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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, ISSN 0884-0431, 1/2019, Volume 34, Issue 1, pp. 59 - 66
27-hydroxycholesterol (27HC) is a purported, novel endogenous SERM. In animal models, 27HC has an anti-estrogen effect in bone, and 17β-estradiol mitigates... 
oxysterol | postmenopausal women | 27-hydroxycholesterol | fracture | estradiol
Journal Article
Revista Medica de Chile, ISSN 0034-9887, 11/2016, Volume 144, Issue 11, pp. 1377 - 1381
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 03/2016, Volume 92, pp. 100 - 109
Familial Cerebral Cavernous Malformation type 1 (CCM1) is an autosomal dominant disease caused by mutations in the Krev Interaction Trapped 1 gene, and... 
Disease severity | Oxidative stress | Free radicals | Cerebral Cavernous Malformation (CCM) | Familial Cerebral Cavernous Malformation type 1 | Vascular brain lesions | Reactive oxygen species (ROS) | Matrix metalloproteinase (MMP) | Genetic markers set association study | Intracerebral hemorrhage | KRIT1/CCM1 | Inter-individual variability in disease susceptibility and outcome | Cytochrome P450 (CYP) | Cerebrovascular disease | EET epoxyeicosatrienoic acids | 1,25-dihydroxyvitamin D3 | D | 24-OHC 24(S)-hydroxycholesterol | SNP single nucleotide polymorphism | 25-hydroxyvitamin D3 | AA arachidonic acid | ICH intracerebral hemorrhage | Abbreviations CCM Cerebral Cavernous Malformation | LT leukotrienes | CYP cytochrome P450 | ROS reactive oxygen species | ECM extracellular matrix | 27-OHC 27-hydroxycholesterol | BBB blood-brain barrier | PG prostaglandins | 1,25-OH | NVU neurovascular unit | MMP matrix metalloproteinase | 25-OH-D | CHM common hispanic mutation | VITAMIN-D | SIGNALING PATHWAYS | REDUCES OXIDATIVE STRESS | CEREBROVASCULAR-DISEASE | WHITE-MATTER LESIONS | ENDOCRINOLOGY & METABOLISM | MEDIATED REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOOD-BRAIN-BARRIER | CHOLESTEROL 24-HYDROXYLASE | CORONARY-ARTERY-DISEASE | Brain - diagnostic imaging | Matrix Metalloproteinases - genetics | KRIT1 Protein | Microtubule-Associated Proteins - genetics | Humans | Middle Aged | Male | Hemangioma, Cavernous, Central Nervous System - genetics | Brain - metabolism | Adult | Female | Multigene Family - genetics | Severity of Illness Index | Hemangioma, Cavernous, Central Nervous System - diagnostic imaging | Oxidative Stress - genetics | Genotype | Proto-Oncogene Proteins - genetics | Magnetic Resonance Imaging | Phenotype | Hemangioma, Cavernous, Central Nervous System - pathology | Brain - pathology | Cytochrome P-450 Enzyme System - genetics | Heterozygote | Aged | Polymorphism, Single Nucleotide | Mutation | Brain | Genetic markers | Analysis | Pharmacy | Cytochrome P-450 | Genetic research | Drugstores | Brain damage | Epidemiology | ECM, extracellular matrix | 27-OHC, 27-hydroxycholesterol | 25-OH-D3, 25-hydroxyvitamin D3 | CHM, common hispanic mutation | NVU, neurovascular unit | ICH, intracerebral hemorrhage | PG, prostaglandins | CCM, Cerebral Cavernous Malformation | KRIT1 | ROS, reactive oxygen species | CYP, cytochrome P450 | EET, epoxyeicosatrienoic acids | LT, leukotrienes | Original Contribution | BBB, blood–brain barrier | SNP, single nucleotide polymorphism | AA, arachidonic acid | 24-OHC, 24(S)-hydroxycholesterol | 1,25-OH2-D3, 1,25-dihydroxyvitamin D3 | CCM1 | MMP, matrix metalloproteinase
Journal Article
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, ISSN 1055-9965, 06/2019, Volume 28, Issue 6, pp. 1052 - 1058
Background: Higher intratumoral cholesterol synthesis is associated with a worse prognosis in prostate cancer. The vitamin D-regulated enzyme... 
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | METABOLISM | ONCOLOGY | 27-HYDROXYCHOLESTEROL | ESTROGEN | PREVENTION | RISK | HDL CHOLESTEROL | HEALTH | BETA
Journal Article
Redox Biology, ISSN 2213-2317, 07/2018, Volume 17, pp. 400 - 410
Autophagy has been shown to be stimulated in advanced atherosclerotic plaques by metabolic stress, inflammation and oxidized lipids. The lack of published... 
27-hydroxycholesterol | Autophagy | Survival signaling | Oxysterols | ROS | OXIDATIVE STRESS | ACTIVATION | BECLIN 1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | LXR-ALPHA | 7-KETOCHOLESTEROL | TRANSCRIPTION FACTOR NRF2 | SIGNALING PATHWAY | SMOOTH-MUSCLE-CELLS | ATHEROSCLEROTIC PLAQUE
Journal Article
Redox Biology, ISSN 2213-2317, 08/2017, Volume 12, pp. 522 - 527
Oxysterols are known pleiotropic molecules whose antiviral action has been recently discovered. Here reported is the activity of a panel of oxysterols against... 
25-hydroxycholesterol | 27-hydroxycholesterol | Herpes simplex-1 | Oxysterols | Viral inhibition | Interleukin-6 | CELLS | ACTIVATION | CYTOKINES | BIOCHEMISTRY & MOLECULAR BIOLOGY | P65/RELA | PRODUCTS | INFECTION | NF-KAPPA-B | EXPRESSION
Journal Article
Natural Product Sciences, ISSN 1226-3907, 2017, Volume 23, Issue 4, p. 239
27-Hydroxycholesterol (27OHChol) has been reported to induce differentiation of monocytic cells into a mature dendritic cell phenotype. We examined the effect... 
27-Hydroxycholesterol | Nardostachys chinensis | Dendritic cells | Monocyte | Differentiation
Journal Article
AGING CELL, ISSN 1474-9726, 08/2015, Volume 14, Issue 4, pp. 569 - 581
Journal Article
Cancer Research, ISSN 0008-5472, 09/2018, Volume 78, Issue 17, pp. 4803 - 4808
Epidemiologic studies are controversial concerning the roles played by cholesterol in cancer risk and development, possibly as it is not cholesterol per se... 
POSITIVE BREAST-CANCER | CELLS | LIVER X RECEPTORS | GLUCOCORTICOID-RECEPTOR | METABOLISM | ONCOLOGY | 27-HYDROXYCHOLESTEROL | ESTROGEN | ALPHA | IDENTIFICATION | INHIBIT | Life Sciences | Human health and pathology | Biochemistry, Molecular Biology | Biomolecules | Food and Nutrition | Endocrinology and metabolism | Subcellular Processes | Cellular Biology | Cancer
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2014, Volume 75, pp. 48 - 59
Elevated total cholesterol in midlife has been associated with increased risk of dementia in later life. We have previously shown that low-density lipoprotein... 
BACE1 | Low-density lipoprotein | Lipid raft | Free radicals | Lipid oxidation | Redox | Aging | OxLDL | GSH | Cholesterol | COMMON VARIANTS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | 24-HYDROXYCHOLESTEROL | INHIBITION | ENDOCRINOLOGY & METABOLISM | 27-HYDROXYCHOLESTEROL | ACCUMULATION | ACID SPHINGOMYELINASE | ASSOCIATION | Free Radical Scavengers - pharmacology | Aspartic Acid Endopeptidases - biosynthesis | Glutathione - metabolism | Membrane Microdomains - metabolism | Humans | Amyloid beta-Peptides - secretion | Alzheimer Disease - pathology | Desipramine - pharmacology | Sphingomyelin Phosphodiesterase - biosynthesis | Aged, 80 and over | Cell Survival - drug effects | Oxidation-Reduction | Amyloid beta-Peptides - biosynthesis | Enzyme Inhibitors - pharmacology | Lipoproteins, LDL - pharmacology | Lipid Metabolism | Hydroxycholesterols - pharmacology | Amyloid Precursor Protein Secretases - metabolism | Sphingomyelin Phosphodiesterase - antagonists & inhibitors | Aspartic Acid Endopeptidases - metabolism | Acetylcysteine - pharmacology | Cell Line, Tumor | Cholesterol, LDL - metabolism | Aged | Glutathione - chemistry | Enzyme Activation | Glutathione Disulfide - chemistry | Lipoproteins, LDL - blood | Amyloid Precursor Protein Secretases - biosynthesis | BACE, β-secretase β-site amyloid cleaving enzyme | GSH, glutathione | SM, sphingomyelin | EDTA, ethylenediamine tetraacetic acid | NAC, N-acetylcysteine | ELISA, enzyme-linked immunosorbent assay | GCL, glutamate–cysteinyl ligase | PVDF, polyvinylidene fluoride | E-64, proteinase inhibitor E-64 | PBS, phosphate-buffered saline | AD, Alzheimer disease | BSO, buthionine sulfoximine | LDL, low-density lipoprotein | CTB, cholera toxin B | GSSG, oxidized glutathione | BCA, bicinchoninic acid | Original Contribution | BBB, blood–brain barrier | BHT, butylated hydroxytoluene | ASMase, acid sphingomyelinase | ESI–MS, electrospray ionization mass spectrometry | Aβ, β-amyloid | SDS–PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis | MDA, malondialdehyde | oxLDL, oxidized low-density lipoprotein | 27OH-C, 27-hydroxycholesterol | PBST, phosphate-buffered saline with 1% Tween 20 | EGTA, ethylene glycol tetraacetic acid | CSF, cerebrospinal fluid | APP, amyloid precursor protein
Journal Article
Journal of Neuropathology & Experimental Neurology, ISSN 0022-3069, 03/2019, Volume 78, Issue 3, pp. 238 - 247
Abstract This study aimed to explore the neurotoxic effects of 27-hydroxycholesterol (27-OHC), a major circulating cholesterol active derivative in brain on... 
BRAIN CHOLESTEROL | DEMENTIA | PROTEIN | Hippocampal plasticity | DIETARY-CHOLESTEROL | ALZHEIMERS-DISEASE | RISK | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | COGNITIVE DECLINE | MEMORY | Synaptic proteins | 27-Hydroxycholesterol | EXPRESSION | Neurite outgrowth | OXYSTEROLS
Journal Article
Journal of the Neurological Sciences, ISSN 0022-510X, 2015, Volume 358, Issue 1, pp. 201 - 206
Journal Article