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BBA - Proteins and Proteomics, ISSN 1570-9639, 01/2020, Volume 1868, Issue 1, p. 140247
Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) have an independent origin; however, they have distinctly evolved to catalyze the same... 
Molecular evolution | Indoleamine 2,3-dioxygenase | Tryptophan 2,3-dioxygenase | Allosteric regulation | Enzyme kinetics
Journal Article
Experimental Gerontology, ISSN 0531-5565, 01/2020, Volume 129, p. 110770
The essential amino acid L-tryptophan (Trp) appears to play an important role in aging by acting as a general regulator of protein homeostasis. The major route... 
Aging | Indoleamine 2,3-dioxygenase | Kynurenine pathway enzymes | Tryptophan 2,3-dioxygenase | Tryptophan binding | Plasma free tryptophan
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2018, Volume 157, pp. 423 - 436
Indoleamine 2,3-dioxygenase 1 (IDO1) mediated kynurenine pathway of tryptophan degradation is identified as an appealing and novel target in immunotherapy for... 
Naphthoquinone derivatives | Tryptophan 2,3-dioxygenase | Cancer immunotherapy | Indoleamine 2,3-dioxygenase 1 | KYNURENINE | CATABOLISM | CHEMISTRY, MEDICINAL | TOLERANCE | INDOLEAMINE 2,3-DIOXYGENASE | IMMUNE ESCAPE | ANTICANCER | ARYL-HYDROCARBON RECEPTOR | EXPRESSION | T-CELLS | Tryptophan | Derivatives (Financial instruments) | Analysis | Immunotherapy
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2019, Volume 27, Issue 6, pp. 1087 - 1098
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important... 
Antitumor activity | Dual inhibitor | 1H-Indazoles | Cancer immunotherapy | Tryptophan 2,3-dioxygenase (TDO) | Indoleamine 2,3-dioxygenase 1 (IDO1)
Journal Article
Nature, ISSN 0028-0836, 10/2011, Volume 478, Issue 7368, pp. 197 - 203
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