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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2016, Volume 113, Issue 8, pp. 2241 - 2246
The 2′,5′-oligoadenylate (2-5A) synthetase (OAS)–RNase L system is an IFN-induced antiviral pathway. RNase L activity depends on 2-5A, synthesized by OAS.... 
2-5A | Oligoadenylate synthetase 3 | Antiviral response | Type I interferon | Ribonuclease L | ENCEPHALOMYOCARDITIS VIRUS | L PATHWAY | HUMAN 2',5'-OLIGOADENYLATE SYNTHETASE | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | HUMAN OLIGOADENYLATE SYNTHETASE | CRISPR-CAS9 SYSTEM | RIG-I | oligoadenylate synthetase 3 | VACCINIA VIRUS | antiviral response | type I interferon | MURINE CORONAVIRUS | ribonuclease L | ANTIVIRAL ACTIVITY | Endoribonucleases - genetics | Humans | 2',5'-Oligoadenylate Synthetase - antagonists & inhibitors | Endoribonucleases - antagonists & inhibitors | RNA, Ribosomal - genetics | Alphavirus Infections - genetics | Sindbis Virus | RNA, Viral - genetics | Alphavirus Infections - metabolism | RNA, Viral - metabolism | Virus Diseases - genetics | Vaccinia - metabolism | 2',5'-Oligoadenylate Synthetase - metabolism | Cell Line | Influenza, Human - metabolism | West Nile Fever - genetics | Endoribonucleases - metabolism | RNA, Ribosomal - metabolism | West Nile Fever - metabolism | Virus Diseases - metabolism | Gene Knockout Techniques | Vaccinia - genetics | 2',5'-Oligoadenylate Synthetase - genetics | Models, Biological | Influenza, Human - genetics | CRISPR-Cas Systems | Enzyme Activation | Genetic aspects | Interferon | Host-virus relationships | Gene expression | Observations | Health aspects | RNA polymerases | Biological Sciences
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 04/2013, Volume 14, Issue 4, pp. 346 - 355
The production of type I interferon is essential for viral clearance but is kept under tight control to avoid unnecessary tissue damage from hyperinflammatory... 
PLASMACYTOID DENDRITIC CELLS | SYNTHETASE GENE FAMILY | ANTIVIRAL RESPONSE | DOUBLE-STRANDED-RNA | ACTIVATION | IMMUNE-SYSTEM | 2',5'-OLIGOADENYLATE SYNTHETASE | 2'-5'-OLIGOADENYLATE SYNTHETASE | IMMUNOLOGY | NF-KAPPA-B | PATTERN-RECOGNITION RECEPTORS | Protein Biosynthesis | Poly I-C - administration & dosage | Humans | Molecular Sequence Data | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | RNA, Messenger - metabolism | Interferon Type I - biosynthesis | Base Sequence | Bone Marrow Cells - immunology | Protein Interaction Domains and Motifs | Nucleic Acid Conformation | Virus Diseases - genetics | Macrophages - immunology | 2',5'-Oligoadenylate Synthetase - metabolism | Cell Line | Poly I-C - pharmacology | Virus Diseases - immunology | Gene Expression Regulation | Encephalomyocarditis virus - immunology | Interferon Regulatory Factor-7 - metabolism | 2',5'-Oligoadenylate Synthetase - genetics | Mice, Knockout | Homozygote | Macrophages - metabolism | Animals | 5' Untranslated Regions | Protein Binding | Mice | Interferon Inducers - administration & dosage | Bone Marrow Cells - metabolism | Interferon Inducers - pharmacology | Virus diseases | Care and treatment | Immune response | Primers (Molecular genetics) | Ligases | Physiological aspects | Interferon | Genetic aspects | Research | Properties | Genetic translation
Journal Article