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20-hydroxysteroid dehydrogenases - genetics (112) 112
science & technology (95) 95
20-hydroxysteroid dehydrogenases - metabolism (93) 93
humans (92) 92
life sciences & biomedicine (92) 92
animals (78) 78
female (73) 73
rats (35) 35
gene expression (28) 28
3-hydroxysteroid dehydrogenases - genetics (27) 27
3-hydroxysteroid dehydrogenases - metabolism (25) 25
hydroxysteroid dehydrogenases - genetics (25) 25
male (25) 25
20-alpha-hydroxysteroid dehydrogenase (24) 24
mice (23) 23
cells, cultured (22) 22
rna, messenger - metabolism (22) 22
aldo-keto reductase family 1 member c3 (21) 21
cell line, tumor (21) 21
molecular sequence data (21) 21
pregnancy (21) 21
progesterone - metabolism (21) 21
biochemistry & molecular biology (20) 20
hydroxyprostaglandin dehydrogenases - genetics (20) 20
kinetics (20) 20
cloning, molecular (19) 19
endocrinology & metabolism (19) 19
rna, messenger - genetics (19) 19
aldo-keto reductase (18) 18
amino acid sequence (18) 18
hydroxyprostaglandin dehydrogenases - metabolism (18) 18
oncology (18) 18
reverse transcriptase polymerase chain reaction (18) 18
20-hydroxysteroid dehydrogenases - biosynthesis (17) 17
base sequence (17) 17
enzymes (16) 16
hydroxysteroid dehydrogenases - metabolism (16) 16
pharmacology & pharmacy (16) 16
20-hydroxysteroid dehydrogenases - chemistry (15) 15
progesterone (15) 15
abridged index medicus (14) 14
gene expression regulation, enzymologic (14) 14
genes (14) 14
adult (13) 13
cancer (13) 13
cell biology (13) 13
cell line (13) 13
physiological aspects (13) 13
reproductive biology (13) 13
research article (13) 13
transfection (13) 13
rats, sprague-dawley (12) 12
substrate specificity (12) 12
sequence homology, amino acid (11) 11
alcohol oxidoreductases - genetics (10) 10
cattle (10) 10
genetic aspects (10) 10
middle aged (10) 10
ovary - enzymology (10) 10
oxidoreductases - metabolism (10) 10
recombinant proteins - metabolism (10) 10
research (10) 10
17-hydroxysteroid dehydrogenases - metabolism (9) 9
20-hydroxysteroid dehydrogenases - antagonists & inhibitors (9) 9
alcohol oxidoreductases - metabolism (9) 9
blotting, western (9) 9
gene expression profiling (9) 9
gene expression regulation, neoplastic (9) 9
isoenzymes - genetics (9) 9
isoenzymes - metabolism (9) 9
mutagenesis, site-directed (9) 9
oxidoreductases - genetics (9) 9
rna, messenger - analysis (9) 9
akr1c1 (8) 8
aldehyde reductase - genetics (8) 8
aldehyde reductase - metabolism (8) 8
aldo-keto reductases (8) 8
corpus luteum - metabolism (8) 8
genetic research (8) 8
ovary - metabolism (8) 8
recombinant proteins - genetics (8) 8
studies (8) 8
toxicology (8) 8
17-hydroxysteroid dehydrogenases - genetics (7) 7
3-oxo-5-alpha-steroid 4-dehydrogenase - genetics (7) 7
aged (7) 7
analysis (7) 7
apoptosis (7) 7
binding sites (7) 7
cholesterol side-chain cleavage enzyme - genetics (7) 7
corpus luteum - enzymology (7) 7
dna, complementary - genetics (7) 7
gene expression - drug effects (7) 7
gene expression regulation, enzymologic - drug effects (7) 7
granulosa cells - metabolism (7) 7
immunohistochemistry (7) 7
ovary - drug effects (7) 7
receptors, progesterone - metabolism (7) 7
rna (7) 7
tumor cells, cultured (7) 7
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The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 533 - 545
Journal Article
Oncology reports, ISSN 1021-335X, 04/2017, Volume 37, Issue 4, pp. 2025 - 2032
Journal Article
BMC cancer, ISSN 1471-2407, 08/2012, Volume 12, Issue 1, pp. 381 - 381
Background: Since proteins involved in chemotherapy drug pharmacokinetics and pharmacodynamics have a strong impact on the uptake, metabolism, and efflux of... 
Resistance | Lysosome | Cytotoxicity | Drug localization | Aldo-keto reductases | Pharmacokinetics | Doxorubicin | DNA-binding | Gene profiling | PharmGKB | Life Sciences & Biomedicine | Oncology | Science & Technology | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Aldehyde Reductase - genetics | Oligonucleotide Array Sequence Analysis | Cyclosporine - pharmacology | DNA, Neoplasm - metabolism | Humans | Drug Resistance, Neoplasm | Gene Expression Profiling | Hydroxyprostaglandin Dehydrogenases - metabolism | Breast Neoplasms - metabolism | Cell Nucleus - metabolism | MCF-7 Cells | Doxorubicin - analogs & derivatives | 3-Hydroxysteroid Dehydrogenases - metabolism | Aldehyde Reductase - metabolism | 20-Hydroxysteroid Dehydrogenases - biosynthesis | 20-Hydroxysteroid Dehydrogenases - genetics | Intracellular Space - drug effects | Aldehyde Reductase - biosynthesis | Hydroxyprostaglandin Dehydrogenases - biosynthesis | 20-Hydroxysteroid Dehydrogenases - metabolism | Breast Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Hydroxyprostaglandin Dehydrogenases - genetics | Cholic Acids - pharmacology | Breast Neoplasms - genetics | Aldo-Keto Reductase Family 1 Member C3 | Intracellular Space - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Cell Nucleus - drug effects | Doxorubicin - pharmacology | Anthracyclines | Genes | Genomics | Genomes | Drug resistance | Proteins | Chemotherapy | Metabolites | Aldose reductase | Analysis | DNA | Genetic research | DNA-ligand interactions | Cancer | Index Medicus
Journal Article
Journal Article
Biochemical journal, ISSN 0264-6021, 12/2011, Volume 440, Issue 3, pp. 335 - 344
Journal Article
Chemico-biological interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 210 - 217
► In endometrial cancer progesterone biosynthesis genes are down-regulated. ► Expression of most progesterone metabolism genes is not altered in cancerous... 
Steroidogenic acute regulatory protein | 5α-Reductase | Pre-receptor metabolism | Side-chain cleavage enzyme | 3-Keto/20-keto-reductase | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Progesterone Reductase - metabolism | Humans | Middle Aged | Endometrial Neoplasms - metabolism | Multienzyme Complexes - metabolism | Receptors, Progesterone - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Receptors, Progesterone - metabolism | Cholesterol Side-Chain Cleavage Enzyme - genetics | Endometrial Neoplasms - genetics | Phosphoproteins | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Adult | Female | Progesterone - biosynthesis | Membrane Proteins - metabolism | Steroid Isomerases - genetics | Endometrium - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Membrane Proteins - genetics | Steroid Isomerases - metabolism | RNA, Messenger - genetics | Multienzyme Complexes - genetics | Progesterone Reductase - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Down-Regulation - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Estradiol Dehydrogenases - metabolism | Progesterone - metabolism | Aged | Progesterone - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Endometrial cancer | RNA | Genes | Cytochrome P-450 | Physiological aspects | Genetic aspects | Progesterone | Cancer | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e97448 - e97448
...)1C1, AKR1C2 and AKR1C3, which are hydroxysteroid dehydrogenases (HSDs) involved in steroid... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cyclin D1 - metabolism | Cytochrome P-450 CYP1B1 - genetics | Cell Proliferation | Cyclin-Dependent Kinase 4 - genetics | Humans | Gene Expression Regulation, Neoplastic | Aromatase - metabolism | Cytochrome P-450 CYP1B1 - metabolism | Mammary Glands, Human - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Aromatase - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Hydroxysteroid Dehydrogenases - metabolism | G1 Phase - genetics | Estrogens - metabolism | Estradiol - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Signal Transduction | Cyclin-Dependent Kinase 6 - genetics | Mammary Glands, Human - pathology | Cyclin-Dependent Kinase 6 - metabolism | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Cyclin D1 - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | Estrone - metabolism | Estradiol Dehydrogenases - metabolism | Cell Line, Tumor | 3-Hydroxysteroid Dehydrogenases - genetics | Genes | Estrogen | Cytochrome P-450 | Physiological aspects | Phenols | Breast cancer | Small and medium sized companies | Phosphotransferases | Cytochrome | Cell proliferation | Cell culture | Pediatrics | Phosphorylation | Transcription | Estrogens | 17β-Estradiol | Homology | Biology | Kinases | Cyclin D1 | Experiments | Estradiol | Cyclin-dependent kinase 4 | Proteins | Alterations | Cell growth | Xenoestrogens | Rodents | Aromatase | Cell cycle | Enzymes | Tumor cells | Cyclin-dependent kinases | Cytochrome P450 | Tumor cell lines | Metabolism | Gene expression | Aldo-keto reductase | Sex hormones | Gene amplification | Estrone | Tumors | Index Medicus
Journal Article