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2‐hydroxyglutarate (27) 27
life sciences & biomedicine (25) 25
science & technology (25) 25
humans (22) 22
2-hydroxyglutarate (21) 21
isocitrate dehydrogenase (19) 19
isocitrate dehydrogenase - genetics (16) 16
mutation (16) 16
glioma (14) 14
gliomas (14) 14
brain tumors (11) 11
oncology (11) 11
female (10) 10
adult (9) 9
glioma - genetics (9) 9
glutarates - metabolism (9) 9
middle aged (9) 9
tumors (9) 9
male (8) 8
metabolites (8) 8
glutarates - blood (7) 7
aged (6) 6
brain neoplasms - genetics (6) 6
brain neoplasms - metabolism (6) 6
dehydrogenases (6) 6
metabolism (6) 6
1h mrs (5) 5
dehydrogenase (5) 5
glioma - metabolism (5) 5
glioma - pathology (5) 5
idh1 (5) 5
in vivo methods and tests (5) 5
magnetic resonance spectroscopy (5) 5
mass spectrometry (5) 5
mutation - genetics (5) 5
neurosciences & neurology (5) 5
patients (5) 5
radiology, nuclear medicine & medical imaging (5) 5
spectrum analysis (5) 5
young adult (5) 5
algorithms (4) 4
brain neoplasms - pathology (4) 4
cancer (4) 4
data processing (4) 4
glutarates - urine (4) 4
h mrs (4) 4
idh2 (4) 4
isocitrate dehydrogenase - metabolism (4) 4
neurosciences (4) 4
aged, 80 and over (3) 3
biochemistry & molecular biology (3) 3
biomarkers (3) 3
biomarkers, tumor - blood (3) 3
brain cancer (3) 3
choline (3) 3
chromatography, liquid (3) 3
clinical neurology (3) 3
genes (3) 3
genotype (3) 3
glioma - blood (3) 3
human brain tumor (3) 3
lower bounds (3) 3
magnetic resonance (3) 3
magnetic resonance imaging (3) 3
neuro-oncology (3) 3
nuclear magnetic resonance spectroscopy (3) 3
pathology (3) 3
prognosis (3) 3
spectra (3) 3
spectroscopy (3) 3
abridged index medicus (2) 2
animals (2) 2
biomarkers, tumor - metabolism (2) 2
biomarkers, tumor - urine (2) 2
brain (2) 2
cell biology (2) 2
child (2) 2
dna mutational analysis (2) 2
dual-readout alternated-gradients epsi (2) 2
dual‐readout alternated‐gradients epsi (2) 2
echo-planar spectroscopy imaging (2) 2
echo‐planar spectroscopy imaging (2) 2
eddy currents (2) 2
enzymes (2) 2
epigenetics (2) 2
follow-up studies (2) 2
gaba (2) 2
glioblastoma (2) 2
glioma - enzymology (2) 2
glioma - urine (2) 2
glutamate (2) 2
glutamine (2) 2
hematology (2) 2
idh (2) 2
idh mutation (2) 2
immunohistochemistry (2) 2
leukemia, myeloid, acute - blood (2) 2
magnetic resonance spectroscopy - methods (2) 2
mass spectroscopy (2) 2
mega‐press (2) 2
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1. Full Text Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad‐Based Tumor Genotyping
by Borger, Darrell R and Tanabe, Kenneth K and Fan, Kenneth C and Lopez, Hector U and Fantin, Valeria R and Straley, Kimberly S and Schenkein, David P and Hezel, Aram F and Ancukiewicz, Marek and Liebman, Hannah M and Kwak, Eunice L and Clark, Jeffrey W and Ryan, David P and Deshpande, Vikram and Dias‐Santagata, Dora and Ellisen, Leif W and Zhu, Andrew X and Iafrate, A. John
The oncologist (Dayton, Ohio), ISSN 1083-7159, 01/2012, Volume 17, Issue 1, pp. 72 - 79
2‐Hydroxyglutarate | Mutation | Biliary tract cancer | IDH1 | Cholangiocarcinoma | IDH2 | 2-Hydroxyglutarate | Life Sciences & Biomedicine | Oncology | Science & Technology | Bile Ducts, Intrahepatic - pathology | Humans | Middle Aged | Gallbladder Neoplasms - genetics | Genotype | Isocitrate Dehydrogenase - genetics | Male | Bile Duct Neoplasms - enzymology | Young Adult | Gallbladder Neoplasms - enzymology | Adolescent | Cholangiocarcinoma - genetics | Adult | Female | Isocitrate Dehydrogenase - metabolism | Bile Duct Neoplasms - genetics | Child | Cholangiocarcinoma - enzymology | Index Medicus | Hepatobiliary
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2. Full Text The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
by Claridge, Timothy D W and Yang, Ming and Rose, Nathan R and Clifton, Ian J and King, Oliver N and Leung, Ivanhoe K H and Ratcliffe, Peter J and Kawamura, Akane and Hillringhaus, Lars and Woon, Esther C Y and Li, Xuan S and Yeoh, Kar Kheng and McDonough, Michael A and Schofield, Christopher J and Chowdhury, Rasheduzzaman and Bagg, Eleanor A and Klose, Robert J and Tian, Ya-Min
EMBO reports, ISSN 1469-221X, 05/2011, Volume 12, Issue 5, pp. 463 - 469
oxygenases | hypoxia‐inducible factor | isocitrate dehydrogenase | 2‐hydroxyglutarate | 2‐oxoglutarate | 2-oxoglutarate | 2-hydroxyglutarate | hypoxia-inducible factor | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Repressor Proteins - chemistry | Histone Demethylases - antagonists & inhibitors | Magnetic Resonance Spectroscopy | Humans | Models, Molecular | Neoplasms - enzymology | Isocitrate Dehydrogenase - genetics | Mutation - genetics | Crystallography | Repressor Proteins - antagonists & inhibitors | Mixed Function Oxygenases | Neoplasms - genetics | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Mass Spectrometry | Cell Line, Tumor | Inhibitory Concentration 50 | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Isocitrate Dehydrogenase - metabolism | Signal Transduction - physiology | Glutarates - metabolism | Chemical reactions | Index Medicus | Scientific Reports
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3. Full Text Isocitrate dehydrogenase‐mutant glioma: Evolving clinical and therapeutic implications
by Miller, Julie J and Shih, Helen A and Andronesi, Ovidiu C and Cahill, Daniel P
Cancer, ISSN 0008-543X, 12/2017, Volume 123, Issue 23, pp. 4535 - 4546
neuro‐oncology | glioblastoma | isocitrate dehydrogenase | 2‐hydroxyglutarate | radiotherapy | glioma | IDH | neuro-oncology | 2-hydroxyglutarate | Life Sciences & Biomedicine | Oncology | Science & Technology | Glioma - genetics | Isocitrate Dehydrogenase - genetics | Mutation | Glioma - diagnosis | Humans | Glioma - therapy | Care and treatment | Research | Gene mutations | Gliomas | Isocitrate dehydrogenase | Dehydrogenases | p53 Protein | Brain tumors | Genes | Biological evolution | Glioblastoma | Thalassemia | Metabolism | Dehydrogenase | Alterations | Glioma | Quality | Classification | Tumor suppressor genes | Tumors | Cancer | Index Medicus | Abridged Index Medicus
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4. Full Text Oncometabolite L‐2‐hydroxyglurate directly induces vasculogenic mimicry through PHLDB2 in renal cell carcinoma
by Wang, Huan and Wang, Liya and Zheng, Qiming and Lu, Zeyi and Chen, Yuanlei and Shen, Danyang and Xue, Dingwei and Jiang, Minxiao and Ding, Lifeng and Zhang, Jie and Wu, Haiyang and Xia, Liqun and Qian, Jun and Li, Gonghui and Lu, Jieyang
International journal of cancer, ISSN 0020-7136, 04/2021, Volume 148, Issue 7, pp. 1743 - 1755
renal cell carcinoma | oncometabolite | 2‐hydroxyglutarate | vasculogenic mimicry | epigenetics | Life Sciences & Biomedicine | Oncology | Science & Technology | Demethylation | Renal cell carcinoma | Kidney cancer | Histones | Extracellular signal-regulated kinase | Epigenetics | Tumor cell lines | Metabolism | Mimicry | Index Medicus
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5. Full Text Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
by Pope, Whitney B and Pope, Whitney B and Prins, Robert M and Prins, Robert M and Albert Thomas, M and Albert Thomas, M and Nagarajan, Rajakumar and Nagarajan, Rajakumar and Yen, Katharine E and Yen, Katharine E and Bittinger, Mark A and Bittinger, Mark A and Salamon, Noriko and Salamon, Noriko and Chou, Arthur P and Chou, Arthur P and Yong, William H and Yong, William H and Soto, Horacio and Soto, Horacio and Wilson, Neil and Wilson, Neil and Driggers, Edward and Driggers, Edward and Jang, Hyun G and Jang, Hyun G and Su, Shinsan M and Su, Shinsan M and Schenkein, David P and Schenkein, David P and Lai, Albert and Lai, Albert and Cloughesy, Timothy F and Cloughesy, Timothy F and Kornblum, Harley I and Kornblum, Harley I and Wu, Hong and Wu, Hong and Fantin, Valeria R and Fantin, Valeria R and Liau, Linda M and Liau, Linda M
Journal of neuro-oncology, ISSN 0167-594X, 3/2012, Volume 107, Issue 1, pp. 197 - 205
Magnetic resonance spectroscopy | Brain tumor | Neurology | Medicine & Public Health | Glioma | LC-Model | 2 hydroxyglutarate (2-HG) | Oncology | Isocitrate dehydrogenase | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Brain Neoplasms - pathology | Male | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Young Adult | Glioma - pathology | Mass Spectrometry | Polymerase Chain Reaction | Aged, 80 and over | Biomarkers, Tumor - metabolism | Chromatography, Liquid | Adult | Female | Magnetic Resonance Spectroscopy | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Mutation - genetics | Magnetic Resonance Imaging | Aged | Glutarates - metabolism | DNA, Neoplasm - genetics | Immunohistochemistry | Medical colleges | Enzymes | Metabolites | Gliomas | Brain tumors | DNA | Choline | Genes | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Index Medicus | Protons | software | biomarkers | Data processing | Computer programs | Spectrometry | Magnetic resonance imaging | Surgery | genomics | Mutation | Glutathione
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6. Full Text In vivo 1H MRS detection of cystathionine in human brain tumors
by Branzoli, Francesca and Deelchand, Dinesh K and Sanson, Marc and Lehéricy, Stéphane and Marjańska, Małgorzata
Magnetic resonance in medicine, ISSN 0740-3194, 10/2019, Volume 82, Issue 4, pp. 1259 - 1265
brain glioma | 2‐hydroxyglutarate | MEGA‐PRESS | cystathionine | editing | Brain | Nuclear magnetic resonance spectroscopy | Gliomas | Brain tumors | Spectroscopy | Nuclear magnetic resonance--NMR | Brain cancer | Editing | Spectra | Metabolism | Organic chemistry | Glioma | Spectrum analysis | In vivo methods and tests | Isocitrate dehydrogenase | MEGA-PRESS | 2-hydroxyglutarate
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7. Full Text Preoperative Determination of Isocitrate Dehydrogenase Mutation in Gliomas Using Spectral Editing MRS: A Prospective Study
by Nguyen, Thanh B and Melkus, Gerd and Taccone, Michael and Moldovan, Ioana D and Ghinda, Diana and Gotfrit, Ryan and Torres, Carlos H and Zakhari, Nader and Chakraborty, Santanu and Woulfe, John and Jansen, Gerard and McInnes, Matthew DF and Thornhill, Rebecca E and Cameron, Ian and AlKherayf, Fahad
Journal of magnetic resonance imaging, ISSN 1053-1807, 02/2021, Volume 53, Issue 2, pp. 416 - 426
isocitrate dehydrogenase | gliomas | 2‐hydroxyglutarate | MEGA‐PRESS | MR spectroscopy | Immunohistochemistry | Neuroimaging | Amplitudes | Dehydrogenases | Brain tumors | Brain cancer | Population studies | Creatine | Dehydrogenase | Gene sequencing | Magnetic resonance spectroscopy | Confidence intervals | Isocitrate dehydrogenase | Deoxyribonucleic acid--DNA | Evaluation | Statistical analysis | Magnetic resonance | Phosphocreatine | Statistical tests | Mutants | Field strength | Lower bounds | Sensitivity | Choline | In vivo methods and tests | Diagnostic systems | Mutation | DNA sequencing | Index Medicus
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8. Full Text In vivo detection of 2‐hydroxyglutarate in brain tumors by optimized point‐resolved spectroscopy (PRESS) at 7T
by Ganji, Sandeep K and An, Zhongxu and Tiwari, Vivek and McNeil, Sarah and Pinho, Marco C and Pan, Edward and Mickey, Bruce E and Maher, Elizabeth A and Choi, Changho
Magnetic resonance in medicine, ISSN 0740-3194, 03/2017, Volume 77, Issue 3, pp. 936 - 944
7T, PRESS (point‐resolved spectroscopy) | 2‐hydroxyglutarate (2HG) | gliomas | 1H MRS | human brain tumors | IDH (isocitrate dehydrogenase) | H MRS | 7T, PRESS (point-resolved spectroscopy) | 2-hydroxyglutarate (2HG) | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Brain - metabolism | Reproducibility of Results | Algorithms | Magnetic Resonance Spectroscopy - methods | Humans | Sensitivity and Specificity | Brain Neoplasms - pathology | Biomarkers, Tumor - metabolism | Brain - pathology | Signal Processing, Computer-Assisted | Glutarates - metabolism | Brain Neoplasms - metabolism | Metabolites | Gliomas | Spectrum analysis | Brain tumors | GABA | Glutamate | Glutamine | Index Medicus
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9. Full Text In vivo MRS measurement of 2‐hydroxyglutarate in patient‐derived IDH‐mutant xenograft mouse models versus glioma patients
by Tiwari, Vivek and Mashimo, Tomoyuki and An, Zhongxu and Vemireddy, Vamsidhara and Piccirillo, Sara and Askari, Pegah and Hulsey, Keith M and Zhang, Shanrong and Graaf, Robin A and Patel, Toral R and Pan, Edward and Mickey, Bruce E and Maher, Elizabeth A and Bachoo, Robert M and Choi, Changho
Magnetic resonance in medicine, ISSN 0740-3194, 09/2020, Volume 84, Issue 3, pp. 1152 - 1160
point‐resolved spectroscopy | 2HG | mouse | isocitrate dehydrogenase | patient‐derived xenograft | 1H magnetic resonance spectroscopy | 2‐hydroxyglutarate | PDX | IDH mutation | gliomas | PRESS | MRS | point-resolved spectroscopy | patient-derived xenograft | H magnetic resonance spectroscopy | 2-hydroxyglutarate | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Animal models | Computer simulation | Brain tumors | Xenotransplantation | Metabolism | Patients | Mutants | Glioma | Metabolites | Xenografts | Biocompatibility | In vivo methods and tests | Mutation | Isocitrate dehydrogenase | Tumors | Index Medicus
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10. Full Text 2‐Hydroxyglutarate concentration in serum from patients with gliomas does not correlate with IDH1/2 mutation status or tumor size
by Capper, David and Simon, Matthias and Langhans, Claus‐Dieter and Okun, Jürgen G and Tonn, Jörg C and Weller, Michael and Deimling, Andreas von and Hartmann, Christian and German Glioma Network and for the German Glioma Network
International journal of cancer, ISSN 0020-7136, 08/2012, Volume 131, Issue 3, pp. 766 - 768
glioma | serum | 2‐hydroxyglutarate | IDH1 | 2-hydroxyglutarate | Life Sciences & Biomedicine | Oncology | Science & Technology | Neurology | Biological and medical sciences | Medical sciences | Tumors of the nervous system. Phacomatoses | Tumors | Humans | Middle Aged | Brain Neoplasms - pathology | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Male | Glutarates - blood | Biomarkers, Tumor - blood | Glioma - genetics | Young Adult | Magnetic Resonance Imaging | Glioma - blood | Neoplasm Grading | Glioma - pathology | Brain Neoplasms - blood | Adult | Female | Aged | Mutation | Cancer | Index Medicus
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