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Journal Article
Cancer Research, ISSN 0008-5472, 12/2012, Volume 72, Issue 23, pp. 6142 - 6152
Androgen receptor (AR) signaling persists in castration-resistant prostate carcinomas (CRPC), because of several mechanisms that include increased AR... 
STEROIDOGENESIS | SELECTIVE INHIBITOR | DIHYDROTESTOSTERONE LEVELS | ONCOLOGY | ABIRATERONE ACETATE | RECEPTOR | INCREASED SURVIVAL | CYP17 INHIBITOR | CASTRATION | I CLINICAL-TRIAL | HORMONAL-THERAPY | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Immunohistochemistry | Neoplasms, Hormone-Dependent - metabolism | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Androgens - biosynthesis | Data Mining | Male | Hydroxyprostaglandin Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - genetics | RNA, Messenger - biosynthesis | Neoplasm Metastasis | Prostatic Neoplasms - genetics | Cytochrome P-450 CYP3A - genetics | Receptors, Androgen - biosynthesis | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - enzymology | Cytochrome P-450 CYP3A - biosynthesis | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Receptors, Androgen - genetics | Aldo-Keto Reductase Family 1 Member C3 | Cytochrome P-450 CYP3A - metabolism | Neoplasms, Hormone-Dependent - pathology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - biosynthesis | Cell Line, Tumor | Prostatic Neoplasms - enzymology | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | Index Medicus | abiraterone | androgen synthesis | testosterone | dihydrotestosterone | AKR1C3 | CYP17 | MDV3100 (enzalutamide) | Prostate cancer
Journal Article
Oncology Reports, ISSN 1021-335X, 03/2017, Volume 37, Issue 4, pp. 2025 - 2032
Resistance to anticancer medications often leads to poor outcomes. The present study explored an effective approach for enhancing chemotherapy targeted against... 
aldo-keto reductase | cisplatin | mefenamic acid | 5-FU | Cisplatin, 5-FU | Mefenamic acid | Aldo-keto reductase | HUMAN OVARIAN | AKR1C3 | CISPLATIN RESISTANCE | TUMOR-CELLS | CHEMOTHERAPY | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | LUNG-CANCER | CARCINOMA CELL-LINE | ONCOLOGY | SUPERFAMILY | EXPRESSION | 20-Hydroxysteroid Dehydrogenases - biosynthesis | 3-Hydroxysteroid Dehydrogenases - biosynthesis | 20-Hydroxysteroid Dehydrogenases - genetics | Humans | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxysteroid Dehydrogenases - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Cisplatin - administration & dosage | Neoplasms - drug therapy | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Fluorouracil - administration & dosage | 20-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Neoplasms - genetics | Aldo-Keto Reductase Family 1 Member C3 | Mefenamic Acid - administration & dosage | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Hydroxysteroid Dehydrogenases - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | HeLa Cells | Oxidoreductases | 3-Hydroxysteroid Dehydrogenases - genetics | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Patient outcomes | Genetic aspects | Drug resistance | Gene expression | Health aspects | Methods | Cancer | Studies | Enzymes | Oxidative stress | Chemotherapy | Genes | Rodents | Prostate | Experiments | Cancer therapies | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus
Journal Article
BMC Cancer, ISSN 1471-2407, 08/2012, Volume 12, Issue 1, pp. 381 - 381
Background: Since proteins involved in chemotherapy drug pharmacokinetics and pharmacodynamics have a strong impact on the uptake, metabolism, and efflux of... 
Resistance | Lysosome | Cytotoxicity | Drug localization | Aldo-keto reductases | Pharmacokinetics | Doxorubicin | DNA-binding | Gene profiling | PharmGKB | BIOLOGICAL PATHWAYS | MINIMUM INFORMATION | CARBONYL REDUCTASE | CELL-LINES | BREAST-CANCER | DRUG TRANSPORTERS | ONCOLOGY | HUMAN LIVER | MULTIDRUG-RESISTANCE | ANTHRACYCLINES | MICROARRAY DATA | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Aldehyde Reductase - genetics | Oligonucleotide Array Sequence Analysis | Cyclosporine - pharmacology | DNA, Neoplasm - metabolism | Humans | Drug Resistance, Neoplasm | Gene Expression Profiling | Hydroxyprostaglandin Dehydrogenases - metabolism | Breast Neoplasms - metabolism | Cell Nucleus - metabolism | MCF-7 Cells | Doxorubicin - analogs & derivatives | 3-Hydroxysteroid Dehydrogenases - metabolism | Aldehyde Reductase - metabolism | 20-Hydroxysteroid Dehydrogenases - biosynthesis | 20-Hydroxysteroid Dehydrogenases - genetics | Intracellular Space - drug effects | Aldehyde Reductase - biosynthesis | Hydroxyprostaglandin Dehydrogenases - biosynthesis | 20-Hydroxysteroid Dehydrogenases - metabolism | Breast Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Hydroxyprostaglandin Dehydrogenases - genetics | Cholic Acids - pharmacology | Breast Neoplasms - genetics | Aldo-Keto Reductase Family 1 Member C3 | Intracellular Space - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Cell Nucleus - drug effects | Doxorubicin - pharmacology | Aldose reductase | Physiological aspects | Research | Drug resistance | DNA-ligand interactions | Anthracyclines | Genes | Genomics | Genomes | Proteins | Chemotherapy | Metabolites | Analysis | DNA | Genetic research | Cancer | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 06/2015, Volume 21, Issue 11, pp. 2569 - 2579
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 2011, Volume 191, Issue 1, pp. 239 - 249
Aldo-keto reductases (AKRs) play central roles in the reductive metabolism of endogenous signaling molecules and in the detoxification of xenobiotics.... 
Aldo-keto reductase | Proteasome inhibitors | Colon cells | RETINOID METABOLISM | DEHYDROGENASE ISOFORMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KAPPA-B | STEROID-HORMONE | BREAST-CANCER | LUNG-CANCER | NRF2 | ALDO-KETO REDUCTASES | GENE-EXPRESSION | REVEALS ROLES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Aldehyde Reductase - genetics | Maleates - pharmacology | Humans | NF-E2-Related Factor 2 - agonists | Alcohol Oxidoreductases - biosynthesis | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Alcohol Oxidoreductases - genetics | Dose-Response Relationship, Drug | Protease Inhibitors - pharmacology | Drug Interactions | Time Factors | Enzyme Induction - drug effects | Thiocyanates - pharmacology | 3-Hydroxysteroid Dehydrogenases - metabolism | Aldehyde Reductase - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Isothiocyanates | 20-Hydroxysteroid Dehydrogenases - biosynthesis | 20-Hydroxysteroid Dehydrogenases - genetics | Bortezomib | RNA, Messenger - genetics | Aldehyde Reductase - biosynthesis | Alcohol Oxidoreductases - metabolism | Hydroxyprostaglandin Dehydrogenases - biosynthesis | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | HT29 Cells | Leupeptins - pharmacology | Aldo-Keto Reductase Family 1 Member C3 | 3-Hydroxysteroid Dehydrogenases - genetics | Proteasome Inhibitors | Pyrazines - pharmacology | Boronic Acids - pharmacology | Phosphates | Care and treatment | Oncology, Experimental | Cytochrome P-450 | Research | Gene expression | Monosaccharides | Antioxidants | Colon cancer | Messenger RNA | Ligases | Physiological aspects | Xenobiotics | Sugars | Cancer | Index Medicus
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 218 - 225
► Genes encoding P4 metabolizing enzymes are expressed in Z-12 endometriotic cells. ► Treatments with progesterone and dydrogesterone decrease expression. ►... 
Dydrogesterone | Peritoneal endometriosis | Medroxyprogesterone acetate | Pre-receptor metabolism | Progesterone resistance | Dienogest | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Epithelial Cells - metabolism | Endometriosis - genetics | Epithelial Cells - drug effects | Humans | Endometrium - drug effects | Medroxyprogesterone Acetate - pharmacology | Receptors, Progesterone - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Receptors, Progesterone - metabolism | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Hydroxysteroid Dehydrogenases - biosynthesis | Hydroxysteroid Dehydrogenases - metabolism | Membrane Proteins - metabolism | Progesterone - pharmacology | Endometrium - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Membrane Proteins - genetics | RNA, Messenger - genetics | Cells, Cultured | Nandrolone - analogs & derivatives | Progestins - pharmacology | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Down-Regulation - drug effects | Down-Regulation - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Membrane Proteins - biosynthesis | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | Nandrolone - pharmacology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - biosynthesis | Dydrogesterone - pharmacology | Endometriosis - metabolism | Estradiol Dehydrogenases - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Receptors, Progesterone - biosynthesis | Medroxyprogesterone | Physiological aspects | Progesterone | RNA | Index Medicus
Journal Article
Hormones and Behavior, ISSN 0018-506X, 2010, Volume 57, Issue 4, pp. 381 - 389
Journal Article
Toxicological Sciences, ISSN 1096-6080, 7/2007, Volume 98, Issue 1, pp. 206 - 215
Perfluorododecanoic acid (PFDoA, C12), a synthetic perfluorinated chemical containing 12 carbons, has broad industrial applications and has been detected in... 
Testis | Steroidogenesis gene | Testosterone | Ultrastructure | Perfluorododecanoic acid | SPRAGUE-DAWLEY RATS | PERFLUORODECANOIC ACID | SR-BI | testosterone | LEYDIG-CELLS | PERFLUORINATED FATTY-ACIDS | testis | ultrastructure | AMMONIUM PERFLUOROOCTANOATE | CARBON-CHAIN LENGTH | ACUTE REGULATORY PROTEIN | steroidogenesis gene | perfluorododecanoic acid | PEROXISOME PROLIFERATION | LIPOPROTEIN RECEPTOR | TOXICOLOGY | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Estradiol - blood | Testis - metabolism | CD36 Antigens - genetics | Gene Expression - drug effects | Receptors, LH - biosynthesis | Cholesterol - blood | Cholesterol Side-Chain Cleavage Enzyme - biosynthesis | Body Weight - drug effects | Male | Lauric Acids - toxicity | Testis - drug effects | Cholesterol Side-Chain Cleavage Enzyme - genetics | RNA, Messenger - biosynthesis | Follicle Stimulating Hormone - blood | Testosterone - blood | Luteinizing Hormone - blood | Rats | Testosterone - biosynthesis | Testis - ultrastructure | Cholesterol - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | CD36 Antigens - biosynthesis | Organ Size - drug effects | 17-Hydroxysteroid Dehydrogenases - biosynthesis | Animals | 17-Hydroxysteroid Dehydrogenases - genetics | Steroid 17-alpha-Hydroxylase - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | Steroid 17-alpha-Hydroxylase - biosynthesis | Index Medicus
Journal Article
Journal Article
Journal Article
Toxicological Sciences, ISSN 1096-6080, 09/2004, Volume 81, Issue 1, pp. 60 - 68
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 07/2017, Volume 326, pp. 7 - 14
Journal Article