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20-hydroxyeicosatetraenoic acid (247) 247
animals (181) 181
index medicus (140) 140
arachidonic-acid (134) 134
male (123) 123
humans (106) 106
rats (100) 100
cytochrome p-450 enzyme system - metabolism (90) 90
arachidonic acid (76) 76
hypertension (76) 76
physiology (75) 75
20-hete (74) 74
hydroxyeicosatetraenoic acids - metabolism (74) 74
cytochrome p-450 (70) 70
arachidonic acid - metabolism (58) 58
cytochrome p-450 enzyme system - genetics (58) 58
cytochrome p450 (56) 56
epoxyeicosatrienoic acids (56) 56
metabolites (55) 55
rats, sprague-dawley (52) 52
blood-pressure (50) 50
biochemistry & molecular biology (47) 47
peripheral vascular disease (46) 46
female (45) 45
pharmacology & pharmacy (44) 44
article (41) 41
cell biology (39) 39
hydroxyeicosatetraenoic acids - pharmacology (37) 37
kidney (36) 36
oxidative stress (36) 36
lipids (34) 34
mice (33) 33
physiological aspects (33) 33
unsaturated fatty acids (32) 32
eicosanoids (30) 30
endothelial dysfunction (30) 30
expression (30) 30
cardiovascular system (29) 29
cytochrome p-450 cyp4a (29) 29
enzyme inhibitors - pharmacology (28) 28
hydroxyeicosatetraenoic acids - antagonists & inhibitors (28) 28
inhibition (28) 28
cytochrome p450 family 4 (27) 27
soluble epoxide hydrolase (27) 27
blood pressure (26) 26
cardiac & cardiovascular systems (26) 26
nitric-oxide (25) 25
kidney - metabolism (24) 24
analysis (23) 23
enzymes (23) 23
nitric oxide (23) 23
thick ascending limb (23) 23
angiotensin-ii (22) 22
blood pressure - drug effects (22) 22
hydroxyeicosatetraenoic acids - biosynthesis (22) 22
metabolism (22) 22
middle aged (22) 22
activation (21) 21
cytochrome p-450 cyp4a - metabolism (21) 21
hypertension - metabolism (21) 21
protein-kinase-c (21) 21
research (20) 20
urology & nephrology (20) 20
endocrinology & metabolism (19) 19
endothelium (19) 19
hypertension - genetics (19) 19
ischemia (19) 19
aged (18) 18
cytochrome p-450 enzyme inhibitors (18) 18
genetic aspects (18) 18
kidney - drug effects (18) 18
kidney - enzymology (18) 18
omega-hydroxylase (18) 18
arachidonic-acid metabolism (17) 17
cyp4a11 (17) 17
hypertension - physiopathology (17) 17
vasoconstriction - drug effects (17) 17
adult (16) 16
amidines - pharmacology (16) 16
blood-flow (16) 16
cerebral-blood-flow (16) 16
inflammation (16) 16
spontaneously hypertensive rats (16) 16
time factors (16) 16
toxicology (16) 16
8,11,14-eicosatrienoic acid - metabolism (15) 15
blood pressure - physiology (15) 15
cells (15) 15
cells, cultured (15) 15
eicosanoids - metabolism (15) 15
gene expression (15) 15
het0016 (15) 15
in vitro techniques (15) 15
kidney - physiology (15) 15
prostaglandins (15) 15
rats, wistar (15) 15
cytochrome-p450 (14) 14
genetics & heredity (14) 14
health aspects (14) 14
mixed function oxygenases - metabolism (14) 14
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American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 03/2017, Volume 312, Issue 3, pp. H528 - H540
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 07/2015, Volume 309, Issue 1, pp. R71 - R78
Increased vascular 20-HETE is associated with hypertension and activation of the renin-angiotensin system (RAS) through induction of vascular... 
Hypertension | Vascular remodeling | 20-HETE | ACE | Angiotensin-converting enzyme | Angiotensin II | SYSTEM | 20-HYDROXYEICOSATETRAENOIC ACID SYNTHESIS | CONVERTING ENZYME | CONTRIBUTE | ACTIVATION | EICOSANOIDS | PHYSIOLOGY | RESISTANCE ARTERIES | vascular remodeling | angiotensin II | SENSITIVE HYPERTENSION | hypertension | EXPRESSION | angiotensin-converting enzyme | Microvessels - physiopathology | Antihypertensive Agents - pharmacology | Cytochrome P-450 Enzyme System - metabolism | Endothelium, Vascular - drug effects | Hypertension - drug therapy | Male | Endothelium, Vascular - enzymology | Angiotensin II Type 1 Receptor Blockers - pharmacology | Peptidyl-Dipeptidase A - genetics | Dihydrotestosterone | Time Factors | Hypertension - chemically induced | Female | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Microvessels - enzymology | Hypertension - enzymology | Hypertension - genetics | Vascular Remodeling - drug effects | Peptidyl-Dipeptidase A - deficiency | Disease Models, Animal | Angiotensin II - metabolism | Endothelium, Vascular - physiopathology | Microvessels - drug effects | Mice, Transgenic | Hypertension - physiopathology | Hydroxyeicosatetraenoic Acids - metabolism | Animals | Cytochrome P-450 Enzyme System - genetics | Renin-Angiotensin System - drug effects | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Physiological aspects | Health aspects | Angiotensin converting enzyme | Endothelium | Lisinopril | Angiotensin | Cardiovascular and Renal Integration | Hormones, Reproduction and Development
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 10/2009, Volume 297, Issue 4, pp. 875 - 884
We have previously reported that adenoviral-mediated delivery of cytochrome P-450 (CYP) 4A2, which catalyzes the synthesis of 20-hydroxyeicosatetraenoic acid... 
Endothelial dysfunction | Lentiviral vectors | Oxidative stress | Endothelial-specific promoter | Cyp4a-derived 20-HETE | OMEGA-HYDROXYLASE ACTIVITY | 20-HYDROXYEICOSATETRAENOIC ACID SYNTHESIS | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | CYTOCHROME-P450 METABOLITES | lentiviral vectors | CYP4A-derived 20-HETE | DAHL S RATS | ANGIOTENSIN-II | ANDROGEN-INDUCED HYPERTENSION | ARACHIDONIC-ACID | endothelial dysfunction | BLOOD-PRESSURE | endothelial-specific promoter | SALT-SENSITIVE RATS | UROLOGY & NEPHROLOGY | oxidative stress | Blood Pressure | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Humans | Cytochrome P-450 Enzyme System - metabolism | Antigens, CD - genetics | Vasodilation | Hydroxyeicosatetraenoic Acids - biosynthesis | Superoxides - metabolism | Nitric Oxide Synthase Type III - metabolism | Cadherins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Cell Line | Gene Targeting | Gene Transfer Techniques | Promoter Regions, Genetic | Oxidation-Reduction | Proteinuria - metabolism | Rats | Lentivirus | Rats, Sprague-Dawley | Hypertension - metabolism | Animals | Endothelium, Vascular - metabolism | Cytochrome P-450 Enzyme System - genetics | Acetylcholine | DNA, Complementary | Hypertension | Cytochrome P-450 | Physiological aspects | Research | Kidney diseases | Risk factors | Endothelium
Journal Article
Journal of Labelled Compounds and Radiopharmaceuticals, ISSN 0362-4803, 03/2006, Volume 49, Issue 3, pp. 245 - 252
Journal Article
Chemistry of Natural Compounds, ISSN 0009-3130, 1/2011, Volume 46, Issue 6, pp. 841 - 847
We have synthesized 20-hydroxyeicosatetraenoic acid (20-HETE) following a new route and delineated its functional effects in human bronchi. Isometric tension... 
synthesis | histamine | Cu-mediated C-C bond formation | 20-hydroxyeicosatetraenoic acid | human bronchi | Pharmacy | Plant Sciences | methacholine | Organic Chemistry | 20-HETE | METABOLITES | ACTIVATION | CHEMISTRY, MEDICINAL | ANALOGS | CHEMISTRY, ORGANIC | ARACHIDONIC-ACID | CONSTRUCTION | AIRWAY SMOOTH-MUSCLE | Histamine | Cytochrome P-450
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 02/1996, Volume 61, Issue 3, pp. 838 - 841
10(S)-(−)-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid methyl ester (2) was synthesized in eight steps starting from enantiomerically pure... 
CHEMISTRY, ORGANIC | PROSTAGLANDIN ENDOPEROXIDES | CYCLOOXYGENASE | OXYGENATION | PLATELETS | 20-HYDROXYEICOSATETRAENOIC ACID
Journal Article
Journal Article