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Journal Article
Journal Article
ChemMedChem, ISSN 1860-7179, 03/2019, Volume 14, Issue 5, p. 545
Herein we present the design, synthesis, and biological evaluation of potent and highly selective [beta]-secretase 2 (memapsin 1, beta-site amyloid precursor... 
Type 2 diabetes | Benzene | Analysis | Amyloid beta-protein
Journal Article
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 06/2012, Volume 23, Issue 12, pp. 2339 - 2351
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2012, Volume 22, Issue 17, pp. 5460 - 5465
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2011, Volume 31, Issue 44, pp. 15751 - 15756
Alzheimer's disease (AD) is the most common cause of dementia, and is characterized by memory loss and cognitive decline, as well as amyloid beta (A beta)... 
NEURONAL CELL-CYCLE | CDK5 ACTIVATION | NEUROTRANSMITTER RELEASE | ALZHEIMERS-DISEASE | MEMORY DEFICITS | MOUSE MODEL | IN-VIVO | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | CYCLIN-DEPENDENT KINASE-5 | BRAIN | Enzyme-Linked Immunosorbent Assay - methods | Memory Disorders - metabolism | tau Proteins - metabolism | Green Fluorescent Proteins - genetics | Synapses - genetics | Phosphorylation - genetics | Cell Death - genetics | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Prosencephalon - metabolism | Electric Stimulation - methods | Phosphotransferases | Disease Models, Animal | Prosencephalon - pathology | Synaptophysin - metabolism | Peptide Fragments - metabolism | Neurodegenerative Diseases - pathology | Gene Expression Regulation - genetics | Synapses - physiology | Mice, Transgenic | Hippocampus - pathology | Long-Term Potentiation - genetics | Avoidance Learning - physiology | Biophysics | Functional Laterality | Nerve Tissue Proteins - genetics | Neurodegenerative Diseases - complications | Cyclin-Dependent Kinase 5 - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Nerve Tissue Proteins - metabolism | Patch-Clamp Techniques | Animals | Memory Disorders - etiology | Analysis of Variance | Memory Disorders - therapy | Amyloid Precursor Protein Secretases - deficiency | Freezing Reaction, Cataleptic - physiology | Mice | Aspartic Acid Endopeptidases - deficiency | In Vitro Techniques | Brief Communications
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2008, Volume 18, Issue 3, pp. 1031 - 1036
Journal Article
BMC Neuroscience, ISSN 1471-2202, 12/2011, Volume 12, Issue 1, pp. 125 - 125
Background: Berberine (BER), the major alkaloidal component of Rhizoma coptidis, has multiple pharmacological effects including inhibition of... 
Beta-amyloid40/42 | Berberine | Extracellular signal-regulated kinase1/2 | Beta-secretase | Alzheimer's disease | CANCER-CELLS | extracellular signal-regulated kinase1/2 | ALZHEIMERS-DISEASE | NEUROSCIENCES | RAT MODEL | berberine | IN-VITRO | MECHANISM DISTINCT | beta-secretase | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | GLUCOSE-METABOLISM | NITRIC-OXIDE | beta-amyloid(40/42) | PRECURSOR PROTEIN | COPTIDIS-RHIZOMA | Amyloid Precursor Protein Secretases - genetics | Butadienes - pharmacology | Nitriles - pharmacology | Amyloid beta-Peptides - biosynthesis | Humans | Alzheimer Disease - drug therapy | Butadienes - antagonists & inhibitors | Down-Regulation - drug effects | Peptide Fragments - biosynthesis | Down-Regulation - physiology | Berberine - pharmacology | Amyloid beta-Peptides - antagonists & inhibitors | Amyloid beta-Protein Precursor - genetics | Neuroprotective Agents - pharmacology | Time Factors | Peptide Fragments - antagonists & inhibitors | Alzheimer Disease - metabolism | HEK293 Cells | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Nitriles - antagonists & inhibitors | Amyloid beta-Protein Precursor - antagonists & inhibitors | Glucose metabolism | Glucose | Cholesterol | Dextrose | Amyloid beta-protein | Neurology | Hospitals | Rodents | Nitric oxide | Colleges & universities | Cytotoxicity | Insulin resistance | Life sciences | Insulin | Polyclonal antibodies | beta-amyloid40/42
Journal Article
ChemMedChem, ISSN 1860-7179, 03/2019, Volume 14, Issue 5, pp. 545 - 560
Journal Article
Journal Article
Protein Science, ISSN 0961-8368, 11/2010, Volume 19, Issue 11, pp. 2175 - 2185
Journal Article