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isoprenoid biosynthesis (168) 168
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nonmevalonate pathway (133) 133
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isopentenyl diphosphate (104) 104
1-deoxy-d-xylulose 5-phosphate reductoisomerase (99) 99
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2-c-methyl-d-erythritol 4-phosphate (92) 92
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mevalonate-independent pathway (60) 60
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physiological aspects (53) 53
4--2-c-methyl-d-erythritol (50) 50
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methylerythritol phosphate-pathway (50) 50
molecular sequence data (47) 47
2-c-methyl-d-erythritol (42) 42
sugar phosphates - metabolism (42) 42
amino acid sequence (41) 41
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terpenoids (37) 37
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crystal-structure (31) 31
mevalonic acid - metabolism (31) 31
bacteria (29) 29
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fosmidomycin (29) 29
biophysics (27) 27
cloning, molecular (27) 27
escherichia coli - genetics (27) 27
protein (27) 27
cell biology (26) 26
escherichia coli - enzymology (26) 26
aldose-ketose isomerases - metabolism (25) 25
biotechnology & applied microbiology (25) 25
catalysis (25) 25
escherichia coli (25) 25
oxidoreductases - metabolism (25) 25
1-deoxy-d-xylulose 5-phosphate synthase (24) 24
analysis (24) 24
dimethylallyl diphosphate (24) 24
escherichia coli - metabolism (24) 24
microbiology (24) 24
models, molecular (24) 24
molecular structure (24) 24
kinetics (23) 23
synthase (23) 23
cloning (22) 22
erythritol - chemistry (22) 22
heterologous expression (22) 22
humans (22) 22
life sciences (22) 22
mevalonate (22) 22
organophosphorus compounds - metabolism (22) 22
precursor (22) 22
bacterial proteins - metabolism (21) 21
fosfomycin - analogs & derivatives (21) 21
genetic aspects (21) 21
isoprenoid (21) 21
gene expression regulation, plant (20) 20
hemiterpenes (20) 20
multienzyme complexes - metabolism (20) 20
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arabidopsis-thaliana (18) 18
metabolism (18) 18
mycobacterium-tuberculosis (18) 18
sequence homology, amino acid (18) 18
1-deoxy-d-xylulose 5-phosphate (17) 17
2-c-methyl-d-erythritol 2,4-cyclodiphosphate (17) 17
aldose-ketose isomerases - genetics (17) 17
animals (17) 17
bacterial proteins - genetics (17) 17
fosfomycin - pharmacology (17) 17
oxidoreductases - chemistry (17) 17
phylogeny (17) 17
aldose-ketose isomerases - chemistry (16) 16
biochemistry (16) 16
food science & technology (16) 16
gcpe (16) 16
multienzyme complexes - genetics (16) 16
plant proteins - metabolism (16) 16
reductoisomerase (16) 16
terpenes (16) 16
-4-hydroxy-3-methylbut-2-enyl diphosphate (15) 15
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Journal of Organic Chemistry, ISSN 0022-3263, 09/2018, Volume 83, Issue 17, pp. 9580 - 9591
Targeting essential bacterial processes beyond cell wall, protein, nucleotide, and folate syntheses holds promise to reveal new antimicrobial agents and expand... 
MYCOBACTERIUM-TUBERCULOSIS | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE | ISOPRENOID BIOSYNTHESIS | PATHWAY | PLASMODIUM-FALCIPARUM | FOSMIDOMYCIN ANALOGS | ENZYMES | DIPHOSPHATE | CHEMISTRY, ORGANIC | CYTIDYLTRANSFERASE | ANTIMALARIAL TARGET | Index Medicus
Journal Article
Journal of Magnetic Resonance, ISSN 1090-7807, 07/2018, Volume 292, pp. 59 - 72
Glyphosate is the world’s most widely used herbicide; popular due to its relative low cost, low toxicity, and high efficacy in controlling most common weed... 
In vivo NMR of plants | Vacuole sequestration | Glyphosate resistance | Glyphosate | UNITED-STATES | RYEGRASS | BIOCHEMICAL RESEARCH METHODS | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | RESISTANT HORSEWEED | VACUOLAR SEQUESTRATION | SHIKIMATE PATHWAY | HERBICIDE | P-31 NMR | INHIBITION | SPECTROSCOPY | 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE | MEP PATHWAY
Journal Article
by Zhang, P and Zhu, YQ and Luo, XJ and Zhou, SJ
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 1 - 11
Cucumber (Cucumis sativus L.) is an important crop distributed in many countries. Downy mildew (DM) caused by the obligate oomycete Pseudoperonospora cubensis... 
PATHWAYS | SALICYLIC-ACID | GENE | TOLERANCE | MULTIDISCIPLINARY SCIENCES | RESISTANCE | PLANTS | IDENTIFICATION | EXPRESSION | REVEALS | Pathogenesis-related proteins | D-Xylulose 5-phosphate | Sucrose | Starch | Heat shock proteins | Infections | Metabolism | Erythritol | Reductoisomerase | Proteins | 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase | Xylulose | Metabolic pathways | Downy mildew
Journal Article
Bioscience Reports, ISSN 0144-8463, 02/2018, Volume 38, Issue 1, p. 1
2-C-Methyl-d-erythritol 2,4-cyclodiphosphate synthase (IspF) is a key enzyme in the 2-C-Methyl-d-erythritol-4-phosphate (MEP) pathway of isoprenoid... 
Phosphates | Enzymes | Size exclusion chromatography | Escherichia coli | Gram-positive bacteria | Biosynthesis | Kinases | Erythritol | Proteins | 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase | Metabolic engineering | Terpenes | Assembly | Crystal structure
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 17499 - 9
The 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate synthase (HDS) gene and the 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) gene are two... 
METHYLERYTHRITOL 4-PHOSPHATE PATHWAY | ISOPRENOID BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | SALINITY STRESS | LEAVES | RHODOPHYTA | ARABIDOPSIS | ACCUMULATION | INHIBITORS | 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE | NONMEVALONATE PATHWAY | Salicylic acid | Genes | Gene regulation | Amino acids | Jasmonic acid | Methyl jasmonate | Reductase | Erythritol
Journal Article
BMC Genomics, ISSN 1471-2164, 03/2012, Volume 13, Issue 1, pp. 126 - 126
Background: Picrorhiza kurrooa Royle ex Benth. is an endangered plant species of medicinal importance. The medicinal property is attributed to monoterpenoids... 
Mevalonate | Picrorhiza kurrooa | Transcriptome | Picrosides | Gene expression | Next generation sequencing | 2-C-methyl-d-erythritol 4-phosphate | Phenylpropanoid | FACTOR FAMILY | ARABIDOPSIS-THALIANA | SAGE SALVIA-OFFICINALIS | ACID BIOSYNTHESIS | ISOPRENOID BIOSYNTHESIS | RNA-SEQ | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | GENE-EXPRESSION | GENOME-WIDE | PLANT-METABOLISM | 2-C-methyl-D-erythritol 4-phosphate | MONOTERPENE BIOSYNTHESIS | Reproducibility of Results | Temperature | Picrorhiza - enzymology | Molecular Sequence Annotation | RNA, Messenger - genetics | Computational Biology | Exons - genetics | Gene Expression Profiling - methods | RNA, Plant - genetics | Picrorhiza - genetics | Sequence Homology, Nucleic Acid | Microsatellite Repeats - genetics | Sequence Analysis, RNA - methods | Picrorhiza - metabolism | Base Composition | Cinnamates - metabolism | Cytochrome P-450 Enzyme System - genetics | Expressed Sequence Tags - metabolism | Iridoid Glucosides - metabolism | Glycosyltransferases - genetics | Cluster Analysis | Polymerase chain reaction | Usage | Scrophulariaceae | Physiological aspects | Genetic aspects | Nucleotide sequencing | Research | Genetic transcription | DNA sequencing | Scholarships & fellowships | Wildlife conservation | Councils | Industrial research | Genomics | Biosynthesis | Genomes | Bioinformatics | Manuscripts | Index Medicus
Journal Article
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 07/2014, Volume 193, Issue 2, pp. 708 - 721
Human V gamma 2V delta 2 T cells monitor isoprenoid metabolism by recognizing foreign (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), a metabolite in... 
MYCOBACTERIUM-TUBERCULOSIS | RECEPTOR-GAMMA-DELTA | GENE-CLUSTER | VITAMIN-B METABOLITES | ISOPRENOID BIOSYNTHESIS | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE PATHWAY | ESCHERICHIA-COLI | IN-VIVO | (E)-4-HYDROXY-3-METHYL-BUT-2-ENYL PYROPHOSPHATE | IMMUNOLOGY | MEVALONATE PATHWAY
Journal Article
Geophysical Research Letters, ISSN 0094-8276, 06/2011, Volume 38, Issue 11, p. 715
Isoprene, a compound emitted by vegetation, could be a major contributor to secondary organic aerosols (SOA) in the atmosphere. The main evidence for this... 
UNITED-STATES | BOREAL FOREST AEROSOLS | 2-C-METHYL-ERYTHRITOL | GEOSCIENCES, MULTIDISCIPLINARY | 2-METHYLTETROLS | 2-C-METHYL-D-ERYTHRITOL | BIOSYNTHESIS | PM2.5 | OXIDATION-PRODUCTS | DIEL VARIATIONS | PHOTOOXIDATION | Biosphere | Atmospheric sciences | Atmospheric aerosols | Troposphere | Catalysis | Environmental and Society | Chemical Sciences | Environmental Sciences
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/1998, Volume 95, Issue 17, pp. 9879 - 9884
Several eubacteria including Esherichia coli use an alternative nonmevalonate pathway for the biosynthesis of isopentenyl diphosphate instead of the ubiquitous... 
PROTEIN | ISOPRENOID BIOSYNTHESIS | CLONING | HIGHER-PLANT CHLOROPLASTS | ISOPENTENYL DIPHOSPHATE | 2-C-METHYL-D-ERYTHRITOL | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | SEQUENCE | KETOL-ACID REDUCTOISOMERASE | MEVALONATE-INDEPENDENT PATHWAY
Journal Article
Journal of Experimental Botany, ISSN 0022-0957, 03/2016, Volume 67, Issue 5, pp. 1557 - 1566
Journal Article
FEBS LETTERS, ISSN 0014-5793, 12/2001, Volume 509, Issue 2, pp. 317 - 322
The gcpE and lytB gene products control the terminal steps of isoprenoid biosynthesis via the 2-C-methyl-D-erythritol 4-phosphate pathway in Escherichia coli.... 
4-hydroxy-3-methyl-but-2-enyl pyrophosphate | gcpE | 2-C-methyl-D-erythritol 4-phosphate pathway | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | lytB | gamma delta T cell | CELL BIOLOGY | EVOLUTION | BIOPHYSICS | ISOPRENOID BIOSYNTHESIS | MEVALONATE-INDEPENDENT PATHWAY | NONMEVALONATE PATHWAY | LYMPHOCYTES | ANTIGEN
Journal Article
Plant, Cell & Environment, ISSN 0140-7791, 02/2013, Volume 36, Issue 2, pp. 429 - 437
The methylerythritol phosphate (MEP) pathway in plants produces the prenyl precursors for all plastidic isoprenoids, including carotenoids and quinones. The... 
MEP pathway | isoprenoids | methylerythritol cyclodiphosphate (MEcDP) | hydroxymethylbutenyl diphosphate synthase (HDS) | dimethylallyl diphosphate (DMADP) | Hydroxymethylbutenyl diphosphate synthase (HDS) | Dimethylallyl diphosphate (DMADP) | Methylerythritol cyclodiphosphate (MEcDP) | Isoprenoids | DIFFERENT ENVIRONMENTAL-CONDITIONS | CHLOROPLASTS | NON-MEVALONATE PATHWAY | 4FE-4S PROTEIN | PLANT SCIENCES | ASPEN LEAVES | BIOSYNTHESIS | DIPHOSPHATE SYNTHASE GCPE | EMISSION | 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE | Darkness | Erythritol - analogs & derivatives | Erythritol - chemistry | Populus - radiation effects | Chromatography, High Pressure Liquid | Acclimatization - radiation effects | Hemiterpenes - metabolism | Reference Standards | Time Factors | Light | Mass Spectrometry | Populus - metabolism | Nitrogen - pharmacology | Erythritol - metabolism | Plant Leaves - drug effects | Fosfomycin - analogs & derivatives | Pentanes - metabolism | Metabolome - radiation effects | Fosfomycin - pharmacology | Plant Extracts | Plant Leaves - radiation effects | Metabolome - drug effects | Plant Leaves - metabolism | Butadienes - metabolism | Metabolic Networks and Pathways - drug effects | Acclimatization - drug effects | Metabolic Networks and Pathways - radiation effects | Phosphates | Hydrogen sulfide | Carotenoids | Metabolites | Phytochemistry | Quinone | Nitriles | Mass spectrometry | Index Medicus
Journal Article