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1992, ISBN 0881678201, Volume 25., xvii, 429 p. : ill. ; 24 cm.
Book
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0157308
Endogenous cyclic diadenylate phosphodiesterase activity was accidentally detected in lysates of Escherichia coli BL21. Since this kind of activity is uncommon... 
MYCOBACTERIUM-TUBERCULOSIS | CELLULOSE SYNTHESIS | 3-NUCLEOTIDASE ACTIVITY | BACILLUS-SUBTILIS | AFFECT BACTERIAL-GROWTH | MULTIDISCIPLINARY SCIENCES | ENTERICA SEROVAR PULLORUM | GMP-SPECIFIC PHOSPHODIESTERASE | C-DI-AMP | DIPHOSPHATE-SUGAR HYDROLASE | ACETOBACTER-XYLINUM | Nucleotidases - genetics | Nucleotides, Cyclic - metabolism | Recombinant Proteins - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | 2',3'-Cyclic-Nucleotide Phosphodiesterases - genetics | Phosphoric Diester Hydrolases - metabolism | Escherichia coli Proteins - metabolism | Phosphoric Diester Hydrolases - genetics | Recombinant Proteins - genetics | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism | Nucleotidases - metabolism | Escherichia coli - genetics | Cloning, Molecular | Escherichia coli - metabolism | Escherichia coli Proteins - genetics | Escherichia coli | Analysis | Physiological aspects | Genetic aspects | Research | Recombinant proteins | Nucleotidases | Nucleotidase | Salmonella | Cellulose | Homeostasis | Proteins | Lysates | Annotations | E coli | Cell cycle | Bacteria | Gram-negative bacteria | Catalysis | DNA fingerprinting | Fusion protein | Deoxyribonucleic acid--DNA | Recombinant | Phosphodiesterase | Immune system | Enzymes | AMP | Gel electrophoresis | Cloning | Amino acid sequence | Substrates | Biofilms | Tuberculosis | Fingerprinting | Periplasm | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Cell, ISSN 0092-8674, 02/2012, Volume 148, Issue 3, pp. 421 - 433
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 49, pp. 19532 - 19537
Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may... 
Protein isoforms | T lymphocytes | Chronic lymphocytic leukemia | Messenger RNA | Cyclic nucleotides | B lymphocytes | Medical treatment | Apoptosis | Vehicles | B cell leukemia | B cell | Survivin | cAMP | survivin | CELLS | CAMP-SPECIFIC PHOSPHODIESTERASE | AMP | INHIBITOR-INDUCED APOPTOSIS | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | apoptosis | HUMAN B-LYMPHOCYTES | THEOPHYLLINE | PATHWAY | THERAPEUTIC TARGET | GENE-EXPRESSION | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 | Humans | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | RNA, Messenger - metabolism | Enzyme Activation - immunology | Cell Division - immunology | Cyclic Nucleotide Phosphodiesterases, Type 7 - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - physiopathology | Membrane Potential, Mitochondrial | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Phosphodiesterase 3 Inhibitors | Cells, Cultured | Cyclic Nucleotide Phosphodiesterases, Type 7 - metabolism | Phosphodiesterase Inhibitors - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Gene Expression Regulation, Leukemic | Gene Expression Regulation, Enzymologic | Apoptosis - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 7 - antagonists & inhibitors | Physiological aspects | Genetic aspects | Cyclic adenylic acid | Research | Drug therapy | Phosphodiesterases | Biological Sciences
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2006, Volume 533, Issue 1-3, pp. 110 - 117
Phosphodiesterases hydrolyse intracellular cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) into inactive 5′... 
Phosphodiesterase inhibitor | Rolipram | Chronic obstructive pulmonary disease | Roflumilast | Cilomilast | Phosphodiesterase | Asthma | roflumilast | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | EOSINOPHIL INFILTRATION | rolipram | asthma | NECROSIS-FACTOR-ALPHA | GM-CSF RELEASE | PDE4 INHIBITORS | OBSTRUCTIVE PULMONARY-DISEASE | phosphodiesterase inhibitor | CAMP-PHOSPHODIESTERASES | PHARMACOLOGY & PHARMACY | CD8(+) T-LYMPHOCYTES | phosphodiesterase | TNF-ALPHA | cilomilast | ANTIINFLAMMATORY DRUGS | chronic obstructive pulmonary disease | Phosphodiesterase Inhibitors - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 | Nitriles - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 | Humans | Cyclopropanes - therapeutic use | Benzamides - therapeutic use | Aminopyridines - therapeutic use | Isoenzymes - metabolism | Anti-Inflammatory Agents - therapeutic use | Carboxylic Acids - therapeutic use | Benzamides - pharmacology | Carboxylic Acids - pharmacology | Cyclopropanes - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Phosphoric Diester Hydrolases - metabolism | Anti-Inflammatory Agents - pharmacology | Asthma - enzymology | Phosphodiesterase Inhibitors - pharmacology | Clinical Trials as Topic | Asthma - drug therapy | Pulmonary Disease, Chronic Obstructive - enzymology | Animals | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Aminopyridines - pharmacology | 3',5'-Cyclic-GMP Phosphodiesterases | Cyclohexanecarboxylic Acids | Cyclic Nucleotide Phosphodiesterases, Type 7 | Isoenzymes - antagonists & inhibitors | Nitriles - therapeutic use | Pulmonary Disease, Chronic Obstructive - drug therapy | Hydrolysis | Hypertension | Isoenzymes | Guanosine | Cyclic adenylic acid | Esterases | T cells | Adenylic acid | Cyclic guanylic acid
Journal Article
Oral Diseases, ISSN 1354-523X, 01/2015, Volume 21, Issue 1, pp. e25 - e50
By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical... 
protein kinase A (PKA) | phosphodiesterase (PDE) | A‐kinase anchoring protein (AKAP) | signalosome | oral and systemic diseases | cancer | cAMP | Phosphodiesterase (PDE) | Signalosome | A-kinase anchoring protein (AKAP) | Protein kinase A (PKA) | Oral and systemic diseases | Cancer | BONE MORPHOGENETIC PROTEIN-2 | MULTIPLE MOLECULAR-FORMS | GLUCOCORTICOID-INDUCED OSTEOPOROSIS | ROD CGMP PHOSPHODIESTERASE | OBSTRUCTIVE PULMONARY-DISEASE | DENTISTRY, ORAL SURGERY & MEDICINE | CHRONIC LYMPHOCYTIC-LEUKEMIA | DUCHENNE MUSCULAR-DYSTROPHY | TYPE-2 DIABETES-MELLITUS | CAMP-SPECIFIC PHOSPHODIESTERASES | STATIONARY NIGHT BLINDNESS | 3',5'-Cyclic-GMP Phosphodiesterases - drug effects | Phosphodiesterase Inhibitors - therapeutic use | Animals | Signal Transduction - drug effects | 3',5'-Cyclic-GMP Phosphodiesterases - physiology | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors | Humans | Phosphodiesterase Inhibitors - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - drug effects | Signal Transduction - physiology | 3',5'-Cyclic-AMP Phosphodiesterases - physiology | Medical research | Enzymes | Oral diseases | Mutation | Rodents | Crystal structure | Protein Kinase A | Phosphodiesterase | A Kinase Anchoring Protein | Oral and Systemic Diseases | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | protein (AKAP) | Clinical Medicine | Endokrinologi och diabetes | A-kinase anchoring | Endocrinology and Diabetes
Journal Article