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Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 03/2015, Volume 403, Issue C, pp. 10 - 20
Journal Article
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 07/2006, Volume 15, Issue 7, pp. 733 - 742
Cyclic nucleotide phosphodiesterases (PDE) 3 and 5 regulate cAMP and cGMP signalling in cardiac and smooth muscle myocytes. Important advances in the... 
heart failure | vasodilation | phosphodiesterase inhibitor | cyclic GMP | cyclic nucleotide phosphodiesterase | cyclic AMP | inotropy | myocardium | Heart failure | Phosphodiesterase inhibitor | Inotropy | Cyclic GMP | Cyclic AMP | Myocardium | Vasodilation | Cyclic nucleotide phosphodiesterase | Prospective Studies | Cyclic Nucleotide Phosphodiesterases, Type 5 | Humans | Cyclic Nucleotide Phosphodiesterases, Type 3 | Drugs, Investigational - therapeutic use | Half-Life | Cardiomyopathy, Hypertrophic - enzymology | Hypertension, Pulmonary - drug therapy | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cyclic AMP - metabolism | Hypertension, Pulmonary - enzymology | Muscle, Smooth, Vascular - drug effects | Heart Failure - complications | Rats | Cardiotonic Agents - pharmacology | Forecasting | Heart Failure - drug therapy | Myocytes, Cardiac - drug effects | Cyclic GMP - metabolism | 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors | Pulmonary Circulation - drug effects | Cardiomyopathy, Hypertrophic - prevention & control | Coronary Circulation - drug effects | Hypertension, Pulmonary - etiology | Muscle, Smooth, Vascular - enzymology | Phosphodiesterase Inhibitors - therapeutic use | Drugs, Investigational - pharmacology | Vasodilator Agents - therapeutic use | Heart Failure - enzymology | 3',5'-Cyclic-AMP Phosphodiesterases - classification | 3',5'-Cyclic-GMP Phosphodiesterases - classification | Cardiomyopathy, Hypertrophic - drug therapy | 3',5'-Cyclic-AMP Phosphodiesterases - physiology | Cardiotonic Agents - therapeutic use | Myocytes, Cardiac - enzymology | Multicenter Studies as Topic | Protein Processing, Post-Translational - drug effects | Drug Evaluation, Preclinical | Drug Therapy, Combination | Adrenergic beta-Antagonists - administration & dosage | Adrenergic beta-Antagonists - therapeutic use | Isoenzymes - physiology | Cyclic AMP-Dependent Protein Kinases - metabolism | Vasodilator Agents - pharmacology | 3',5'-Cyclic-GMP Phosphodiesterases - physiology | Phosphodiesterase Inhibitors - pharmacology | Treatment Outcome | Enzyme Activation - drug effects | Randomized Controlled Trials as Topic | Animals | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Isoenzymes - antagonists & inhibitors
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/1999, Volume 128, Issue 7, pp. 1393 - 1398
Of the four major phosphodiesterase 4 (PDE4) subtypes, PDE4A, PDE4B and PDE4D are widely expressed in human inflammatory cells, including monocytes and T... 
T lymphocytes | monocytes | tumour necrosis factor α | PDE4 subtypes | PDE4 | PDE4 inhibitors | T lymphocyte proliferation | Cyclic nucleotide phosphodiesterase | Tumour necrosis factor α | Monocytes | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN | AFFINITY ROLIPRAM BINDING | DROSOPHILA-MELANOGASTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMP-SPECIFIC PHOSPHODIESTERASE | MESSENGER-RNA | cyclic nucleotide phosphodiesterase | N-TERMINAL DOMAIN | CATALYTIC ACTIVITY | PHARMACOLOGY & PHARMACY | MOLECULAR-CLONING | tumour necrosis factor alpha | MEMBRANE ASSOCIATION | Cyclic Nucleotide Phosphodiesterases, Type 4 | T-Lymphocytes - enzymology | Humans | Cyclic Nucleotide Phosphodiesterases, Type 3 | 3',5'-Cyclic-AMP Phosphodiesterases - classification | Substrate Specificity | Monocytes - immunology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Isoenzymes - classification | T-Lymphocytes - drug effects | Immunosuppressive Agents - classification | Phosphodiesterase Inhibitors - classification | Immunosuppressive Agents - pharmacology | Monocytes - secretion | Mites - immunology | Tumor Necrosis Factor-alpha - secretion | Phosphodiesterase Inhibitors - pharmacology | Inflammation - immunology | Monocytes - drug effects | Monocytes - enzymology | Animals | Lymphocyte Activation - drug effects | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Antigens - immunology | T-Lymphocytes - immunology | Inflammation - enzymology | Isoenzymes - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Papers
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 1996, Volume 17, Issue 8, pp. 294 - 298
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 2007, Volume 22, Issue 3, pp. 309 - 318
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2004, Volume 14, Issue 18, pp. 4627 - 4631
Journal Article
Neuroscience, ISSN 0306-4522, 2003, Volume 117, Issue 3, pp. 627 - 638
Hippocampal long-term potentiation (LTP), the most prominent cellular model for learning and memory formation, consists of phases: early-LTP (<4 h) and... 
neuronal plasticity | cAMP-specific phosphodiesterase | hippocampal slice in vitro | late-LTP | gene expression | long-term potentiation (LTP) | Neuronal plasticity | Gene expression | Hippocampal slice in vitro | Late-LTP | Long-term potentiation (LTP) | IMMEDIATE-EARLY GENE | ACTIVATED PROTEIN-KINASE | NMDA RECEPTOR ACTIVATION | AREA CA1 | NEUROSCIENCES | CYCLIC-AMP | MESSENGER-RNA | ADENYLYL-CYCLASE | RECENT PROGRESS | MOLECULAR-CLONING | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Cyclic Nucleotide Phosphodiesterases, Type 4 | Gene Expression - drug effects | Rats, Wistar | 3',5'-Cyclic-AMP Phosphodiesterases - classification | Electrophysiology | Male | Hippocampus - drug effects | 3',5'-Cyclic-AMP Phosphodiesterases - physiology | RNA, Messenger - biosynthesis | Time Factors | Gene Expression - physiology | Reverse Transcriptase Polymerase Chain Reaction - methods | Neurons - physiology | Long-Term Potentiation - physiology | Electric Stimulation - methods | Animals, Newborn | Blotting, Western - methods | Hemolysin Proteins | Valine - analogs & derivatives | Rats | Long-Term Potentiation - genetics | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Animals | Bacterial Proteins - metabolism | Blotting, Northern - methods | Valine - pharmacology | Hippocampus - physiology | In Vitro Techniques | Neurofilament Proteins - metabolism
Journal Article