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JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 06/2015, Volume 125, Issue 6, pp. 2532 - 2546
Cyclic dinucleotides (CONS) are agonists of stimulator of IFN genes (STING) and have potential as vaccine adjuvants. However, cyclic di-GMP (cdGMP) injected... 
NONHUMAN-PRIMATES | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | CYCLIC-DI-GMP | T-CELL RESPONSES | PROXIMAL EXTERNAL REGION | I INTERFERON RESPONSE | BACTERIAL 2ND-MESSENGER | ANTIBODY-RESPONSES | SYNTHETIC VACCINES | MUCOSAL ADJUVANT
Journal Article
Cellular and Molecular Immunology, ISSN 1672-7681, 11/2018, Volume 15, Issue 11, pp. 983 - 985
Journal Article
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 04/2019, Volume 79, Issue 7, pp. 1465 - 1479
Given the integral role of stimulator of interferon genes (STING, TMEM173) in the innate immune response, its loss or impairment in cancer is thought to... 
2ND-MESSENGER | CYCLIC GMP-AMP | MITOTIC CHECKPOINT GENES | INSTABILITY | ONCOLOGY | DNA | ADAPTER | CGAS | SENESCENCE | NF-KAPPA-B | CANCER | Index Medicus
Journal Article
Cell Research, ISSN 1001-0602, 10/2018, Volume 28, Issue 10, pp. 967 - 968
Journal Article
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 11/2015, Volume 21, Issue 21, pp. 4774 - 4779
Novel immunotherapy approaches are transforming the treatment of cancer, yet many patients remain refractory to these agents. One hypothesis is that... 
CYCLIC GMP-AMP | INNATE IMMUNE RECOGNITION | ONCOLOGY | I IFN SIGNALS | C-DI-GMP | CYTOSOLIC DNA | BACTERIAL 2ND-MESSENGER | ANTITUMOR IMMUNITY | IMMUNOGENIC TUMORS | TUMOR MICROENVIRONMENT | 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID
Journal Article
Immunity, ISSN 1074-7613, 11/2014, Volume 41, Issue 5, pp. 843 - 852
Journal Article
by Liu, C and Huang, S and Wang, XL and Wen, MJ and Zheng, JR and Wang, WJ and Fu, YB and Tian, SL and Li, L and Li, ZX and Wang, X
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 05/2019, Volume 202, Issue 10, pp. 2957 - 2970
MAVS is a critical adaptor required for activating an innate antiviral immune response against viral infection. The activation of MAVS requires modification of... 
ANTIVIRAL RESPONSE | UBIQUITINATION | 2ND-MESSENGER | CYCLIC GMP-AMP | DINUCLEOTIDE | PROTEIN | RECOGNITION | I INTERFERON INDUCTION | RIG-I | IMMUNOLOGY | DNA SENSOR CGAS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 7, pp. 1637 - 1642
cGMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses. cGAS catalyzes the synthesis of cGAMP, which functions as a... 
cGAS | PD-L1 | STING | cGAMP | Cancer | CYCLIC GMP-AMP | ACTIVATION | MULTIDISCIPLINARY SCIENCES | CYTOSOLIC DNA | 2ND-MESSENGER | SYNTHASE | DINUCLEOTIDE | STING PATHWAY | ADAPTER | cancer | IMMUNOGENIC TUMORS | PROMOTES | Interferon | Immune response | Observations | Cyclic guanylic acid | Health aspects | Molecules | Effects | Lymphocytes | Rodents | Tumors | Immune system | Index Medicus | Biological Sciences
Journal Article
by Li, TJ and Cheng, H and Yuan, H and Xu, QM and Shu, C and Zhang, YF and Xu, PB and Tan, JS and Rui, YC and Li, PW and Tan, XS
SCIENTIFIC REPORTS, ISSN 2045-2322, 01/2016, Volume 6
Immunotherapy is one of the key strategies for cancer treatment. The cGAS-cGAMP-STING-IRF3 pathway of cytosolic DNA sensing plays a pivotal role in antiviral... 
2ND-MESSENGER | DNA SENSOR | CYCLIC GMP-AMP | DINUCLEOTIDE | DENDRITIC CELLS | MECHANISM | VASCULAR DISRUPTING AGENT | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | TUMOR MICROENVIRONMENT | I INTERFERON
Journal Article
Journal Article