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Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 11/2017, Volume 9, Issue 11, p. a028209
Autosomal-dominant polycystic kidney disease (ADPKD) is a disease of defective tissue homeostasis resulting in active remodeling of nephrons and bile ducts to... 
2-HIT MODEL | COILED-COIL DOMAIN | HEDGEHOG PATHWAY | NODAL CILIA | PROTEOLYTIC SITE | PROTEIN-COUPLED RECEPTORS | LEFT-RIGHT ASYMMETRY | MEMBRANE-PROTEINS | PRIMARY CILIUM | MICE LACKING | CELL BIOLOGY | PERSPECTIVES | 010
Journal Article
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, ISSN 2157-1422, 12/2017, Volume 7, Issue 12
Autosomal-dominant polycystic kidney disease (ADPKD) is a disease of defective tissue homeostasis resulting in active remodeling of nephrons and bile ducts to... 
2-HIT MODEL | MEDICINE, RESEARCH & EXPERIMENTAL | COILED-COIL DOMAIN | HEDGEHOG PATHWAY | NODAL CILIA | PROTEOLYTIC SITE | PROTEIN-COUPLED RECEPTORS | LEFT-RIGHT ASYMMETRY | MEMBRANE-PROTEINS | PRIMARY CILIUM | MICE LACKING
Journal Article
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, ISSN 2157-1422, 11/2017, Volume 7, Issue 11
Autosomal-dominant polycystic kidney disease (ADPKD) is a disease of defective tissue homeostasis resulting in active remodeling of nephrons and bile ducts to... 
2-HIT MODEL | MEDICINE, RESEARCH & EXPERIMENTAL | COILED-COIL DOMAIN | HEDGEHOG PATHWAY | NODAL CILIA | PROTEOLYTIC SITE | PROTEIN-COUPLED RECEPTORS | LEFT-RIGHT ASYMMETRY | MEMBRANE-PROTEINS | PRIMARY CILIUM | MICE LACKING
Journal Article
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, ISSN 2157-1422, 10/2017, Volume 7, Issue 10
Autosomal-dominant polycystic kidney disease (ADPKD) is a disease of defective tissue homeostasis resulting in active remodeling of nephrons and bile ducts to... 
2-HIT MODEL | MEDICINE, RESEARCH & EXPERIMENTAL | COILED-COIL DOMAIN | HEDGEHOG PATHWAY | NODAL CILIA | PROTEOLYTIC SITE | PROTEIN-COUPLED RECEPTORS | LEFT-RIGHT ASYMMETRY | MEMBRANE-PROTEINS | PRIMARY CILIUM | MICE LACKING
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7597, pp. 122 - 126
Journal Article
Human Mutation, ISSN 1059-7794, 12/2013, Volume 34, Issue 12, pp. 1632 - 1641
Journal Article
FASEB Journal, ISSN 0892-6638, 05/2018, Volume 32, Issue 5, pp. 2615 - 2629
Familial cerebral cavernous malformations type III (fCCM3) is a disease of the cerebrovascular system caused by loss-of-function mutations in ccm3 that result... 
Permeability | Cell-cell interaction | Zonula occludens-1 | PDCD10 | zonula occludens-1 | cell-cell interaction | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | permeability | BINDING DOMAIN | IDENTIFICATION | CELL BIOLOGY | INTERCELLULAR COMMUNICATION | INTEGRITY | CALMODULIN | BIOLOGY | CCM3 | 2-HIT MECHANISM | Research
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 04/2010, Volume 207, Issue 4, pp. 881 - 896
Endothelial cell-cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans... 
CELL PERMEABILITY | PATHOGENESIS | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | P38 MAPK ACTIVATION | ACUTE LUNG INJURY | VE-CADHERIN | CCM2 | IMMUNOLOGY | 2-HIT MECHANISM | BRAIN | ENDOTHELIAL BARRIER FUNCTION | RNA, Small Interfering - genetics | Humans | Capillary Permeability - drug effects | Endothelium, Vascular - drug effects | rhoA GTP-Binding Protein - metabolism | Animal Structures - blood supply | Mutation - physiology | Phosphorylation - genetics | rho-Associated Kinases - metabolism | Edema, Cardiac - pathology | Phosphorylation - drug effects | Endothelial Cells - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use | Hemangioma, Cavernous, Central Nervous System - drug therapy | Edema, Cardiac - genetics | Hemangioma, Cavernous, Central Nervous System - pathology | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Endothelium, Vascular - pathology | Mice | Myosin Light Chains - metabolism | Animal Structures - metabolism | Protein Binding - physiology | Capillary Permeability - physiology | KRIT1 Protein | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Hemangioma, Cavernous, Central Nervous System - metabolism | rho-Associated Kinases - antagonists & inhibitors | Brain Edema - genetics | Edema, Cardiac - drug therapy | Mice, Mutant Strains | Pulmonary Edema - pathology | Microfilament Proteins - metabolism | Microfilament Proteins - genetics | Proto-Oncogene Proteins - metabolism | Pulmonary Edema - genetics | Brain Edema - pathology | Mice, Inbred C57BL | Proto-Oncogene Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Protein Kinase Inhibitors - therapeutic use | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Signal Transduction - physiology | Brain Edema - drug therapy | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - drug effects
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 2013, Volume 19, Issue 5, pp. 302 - 308
Journal Article