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Cell, ISSN 0092-8674, 02/2012, Volume 148, Issue 3, pp. 421 - 433
Journal Article
Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7544, pp. 472 - 476
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, pp. e0157308 - e0157308
Endogenous cyclic diadenylate phosphodiesterase activity was accidentally detected in lysates of Escherichia coli BL21. Since this kind of activity is uncommon... 
MYCOBACTERIUM-TUBERCULOSIS | CELLULOSE SYNTHESIS | 3-NUCLEOTIDASE ACTIVITY | BACILLUS-SUBTILIS | AFFECT BACTERIAL-GROWTH | MULTIDISCIPLINARY SCIENCES | ENTERICA SEROVAR PULLORUM | GMP-SPECIFIC PHOSPHODIESTERASE | C-DI-AMP | DIPHOSPHATE-SUGAR HYDROLASE | ACETOBACTER-XYLINUM | Nucleotidases - genetics | Nucleotides, Cyclic - metabolism | Recombinant Proteins - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | 2',3'-Cyclic-Nucleotide Phosphodiesterases - genetics | Phosphoric Diester Hydrolases - metabolism | Escherichia coli Proteins - metabolism | Phosphoric Diester Hydrolases - genetics | Recombinant Proteins - genetics | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism | Nucleotidases - metabolism | Escherichia coli - genetics | Cloning, Molecular | Escherichia coli - metabolism | Escherichia coli Proteins - genetics | Escherichia coli | Analysis | Physiological aspects | Genetic aspects | Research | Recombinant proteins | Nucleotidases | Nucleotidase | Salmonella | Cellulose | Homeostasis | Proteins | Lysates | Annotations | E coli | Cell cycle | Bacteria | Gram-negative bacteria | Catalysis | DNA fingerprinting | Fusion protein | Deoxyribonucleic acid--DNA | Recombinant | Phosphodiesterase | Immune system | Enzymes | AMP | Gel electrophoresis | Cloning | Amino acid sequence | Substrates | Biofilms | Tuberculosis | Fingerprinting | Periplasm | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3668 - 3681
The intracellular infections of Mycobacterium tuberculosis, which is the causative agent of tuberculosis, are regulated by many cyclic dinucleotide signaling.... 
enzyme degradation | PROTEIN | LONG-TERM SURVIVAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | structure-function | GMP | SPORULATION | IDENTIFICATION | Mycobacterium tuberculosis | AFFECT BACTERIAL-GROWTH | phosphodiesterases | LEADS | cyclic diadenosine monophosphate (c-di-AMP) | AMP PHOSPHODIESTERASE | REVEALS | Exoribonucleases - genetics | Bacterial Proteins - chemistry | Exoribonucleases - chemistry | Molecular Sequence Data | Substrate Specificity | Dinucleoside Phosphates - chemistry | Recombinant Fusion Proteins - metabolism | Cyclic AMP - chemistry | Cyclic AMP - analogs & derivatives | Cyclic GMP - analogs & derivatives | Cyclic GMP - chemistry | Conserved Sequence | Cyclic AMP - metabolism | Peptide Fragments - genetics | Recombinant Proteins - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Amino Acid Sequence | Catalytic Domain | Peptide Fragments - metabolism | Biocatalysis | 3',5'-Cyclic-GMP Phosphodiesterases - genetics | Bacterial Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | 3',5'-Cyclic-GMP Phosphodiesterases - chemistry | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Recombinant Fusion Proteins - chemistry | Dinucleoside Phosphates - metabolism | Peptide Fragments - chemistry | Sequence Alignment | 3',5'-Cyclic-AMP Phosphodiesterases - chemistry | 3',5'-Cyclic-GMP Phosphodiesterases - metabolism | Cyclic GMP - metabolism | Mycobacterium tuberculosis - enzymology | Bacterial Proteins - metabolism | Protein Conformation | Mutation | Exoribonucleases - metabolism | Index Medicus | Enzymology
Journal Article
Circulation research, ISSN 0009-7330, 04/2015, Volume 116, Issue 8, pp. 1304 - 1311
Rationale: Cyclic nucleotides are second messengers that regulate cardiomyocyte function through compartmentalized signaling in discrete subcellular... 
phosphodiesterase 3 inhibitors | membrane microdomains | 3',5'-cyclic-AMP phosphodiesterases | hypertrophy | atrial natriuretic factor | receptors, adrenergic | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | ATRIAL-NATRIURETIC-PEPTIDE | MYOCYTES | HEART-FAILURE | RECEPTOR | CARDIOMYOCYTES | 3 ',5 '-cyclic-AMP phosphodiesterases | PERIPHERAL VASCULAR DISEASE | MICE | GUANYLYL CYCLASE-A | HEMATOLOGY | COMPARTMENTATION | CAMP | Myocardial Contraction - drug effects | Cardiomegaly - pathology | Receptors, Adrenergic, beta-2 - drug effects | Myocytes, Cardiac - enzymology | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Fluorescence Resonance Energy Transfer | Female | Receptors, Adrenergic, beta-1 - drug effects | Atrial Natriuretic Factor - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Receptors, Adrenergic, beta - drug effects | Receptors, Adrenergic, beta - metabolism | Disease Models, Animal | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Second Messenger Systems - drug effects | Membrane Microdomains - enzymology | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Adrenergic beta-Agonists - pharmacology | Cardiomegaly - physiopathology | Mice, Transgenic | Receptors, Adrenergic, beta-1 - metabolism | Cardiomegaly - enzymology | Receptors, Adrenergic, beta-2 - metabolism | Protein Transport | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Cyclic GMP - metabolism | Membrane Microdomains - drug effects | Isoproterenol - pharmacology | Biosensing Techniques | Mice | Enzyme Activation | Receptor Cross-Talk - drug effects | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 49, pp. 19532 - 19537
Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may... 
Protein isoforms | T lymphocytes | Chronic lymphocytic leukemia | Messenger RNA | Cyclic nucleotides | B lymphocytes | Medical treatment | Apoptosis | Vehicles | B cell leukemia | B cell | Survivin | cAMP | survivin | CELLS | CAMP-SPECIFIC PHOSPHODIESTERASE | AMP | INHIBITOR-INDUCED APOPTOSIS | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | apoptosis | HUMAN B-LYMPHOCYTES | THEOPHYLLINE | PATHWAY | THERAPEUTIC TARGET | GENE-EXPRESSION | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 | Humans | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | RNA, Messenger - metabolism | Enzyme Activation - immunology | Cell Division - immunology | Cyclic Nucleotide Phosphodiesterases, Type 7 - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - physiopathology | Membrane Potential, Mitochondrial | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Phosphodiesterase 3 Inhibitors | Cells, Cultured | Cyclic Nucleotide Phosphodiesterases, Type 7 - metabolism | Phosphodiesterase Inhibitors - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Gene Expression Regulation, Leukemic | Gene Expression Regulation, Enzymologic | Apoptosis - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 7 - antagonists & inhibitors | Physiological aspects | Genetic aspects | Cyclic adenylic acid | Research | Drug therapy | Phosphodiesterases | Enzymes | Protein folding | Leukemia | Gene expression | Ribonucleic acid--RNA | Cells | Index Medicus | Biological Sciences
Journal Article
Cell, ISSN 0092-8674, 2005, Volume 123, Issue 1, pp. 25 - 35
Phosphodiesterases (PDEs) regulate the local concentration of 3′,5′ cyclic adenosine monophosphate (cAMP) within cells. cAMP activates the cAMP-dependent... 
PROTEIN-KINASE-A | CYCLIC-AMP | CAMP-SPECIFIC PHOSPHODIESTERASE | SUDDEN-DEATH | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC MYOCYTES | VENTRICULAR MYOCYTES | RELEASE | FAILING HEARTS | CA2+ LEAK | CELL BIOLOGY | Phosphorylation | Arrhythmias, Cardiac - chemically induced | Cyclic Nucleotide Phosphodiesterases, Type 4 | Heart Failure - enzymology | Cyclic Nucleotide Phosphodiesterases, Type 3 | Ryanodine Receptor Calcium Release Channel - metabolism | Myocytes, Cardiac - enzymology | 3',5'-Cyclic-AMP Phosphodiesterases - deficiency | Arrhythmias, Cardiac - genetics | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Enzyme Inhibitors - adverse effects | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Heart Failure - genetics | Mice, Transgenic | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Mice, Knockout | Myocardium - enzymology | Animals | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Muscle Contraction - physiology | Arrhythmias, Cardiac - enzymology | Mice | Heart Failure - chemically induced | Macromolecular Substances - metabolism | Heart failure | Cyclic adenylic acid | Research | Arrhythmia | Phosphodiesterases | Risk factors | Medical colleges | Medical societies | Cardiac patients | Esterases | Adenylic acid | Protein kinases | Heart attack | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2006, Volume 116, Issue 12, pp. 3240 - 3251
Journal Article