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3,5-disubstituted 1,2,4-thiadiazoles (29) 29
chemistry, organic (20) 20
oxidative dimerization (16) 16
thioamides (14) 14
derivatives (13) 13
dimerization (11) 11
heterocycles (10) 10
chemistry, multidisciplinary (7) 7
1,2,4-thiadiazoles (6) 6
index medicus (6) 6
chemistry, medicinal (5) 5
humans (5) 5
mild (5) 5
oxidizing-agents (5) 5
structure-activity relationship (5) 5
3,5-diaryl-1,2,4-thiadiazoles (4) 4
biological evaluation (4) 4
cyclization (4) 4
inhibitors (4) 4
sulfur (4) 4
animals (3) 3
article (3) 3
cancer (3) 3
chemistry (3) 3
diacetate (3) 3
medicinal chemistry (3) 3
nitriles (3) 3
nonpeptide inhibitors (3) 3
one-pot synthesis (3) 3
oxidation (3) 3
resveratrol (3) 3
sulfides (3) 3
synthesis (3) 3
thiadiazole (3) 3
thiadiazoles (3) 3
thiadiazoles - chemistry (3) 3
thioamide (3) 3
1,2,4-thiadiazole (2) 2
agents (2) 2
aliphatic compounds (2) 2
analogs (2) 2
analytical chemistry (2) 2
antineoplastic agents - chemistry (2) 2
antineoplastic agents - pharmacology (2) 2
aromatic compounds (2) 2
beta-secretase (2) 2
biochemistry & molecular biology (2) 2
chemoprevention (2) 2
convenient (2) 2
conversion (2) 2
crystal structure (2) 2
drug design (2) 2
drug discovery (2) 2
efficient (2) 2
efficient synthesis (2) 2
elemental sulfur (2) 2
green chemistry (2) 2
hypervalent iodine (2) 2
iodine (2) 2
ligands (2) 2
mice (2) 2
molecular structure (2) 2
nadh dehydrogenase (2) 2
neoplasms - drug therapy (2) 2
organic chemistry (2) 2
oxone (2) 2
oxygen (2) 2
pharmacology & pharmacy (2) 2
polyoxometalate (2) 2
selenium (2) 2
stilbenes - chemistry (2) 2
structural basis (2) 2
sulfur compounds (2) 2
thiadiazoles - chemical synthesis (2) 2
thiadiazoles - pharmacology (2) 2
thiazoles (2) 2
thiazoles - chemical synthesis (2) 2
thiazoles - chemistry (2) 2
thiols (2) 2
1,2,4-oxadiazoles (1) 1
1,2,4-selenodiazoles (1) 1
1,2,4-triazoles (1) 1
1,2,4‐thiadiazoles (1) 1
1,3-dibromo-5,5-dimethylhydantoin (1) 1
2,1-benzisoxazoles (1) 1
3,5-bis-1,2,4-thiadiazole (1) 1
3,5-disubstituted (1) 1
3,5-disubstituted indole-derivatives (1) 1
acids, noncarboxylic - chemistry (1) 1
acute-pancreatitis (1) 1
aeorbic oxidative cyclization (1) 1
aerobic oxidation (1) 1
aerobiosis (1) 1
agonist (1) 1
allosteric modulator (1) 1
alpha-tocopherolhydroquinone (1) 1
alzheimers-disease (1) 1
amides (1) 1
amides - chemistry (1) 1
amidines (1) 1
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The Journal of Organic Chemistry, ISSN 0022-3263, 08/2018, Volume 83, Issue 16, pp. 9334 - 9343
A copper-catalyzed aerobic oxidative annulation reaction of 2-aminopyridine/amidine with isothiocyanate has been reported. This strategy involving C–N/N–S bond... 
BETA-SECRETASE | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | REGIOSPECIFIC SYNTHESIS | HETEROCYCLES | ONE-POT SYNTHESIS | NONPEPTIDE INHIBITORS | FUSED QUINAZOLINONES | CHEMISTRY, ORGANIC | OXIME ACETATES | UNEXPECTED SYNTHESIS | CYCLIZATION
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 06/2017, Volume 58, Issue 26, pp. 2571 - 2573
[Display omitted] •High chemical diversity and complexity of the products by multicomponent reaction.•The employment of elemental sulfur and commercially... 
Elemental sulfur | Transition-metal free | Multicomponent reactions | 1,2,4-Thiadiazoles | DICHLORIDE | CHEMISTRY, ORGANIC | RECEPTOR | OXIDATIVE DIMERIZATION | THIOAMIDES | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | HETEROCYCLES | NITRILES | SELECTIVE METHOD | Sulfur compounds | Transition metal compounds | Sulfur
Journal Article
Synlett, ISSN 0936-5214, 03/2013, Volume 24, Issue 4, pp. 465 - 470
Abstract A new approach for an efficient metal-free synthesis of 1,2,4-thiadiazoles from primary thioamides using visible light and air in the presence of... 
letter | eosin Y | visible light | photoredox | thioamides | cyclization | thiadiazoles | PHOTOCATALYSIS | CHEMISTRY, ORGANIC | DIMERIZATION | PHOTOREDOX CATALYSIS | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | DIASTEREOSELECTIVE SYNTHESIS | HETEROCYCLES | OXIDIZING-AGENTS | INHIBITORS | EFFICIENT | DERIVATIVES
Journal Article
Chemical Communications: Chem Comm, ISSN 1359-7345, 05/2014, Volume 50, Issue 51, pp. 6748 - 6750
In the presence of Keggin-type phosphovanadomolybdic acids, e.g., H sub(6)PV sub(3)Mo sub(9)O sub(40), oxidative dimerization of various kinds of primary... 
Dimerization | Aliphatic compounds
Journal Article
Heterocycles, ISSN 0385-5414, 2018, Volume 96, Issue 3, pp. 509 - 517
A novel, simple protocol is disclosed for the synthesis of 1,2,4-thiadiazoles starting from thioamides with Na-2-eosin Y-sensitized titanium dioxide as... 
REAGENT | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | PHOSPHORUS PENTASULFIDE | 3,5-DIARYL-1,2,4-THIADIAZOLES | CONVERSION | NITRILES | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | OXIDATIVE DIMERIZATION | THIONATION | CARBOXYLIC-ACIDS
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 08/2014, Volume 2014, Issue 24, pp. 5149 - 5152
1,2,4‐Thiadiazoles were efficiently synthesized in good yields through the oxidative dimerization of carbothioamides by using Oxone as a readily available,... 
Heterocycles | Oxidation | Selenium | Oxone | Sulfur | CHEMISTRY, ORGANIC | CONVENIENT | THIOAMIDES | CLEAVAGE | C-H BONDS | ALLOSTERIC MODULATOR | REARRANGEMENT | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | HYPERVALENT IODINE | INTRAMOLECULAR OXIDATION | DERIVATIVES | Sulfur compounds
Journal Article
Synthetic Communications, ISSN 0039-7911, 07/2015, Volume 45, Issue 14, pp. 1681 - 1687
2,4,6-Tribromo-1,3,5-trihydroxybenzene (TBTHB) as a reagent was efficiently reacted with 6 molar equivalents of benzothioamides in dimethyl sulfoxide (DMSO),... 
thiadiazole | Heterocycles | thioamide | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | CHEMISTRY, ORGANIC | DERIVATIVES | THIOPHENE
Journal Article
Journal of Sulfur Chemistry, ISSN 1741-5993, 04/2012, Volume 33, Issue 2, pp. 165 - 170
In this paper, a facile and highly efficient synthesis of 3,5-disubstituted 1,2,4-thiadiazoles by oxidative dimerization of thioamides using pentylpyridinium... 
3,5-disubstituted 1,2,4-thiadiazoles | ionic liquid | thiobenzamide | oxidative cyclization | pentylpyridinium tribromide | MILD | OXIDATIVE DIMERIZATION | THIOAMIDES | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 03/2018, Volume 59, Issue 10, pp. 904 - 908
[Display omitted] •First organocatalytic methods are devised towards 1,2,4-selenadiazoles and thiadiazoles.•The methods exclude the need of metal-salts, toxic... 
Thiourea | Vitamin B3 | Aeorbic oxidative cyclization | Organocatalysis | 1,2,4-Selenodiazoles | 1,2,4-Thiadiazoles | Vitamin B | ANTIOXIDANT ACTIVITY | Vitamin B-3 | CHEMISTRY, ORGANIC | OXIDATIVE DIMERIZATION | SELENIUM | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | SELENYLATION | ORGANOSELENIUM | ANTIBACTERIAL ACTIVITY | CHEMISTRY | ARYL
Journal Article
Journal of the Iranian Chemical Society, ISSN 1735-207X, 9/2009, Volume 6, Issue 3, pp. 547 - 551
A novel and simple method for rapid conversion of thioamides to the corresponding 1,2,4-thiadiazole derivatives was developed. It was shown that, thioamides... 
Biochemistry, general | Chemistry | Analytical Chemistry | Synthesis | Physical Chemistry | N-Benzyl-DABCO-tribromide | 3,5-Disubstituted 1,2,4-thiadiazoles | Inorganic Chemistry | Aqueous media | Organic Chemistry | 3,5-Disubstituted | 1,2,4-thiadiazoles | NA+ OVERLOAD | CARDIOPROTECTIVE ACTIONS | INHIBITORS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | KC 12291
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 05/2017, Volume 2017, Issue 19, pp. 2670 - 2682
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 05/2017, Volume 82, Issue 10, pp. 5310 - 5316
A novel and expeditious approach for the synthesis of N-fused and 3,4-disubstituted 5-imino-1,2,4-thiadiazole derivatives has been achieved through the... 
1,2,4-OXADIAZOLES | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | ORGANIC-SYNTHESIS | MOLECULAR-IODINE | 3,5-DIARYL-1,2,4-THIADIAZOLES | AMIDINES | NITRILES | CHEMISTRY, ORGANIC | DIMERIZATION | 1,2,4-TRIAZOLES | THIOAMIDES
Journal Article
Organic Letters, ISSN 1523-7060, 05/2016, Volume 18, Issue 9, pp. 2196 - 2199
A novel route is disclosed for the synthesis of 1,2,4-thiadiazoles starting from amidines, elemental sulfur, and 2-methylquinolines or aldehydes under... 
VITRO ANTITUBERCULOSIS ACTIVITY | ELEMENTAL SULFUR | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | DESIGN | COUPLING REACTIONS | CHEMISTRY, ORGANIC | OXIDATIVE DIMERIZATION | AGENTS | REVERSIBLE INHIBITORS | DERIVATIVES | GASTRIC (H+/K+)-ATPASE
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 08/2016, Volume 81, Issue 15, pp. 6573 - 6579
An efficient synthesis of 3-substituted-5-arylamino-1,2,4-thiadiazoles through intramolecular oxidative S–N bond formation of imidoyl thioureas by... 
METAL-FREE SYNTHESIS | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | 3,5-DIARYL-1,2,4-THIADIAZOLES | ONE-POT SYNTHESIS | CYCLIZATION REACTIONS | 2,1-BENZISOXAZOLES | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | DIMERIZATION | PARALLEL SYNTHESIS | DERIVATIVES
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2011, Volume 52, Issue 38, pp. 4941 - 4943
Aryl thioamides undergo very rapid condensation in the presence of methyl bromocyanoacetate to provide quantitative yields of 3,5-diaryl-1,2,4-thiadiazoles... 
Thioamides | Condensation | 1,2,4-Thiadiazoles | Methyl bromocyanoacetate | MILD | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | DIARYL SELENOXIDE | OXIDIZING-AGENTS | CHEMISTRY, ORGANIC | OXIDATIVE DIMERIZATION | DIACETATE | Tetrahedrons | Purity | Synthesis (chemistry) | Condensates | Aromatic compounds
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 01/2018, Volume 59, Issue 3, pp. 272 - 276
[Display omitted] •Dimerization of thioamides and seleoamides was achieved with tert-butyl nitrite.•Reaction proceeds under catalyst and metal free conditions... 
Thiadiazoles | tert-Butyl nitrite | Green chemistry | Thiobenzamides | Dimerization | CHEMISTRY, ORGANIC | OXIDATIVE DIMERIZATION | BOND-CLEAVAGE | ARYLBORONIC ACIDS | MEDICINAL CHEMISTRY | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | METAL | DERIVATIVES | N-NITROSAMINES
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 08/2014, Volume 2014, Issue 22, pp. 4795 - 4804
The activation of the sulfur atom of thiols with (diacetoxyiodo)benzene (DIB) has been explored in the preparation of symmetrical disulfides and sulfenamides.... 
Heterocycles | Oxidation | Sulfur | Hypervalent compounds | Disulfides | Iodine | ASSISTED SYNTHESIS | CHEMISTRY, ORGANIC | OXIDATIVE DIMERIZATION | SYMMETRICAL DISULFIDES | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | THIOLS | SULFUR-NITROGEN BOND | AEROBIC OXIDATION | ORGANIC DISULFIDES | IODINE REAGENTS | DIARYL DISULFIDES | Chemical tests and reagents | Aromatic compounds | Thiols
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 09/2018, Volume 2018, Issue 34, pp. 4648 - 4672
Oxidative strategies are a powerful tool in organic synthesis for the formation of heteroatom–heteroatom, carbon–heteroatom, and carbon–carbon bonds. Among... 
S–N bonds | Cross‐coupling | Oxidation | Sulfur | Nitrogen | Reaction mechanisms | Oxidative coupling | Cross-coupling | ONE-STEP SYNTHESIS | ONE-POT SYNTHESIS | C-N | MEDIATED SYNTHESIS | CHEMISTRY, ORGANIC | ARENESULFONYL CHLORIDES | ELECTROCHEMICAL SYNTHESIS | 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES | ELECTROPHILIC NH | COPPER-CATALYZED SYNTHESIS | SULFONYL HYDRAZIDES | S-N bonds
Journal Article
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