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Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/2002, Volume 22, Issue 10, pp. 1567 - 1572
Objective-Atherosclerosis and restenosis after vascular injury are both characterized by endothelial dysfunction, apoptosis, inappropriate endothelialization,... 
Neointima | Vascular injury | 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition | Endothelial progenitor cells | Endothelium | endothelium | neointima | MOBILIZATION | ANGIOBLASTS | ATHEROSCLEROSIS | MUSCLE | ISCHEMIC MYOCARDIUM | TRANSPLANTATION | HEART | vascular injury | IMPLANTATION | endothelial progenitor cells | ENDOTHELIAL-CELLS | RESTENOSIS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Green Fluorescent Proteins | Bone Marrow Cells - physiology | Endothelium, Vascular - drug effects | Male | Endothelium, Vascular - enzymology | Endothelium, Vascular - physiology | Fluorobenzenes - pharmacology | Stem Cell Transplantation | Bone Marrow Cells - virology | Luminescent Proteins - analysis | Pyrimidines | Retroviridae - genetics | Bone Marrow Transplantation | Hematopoietic Stem Cells - physiology | Bone Marrow Cells - drug effects | Hematopoietic Stem Cells - virology | Carotid Artery Injuries - metabolism | Disease Models, Animal | Hematopoietic Stem Cells - drug effects | Cell Line | Gene Transfer Techniques | Mice, Inbred C57BL | Tunica Intima - physiology | Rosuvastatin Calcium | Tunica Intima - enzymology | Carotid Artery Injuries - therapy | Tunica Intima - drug effects | Animals | Carotid Artery Injuries - enzymology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Sulfonamides | Luminescent Proteins - genetics | Mice | Index Medicus
Journal Article
Rheumatology (United Kingdom), ISSN 1462-0324, 2017, Volume 56, Issue 2, pp. 287 - 293
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e60581 - e60581
Most conditions detected by expanded newborn screening result from deficiency of one of the enzymes that degrade acyl-coenzyme A (CoA) esters in mitochondria.... 
RAT-LIVER | 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE | INHIBITION | METABOLISM | COENZYME-A PROFILES | PYRUVATE-CARBOXYLASE | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | DEFICIENT MICE | LYASE HL | SPECTROMETRY | Hyperammonemia - metabolism | Humans | Hypoglycemia - mortality | Acetyl Coenzyme A - genetics | Acyl Coenzyme A - genetics | Hepatocytes - metabolism | Mitochondria - ultrastructure | Genes, Lethal | Mitochondria - genetics | Pyruvic Acid - metabolism | Hyperammonemia - mortality | Gene Order | Hypoglycemia - genetics | Gene Targeting | Hyperammonemia - genetics | Leucine - metabolism | Carbon Dioxide - metabolism | Liver - metabolism | Acyl Coenzyme A - deficiency | Metabolome | Mitochondria - metabolism | Gene Knockout Techniques | Hypoglycemia - metabolism | Acetyl Coenzyme A - metabolism | Mice, Knockout | Peroxisomes | Phenotype | Animals | Gluconeogenesis - genetics | Metabolic Networks and Pathways | Models, Biological | Lethargy | Mice | Enzymes | Esters | Metabolites | Glutamate | Analysis | Organic acids | Glutamic acid | Inborn errors of metabolism | Ketogenesis | Laboratories | Liver | Pyruvic acid | Leucine | Defects | Degradation | Proteins | Mitochondria | Rodents | Coenzyme A | Chemical synthesis | Gluconeogenesis | Urine | Medical research | Incubation | Hyperammonemia | Hypoglycemia | Metabolism | Fatty acids | Studies | Urea | Hepatocytes | Carboxylation | Scientific imaging | Mass spectrometry | Index Medicus | Acetyl Coenzyme A | Life Sciences | Hépatology and Gastroenterology | Carbon Dioxide | Human health and pathology | Pyruvic Acid | Acyl Coenzyme A
Journal Article
06/2012
The endothelium plays an essential role in the regulation of vascular homeostasis and a state of endothelial dysfunction, which develops in the presence of... 
Endothelial Function | Flow-mediated dilation | 0419 | Statin | 3-hydroxy-3-methylglutaryl coenzyme A Reductase Inhibitors
Dissertation
Neuromuscular Disorders, ISSN 0960-8966, 07/2019, Volume 29, Issue 7, pp. 543 - 548
Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase myopathy is less common in children but has been associated with more favorable prognosis than adult... 
Immune mediated necrotizing myopathy | IMNM | HMGCR | Reducing body myopathy | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | FHL1 | AUTOANTIBODIES | NECROTIZING MYOPATHY | MYOSITIS | NEUROSCIENCES | CLINICAL NEUROLOGY | FEATURES | BODIES | Viral antibodies | Enzymes | Thiols | Creatine kinase | Immunotherapy | Antibodies | Creatine | Index Medicus
Journal Article
Industrial Crops & Products, ISSN 0926-6690, 04/2013, Volume 46, pp. 15 - 24
Journal Article
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 11/2003, Volume 93, Issue 10, pp. 948 - 956
Journal Article
Circulation Research: Journal of The American Heart Association, ISSN 0009-7330, 07/2002, Volume 91, Issue 2, pp. 143 - 150
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 02/2016, Volume 5, Issue 2, p. n/a
Background-Despite the high prevalence of chronic venous insufficiency and varicose veins in the Western world, suitable pharmaceutical therapies for these... 
smooth muscle cells | veins | activator protein 1 | 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors | vascular remodeling | Vascular remodeling | Veins | Smooth muscle cells | 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors | Activator protein 1 | CARDIAC & CARDIOVASCULAR SYSTEMS | VIVO | CHRONIC VENOUS INSUFFICIENCY | PROLIFERATION | RANDOMIZED CONTROLLED-TRIAL | DECOY OLIGODEOXYNUCLEOTIDES | IN-VITRO | MATRIX-METALLOPROTEINASE-9 | SMOOTH-MUSCLE-CELLS | ACTIVATOR PROTEIN-1 | EXPRESSION | Muscle, Smooth, Vascular - metabolism | Transcription Factor AP-1 - genetics | Humans | Middle Aged | Varicose Veins - prevention & control | Myocytes, Smooth Muscle - pathology | Male | Transcription Factor AP-1 - metabolism | Case-Control Studies | Dose-Response Relationship, Drug | Time Factors | Varicose Veins - metabolism | Female | Chemokine CCL2 - metabolism | Vascular Remodeling - drug effects | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Rosuvastatin Calcium - pharmacology | Cells, Cultured | Varicose Veins - pathology | Atorvastatin - pharmacology | Veins - drug effects | Muscle, Smooth, Vascular - pathology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Signal Transduction - drug effects | Veins - metabolism | Cell Proliferation - drug effects | Mice | Veins - pathology | Index Medicus
Journal Article
by Zhao, Q and Li, R and Chen, X and Yang, Q and Li, J
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY, ISSN 1516-8913, 2018, Volume 61
The enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR; EC1.1.1.34) catalyzes the first committed step of isoprenoids biosynthesis in Mevalonate (MVA)... 
3-Hydroxy-3-methylglutaryl-CoA reductases | Prokaryotic expression | Expression pattern | Fritillaria cirrhosa | BIOLOGY | Molecular cloning | ALKALOIDS
Journal Article