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Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2007, Volume 103, Issue 1, pp. 61 - 64
Lung maturation is delayed in male fetuses compared to females and androgens are responsible of this delay. On the other hand, a normal role was proposed for... 
Lung maturation | Androgens | 3α-HSD | 5α-Reductase | Surfactant
Journal Article
Psychopharmacology, ISSN 0033-3158, 9/2014, Volume 231, Issue 17, pp. 3597 - 3608
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 52, Issue 5, pp. 705 - 711
Background & Aims Suppression of the hypothalamic–pituitary–adrenal axis occurs in cirrhosis and cholestasis and is associated with increased concentrations of... 
Gastroenterology and Hepatology | Jaundice | 5β-reductase | Adrenal | Glucocorticoid | Bile acid | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | OBESE ZUCKER RATS | TISSUE | MINERALOCORTICOID RECEPTOR | 5 beta-reductase | CIRRHOSIS | IN-VIVO | LIVER | GENE-EXPRESSION | SEPTIC SHOCK | CHENODEOXYCHOLIC ACID | GASTROENTEROLOGY & HEPATOLOGY | Jaundice, Obstructive - metabolism | Transcription, Genetic - drug effects | Bile Acids and Salts - pharmacology | Liver - enzymology | Tetrahydrocortisol - urine | Rats, Wistar | Humans | Hydrocortisone - metabolism | Male | Promoter Regions, Genetic - drug effects | Promoter Regions, Genetic - genetics | Cytosol - enzymology | Ligation | Glucocorticoids - metabolism | Base Sequence | Female | Hypothalamo-Hypophyseal System - physiology | Jaundice, Obstructive - drug therapy | Pituitary-Adrenal System - physiology | Hypothalamo-Hypophyseal System - drug effects | Pituitary-Adrenal System - drug effects | Rats | Bile Ducts - physiology | Animals | Bile Acids and Salts - therapeutic use | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Jaundice, Obstructive - urine | Index Medicus | Cyp11b1, 11β-hydroxylase | NEFA, non-esterified fatty acids | ALP, alkaline phosphatase | DHB, dihydrocorticosterone | GCMS, gas chromatography mass spectrometry | DCA, deoxycholic acid | FF, fat-free | THB, tetrahydrocorticosterone | SEM, standard error of mean | CA, cholic acid | ANOVA, analysis of variance | GCDCA, glyco-CDCA | TCDCA, tauro-CDCA | FXR, farnesoid X receptor | CDCA, chenodeoxycholic acid | ECRP, endoscopic retrograde cholangiopancreatography | 11βHSD, 11β-hydroxysteroid dehydrogenase | ALT, alanine transaminase | 3αHSD, 3α-hydroxysteroid dehydrogenase | DMEM, Dulbecco’s modified Eagle’s medium | ACTH, adrenocorticotropic hormone | Cyp7a1, cholesterol 7α-hydroxylase | BDL, bile duct ligation | PCR, polymerase chain reaction | HPA, hypothalamic–pituitary–adrenal | Ki, inhibitor constant
Journal Article
Journal Article
Brain Research Bulletin, ISSN 0361-9230, 2011, Volume 87, Issue 2, pp. 280 - 285
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2009, Volume 311, Issue 1, pp. 109 - 119
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 3, pp. 1084 - 1089
We report the substituent effects on the mechanism of reduction of acetophenone derivatives that were contained in the number of the structure of the drug,... 
Metabolic enantioselective reduction | Hammett’s reaction constant | 3α-HSD | Hammett's reaction constant | KETONES | CHEMISTRY, MEDICINAL | INHIBITION | REDUCTION | MECHANISM | KINETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURIFICATION | CHEMISTRY, ORGANIC | CYTOSOL | BOROHYDRIDE
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2005, Volume 391, Issue 3, pp. 549 - 560
Although the physiological roles of the individual bile acid synthetic enzymes have been extensively examined, relatively little is known regarding the... 
Cholesteryl ester | Gene ablation | Bile acid | Fatty-acid-binding protein | Liver | Cholesterol | RAT | bile acid | liver | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BILIARY CHOLESTEROL | STEROL CARRIER PROTEIN-2 | CHOLESTEROL TRAFFICKING | CHAIN | gene ablation | TRANSPORT | cholesterol | fatty-acid-binding protein | SECRETION | L-CELL FIBROBLASTS | cholesteryl ester | MODULATION | Up-Regulation | Bile Acids and Salts - blood | Liver - enzymology | Gallbladder - metabolism | Down-Regulation | Liver - metabolism | Bile Acids and Salts - metabolism | Cytoplasm - metabolism | Lipid Metabolism | Male | Fatty Acid-Binding Proteins - metabolism | Cholesterol - metabolism | Fatty Acid-Binding Proteins - genetics | Gene Expression Regulation, Enzymologic | Fatty Acid-Binding Proteins - deficiency | Phenotype | Animals | Gene Deletion | Protein Binding | Mice | Fatty Acids - metabolism | Index Medicus | L-FABP, liver fatty-acid-binding protein | SHP, short heterodimer partner | apo A1, apolipoprotein A1 | HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA | OATP-1, organic anion transporting polypeptide 1 | SCP-2, sterol carrier protein-2 | BSEP, bile salt export pump | PPARα, peroxisome-proliferator-activated receptor α | 3α-HSD, 3α-hydroxysteroid dehydrogenase | FTM, fat tissue mass | LDL, low-density lipoprotein | MRP2, multidrug resistance associated protein 2 | SREBP-1, sterol-regulatory-element-binding protein 1 | CYP7A1, cholesterol 7α-hydroxylase | GST, glutathione S-transferase | FXR, farnesoid X receptor | ACAT, acyl-CoA:cholesterol acyltransferase | 3-ketoacyl-CoA thiolase | LTM, lean tissue mass | ACBP, acyl-CoA-binding protein | CYP27A1, sterol 27α-hydroxylase | SCP-x, sterol carrier protein-x | SRB-1, scavenger receptor class B type I | DEXA, dual-energy X-ray absorptiometry | LXRα, liver X receptor α
Journal Article
Journal of Biotechnology, ISSN 0168-1656, 2007, Volume 129, Issue 1, pp. 131 - 139
3α-Hydroxysteroid dehydrogenase/carbonyl reductase (3α-HSD/CR) from belongs to the short chain dehydrogenase/reductase (SDR) protein superfamily and catalyzes... 
SDR | MD-simulation | 3α-HSD/CR | Dimerization | CATABOLISM | 3 alpha-HSD/CR | CRYSTAL-STRUCTURE | dimerization | CARBONYL REDUCTASE | DROSOPHILA ALCOHOL-DEHYDROGENASE | ANGSTROM RESOLUTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PURIFICATION | CONSEQUENCES | BINDING | EXPRESSION | SHORT-CHAIN DEHYDROGENASES
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2004, Volume 91, Issue 3, pp. 157 - 170
The growth and development of the prostate gland are regulated by androgens. Despite our understanding of molecular actions of 5α-dihydrotestosterone (5α-DHT)... 
5α-Androstane-3α,17β-diol | Array analysis | 5α-Dihydrotesotsterone | Androgen receptor | Androgen receptor target genes | DHT | androgen receptor | androgen response elements | 3α-hydroxysteroid dehydrogenase | androgen responsive gene | ARE | ARG | 3α-HSD | 3α-Diol | 5α-androstane-3α,17β-diol
Journal Article