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2-pyridones (248) 248
chemistry, organic (182) 182
derivatives (94) 94
chemistry, multidisciplinary (63) 63
index medicus (42) 42
inhibitors (38) 38
synthesis (38) 38
chemistry (35) 35
heterocycles (29) 29
organic chemistry (29) 29
design (27) 27
pyridones (27) 27
ring-fused 2-pyridones (25) 25
cyclization (24) 24
catalysis (23) 23
chemistry, medicinal (22) 22
pyridones - chemistry (22) 22
efficient synthesis (21) 21
molecular structure (21) 21
agents (18) 18
pyridine (18) 18
2-pyridone (17) 17
pyridones - chemical synthesis (17) 17
alkylation (16) 16
construction (16) 16
cycloaddition (16) 16
diels-alder reactions (16) 16
one-pot synthesis (16) 16
pyridines (16) 16
pyridone (16) 16
research (16) 16
acid (15) 15
alkaloids (15) 15
alkynes (15) 15
biological evaluation (15) 15
substituted 2-pyridones (15) 15
analysis (14) 14
functionalization (13) 13
paper (13) 13
regioselective synthesis (13) 13
acids (12) 12
complexes (12) 12
stereoisomerism (12) 12
chemical synthesis (11) 11
diels-alder cycloadditions (11) 11
esters (11) 11
isocyanates (11) 11
ketones (11) 11
regioselectivity (11) 11
structure-activity relationship (11) 11
tetrahedrons (11) 11
annulation (10) 10
chemical properties (10) 10
chemical sciences (10) 10
functionalized 2-pyridones (10) 10
nitriles (10) 10
rearrangement (10) 10
activation (9) 9
aldehydes (9) 9
alkenes (9) 9
anti-bacterial agents - chemistry (9) 9
anti-bacterial agents - pharmacology (9) 9
arylation (9) 9
diels-alder reaction (9) 9
efficient (9) 9
halides (9) 9
natural sciences (9) 9
naturvetenskap (9) 9
olefins (9) 9
rhodium (9) 9
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letter (8) 8
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photochemistry (8) 8
pilus biogenesis (8) 8
pyridin-2-ones (8) 8
pyridines - chemistry (8) 8
pyridones - pharmacology (8) 8
route (8) 8
anti-bacterial agents - chemical synthesis (7) 7
antibacterial agents (7) 7
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chemical reactions (7) 7
chemistry, inorganic & nuclear (7) 7
cycloadditions (7) 7
direct alkylation (7) 7
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Organic Letters, ISSN 1523-7060, 01/2013, Volume 15, Issue 1, pp. 196 - 199
A cobalt–triarylphosphine catalyst promotes an annulation reaction of an α,β-unsaturated imine and an internal alkyne to afford a polysubstituted... 
FUNCTIONALIZATION | ALKENE | INSERTION | DIRECT ARYLATION | 2-PYRIDONES | ALKYLATION | AROMATIC IMINES | CHEMISTRY, ORGANIC | BOND ACTIVATION | IRON | CARBON-HYDROGEN
Journal Article
Organic Letters, ISSN 1523-7060, 10/2016, Volume 18, Issue 20, pp. 5376 - 5379
In this study we developed a method for the pyridine-directed, rhodium-catalyzed, site-selective C–H alkylation and arylation of pyridones using commercially... 
FUNCTIONALIZATION | CATALYSIS | ARYL BORONIC ACIDS | ARYLBORON REAGENTS | HETEROCYCLES | 2-PYRIDONES | C3-SELECTIVE DIRECT ALKYLATION | CHEMISTRY, ORGANIC | BOND ACTIVATION | SINGLE-ELECTRON TRANSMETALATION | DERIVATIVES
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2018, Volume 140, Issue 13, pp. 4489 - 4493
Annulated pyridones are an important scaffold found in many biologically active compounds. A Ni(0)-catalyzed C–H functionalization of 2- and 4-pyridones is... 
CHIRAL NHC LIGAND | ACTIVATION | 2-PYRIDONES | ALKYLATION | ACID CATALYSIS | RESISTANCE | COUPLINGS | SELECTIVE ALKENYLATION | INHIBITOR | CHEMISTRY, MULTIDISCIPLINARY | ACCESS | Olefins | Analysis | Chemical bonds | Chemical reactions | Chemical properties | Research | Organic compounds
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2016, Volume 59, Issue 5, pp. 2094 - 2108
Journal Article
Organic Letters, ISSN 1523-7060, 03/2016, Volume 18, Issue 5, pp. 1064 - 1067
A rhodium-catalyzed/copper-mediated tandem C­(sp2)–H alkynylation and intramolecular annulation of 2H-[1,2′-bipyridin]-2-ones with propargyl alcohols for the... 
C(SP)-H BONDS | HETEROCYCLES | 2-PYRIDONES | ARENES | CHEMISTRY, ORGANIC | TERMINAL ALKYNES | BOND ACTIVATION | CLEAVAGE | DERIVATIVES | C-H ALKYNYLATION | DIRECT ALKYLATION
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 07/2019, Volume 21, Issue 13, pp. 5363 - 5367
Pyridones are important heteroaromatic scaffolds found in natural products and pharmaceuticals and are, therefore, of major interest in organic synthetic... 
SUBSTITUTION | CATALYZED N-ARYLATION | AMINATION | HETEROCYCLES | 2-PYRIDONES | ARENES | CHEMISTRY, ORGANIC | PRIMARY AMINES | BOND FORMATION | DIRECT ALKYLATION | IMIDATION
Journal Article
Organic Letters, ISSN 1523-7060, 03/2017, Volume 19, Issue 5, pp. 984 - 987
8-Azacoumarins have emerged as a promising class of compounds but are rarely explored due to challenging access. A novel, general, and practical method is... 
HALIDES | ANTICANCER ACTIVITY | DESIGN | 2-PYRIDONES | NATURAL-PRODUCTS | CHEMISTRY, ORGANIC | PHOTOLABILE PROTECTING GROUPS | AGENTS | ARYL | OXIDES | COUMARIN DERIVATIVES
Journal Article
by Huang, JJ and Hu, G and An, SY and Chen, DD and Li, ML and Li, PF
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 08/2019, Volume 84, Issue 15, pp. 9758 - 9769
N-Alkylated 4-pyridones were obtained through a one-pot procedure involving either normal or interrupted Pummerer reactions between triflic anhydride-activated... 
C-H ALKYLATION | SULFOXIDES | ENANTIOSELECTIVE SYNTHESIS | SECONDARY AMIDES | 2-PYRIDONES | 4-PYRIDONE | CHEMISTRY, ORGANIC | INHIBITORS | DERIVATIVES | OLIGOMERS | ANHYDRIDE
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 10/2019, Volume 21, Issue 19, pp. 8110 - 8115
Tosylhydrazones under palladium catalysis were found to perform cross -coupling reactions with 4-hydroxy-2-pyridones. The umpolung-like reactivity, between the... 
PYRIDONE ALKALOIDS | FUNCTIONALIZATION | DIRECT ARYLATION | HETEROCYCLES | 2-PYRIDONES | C3-SELECTIVE DIRECT ALKYLATION | CHEMISTRY, ORGANIC | DIAZO-COMPOUNDS | ALKYNYLATION | ALKENYLATION | N-TOSYLHYDRAZONES
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 02/2019, Volume 84, Issue 4, pp. 1863 - 1870
Ru-catalyzed regioselective cascade annulation of acrylamides with 2-alkynoates via aza-Michael/C-H activation sequence for the synthesis of various 6-oxo... 
ROUTE | 2-PYRIDONES | AMIDE | OXIDANT | PYRIDONE | CHEMISTRY, ORGANIC | N BOND FORMATION | OXIDATIVE ANNULATION | ALKYNES | C-H ACTIVATION | ISOQUINOLONE SYNTHESIS
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 06/2018, Volume 83, Issue 12, pp. 6769 - 6775
A specific N-alkylation of 2-hydroxypyridines is achieved by reacting with organohalides under catalyst- and base-free conditions. The observed HX-facilitated... 
ALCOHOLS | REARRANGEMENT | TAUTOMERIZATION | HETEROCYCLIC AMBIDENT ANIONS | FACTOR VIIA INHIBITORS | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | O-ALKYLATION | HYDROAMINATION | SUBSTITUTED 2-PYRIDONES | PYRIDONES
Journal Article
Organic Letters, ISSN 1523-7060, 10/2017, Volume 19, Issue 19, pp. 5212 - 5215
A direct route to branched N-allylpyrimidine analogues is herein reported via the highly regio- and enantioselective asymmetric allylation of pyrimidines with... 
PHOSPHONATES | 2-PYRIDONES | MITSUNOBU | REGIODIVERGENT | CHEMISTRY, ORGANIC | ALLYLIC AMINATION | HYDROAMINATION | ALKYNES | IMIDAZOLE | DERIVATIVES | TERMINAL ALLENES | Pyrimidines | Molecular Structure | Pyrimidine Nucleosides - chemistry | Rhodium | Stereoisomerism | Allyl Compounds
Journal Article
Chemical Communications, ISSN 1359-7345, 11/2012, Volume 48, Issue 91, pp. 11232 - 11234
Ruthenium- and rhodium-catalyzed direct oxidative cross-coupling reactions of acrylamides with alkenes were developed. These methods provide an efficient route... 
H BOND ACTIVATION | OXIDATIVE OLEFINATION | FUNCTIONALIZATIONS | MECHANISM | 2-PYRIDONES | CYTOTOXIC MACROLIDE | SELECTIVE SYNTHESIS | LINEAR 1,3-BUTADIENES | CHEMISTRY, MULTIDISCIPLINARY | ALKENYLATION | ACRYLATES | Alkenes - chemistry | Oxidation-Reduction | Stereoisomerism | Amides - chemistry | Catalysis | Ruthenium - chemistry | Rhodium - chemistry | Acrylamides - chemistry
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 09/2015, Volume 13, Issue 46, pp. 11228 - 11234
Ruthenium(II)-catalyzed oxidative coupling of NH protic amides with alkynes has been developed for the synthesis of a diversity of complex structures, such as... 
BENZAMIDES | FUNCTIONALIZATIONS | 2-PYRIDONES | CONSTRUCTION | CHEMISTRY, ORGANIC | N BOND FORMATION | PYRROLE SYNTHESIS | INTERNAL ALKYNES | CATALYZED OXIDATIVE COUPLING/CYCLIZATION | ISOQUINOLONE SYNTHESIS
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 12/2015, Volume 13, Issue 46, pp. 11228 - 11234
Ruthenium(ii)-catalyzed oxidative coupling of NH protic amides with alkynes has been developed for the synthesis of a diversity of complex structures, such as... 
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 12/2013, Volume 54, Issue 50, pp. 6905 - 6908
A fast, versatile and practical one-pot, two-step microwave-assisted protocol for the direct synthesis of N1-substituted 5,6-ring-fused 2-pyridones has been... 
Microwave | N1-substituted | Multicomponent reaction | 2-Pyridones | One-pot two-step | Ring-fused | REVERSE-TRANSCRIPTASE | PROTOCOL | CHEMISTRY, ORGANIC | SUBSTITUTED 2-PYRIDONES | MULTICOMPONENT REACTIONS | CHEMISTRY | AGENTS | INHIBITORS | DERIVATIVES | Tetrahedrons | Synthesis (chemistry) | Biological effects | Amines | Ketones | Aldehydes
Journal Article
Russian Journal of Organic Chemistry, ISSN 1070-4280, 6/2016, Volume 52, Issue 6, pp. 857 - 861
Michael addition of ethyl N-arylmalonamates to ethyl 2-(ethoxymethylidene)-3-oxobutanoate in ethanol in the presence of triethylamine at room temperature... 
Chemistry | Organic Chemistry | CHEMISTRY, ORGANIC | 2-PYRIDONES | Esters
Journal Article
RSC Advances, ISSN 2046-2069, 2018, Volume 8, Issue 48, pp. 27131 - 27143
A simple and convenient protocol has been developed for the synthesis of N-amino-3-cyano-2-pyridone derivatives by a one-pot reaction of cyanoacetohydrazide,... 
2-PYRIDONES | NITRILES | AGENTS | INHIBITORS | RECEPTORS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | DITHIOACETALS | MULTICOMPONENT REACTION
Journal Article
Journal Article
Chemical science, ISSN 2041-6520, 06/2017, Volume 8, Issue 6, pp. 4299 - 4305
We have identified an enantioselective copper-catalyzed -to- formal [1,3]-rearrangement to form -propargylic-2-pyridones. This enantioconvergent -to-... 
Journal Article
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