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Journal of Neurochemistry, ISSN 0022-3042, 06/1999, Volume 72, Issue 6, pp. 2278 - 2285
: Deficiency of nonsterol isoprenoids, intermediate metabolites of the cholesterol biosynthetic pathway, has been known to cause an inhibition of DNA synthesis... 
3‐Hydroxy‐3‐methyl‐glutaryl coenzyme A reductase inhibitor | β‐Migrating very low density lipoprotein | Isoprenoid products | Neuronal cell death | Cholesterol | Compactin | 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor | β- Migrating very low density lipoprotein | LOVASTATIN | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HMG-COA REDUCTASE | isoprenoid products | compactin | NEUROSCIENCES | DNA-REPLICATION | neuronal cell death | MEVALONIC ACID | beta-migrating very low density lipoprotein | HUMAN-FIBROBLASTS | METABOLISM | LAMIN-B | 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor | cholesterol | GROWTH-FACTOR | PROTEINS | Lovastatin - pharmacology | Apoptosis - drug effects | Embryo, Mammalian | Neurons - cytology | Lovastatin - analogs & derivatives | Cerebral Cortex - cytology | PC12 Cells | Squalene - metabolism | Cerebral Cortex - metabolism | Neurons - metabolism | Neurons - drug effects | Mevalonic Acid - pharmacology | Cell Survival - drug effects | Rabbits | Tricarboxylic Acids - pharmacology | Acetates - metabolism | Lipoproteins, VLDL - pharmacology | Rats | Mevalonic Acid - metabolism | Rats, Sprague-Dawley | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Squalene - pharmacology | Mice | Kinetics | Cholesterol - biosynthesis | 3T3 Cells | isoprenoids
Journal Article
Clinical Cardiology, ISSN 0160-9289, 09/2000, Volume 23, Issue 9, pp. 682 - 688
Background: Simvastatin and atorvastatin are effective statins for treating hypercholesterolemia. Hypothesis: The study was undertaken to compare the efficacy... 
simvastatin | 3‐hydroxy‐3‐methyl‐glutaryl coenzyme A reductase inhibitors | triglycerides | atorvastatin | low‐density lipoprotein cholesterol | hypercholesterolemia | Atorvastatin | Triglycerides | Hypercholesterolemia | 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors | Simvastatin | Low-density lipoprotein cholesterol | MORTALITY | TRIGLYCERIDE | CARDIAC & CARDIOVASCULAR SYSTEMS | CHOLESTEROL | SAFETY | low-density lipoprotein cholesterol | FOLLOW-UP | CORONARY HEART-DISEASE | REDUCTION | 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Simvastatin - therapeutic use | Simvastatin - adverse effects | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Male | Heptanoic Acids - adverse effects | Hypercholesterolemia - drug therapy | Pyrroles - administration & dosage | Lipids - blood | Statistics, Nonparametric | Heptanoic Acids - administration & dosage | Pyrroles - adverse effects | Adult | Female | Pyrroles - therapeutic use | Hypercholesterolemia - blood | Drug Administration Schedule | Simvastatin - administration & dosage | Lipoproteins - blood | Anticholesteremic Agents - adverse effects | Cross-Over Studies | Anticholesteremic Agents - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Analysis of Variance | Anticholesteremic Agents - administration & dosage | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Aged
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