, pp. 279 - 288
Journal Article
British Journal of Neurosurgery, ISSN 0268-8697, 09/2019, Volume 33, Issue 5, pp. 536 - 540
Purpose: The 2016 WHO tumour classification highlights the role of IDH1/2 gene mutation and 1p/19q co-deletion in classifying grade II/III gliomas. A recent...
grade II/III glioma | 1p/19q co-deletion | ATRX
grade II/III glioma | 1p/19q co-deletion | ATRX
Journal Article
17.
Static and dynamic F-18-FET PET for the characterization of gliomas defined by IDH and 1p/19q status
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, ISSN 1619-7070, 03/2018, Volume 45, Issue 3, pp. 443 - 451
Purpose The molecular features isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion have gained major importance for both glioma typing and prognosis...
SURVIVAL | MRI | RESPONSE ASSESSMENT | IDH mutation | CLASSIFICATION | PROGNOSTIC VALUE | TUMORS | PROCARBAZINE | O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET | GRADE II | Glioma | 1p/19q co-deletion | FET pet | VINCRISTINE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
SURVIVAL | MRI | RESPONSE ASSESSMENT | IDH mutation | CLASSIFICATION | PROGNOSTIC VALUE | TUMORS | PROCARBAZINE | O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET | GRADE II | Glioma | 1p/19q co-deletion | FET pet | VINCRISTINE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 5/2015, Volume 129, Issue 5, pp. 679 - 693
Cerebral gliomas of World Health Organization (WHO) grade II and III represent a major challenge in terms of histological classification and clinical...
Pathology | Neurosciences | Medicine & Public Health | 1p/19q co-deletion | Gene expression profiles | Array-based comparative genomic hybridization | Isocitrate dehydrogenase | Astrocytoma | Integrative bioinformatics | Oligodendroglioma | MGMT PROMOTER METHYLATION | ASTROCYTIC TUMORS | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | FREQUENT ATRX | PHASE-III TRIAL | ADJUVANT PROCARBAZINE | GLIOBLASTOMA | ANAPLASTIC OLIGODENDROGLIOMA | GENE-EXPRESSION | MALIGNANT GLIOMAS | IDH1 MUTATION | Promoter Regions, Genetic | Sequence Deletion | Prognosis | World Health Organization | Glioma - classification | Neoplasm Grading - methods | Humans | Middle Aged | Brain Neoplasms - genetics | Gene Expression Profiling - methods | Isocitrate Dehydrogenase - genetics | Male | Glioma - genetics | Young Adult | Glioma - pathology | Aged, 80 and over | Adult | Female | Aged | Glioma - physiopathology | Mutation | Genomics - methods | Gliomas | Analysis | Genomics | Genomes | Genetic aspects | Gene expression | Telomerase | Cancer
Pathology | Neurosciences | Medicine & Public Health | 1p/19q co-deletion | Gene expression profiles | Array-based comparative genomic hybridization | Isocitrate dehydrogenase | Astrocytoma | Integrative bioinformatics | Oligodendroglioma | MGMT PROMOTER METHYLATION | ASTROCYTIC TUMORS | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | FREQUENT ATRX | PHASE-III TRIAL | ADJUVANT PROCARBAZINE | GLIOBLASTOMA | ANAPLASTIC OLIGODENDROGLIOMA | GENE-EXPRESSION | MALIGNANT GLIOMAS | IDH1 MUTATION | Promoter Regions, Genetic | Sequence Deletion | Prognosis | World Health Organization | Glioma - classification | Neoplasm Grading - methods | Humans | Middle Aged | Brain Neoplasms - genetics | Gene Expression Profiling - methods | Isocitrate Dehydrogenase - genetics | Male | Glioma - genetics | Young Adult | Glioma - pathology | Aged, 80 and over | Adult | Female | Aged | Glioma - physiopathology | Mutation | Genomics - methods | Gliomas | Analysis | Genomics | Genomes | Genetic aspects | Gene expression | Telomerase | Cancer
Journal Article