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3-alkylidene oxindoles (27) 27
catalysis (15) 15
chemistry, organic (14) 14
michael addition (14) 14
chemistry, multidisciplinary (13) 13
construction (11) 11
aldol reaction (9) 9
organocatalysis (9) 9
asymmetric-synthesis (8) 8
alpha,beta-unsaturated gamma-butyrolactam (6) 6
asymmetric catalysis (6) 6
enantioselective synthesis (6) 6
ketones (6) 6
chemistry, applied (5) 5
mannich reaction (5) 5
cascade reaction (4) 4
catalysts (4) 4
cinchona alkaloids (4) 4
enantio-selectivity (4) 4
enantioselektivität (4) 4
gamma-butenolides (4) 4
nitroolefins (4) 4
reactivity (4) 4
synthesis (4) 4
aldehydes (3) 3
allyl aryl ketones (3) 3
asymmetry (3) 3
carbon (3) 3
cyclization cascade reaction (3) 3
diels-alder reaction (3) 3
index medicus (3) 3
organic chemistry (3) 3
oxindoles (3) 3
stereoselective-synthesis (3) 3
thiourea (3) 3
vinylogous michael addition (3) 3
vinylogy (3) 3
3-component reactions (2) 2
access (2) 2
acid catalysis (2) 2
acrylates (2) 2
activation (2) 2
adducts (2) 2
aldehyd (2) 2
aldol-reaction (2) 2
aldolreaktion (2) 2
allylic alkylation (2) 2
alpha,beta-unsaturated aldehydes (2) 2
amide (2) 2
amides (2) 2
amines (2) 2
asymmetric-catalysis (2) 2
asymmetrische katalyse (2) 2
bifunctional organocatalysts (2) 2
bronsted bases (2) 2
brønsted bases (2) 2
carbene insertion (2) 2
cascade (2) 2
cascade chemical reactions (2) 2
complex (2) 2
conjugate addition (2) 2
cooperative catalysis (2) 2
cyclization (2) 2
diels-alder reactions (2) 2
doppelbindung (2) 2
double-bonds (2) 2
enantiomers (2) 2
enantioselective construction (2) 2
enantioselective cyanosilylation (2) 2
enantioselectivity (2) 2
functionalisation (2) 2
funktionalisierung (2) 2
h bond functionalization (2) 2
kohlenstoff (2) 2
lewis-base activation (2) 2
mannich-type reactions (2) 2
mukaiyama aldol reactions (2) 2
multicomponent reactions (2) 2
nitrones (2) 2
optical activity (2) 2
organic compounds (2) 2
quaternary stereocenters (2) 2
recycle waste (2) 2
regioselectivity (2) 2
regioselektivität (2) 2
remote functionalization (2) 2
review (2) 2
spirocyclic oxindoles (2) 2
stereoselectivity (2) 2
substituted butenolides (2) 2
thioharnstoff (2) 2
unsaturated butyrolactones (2) 2
vinylogous aldol reaction (2) 2
vinylogous michael reaction (2) 2
vinylogous reaction (2) 2
1,2-dicarbonyl compounds (1) 1
1,3-dipolar cycloadditions (1) 1
2-oxindole (1) 1
2‐oxindole (1) 1
3+2 cycloaddition (1) 1
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1. Full Text Asymmetric Vinylogous Aldol Reaction of α‐ketoesters with 3‐alkylidene oxindoles
by Kumar, Krishna and Jaiswal, Manish K and Singh, Ravi P
Advanced Synthesis & Catalysis, ISSN 1615-4150, 12/2017, Volume 359, Issue 23, pp. 4136 - 4140
An efficient enantioselective vinylogous aldol reaction of 3‐alkylidene oxindoles with α‐ketoesters by a bifunctional thiourea catalyst derived from cinchona... 
Aldol reaction | α-Ketoesters | Vinylogous reaction | Organocatalysis | 3-Alkylidene oxindoles | ORGANIC-SYNTHESIS | CATALYSIS | ACTIVATION | alpha-Ketoesters | MUKAIYAMA 1,6-MICHAEL/MICHAEL ADDITION | CHEMISTRY, ORGANIC | MICHAEL ADDITION | MANNICH REACTION | ALPHA,BETA-UNSATURATED GAMMA-BUTYROLACTAM | UNSATURATED BUTYROLACTONES | LEWIS-ACIDS | CHEMISTRY, APPLIED | CONJUGATE ADDITION
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2. Full Text Enantioselective Vinylogous Michael/Cyclization Cascade Reaction of Acyclic β,γ‐Unsaturated Amides with Isatylidene Malononitriles: Asymmetric Construction of Spirocyclic Oxindoles
by Li, Tian‐Ze and Xie, Jin and Jiang, Yu and Sha, Feng and Wu, Xin‐Yan
Advanced Synthesis & Catalysis, ISSN 1615-4150, 11/2015, Volume 357, Issue 16‐17, pp. 3507 - 3511
The first direct and enantioselective vinylogous Michael/cyclization cascade reaction between acyclic β,γ‐unsaturated amides and isatylidene malononitriles has... 
spirocyclic oxindoles | enantioselective organocatalysis | cascade reaction | cyclization | vinylogous Michael reaction | CATALYSIS | BAYLIS-HILLMAN REACTION | CHEMISTRY, ORGANIC | ALDEHYDES | BUTENOLIDE | PYRAZOLEAMIDES | MICHAEL ADDITION | ALPHA,BETA-UNSATURATED GAMMA-BUTYROLACTAM | spirocyclic oxindoles: vinylogous Michael reaction | CHEMISTRY, APPLIED | 3-ALKYLIDENE OXINDOLES | CONJUGATE ADDITION | ACRYLATES | Construction | Synthesis | Asymmetry | Optical activity | Amides | Malononitrile | Cascade chemical reactions | Catalysis
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3. Full Text Non-covalent organocatalyzed domino reactions involving oxindoles: Recent advances
by Gasperi, Tecla and Miceli, Martina and Campagne, Jean-Marc and De Figueiredo, Renata Marcia
Molecules, ISSN 1420-3049, 10/2017, Volume 22, Issue 10, p. 1636
The ubiquitous presence of spirooxindole architectures with several functionalities and stereogenic centers in bioactive molecules has been appealing for the... 
Domino | Chiral building blocks | Hydrogen-bonding | Enantioselectivity | Non-covalent organocatalysis | Spirooxindole derivatives | Tandem | Cascade | enantioselectivity | ENANTIOSELECTIVE SYNTHESIS | cascade | BIOCHEMISTRY & MOLECULAR BIOLOGY | 3-ISOTHIOCYANATO OXINDOLES | CONTIGUOUS STEREOCENTERS | SPIROCYCLIC OXINDOLES | QUATERNARY CENTERS | CHEMISTRY, MULTIDISCIPLINARY | spirooxindole derivatives | hydrogen-bonding | MICHAEL-CYCLIZATION | MULTIPLE STEREOCENTERS | tandem | non-covalent organocatalysis | MICHAEL/CYCLIZATION CASCADE REACTION | domino | chiral building blocks | 3-ALKYLIDENE OXINDOLES | CATALYTIC ASYMMETRIC-SYNTHESIS | Chemistry Techniques, Synthetic | Hydrogen Bonding | Stereoisomerism | Spiro Compounds - chemical synthesis | Indoles - chemical synthesis | Molecular Structure | Catalysis | Indoles - chemistry | Cinchona Alkaloids - chemistry | Spiro Compounds - chemistry | State-of-the-art reviews | Cascade chemical reactions | Organic chemistry | Chemical Sciences
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4. Full Text Asymmetric vinylogous aldol addition of alkylidene oxindoles on trifluoromethyl-α,β-unsaturated ketones
by Crotti, Simone and Belletti, Giada and Di Iorio, Nicola and Marotta, Emanuela and Mazzanti, Andrea and Righi, Paolo and Bencivenni, Giorgio
RSC Advances, ISSN 2046-2069, 2018, Volume 8, Issue 58, pp. 33451 - 33458
A novel vinylogous aldol addition of alkylidene oxindole with 1-trifluoromethyl-3-alkylidene-propan-2-ones is presented. The reaction, catalyzed by a... 
CINCHONA ALKALOIDS | CATALYSIS | TERTIARY ALCOHOLS | DIELS-ALDER REACTIONS | CONSTRUCTION | CARBONYL-COMPOUNDS | FLUORINATION | 3-ALKYLIDENE OXINDOLES | TRIFLUOROMETHYL KETONES | CHEMISTRY, MULTIDISCIPLINARY | MICHAEL ADDITION
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5. Full Text A facile and convenient synthesis of 3‐alkylidene‐oxindoles bearing tetrahydropyrazine scaffold under catalyst‐free conditions
by Matloubi Moghaddam, Firouz and Moafi, Atiyeh
Heteroatom Chemistry, ISSN 1042-7163, 03/2018, Volume 29, Issue 2, pp. e21416 - n/a
A facile and efficient synthesis of 2‐oxindole derivatives bearing tetrahydropyrazine scaffold has been developed. Using water as solvent without any... 
pyrazine | catalyst free | water | 2‐oxindole | 3‐alkylidene‐oxindoles | 3-alkylidene-oxindoles | 2-oxindole | INHIBITORS | OXINDOLE | CHEMISTRY, MULTIDISCIPLINARY | ACCESS
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6. Full Text Highly enantioselective sequential vinylogous aldol reaction/transesterification of methyl-substituted olefinic butyrolactones with isatins for the construction of chiral spirocyclic oxindole-dihydropyranones
by Wang, ZH and Zhang, XY and Lei, CW and Zhao, JQ and You, Y and Yuan, WC
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 08/2019, Volume 55, Issue 63, pp. 9327 - 9330
A highly stereoselective sequential vinylogous aldol reaction/transesterification of methyl-substituted olefinic butyrolactones and isatins was developed. With... 
MANNICH REACTION | KETONES | ALPHA,BETA-UNSATURATED GAMMA-BUTYROLACTAM | ASYMMETRIC-SYNTHESIS | CYCLIZATION CASCADE REACTION | DIELS-ALDER REACTION | 3-ALKYLIDENE OXINDOLES | CHEMISTRY, MULTIDISCIPLINARY | 3+2 CYCLOADDITION | ACCESS | MICHAEL ADDITION
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7. Full Text (E)‐3‐(Alkoxycarbonyl‐2‐Alkyliden)‐2‐Oxindoles: Multidentate Pronucleophiles for the Organocatalytic, Vinylogous Michael Addition to Nitroolefins
by Curti, Claudio and Battistini, Lucia and Sartori, Andrea and Rassu, Gloria and Pelosi, Giorgio and Lombardo, Marco and Zanardi, Franca
Advanced Synthesis & Catalysis, ISSN 1615-4150, 02/2018, Volume 360, Issue 4, pp. 711 - 721
We introduce 3‐(alkoxycarbonyl‐2‐alkyliden)‐2‐oxindoles as pronucleophilic donors in the direct, vinylogous Michael addition to nitroolefins orchestrated by a... 
organocatalysis | oxindoles | density functional calculations | asymmetric catalysis | vinylogous Michael reaction | REACTIVITY | CHEMISTRY, ORGANIC | 3-(2-OXOINDOLIN-3-YLIDENE)BUTANOATES | ASYMMETRIC TRANSFORMATIONS | MUKAIYAMA ALDOL REACTIONS | THIOUREA ORGANOCATALYSTS | CONSTRUCTION | CHEMISTRY | STEREOSELECTIVE-SYNTHESIS | CHEMISTRY, APPLIED | 3-ALKYLIDENE OXINDOLES | 1,2-DICARBONYL COMPOUNDS | Proline | Catalysis | Catalysts | Adducts
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8. Full Text Asymmetric Synthesis of Spirooxindole δ‐Lactones with Vicinal Tertiary and Quaternary Stereocenters via Regio‐, Diastereo‐, and Enantioselective Organocatalytic Vinylogous Aldol‐cyclization Cascade Reaction
by Han, Jeng‐Liang and Tsai, You‐Da and Chang, Chia‐Hao
Advanced Synthesis & Catalysis, ISSN 1615-4150, 11/2017, Volume 359, Issue 22, pp. 4043 - 4049
A highly region‐, diastereo‐, and enantioselective organocatalytic vinylogous aldol‐cyclization cascade reaction of prochiral 3‐akylidene oxindoles to isatins... 
Organocatalysis | 3-Akylidene oxindoles | Spirooxindole δ-lactones | Vinylogous aldol−cyclization | CATALYSIS | 1,3-DIPOLAR CYCLOADDITIONS | ACTIVATION | SPIROCYCLIC OXINDOLE-DIHYDROPYRANONES | THIOUREA | ALLYLIC ALKYLATION | CHEMISTRY, ORGANIC | MICHAEL ADDITION | Spirooxindole delta-lactones | Vinylogous aldol - cyclization | ISATINS | FACILE CONSTRUCTION | CHEMISTRY, APPLIED | 3-ALKYLIDENE OXINDOLES
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9. Full Text A vinylogous Michael addition-triggered quadruple cascade reaction for the enantioselective generation of multiple quaternary stereocenters
by Yang, Shu-Mei and Karanam, Praneeth and Wang, Min and Jang, Yeong-Jiunn and Yeh, Yu-Sheng and Tseng, Ping-Yao and Ganapuram, Madhusudhan Reddy and Liou, Yan-Cheng and Lin, Wenwei
Chemical Communications, ISSN 1359-7345, 2019, Volume 55, Issue 10, pp. 1398 - 1401
An efficient organocatalytic quadruple cascade reaction resulting in spiroxindole scaffolds bearing five quaternary stereocenters is reported. The complex... 
ASYMMETRIC-SYNTHESIS | 3-ALKYLIDENE OXINDOLES | PRODUCTS | CHEMISTRY, MULTIDISCIPLINARY | CONSTRUCTION | ACRYLATES
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10. Full Text Enantioselective Synthesis of Trifluoromethyl α,β-Unsaturated δ‑Lactones via Vinylogous Aldol-Lactonization Cascade
by Crotti, Simone and Di Iorio, Nicola and Mazzanti, Andrea and Righi, Paolo and Bencivenni, Giorgio
The Journal of Organic Chemistry, ISSN 0022-3263, 10/2018, Volume 83, Issue 20, pp. 12440 - 12448
The novel vinylogous aldol-lactonization cascade of alkylidene oxindole with trifluoromethyl ketones is presented. The reaction, catalyzed by a bifunctional... 
FUNCTIONALIZATION | KETONES | ASYMMETRIC-SYNTHESIS | DISCODERMOLIDE | CONSTRUCTION | REACTIVITY | CHEMISTRY, ORGANIC | REGIO | 3-ALKYLIDENE OXINDOLES | MICHAEL ADDITION | ENALS
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11. Full Text Bismuth Triflate-Catalyzed Vinylogous Nucleophilic 1,6-Conjugate Addition of para-Quinone Methides with 3‑Propenyl-2-silyloxyindoles
by Xie, Kai-Xue and Zhang, Zhi-Pei and Li, Xin
Organic Letters, ISSN 1523-7060, 12/2017, Volume 19, Issue 24, pp. 6708 - 6711
A highly diastereoselective vinylogous nucleophilic 1,6-conjugate addition reaction of para-quinone methides with 3-propenyl-2-silyloxyindoles by a bismuth... 
DECONJUGATED BUTENOLIDES | ASYMMETRIC-SYNTHESIS | DIELS-ALDER REACTIONS | PHOSPHORIC-ACID | MANNICH REACTIONS | NITROOLEFINS | CHEMISTRY, ORGANIC | STEREOGENIC CENTERS | 3-ALKYLIDENE OXINDOLES | ENANTIOSELECTIVE CONSTRUCTION | MICHAEL ADDITION
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12. Full Text Pushing the Boundaries of Vinylogous Reactivity: Catalytic Enantioselective Mukaiyama Aldol Reactions of Highly Unsaturated 2‐Silyloxyindoles
by Curti, Claudio and Sartori, Andrea and Battistini, Lucia and Brindani, Nicoletta and Rassu, Gloria and Pelosi, Giorgio and Lodola, Alessio and Mor, Marco and Casiraghi, Giovanni and Zanardi, Franca
Chemistry – A European Journal, ISSN 0947-6539, 04/2015, Volume 21, Issue 17, pp. 6433 - 6442
The first example of catalytic, enantioselective hypervinylogous Mukaiyama aldol reaction (HVMAR) involving multiply unsaturated 2‐silyloxyindoles is reported.... 
oxindoles | aldol reaction | amides | vinylogy | asymmetric synthesis | Amides | Oxindoles | Aldol reaction | Asymmetric synthesis | Vinylogy | ACIDS | LEWIS-BASE ACTIVATION | 3-ALKYLIDENE OXINDOLES | CHEMISTRY, MULTIDISCIPLINARY | MICHAEL ADDITION | Synthesis | Enantiomers | Aldehydes | Analysis | Organic compounds | Catalysts | Pushing | Olefins | Unsaturated | Selectivity | Boundaries | Catalysis
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13. Full Text Asymmetric sequential Au(i)/chiral tertiary amine catalysis: an enone-formation/cyanosilylation sequence to synthesize optically active 3-alkenyloxindoles from diazooxindoles
by Zhao, Yu-Lei and Cao, Zhong-Yan and Zeng, Xing-Ping and Shi, Jia-Meng and Yu, Yi-Hua and Zhou, Jian
Chemical communications (Cambridge, England), ISSN 1359-7345, 03/2016, Volume 52, Issue 20, pp. 3943 - 3946
An unprecedented sequential gold-catalyzed enone-formation and bifunctional tertiary amine mediated asymmetric cyanosilylation reaction is developed, allowing... 
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14. Full Text Highly Enantioselective Construction of Hajos–Wiechert Ketone Skeletons via an Organocatalytic Vinylogous Michael/Stetter Relay Sequence
by Jia, Zhi-Long and Wang, Yao and Zhao, Chuan-Gang and Zhang, Xiao-Hai and Xu, Peng-Fei
Organic Letters, ISSN 1523-7060, 04/2017, Volume 19, Issue 8, pp. 2130 - 2133
A highly enantioselective supramolecular iminium-catalyzed vinylogous Michael addition/Stetter relay sequence has been developed. This transformation provided... 
COMPLEX | ASYMMETRIC-SYNTHESIS | ALDOL REACTION | IMINIUM CATALYSIS | CHEMISTRY, ORGANIC | CASCADE | APLYKURODINONE-1 | 3-ALKYLIDENE OXINDOLES | CYCLOPENTENONES | DERIVATIVES | MICHAEL ADDITION
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15. Full Text Asymmetric sequential Au(i)/chiral tertiary amine catalysis: An enone-formation/cyanosilylation sequence to synthesize optically active 3-alkenyloxindoles from diazooxindoles
by Zhao, Yu-Lei and Cao, Zhong-Yan and Zeng, Xing-Ping and Shi, Jia-Meng and Yu, Yi-Hua and Zhou, Jian
Chemical Communications, ISSN 1359-7345, 2016, Volume 52, Issue 20, pp. 3943 - 3946
An unprecedented sequential gold-catalyzed enone-formation and bifunctional tertiary amine mediated asymmetric cyanosilylation reaction is developed, allowing... 
MULTICOMPONENT REACTIONS | COOPERATIVE CATALYSIS | ACID CATALYSIS | CARBENE INSERTION | VINYLOGOUS MICHAEL ADDITION | H BOND FUNCTIONALIZATION | 3-ALKYLIDENE OXINDOLES | ENANTIOSELECTIVE CYANOSILYLATION | 3-COMPONENT REACTIONS | RECYCLE WASTE | CHEMISTRY, MULTIDISCIPLINARY | Synthesis (chemistry) | Amines | Asymmetry | Optical activity | Cyanides | Furans | Catalysis
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16. Full Text Organocatalytic Asymmetric Vinylogous Michael Addition of 3‐(2‐Oxoindolin‐3‐ylidene)butanoates to Nitroalkenes Catalyzed by a Bifunctional Cinchona‐Based Squaramide
by Zheng, Chen and Wang, Hai‐Feng and Chen, Wei‐Qi and Chen, Wen‐Xue and Chen, Fen‐Er
Asian Journal of Organic Chemistry, ISSN 2193-5807, 07/2015, Volume 4, Issue 7, pp. 619 - 621
The highly efficient asymmetric vinylogous Michael addition of 3‐(2‐oxoindolin‐3‐ylidene)butanoates to nitroalkenes, catalyzed by a cinchona‐based squaramide,... 
squaramides | Michael addition | oxindoles | Cinchona alkaloids | alkenes | Oxindoles | Squaramides | Alkenes | ENANTIOSELECTIVE SYNTHESIS | SUBSTITUTED BUTENOLIDES | CHEMISTRY, ORGANIC | MALONONITRILES | CASCADE REACTION | ALPHA,BETA-UNSATURATED GAMMA-BUTYROLACTAM | MALEIMIDES | ALDOL REACTION | CONSTRUCTION | NITROOLEFINS | 3-ALKYLIDENE OXINDOLES
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17. Full Text Organocatalytic Enantioselective Synthesis of Tetrahydrofluoren-9-ones via Vinylogous Michael Addition/Henry Reaction Cascade of 1,3-Indandione-Derived Pronucleophiles
by Möhlmann, Lennart and Chang, Geng-Hua and Madhusudhan Reddy, G and Lee, Chia-Jui and Lin, Wenwei
Organic Letters, ISSN 1523-7060, 02/2016, Volume 18, Issue 4, pp. 688 - 691
An unprecedented organocatalytic enantioselective vinylogous Michael addition/Henry cyclization cascade is presented for the synthesis of highly substituted... 
CINCHONA ALKALOIDS | ALPHA,BETA-UNSATURATED GAMMA-BUTYROLACTAM | ALPHA-HYDROXY ESTERS | SUBSTITUTED BUTENOLIDES | QUATERNARY STEREOCENTERS | NITROOLEFINS | CHEMISTRY, ORGANIC | STEREOSELECTIVE-SYNTHESIS | 3-ALKYLIDENE OXINDOLES | ASYMMETRIC HENRY REACTION | BIFUNCTIONAL ORGANOCATALYSTS
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