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Endocrine-Related Cancer, ISSN 1351-0088, 04/2018, Volume 25, Issue 4, pp. 381 - 391
Endometrial cancer (EC) is the most common gynaecological malignancy. Obesity is a major risk factor for EC and is associated with elevated cholesterol.... 
Proliferation | Endometrial cancer | 27-hydroxycholesterol | LXR
Journal Article
Revista Medica de Chile, ISSN 0034-9887, 11/2016, Volume 144, Issue 11, pp. 1377 - 1381
Journal Article
Journal Article
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, ISSN 1055-9965, 06/2019, Volume 28, Issue 6, pp. 1052 - 1058
Background: Higher intratumoral cholesterol synthesis is associated with a worse prognosis in prostate cancer. The vitamin D-regulated enzyme... 
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | METABOLISM | ONCOLOGY | 27-HYDROXYCHOLESTEROL | ESTROGEN | PREVENTION | RISK | HDL CHOLESTEROL | HEALTH | BETA
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 03/2016, Volume 92, pp. 100 - 109
Familial Cerebral Cavernous Malformation type 1 (CCM1) is an autosomal dominant disease caused by mutations in the Krev Interaction Trapped 1 gene, and... 
Disease severity | Oxidative stress | Free radicals | Cerebral Cavernous Malformation (CCM) | Familial Cerebral Cavernous Malformation type 1 | Vascular brain lesions | Reactive oxygen species (ROS) | Matrix metalloproteinase (MMP) | Genetic markers set association study | Intracerebral hemorrhage | KRIT1/CCM1 | Inter-individual variability in disease susceptibility and outcome | Cytochrome P450 (CYP) | Cerebrovascular disease | EET epoxyeicosatrienoic acids | 1,25-dihydroxyvitamin D3 | 24-OHC 24(S)-hydroxycholesterol | SNP single nucleotide polymorphism | 25-hydroxyvitamin D3 | AA arachidonic acid | ICH intracerebral hemorrhage | Abbreviations CCM Cerebral Cavernous Malformation | LT leukotrienes | CYP cytochrome P450 | ROS reactive oxygen species | ECM extracellular matrix | 27-OHC 27-hydroxycholesterol | BBB blood-brain barrier | PG prostaglandins | 1,25-OH | NVU neurovascular unit | MMP matrix metalloproteinase | 25-OH-D | CHM common hispanic mutation | VITAMIN-D | SIGNALING PATHWAYS | REDUCES OXIDATIVE STRESS | CEREBROVASCULAR-DISEASE | WHITE-MATTER LESIONS | ENDOCRINOLOGY & METABOLISM | MEDIATED REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOOD-BRAIN-BARRIER | CHOLESTEROL 24-HYDROXYLASE | CORONARY-ARTERY-DISEASE | Brain - diagnostic imaging | Matrix Metalloproteinases - genetics | KRIT1 Protein | Microtubule-Associated Proteins - genetics | Humans | Middle Aged | Male | Hemangioma, Cavernous, Central Nervous System - genetics | Brain - metabolism | Adult | Female | Multigene Family - genetics | Severity of Illness Index | Hemangioma, Cavernous, Central Nervous System - diagnostic imaging | Oxidative Stress - genetics | Genotype | Proto-Oncogene Proteins - genetics | Magnetic Resonance Imaging | Phenotype | Hemangioma, Cavernous, Central Nervous System - pathology | Brain - pathology | Cytochrome P-450 Enzyme System - genetics | Heterozygote | Aged | Polymorphism, Single Nucleotide | Mutation | Brain | Genetic markers | Analysis | Pharmacy | Cytochrome P-450 | Genetic research | Drugstores | Brain damage | Epidemiology | ECM, extracellular matrix | 27-OHC, 27-hydroxycholesterol | 25-OH-D3, 25-hydroxyvitamin D3 | CHM, common hispanic mutation | NVU, neurovascular unit | ICH, intracerebral hemorrhage | PG, prostaglandins | CCM, Cerebral Cavernous Malformation | KRIT1 | ROS, reactive oxygen species | CYP, cytochrome P450 | EET, epoxyeicosatrienoic acids | LT, leukotrienes | Original Contribution | BBB, blood–brain barrier | SNP, single nucleotide polymorphism | AA, arachidonic acid | 24-OHC, 24(S)-hydroxycholesterol | 1,25-OH2-D3, 1,25-dihydroxyvitamin D3 | CCM1 | MMP, matrix metalloproteinase
Journal Article
Natural Product Sciences, ISSN 1226-3907, 2017, Volume 23, Issue 4, pp. 239 - 246
27-Hydroxycholesterol (27OHChol) has been reported to induce differentiation of monocytic cells into a mature dendritic cell phenotype. We examined the effect... 
27-Hydroxycholesterol | Nardostachys chinensis | Dendritic cells | Monocyte | Differentiation
Journal Article
Cancer Research, ISSN 0008-5472, 09/2018, Volume 78, Issue 17, pp. 4803 - 4808
Epidemiologic studies are controversial concerning the roles played by cholesterol in cancer risk and development, possibly as it is not cholesterol per se... 
POSITIVE BREAST-CANCER | CELLS | LIVER X RECEPTORS | GLUCOCORTICOID-RECEPTOR | METABOLISM | ONCOLOGY | 27-HYDROXYCHOLESTEROL | ESTROGEN | ALPHA | IDENTIFICATION | INHIBIT
Journal Article
ENDOCRINOLOGY, ISSN 0013-7227, 07/2019, Volume 160, Issue 7, pp. 1573 - 1589
The involvement of small heterodimer partner (SHP) in the inhibition of hepatic bile acid synthesis from cholesterol has been established. However,... 
CHOLESTEROL | METABOLISM | GENE | REPRESSION | NEGATIVE FEEDBACK-REGULATION | ENDOCRINOLOGY & METABOLISM | 27-HYDROXYCHOLESTEROL | SHP | MECHANISMS | EXPRESSION | ORPHAN NUCLEAR RECEPTOR
Journal Article
Redox Biology, ISSN 2213-2317, 07/2018, Volume 17, pp. 400 - 410
Autophagy has been shown to be stimulated in advanced atherosclerotic plaques by metabolic stress, inflammation and oxidized lipids. The lack of published... 
27-hydroxycholesterol | Autophagy | Survival signaling | Oxysterols | ROS | OXIDATIVE STRESS | ACTIVATION | BECLIN 1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | LXR-ALPHA | 7-KETOCHOLESTEROL | TRANSCRIPTION FACTOR NRF2 | SIGNALING PATHWAY | SMOOTH-MUSCLE-CELLS | ATHEROSCLEROTIC PLAQUE
Journal Article
Natural Product Sciences, ISSN 1226-3907, 2017, Volume 23, Issue 4, pp. 239 - 246
27-Hydroxycholesterol (27OHChol) has been reported to induce differentiation of monocytic cells into a mature dendritic cell phenotype. We examined the effect... 
27-Hydroxycholesterol | Nardostachys chinensis | Dendritic cells | Monocyte | Differentiation
Journal Article
AGING CELL, ISSN 1474-9726, 08/2015, Volume 14, Issue 4, pp. 569 - 581
Journal Article
Clinical Biochemistry, ISSN 0009-9120, 02/2018, Volume 52, pp. 117 - 122
Circulating oxysterols have been proposed as biological markers of disease risk. However, within-person reproducibility of circulating oxysterols over time is... 
Lanosterol | Within-person reproducibility | Cholesterol metabolites | Oxysterols | 27-HYDROXYCHOLESTEROL | 24S-HYDROXYCHOLESTEROL | BILE-ACID SYNTHESIS | MEDICAL LABORATORY TECHNOLOGY | CANCER
Journal Article
Journal of Neuropathology & Experimental Neurology, ISSN 0022-3069, 03/2019, Volume 78, Issue 3, pp. 238 - 247
Abstract This study aimed to explore the neurotoxic effects of 27-hydroxycholesterol (27-OHC), a major circulating cholesterol active derivative in brain on... 
BRAIN CHOLESTEROL | DEMENTIA | PROTEIN | Hippocampal plasticity | DIETARY-CHOLESTEROL | ALZHEIMERS-DISEASE | RISK | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | COGNITIVE DECLINE | MEMORY | Synaptic proteins | 27-Hydroxycholesterol | EXPRESSION | Neurite outgrowth | OXYSTEROLS
Journal Article